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Nigel Mackman
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Journal Articles

Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood

Jun Wan, Sophia Dhrolia, Rohan R. Kasthuri, Yuriy Prokopenko, Anton Ilich, Prakash Saha, Mark Roest, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski, Pavan K. Bendapudi, Nigel Mackman, Steven P. Grover
Journal: Blood Advances
Blood Adv (2024) 8 (12): 3045–3057.
https://doi.org/10.1182/bloodadvances.2024012613
Published: 2024
Includes: Supplemental data
Journal Articles

Tissue factor activates the coagulation cascade in mouse models of acute promyelocytic leukemia

Yohei Hisada, Tomohiro Kawano, Sierra J. Archibald, John S. Welch, Brandi N. Reeves, Nigel Mackman
Journal: Blood Advances
Blood Adv (2023) 7 (18): 5458–5469.
https://doi.org/10.1182/bloodadvances.2023010466
Published: 2023
Includes: Supplemental data
Journal Articles

Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice

Steven P. Grover, Vanthana Bharathi, Jens J. Posma, John H. Griffin, Joseph S. Palumbo, Nigel Mackman, Silvio Antoniak
Journal: Blood Advances
Blood Adv (2023) 7 (10): 1945–1953.
https://doi.org/10.1182/bloodadvances.2022008637
Published: 2023
Journal Articles

A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation

Jun Wan, Pansakorn Tanratana, Mark Roest, Andras Gruber, Rafal Pawlinski, Alisa S. Wolberg, Nigel Mackman, Steven P. Grover
Journal: Blood Advances
Blood Adv (2023) 7 (9): 1915–1925.
https://doi.org/10.1182/bloodadvances.2022008720
Published: 2023
Includes: Supplemental data
Journal Articles

A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C)

Saravanan Subramaniam, Yamini Ogoti, Irene Hernandez, Mark Zogg, Fady Botros, Robert Burns, Jacob T. DeRousse, Chris Dockendorff, Nigel Mackman, Silvio Antoniak, Craig Fletcher, Hartmut Weiler
Journal: Blood Advances
Blood Adv (2021) 5 (13): 2760–2774.
https://doi.org/10.1182/bloodadvances.2021004360
Published: 2021
Includes: Supplemental data
Journal Articles

Inflammasome activation promotes venous thrombosis through pyroptosis

Yan Zhang, Jian Cui, Guoying Zhang, Congqing Wu, Ahmed Abdel-Latif, Susan S. Smyth, Toshihiko Shiroishi, Nigel Mackman, Yinan Wei, Min Tao, Zhenyu Li
Journal: Blood Advances
Blood Adv (2021) 5 (12): 2619–2623.
https://doi.org/10.1182/bloodadvances.2020003041
Published: 2021
Includes: Supplemental data
Journal Articles

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

Nadim Tawil, Rayhaan Bassawon, Brian Meehan, Ali Nehme, Laura Montermini, Tenzin Gayden, Nicolas De Jay, Cristiana Spinelli, Shilpa Chennakrishnaiah, Dongsic Choi, Lata Adnani, Michele Zeinieh, Nada Jabado, Claudia L. Kleinman, Michael Witcher, Yasser Riazalhosseini, Nigel S. Key, David Schiff, Steven P. Grover, Nigel Mackman, Charles P. Couturier, Kevin Petrecca, Mario L. Suvà, Anoop Patel, Itay Tirosh, Hamed Najafabadi, Janusz Rak
Journal: Blood Advances
Blood Adv (2021) 5 (6): 1682–1694.
https://doi.org/10.1182/bloodadvances.2020002998
Published: 2021
Includes: Supplemental data
Journal Articles

Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge

Fien A. von Meijenfeldt, Sebastian Havervall, Jelle Adelmeijer, Annika Lundström, Maria Magnusson, Nigel Mackman, Charlotte Thalin, Ton Lisman
Journal: Blood Advances
Blood Adv (2021) 5 (3): 756–759.
https://doi.org/10.1182/bloodadvances.2020003968
Published: 2021
Journal Articles

Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer

Clinical Trials & Observations
Yohei Hisada, Kenison B. Garratt, Anaum Maqsood, Steven P. Grover, Tomohiro Kawano, Brian C. Cooley, Jonathan Erlich, Florian Moik, Matthew J. Flick, Ingrid Pabinger, Nigel Mackman, Cihan Ay
Journal: Blood Advances
Blood Adv (2021) 5 (2): 487–495.
https://doi.org/10.1182/bloodadvances.2020003149
Published: 2021
Includes: Supplemental data
Journal Articles

Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor

Steven P. Grover, Clare M. Schmedes, Alyson C. Auriemma, Emily Butler, Molly L. Parrish, Adam Miszta, Audrey C. Cleuren, Mayken Visser, Stefan Heitmeier, Jens J. Posma, Henri M. Spronk, Silvio Antoniak, Alisa S. Wolberg, Rafal Pawlinski, David Gailani, Nigel Mackman
Journal: Blood Advances
Blood Adv (2020) 4 (1): 207–216.
https://doi.org/10.1182/bloodadvances.2019000921
Published: 2020
Includes: Supplemental data