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Journal Articles

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD

Qizhen Shi, Scot A. Fahs, Jeremy G. Mattson, Hongyin Yu, Crystal L. Perry, Patricia A. Morateck, Jocelyn A. Schroeder, Jessica Rapten, Hartmut Weiler, Robert R. Montgomery
Journal: Blood Advances
Blood Adv (2022) 6 (9): 2778–2790.
https://doi.org/10.1182/bloodadvances.2021006353
Published: 2022
Includes: Supplemental data
Journal Articles

Bleeding diathesis in mice lacking JAK2 in platelets

Nathan Eaton, Saravanan Subramaniam, Marie L. Schulte, Caleb Drew, David Jakab, Sandra L. Haberichter, Hartmut Weiler, Hervé Falet
Journal: Blood Advances
Blood Adv (2021) 5 (15): 2969–2981.
https://doi.org/10.1182/bloodadvances.2020003032
Published: 2021
Includes: Supplemental data
Journal Articles

A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C)

Saravanan Subramaniam, Yamini Ogoti, Irene Hernandez, Mark Zogg, Fady Botros, Robert Burns, Jacob T. DeRousse, Chris Dockendorff, Nigel Mackman, Silvio Antoniak, Craig Fletcher, Hartmut Weiler
Journal: Blood Advances
Blood Adv (2021) 5 (13): 2760–2774.
https://doi.org/10.1182/bloodadvances.2021004360
Published: 2021
Includes: Supplemental data
Journal Articles

Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice

Mona Saffarzadeh, Kristin Grunz, T. Son Nguyen, Young K. Lee, Maki Kitano, Sven Danckwardt, Carina D. S. Rodrigues, Hartmut Weiler, Sabine Reyda, Wolfram Ruf
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5810–5824.
https://doi.org/10.1182/bloodadvances.2020003299
Published: 2020
Journal Articles

The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression

Qizhen Shi, Jeremy G. Mattson, Scot A. Fahs, Aron M. Geurts, Hartmut Weiler, Robert R. Montgomery
Journal: Blood Advances
Blood Adv (2020) 4 (1): 55–65.
https://doi.org/10.1182/bloodadvances.2019000944
Published: 2020
Journal Articles

Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice

Chunyan Gao, Jocelyn A. Schroeder, Feng Xue, Weiqing Jing, Yuanhua Cai, Amelia Scheck, Saravanan Subramaniam, Sridhar Rao, Hartmut Weiler, Agnieszka Czechowicz, Qizhen Shi
Journal: Blood Advances
Blood Adv (2019) 3 (18): 2700–2711.
https://doi.org/10.1182/bloodadvances.2019000516
Published: 2019
Includes: Supplemental data
Journal Articles

High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (Pl A1 )

Huiying Zhi, Maria Therese Ahlen, Aye Myat Myat Thinn, Hartmut Weiler, Brian R. Curtis, Bjørn Skogen, Jieqing Zhu, Peter J. Newman
Journal: Blood Advances
Blood Adv (2018) 2 (21): 3001–3011.
https://doi.org/10.1182/bloodadvances.2018023341
Published: 2018
Includes: Supplemental data
Journal Articles

Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation

Thijs E. van Mens, Hai-Po H. Liang, Sreemanti Basu, Irene Hernandez, Mark Zogg, Jennifer May, Min Zhan, Qiuhui Yang, Jamie Foeckler, Shawn Kalloway, Rashmi Sood, Caren Sue Karlson, Hartmut Weiler
Journal: Blood Advances
Blood Adv (2017) 1 (15): 1148–1158.
https://doi.org/10.1182/bloodadvances.2017005058
Published: 2017
Journal Articles

TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice

Dipica Haribhai, Xiaofeng Luo, Juan Chen, Shuang Jia, Linzheng Shi, Jocelyn A. Schroeder, Hartmut Weiler, Richard H. Aster, Martin J. Hessner, Jianda Hu, Calvin B. Williams, Qizhen Shi
Journal: Blood Advances
Blood Adv (2016) 1 (2): 139–151.
https://doi.org/10.1182/bloodadvances.2016001453
Published: 2016
Includes: Supplemental data