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Journal Articles

Exploring the pathways to chronic lymphocytic leukemia

Freda K. Stevenson, Francesco Forconi, Thomas J. Kipps
Journal: Blood
Blood (2021) 138 (10): 827–835.
https://doi.org/10.1182/blood.2020010029
Published: 2021
Journal Articles

AML onco-niche: villain or ally?

Marta Derecka
Journal: Blood
Blood (2021) 138 (7): 504–506.
https://doi.org/10.1182/blood.2021012299
Published: 2021
Journal Articles

Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia

Xiaojia Niu, Katharina Rothe, Min Chen, Sarah Grasedieck, Rick Li, Sung-Eun Nam, Xiuyan Zhang, German E. Novakovskiy, Ye-Hyeon Ahn, Irina Maksakova, Shenshen Lai, Hong Zhang, Jun Yan, Hong Liu, Yun Zhao, Depei Wu, Yubin Ge, Wyeth W. Wasserman, Arefeh Rouhi, Florian Kuchenbauer, Calvin K. Yip, Zaihui Zhang, Xiaoyan Jiang
Journal: Blood
Blood (2021) 137 (26): 3641–3655.
https://doi.org/10.1182/blood.2020007651
Published: 2021
Includes: Supplemental data
Journal Articles

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 137 (18): 2463–2480.
https://doi.org/10.1182/blood.2019004547
Published: 2021
Includes: Supplemental data
Journal Articles

Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment

Laura Patrussi, Noemi Manganaro, Nagaja Capitani, Cristina Ulivieri, Vanessa Tatangelo, Francesca Libonati, Francesca Finetti, Federica Frezzato, Andrea Visentin, Mario Milco D’Elios, Livio Trentin, Gianpietro Semenzato, Cosima T. Baldari
Journal: Blood
Blood (2021) 137 (16): 2182–2195.
https://doi.org/10.1182/blood.2020005785
Published: 2021
Includes: Supplemental data
Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W. C. Yu, Ninib Baryawno, Elizabeth W. Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B. Sykes, Mark A. Keibler, Sudeshna Das, John N. Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J. Logan, Stuart Schreiber, Gregory Stephanopoulos, William B. Rizzo, David T. Scadden
Journal: Blood
Blood (2020) 136 (11): 1303–1316.
https://doi.org/10.1182/blood.2019001808
Published: 2020
Includes: Supplemental data
Journal Articles

A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells

Brief Report
Marco Ruella, David M. Barrett, Olga Shestova, Jessica Perazzelli, Avery D. Posey, Jr, Seok Jae Hong, Miroslaw Kozlowski, Simon F. Lacey, J. Joseph Melenhorst, Carl H. June, Saar I. Gill
Journal: Blood
Blood (2020) 135 (7): 505–509.
https://doi.org/10.1182/blood.2019001859
Published: 2020
Includes: Supplemental data
Journal Articles

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Chun Shik Park, Andrew H. Lewis, Taylor J. Chen, Cory S. Bridges, Ye Shen, Koramit Suppipat, Monica Puppi, Julie A. Tomolonis, Paul D. Pang, Toni-Ann Mistretta, Leyuan Ma, Michael R. Green, Rachel Rau, H. Daniel Lacorazza
Journal: Blood
Blood (2019) 134 (22): 1960–1972.
https://doi.org/10.1182/blood.2018875922
Published: 2019
Includes: Supplemental data
Journal Articles

ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show Selective Cytotoxicity in t(1;19) Translocated B-ALL

Swagata Goswami, MSc, Chi-Ling Chiang, PhD, Kevan Zapolnik, BS, Zhiliang Xie, James L. Lee, PhD, Sivasubramanian Baskar, Christoph Rader, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Bhavana Bhatnagar, DO, Natarajan Muthusamy, DVM,PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3798.
https://doi.org/10.1182/blood-2019-128828
Published: 2019
Journal Articles

High Mobility Group A1 Chromatin Regulators Function As Critical Drivers of Leukemogenesis in Preclinical Models of Relapsed, Pediatric B-Cell ALL

Liping Li, MD PhD, Katharina Hayer, Lingling Xian, MD PhD, Li Luo, PhD, Leslie Cope, Andrei Thomas-Tikhonenko, PhD, Linda Resar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3946.
https://doi.org/10.1182/blood-2019-130261
Published: 2019
Journal Articles

Fludarabine, High Dose Cytarabine and Idarubicin-Based Induction Is Highly Effective in Young AML Patients with Concomitant NPM1 and FLT3-ITD Mutation Irrespectively of FLT3-ITD Allelic Burden

Paola Minetto, MD, Anna Candoni, MD, Fabio Guolo, MD, Marino Clavio, MD, Maria Elena Zannier, MD, Maurizio Miglino, PhD, Maria Vittoria Dubbini, MD, Enrico Carminati, Anna Sicuranza, PhD, Sara Ciofini, Elisabetta Tedone, Nicoletta Colombo, PhD, Girolamo Pugliese, Riccardo Marcolin, MD, Filippo Ballerini, MD, Michele Cea, Marco Gobbi, MD, Monica Bocchia, Renato Fanin, MD, Roberto Massimo Lemoli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3828.
https://doi.org/10.1182/blood-2019-131303
Published: 2019
Journal Articles

Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death

Matthew Tcheng, BSc, Alessia Roma, BSc, Nawaz Ahmed, MSc, Richard Smith, PhD, Preethi Jayanth, PhD, Mark D. Minden, MD PhD, Rose Hurren, BSc, Aaron D Schimmer, MD PhD, Gale Bozzo, PhD, David Hess, PhD, Kristin Hope, PhD, Kevin Rea, MSc, Tariq A. Akhtar, PhD, Al-Walid Mohsen, PhD, Jerry Vockley, MD PhD, Paul A. Spagnuolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3922.
https://doi.org/10.1182/blood-2019-122262
Published: 2019
Journal Articles

Single Cell Transcriptomics Predicts Relapse in Infants with Acute Lymphoblastic Leukemia

Tito Candelli, PhD, Pauline Schneider, Patricia Garrido Castro, PhD, Luke A Jones, PhD, Rob Pieters, MDPhDMSc, Thanasis Margaritis, PhD, Ronald W. Stam, PhD, Frank C.P. Holstege, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3951.
https://doi.org/10.1182/blood-2019-123052
Published: 2019
Journal Articles

Single Cell Transcriptomic Analysis of the Histone H3 K27M Mutation in Pre-Leukemic Hematopoietic Stem Cells

Meaghan Boileau, BSc, Selin Jessa, BSc, Samantha Worme, BSc, Damien Faury, Nada Jabado, MD PhD, François Mercier, MD, Claudia Kleinman, PhD, Kolja Eppert, MSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3773.
https://doi.org/10.1182/blood-2019-123769
Published: 2019
Journal Articles

Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL

Amy Guillaumet-Adkins, PhD, Praveen Anand, PhD, Huiyoung Yun, PhD, Yotam Drier, PhD, Anna Rogers, Madhu M. Ouseph, Monica S. Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Guangwu Guo, Julia Frede, PhD MPhil, Marian H. Harris, MD PhD, Lewis B. Silverman, MD, Andrew A. Lane, MD PhD, Daniel J. DeAngelo, MD, Jon C. Aster, MD PhD, Bradley E. Bernstein, MD PhD, Jens G. Lohr, MD PhD, Birgit Knoechel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3953.
https://doi.org/10.1182/blood-2019-130482
Published: 2019
Journal Articles

A Core Proliferative Program Induced By B-Cell Receptor Stimulation in Chronic Lymphocytic Leukemia Cells

Cédric Schleiss, Raphael Carapito, PhD, Luc Mathieu Fornecker, MD PhD, Leslie Muller, Paul Nicodeme, Ouria Tahar, Angélique Pichot, BSc, Laurent Mauvieux, MD PhD, Raoul Herbrecht, MD, Myriam Maumy-Bertrand, Jean-Noel Freund, Christine Carapito, Seiamak Bahram, MD, Frederic Bertrand, Laurent Vallat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3777.
https://doi.org/10.1182/blood-2019-126779
Published: 2019
Journal Articles

Transcriptomic Profile of Bone Marrow-Derived Mesenchymal Stromal Cells of Pediatric Pre-B Acute Lymphoblastic Leukemia Patients and Healthy Donors after Interaction with Leukemic Cells

Tuba Özdemi̇r Sanci, MSc, Hilal Özdağ, PhD, Yasin Köksal, MSc, Seda Tasır Yılmaz, MSc, Husniye Nese Yarali, MD, Namik Yasar Özbek, MD, Habibe Meltem Özgüner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3957.
https://doi.org/10.1182/blood-2019-128282
Published: 2019
Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3765.
https://doi.org/10.1182/blood-2019-123604
Published: 2019
Journal Articles

RUNX2 Regulates Cell Migration in T-Cell Lineage Acute Lymphoblastic Leukemia

Nitesh Devinarayan Sharma, PhD, Christian C. Nickl, Huining Kang, PhD, Wojciech Ornatowski, PhD, Stuart S. Winter, MD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Ksenia Matlawska-Wasowska, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3947.
https://doi.org/10.1182/blood-2019-129337
Published: 2019
Journal Articles

Transcriptome Profiling of Glycosylation Genes Defines Correlation with E-Selectin Ligand Expression and Clinical Outcome in AML

Amanda R. Leonti, MS, Laura Pardo, Todd A. Alonzo, PhD, Robert B. Gerbing, Lisa Eidenschink Brodersen, PhD, Rhonda E. Ries, MA, Jenny L. Smith, MSc, MD, Quy Le, PhD, Richard Aplenc, MD PhD, E. Anders Kolb, MD, John L. Magnani, PhD, William E. Fogler, PhD, Michael R. Loken, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3772.
https://doi.org/10.1182/blood-2019-124525
Published: 2019