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Siddhartha Jaiswal
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Journal Articles

Multi-Omic Profiling of Macrophages Lacking Tet2 or Dnmt3a Reveals Mechanisms of Hyper-Inflammation in Clonal Hematopoiesis

Kameron B Rodrigues, Jayakrishnan Gopakumar, Ziming Weng, Shaneice Renee Mitchell, Margaret Maurer, Daniel Nachun, Tiffany Eulalio, Dorothy Estrada, Thomas Mazumder, Lisa Ma, Stephen Montgomery, Siddhartha Jaiswal
Journal: Blood
Blood (2023) 142 (Supplement 1): 1163.
https://doi.org/10.1182/blood-2023-187890
Published: 2023
Journal Articles

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Caitlyn Vlasschaert, Taralynn Mack, J. Brett Heimlich, Abhishek Niroula, Md Mesbah Uddin, Joshua Weinstock, Brian Sharber, Alexander J. Silver, Yaomin Xu, Michael Savona, Christopher Gibson, Matthew B. Lanktree, Michael J. Rauh, Benjamin L. Ebert, Pradeep Natarajan, Siddhartha Jaiswal, Alexander G. Bick
Journal: Blood
Blood (2023) 141 (18): 2214–2223.
https://doi.org/10.1182/blood.2022018825
Published: 2023
Includes: Supplemental data
Journal Articles

Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia

Clinical Trials & Observations
Eric J. Duncavage, Adam Bagg, Robert P. Hasserjian, Courtney D. DiNardo, Lucy A. Godley, Ilaria Iacobucci, Siddhartha Jaiswal, Luca Malcovati, Alessandro M. Vannucchi, Keyur P. Patel, Daniel A. Arber, Maria E. Arcila, Rafael Bejar, Nancy Berliner, Michael J. Borowitz, Susan Branford, Anna L. Brown, Catherine A. Cargo, Hartmut Döhner, Brunangelo Falini, Guillermo Garcia-Manero, Torsten Haferlach, Eva Hellström-Lindberg, Annette S. Kim, Jeffery M. Klco, Rami Komrokji, Mignon Lee-Cheun Loh, Sanam Loghavi, Charles G. Mullighan, Seishi Ogawa, Attilio Orazi, Elli Papaemmanuil, Andreas Reiter, David M. Ross, Michael Savona, Akiko Shimamura, Radek C. Skoda, Francesc Solé, Richard M. Stone, Ayalew Tefferi, Matthew J. Walter, David Wu, Benjamin L. Ebert, Mario Cazzola
Journal: Blood
Blood (2022) 140 (21): 2228–2247.
https://doi.org/10.1182/blood.2022015853
Published: 2022
Includes: Supplemental data
Journal Articles

Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis

Lachelle D. Weeks, Abhishek Niroula, Donna S. Neuberg, Waihay J. Wong, R. Coleman Lindsley, Marlise R. Luskin, Nancy Berliner, Richard M. Stone, Daniel J DeAngelo, Robert J Soiffer, Md Mesbah Uddin, Christopher J. Gibson, Alexander G. Bick, Gabriel K. Griffin, Siddhartha Jaiswal, Luca Malcovati, Pradeep Natarajan, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (Supplement 1): 2229–2231.
https://doi.org/10.1182/blood-2022-158960
Published: 2022
Journal Articles

TET2 -mutant clonal hematopoiesis and risk of gout

Clinical Trials & Observations
Mridul Agrawal, Abhishek Niroula, Pierre Cunin, Marie McConkey, Veronica Shkolnik, Peter G. Kim, Waihay J. Wong, Lachelle D. Weeks, Amy E. Lin, Peter G. Miller, Christopher J. Gibson, Aswin Sekar, Inga-Marie Schaefer, Donna Neuberg, Richard M. Stone, Alexander G. Bick, Md Mesbah Uddin, Gabriel K. Griffin, Siddhartha Jaiswal, Pradeep Natarajan, Peter A. Nigrovic, Deepak A. Rao, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (10): 1094–1103.
https://doi.org/10.1182/blood.2022015384
Published: 2022
Includes: Supplemental data
Journal Articles

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O’Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert, for the COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium
Journal: Blood
Blood (2022) 139 (3): 357–368.
https://doi.org/10.1182/blood.2021013531
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis Is Driven By Aberrant Activation of TCL1A

Jk Gopakumar, Joshua Weinstock, Bala B Burugula, Nikolaus Jahn, Charles Kooperberg, Pinkal Desai, Pradeep Natarajan, Jacob O Kitzman, Alexander Reiner, Alexander G. Bick, Siddhartha Jaiswal
Journal: Blood
Blood (2021) 138 (Supplement 1): 597.
https://doi.org/10.1182/blood-2021-153242
Published: 2021
Journal Articles

Clonal Hematopoiesis is Associated with Reduced Risk of Alzheimer's Disease

Hind Bouzid, Julia Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Sara Wirth, Lisa Ma, Matthew Chrostek, Herra Ahmad, Daniel Nachun, Winnie Yao, Alexa Beiser, Alexander G. Bick, Joshua Bis, Myriam Fornage, W. T. Longstreth, Oscar Lopez, Pradeep Nataranjan, Bruce Psaty, Claudia Satizabal, Joshua Weinstock, Eric Larson, Paul Crane, C. Dirk Keene, Sudha Seshadri, Ansuman T. Satpathy, Thomas Montine, Siddhartha Jaiswal
Journal: Blood
Blood (2021) 138 (Supplement 1): 5.
https://doi.org/10.1182/blood-2021-151064
Published: 2021
Journal Articles

Clonal hematopoiesis and nonhematologic disorders

Siddhartha Jaiswal
Journal: Blood
Blood (2020) 136 (14): 1606–1614.
https://doi.org/10.1182/blood.2019000989
Published: 2020
Journal Articles

Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice

Philipp J. Rauch, MD, Alexander J. Silver, BA, Jk Gopakumar, BA, Marie McConkey, PhD, Eti Sinha, BS, Maia Fefer, BS, Eugenia Shvartz, BS, Galina Sukhova, PhD, Peter Libby, MD, Benjamin L. Ebert, MDPhD, Siddhartha Jaiswal, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 745.
https://doi.org/10.1182/blood-2018-99-118288
Published: 2018
Journal Articles

PPM1D -truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Josephine D. Kahn, Peter G. Miller, Alexander J. Silver, Rob S. Sellar, Shruti Bhatt, Christopher Gibson, Marie McConkey, Dylan Adams, Brenton Mar, Philipp Mertins, Shaunt Fereshetian, Karsten Krug, Haoling Zhu, Anthony Letai, Steven A. Carr, John Doench, Siddhartha Jaiswal, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (11): 1095–1105.
https://doi.org/10.1182/blood-2018-05-850339
Published: 2018
Includes: Supplemental data
Journal Articles

PPM1D Truncating Mutations Confer Chemotherapy Resistance in Hematopoietic Stem Cells, Which Is Reversible By PPM1D Inhibition

Josephine Kahn, MD, Alexander J. Silver, B.S., Philipp Mertins, PhD, Steven Carr, PhD, Siddhartha Jaiswal, MD PhD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 740.
https://doi.org/10.1182/blood.V128.22.740.740
Published: 2016
Journal Articles

Clonal Hematopoiesis Associated with Adverse Outcomes Following Autologous Stem Cell Transplantation for Non-Hodgkin Lymphoma

Christopher J. Gibson, MD, R. Coleman Lindsley, MD PhD, Vatche Tchekmedyian, MD, Jiantao Shi, PhD, Brenton G. Mar, MD PhD, Siddhartha Jaiswal, MD PhD, Alysia Bosworth, Liton F. Francisco, BS, Jianbo He, MD, Elizabeth A. Morgan, MD, Ann S. LaCasce, MD, John Koreth, MD, Vincent T. Ho, MD, Jerome Ritz, MD, Sarah Nikiforow, MD PhD, Joseph H. Antin, MD, Robert J. Soiffer, MD, Stephen J. Forman, MD, Franziska Michor, PhD, Donna S. Neuberg, ScD, Smita Bhatia, MD MPH, Ravi Bhatia, MD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 986.
https://doi.org/10.1182/blood.V128.22.986.986
Published: 2016
Journal Articles

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

David P. Steensma, Rafael Bejar, Siddhartha Jaiswal, R. Coleman Lindsley, Mikkael A. Sekeres, Robert P. Hasserjian, Benjamin L. Ebert
Journal: Blood
Blood (2015) 126 (1): 9–16.
https://doi.org/10.1182/blood-2015-03-631747
Published: 2015
Journal Articles

Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes

Siddhartha Jaiswal, MDPhD, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter Grauman, Brenton G. Mar, MDPhD, R. Coleman Lindsley, MDPhD, Craig Mermel, Noel Burtt, Alejandro Chavez, John M. Higgins, MD, Vladislav Moltchanov, Leena Kinnunen, Heikki Koistinen, Claes Ladenvall, Gad Getz, PhD, Adolfo Correa, Stacey Gabriel, PhD, Sekar Kathiresan, Heather Stringham, Michael Boehnke on behalf of GoT2D, Brian Henderson on behalf of SIGMA T2D, Mark McCarthy on behalf of T2D-GENES, Jaako Tuomilehto, Christopher A. Haiman, Sc.D., Leif Groop, Gil Atzmon, James Wilson, Donna S. Neuberg, ScD, David Altshuler, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2014) 124 (21): 840.
https://doi.org/10.1182/blood.V124.21.840.840
Published: 2014