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John Doench
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Journal Articles

Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Sara Gandolfi, MD, Huihui Tang, PhD, Sondra L. Downey-Kopyscinski, PhD, Megan Bariteau, B.Sc., Jeffrey Sorrell, BA, Brian Glassner, PhD, John Doench, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
https://doi.org/10.1182/blood-2020-142651
Published: 2020
Journal Articles

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Karina Barbosa, BSc, Anagha Deshpande, PhD, Ping Xiang, PhD, Bo-Rui Chen, PhD, Adam Brown, MSc, Neil Robertson, Younguk Sun, PhD, John Doench, PhD, Peter D Adams, PhD, R. Keith Humphries, MD PhD, Prashant Mali, PhD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-141412
Published: 2020
Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W. C. Yu, Ninib Baryawno, Elizabeth W. Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B. Sykes, Mark A. Keibler, Sudeshna Das, John N. Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J. Logan, Stuart Schreiber, Gregory Stephanopoulos, William B. Rizzo, David T. Scadden
Journal: Blood
Blood (2020) 136 (11): 1303–1316.
https://doi.org/10.1182/blood.2019001808
Published: 2020
Includes: Supplemental data
Journal Articles

PPM1D -truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Josephine D. Kahn, Peter G. Miller, Alexander J. Silver, Rob S. Sellar, Shruti Bhatt, Christopher Gibson, Marie McConkey, Dylan Adams, Brenton Mar, Philipp Mertins, Shaunt Fereshetian, Karsten Krug, Haoling Zhu, Anthony Letai, Steven A. Carr, John Doench, Siddhartha Jaiswal, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (11): 1095–1105.
https://doi.org/10.1182/blood-2018-05-850339
Published: 2018
Includes: Supplemental data
Journal Articles

Targeted ShRNA Screening Identified Critical Role of Pleckstrin-2 in Erythropoiesis

Ganesan Keerthivasan, MBBS, MD, Jing Yang, MS, Piu Wong, PhD, John Doench, PhD, David E. Root, PhD, Peng Ji, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3199.
https://doi.org/10.1182/blood.V120.21.3199.3199
Published: 2012
Journal Articles

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Rushdia Z. Yusuf, MBBS, MPH, Sanket S. Acharya, BA, MBS, Vionnie W.C. Yu, PhD, Borja Saez, PhD, Julien M Cobert, BA, John Doench, PhD, Lars Bullinger, MD, PhD, Dana S'aulis, BA, Dongjun Lee, PhD, Rahul Palchaudhuri, PhD, Akachimere C. Uzosike, Mildred Duvet, BA, David J. Logan, PhD, Sudeshna Das, PhD, Colleen M Cook, BA, Michael Churchill, BS, Elizabeth Scadden, BA, Gohar Warraich, Hao Liu, BA, Shrikanta Chattopadhyay, MD, Adam Brown, PhD, Stephen M. Sykes, PhD, David B. Sykes, MD, PhD, Francois Mercier, MD, Anne E. Carpenter, PhD, Scott A. Armstrong, MD, PhD, Matthew Vander Heiden, MD, PhD, Benjamin L. Ebert, Andrew L. Kung, MD, PhD, William B. Rizzo, MD, Siddhartha Mukherjee, MD, PhD, David T. Scadden, MD
Journal: Blood
Blood (2012) 120 (21): 208.
https://doi.org/10.1182/blood.V120.21.208.208
Published: 2012
Journal Articles

Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model

Rushdia Z. Yusuf, MBBS, MPH, Sanket S. Acharya, BA, MBS, Vionnie Yu, PhD, Borja Saez, PhD, Mildred Duvet, Elizabeth Scadden, BA, Gohar Warraich, Clary Clish, PhD, Michael Churchill, BS, John Doench, PhD, David J. Logan, PhD, Colleen Cook, BA, Sudeshna Das, PhD, Adam Brown, PhD, Stephen M. Sykes, Shrikanta Chattopadhyay, MD, Anne E. Carpenter, PhD, Mathew Vander Heiden, MD, PhD, Scott A. Armstrong, MD, PhD, Siddhartha Mukherjee, MD, PhD, Benjamin L. Ebert, MD, D.Phil, David T. Scadden, MD
Journal: Blood
Blood (2011) 118 (21): 759.
https://doi.org/10.1182/blood.V118.21.759.759
Published: 2011