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Qizhen Shi
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Journal Articles

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD

Qizhen Shi, Scot A. Fahs, Jeremy G. Mattson, Hongyin Yu, Crystal L. Perry, Patricia A. Morateck, Jocelyn A. Schroeder, Jessica Rapten, Hartmut Weiler, Robert R. Montgomery
Journal: Blood Advances
Blood Adv (2022) 6 (9): 2778–2790.
https://doi.org/10.1182/bloodadvances.2021006353
Published: 2022
Includes: Supplemental data
Journal Articles

Platelet-targeted hyperfunctional FIX gene therapy for hemophilia B mice even with preexisting anti-FIX immunity

Jocelyn A. Schroeder, Juan Chen, Yingyu Chen, Yuanhua Cai, Hongyin Yu, Jeremy G. Mattson, Paul E. Monahan, Qizhen Shi
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1224–1238.
https://doi.org/10.1182/bloodadvances.2020004071
Published: 2021
Includes: Supplemental data
Journal Articles

Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice

Qizhen Shi, Christopher V. Carman, Yingyu Chen, Peter T. Sage, Feng Xue, Xin M. Liang, Gary E. Gilbert
Journal: Blood Advances
Blood Adv (2020) 4 (10): 2272–2285.
https://doi.org/10.1182/bloodadvances.2020001468
Published: 2020
Includes: Supplemental data
Journal Articles

The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression

Qizhen Shi, Jeremy G. Mattson, Scot A. Fahs, Aron M. Geurts, Hartmut Weiler, Robert R. Montgomery
Journal: Blood Advances
Blood Adv (2020) 4 (1): 55–65.
https://doi.org/10.1182/bloodadvances.2019000944
Published: 2020
Journal Articles

Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice

Weiqing Jing, Juan Chen, Yuanhua Cai, Yingyu Chen, Jocelyn A. Schroeder, Bryon D. Johnson, Weiguo Cui, Qizhen Shi
Journal: Blood Advances
Blood Adv (2019) 3 (20): 3099–3110.
https://doi.org/10.1182/bloodadvances.2019000650
Published: 2019
Includes: Supplemental data
Journal Articles

Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice

Chunyan Gao, Jocelyn A. Schroeder, Feng Xue, Weiqing Jing, Yuanhua Cai, Amelia Scheck, Saravanan Subramaniam, Sridhar Rao, Hartmut Weiler, Agnieszka Czechowicz, Qizhen Shi
Journal: Blood Advances
Blood Adv (2019) 3 (18): 2700–2711.
https://doi.org/10.1182/bloodadvances.2019000516
Published: 2019
Includes: Supplemental data
Journal Articles

The impact of von Willebrand factor on factor VIII memory immune responses

Juan Chen, Jocelyn A. Schroeder, Xiaofeng Luo, Qizhen Shi
Journal: Blood Advances
Blood Adv (2017) 1 (19): 1565–1574.
https://doi.org/10.1182/bloodadvances.2017009209
Published: 2017
Includes: Supplemental data
Journal Articles

TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice

Dipica Haribhai, Xiaofeng Luo, Juan Chen, Shuang Jia, Linzheng Shi, Jocelyn A. Schroeder, Hartmut Weiler, Richard H. Aster, Martin J. Hessner, Jianda Hu, Calvin B. Williams, Qizhen Shi
Journal: Blood Advances
Blood Adv (2016) 1 (2): 139–151.
https://doi.org/10.1182/bloodadvances.2016001453
Published: 2016
Includes: Supplemental data