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Journal Articles

ABL1 kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

Subodh Kumar, Srikanth Talluri, Jiangning Zhao, Chengcheng Liao, Lakshmi B. Potluri, Leutz Buon, Shidai Mu, Jialan Shi, Chandraditya Chakraborty, Yu-Tzu Tai, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Journal: Blood
Blood (2024) 143 (11): 996–1005.
https://doi.org/10.1182/blood.2023021225
Published: 2024
Includes: Supplemental data
Journal Articles

Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma

Ting Du, Yan Song, Arghya Ray, Xueping Wan, Yao Yao, Mehmet K. Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C. Munshi, Hao Wu, Ruben D. Carrasco, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2023) 141 (21): 2599–2614.
https://doi.org/10.1182/blood.2022017897
Published: 2023
Includes: Supplemental data
Journal Articles

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Eugenio Morelli, Mariateresa Fulciniti, Mehmet K. Samur, Caroline F. Ribeiro, Leon Wert-Lamas, Jon E. Henninger, Annamaria Gullà, Anil Aktas-Samur, Katia Todoerti, Srikanth Talluri, Woojun D. Park, Cinzia Federico, Francesca Scionti, Nicola Amodio, Giada Bianchi, Megan Johnstone, Na Liu, Doriana Gramegna, Domenico Maisano, Nicola A. Russo, Charles Lin, Yu-Tzu Tai, Antonino Neri, Dharminder Chauhan, Teru Hideshima, Masood A. Shammas, Pierfrancesco Tassone, Sergei Gryaznov, Richard A. Young, Kenneth C. Anderson, Carl D. Novina, Massimo Loda, Nikhil C. Munshi
Journal: Blood
Blood (2023) 141 (4): 391–405.
https://doi.org/10.1182/blood.2022016892
Published: 2023
Includes: Supplemental data
Journal Articles

BRD9 Is Essential for Ribosome Biogenesis and the Survival of Multiple Myeloma Cells

Keiji Kurata, Mehmet K. Samur, Priscilla Liow, Kenneth Wen, Leona Yamamoto, Jiye Liu, Eugenio Morelli, Annamaria Gulla, Yu-Tzu Tai, Jun Qi, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 596–597.
https://doi.org/10.1182/blood-2022-162445
Published: 2022
Journal Articles

Γ-Secretase Inhibitors Enhance the Potency of BCMA-Targeting T Cell Engagers Against Multiple Myeloma Cells without Adverse Impact on T-Cell Activation and Differentiation

Hailin Chen, Tengteng Yu, Liang Lin, Lijie Xing, Shih-Feng Cho, Kenneth Wen, Kimberly Aardalen, Mike Daley, Haihui Lu, Adwait Oka, Joni Lam, Nikhil C Munshi, Kenneth C. Anderson, Yu-Tzu Tai
Journal: Blood
Blood (2022) 140 (Supplement 1): 9968–9969.
https://doi.org/10.1182/blood-2022-155553
Published: 2022
Journal Articles

PHF19 Inhibits Multiple Myeloma Cell Response to Immunotherapy Via Promoting Immunosuppressive Microenvironment

Tengteng Yu, Mu Hao, Hailin Chen, Kenneth Wen, Tingjian Wang, Thomas C.M Smits, Mehmet K. Samur, Eugenio Morelli, Lijie Xing, Liang Lin, Jun Qi, Gang An, Nikhil C Munshi, Yu-Tzu Tai, Lugui Qiu, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 854–855.
https://doi.org/10.1182/blood-2022-159137
Published: 2022
Journal Articles

Identification a Novel Molecular Mechanism Underlying the Anti-CD38-Based Treatment Resistance in Multiple Myeloma Patients

Sophia Adamia, Daisuke Ogiya, Evdoxia Hatjiharissi, Michael P. Chu, Zuzana Chyra, Kenneth Wen, Yu-Tzu Tai, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 2081–2082.
https://doi.org/10.1182/blood-2022-169943
Published: 2022
Journal Articles

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

Georgina S.F. Anderson, Jose Ballester-Beltran, George Giotopoulos, Jose A. Guerrero, Sylvanie Surget, James C. Williamson, Tsz So, David Bloxham, Anna Aubareda, Ryan Asby, Ieuan Walker, Lesley Jenkinson, Elizabeth J. Soilleux, James P. Roy, Ana Teodósio, Catherine Ficken, Leah Officer-Jones, Sara Nasser, Sheri Skerget, Jonathan J. Keats, Peter Greaves, Yu-Tzu Tai, Kenneth C. Anderson, Marion MacFarlane, James E. Thaventhiran, Brian J.P. Huntly, Paul J. Lehner, Michael A. Chapman
Journal: Blood
Blood (2022) 139 (16): 2471–2482.
https://doi.org/10.1182/blood.2021015161
Published: 2022
Includes: Supplemental data
Journal Articles

Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma

Sophia Adamia, Zuzana Chyra, Morgan O'Keefe, Shruti Bhatt, Kenneth Wen, Geoffrey G Fell, Yu-Tzu Tai, Anthony G. Letai, Ivane Abiatari, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2688.
https://doi.org/10.1182/blood-2021-152986
Published: 2021
Journal Articles

Genomic Profiling of Smoldering Multiple Myeloma Classifies Molecular Groups with Distinct Pathogenic Phenotypes and Clinical Outcomes

Shankara Anand, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Eileen M Boyle, Yu-Tzu Tai, Carl J Neuse, Selina J Chavda, Cody J. Boehner, Mahshid Rahmat, Benny Zhitomirsky, Andrew Dunford, Ankit K. Dutta, Chip Stewart, Lorenzo Trippa, Tineke Casneuf, Efstathios Kastritis, Brian A Walker, Faith E Davies, Meletios A. Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 723.
https://doi.org/10.1182/blood-2021-150767
Published: 2021
Journal Articles

Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Cirino Botta, Megan Johnstone, Giada Bianchi, Mariateresa Fulciniti, Leona Yamamoto, Rao Prabhala, Kenneth Wen, Paul G. Richardson, Yu-Tzu Tai, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 891.
https://doi.org/10.1182/blood-2021-148621
Published: 2021
Journal Articles

Discovery of Prolyl-tRNA Synthetase As a Novel Target in Multiple Myeloma

Keiji Kurata, Anna-James Bott, Teru Hideshima, James Dunford, Filiz Senbabaoglu, Catrine Johansson, Adam Cribbs, Martin Philpott, Sarah Gooding, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, Mark A Tye, N Connor Payne, Patrick Hagner, Karthik Ramasamy, Anjan Thakurta, Ralph Mazitschek, Udo Oppermann, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 890.
https://doi.org/10.1182/blood-2021-148536
Published: 2021
Journal Articles

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

Eugenio Morelli, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Leon Wert-Lamas, Caroline Ribeiro, Jonathan E Henninger, Woojun D Park, Nicola Amodio, Doriana Gramegna, Megan Johnstone, Pierfrancesco Tassone, Yu-Tzu Tai, Carl D. Novina, Richard A. Young, Massimo Loda, Masood A. Shammas, Sergei Gryaznov, Mariateresa Fulciniti, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 894.
https://doi.org/10.1182/blood-2021-151705
Published: 2021
Journal Articles

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Journal: Blood
Blood (2021) 137 (17): 2360–2372.
https://doi.org/10.1182/blood.2020005885
Published: 2021
Includes: Supplemental data
Journal Articles

The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications

Daisuke Ogiya, Jiye Liu, Hiroto Ohguchi, Keiji Kurata, Mehmet K. Samur, Yu-Tzu Tai, Sophia Adamia, Kiyoshi Ando, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2020) 136 (20): 2334–2345.
https://doi.org/10.1182/blood.2019004332
Published: 2020
Includes: Supplemental data
Journal Articles

Pre-Clinical Validation of a Novel Erk1/2 and CDK4/6 Inhibitor Combination in Multiple Myeloma (MM)

Sophia Adamia, PhD, Shruti Bhatt, PhD, Yu-Tzu Tai, PhD, Kenneth Wen, Catherine A Nicholas, Marissa S Pioso, Ivane Abiatari, MD, Anthony G. Letai, MD PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-142596
Published: 2020
Journal Articles

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

Subodh Kumar, PhD, Srikanth Talluri, PhD, Jiangning Zhao, PhD MD, Chengcheng Liao, PhD MD, Lakshmi B. Potluri, MBBS, Leutz Buon, Shidai Mu, Jialan Shi, MDPhD, Mychell Neptune-Buon, Chandraditya Chakraborty, PhD, Yu-Tzu Tai, PhD, Mehmet K. Samur, PhD, Mariateresa Fulciniti, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 51.
https://doi.org/10.1182/blood-2020-142793
Published: 2020
Journal Articles

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Eugenio Morelli, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Caroline Ribeiro, PhD, Leon Wert-Lamas, PhD, Annamaria Gulla, MD, Anil Aktas-Samur, PhD, Katia Todoerti, PhD, Srikanth Talluri, PhD, Woojun Daniel Park, Jonathan E Henninger, Cinzia Federico, PhD, Giada Bianchi, MD, Francesca Scionti, PhD, Yao Yao, Nicola Amodio, PhD, Charles Y Lin, PhD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Antonino Neri, MD, Dharminder Chauhan, PhD, Teru Hideshima, MD PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Carl D. Novina, MD PhD, Massimo Loda, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-142514
Published: 2020
Journal Articles

The Prognostic Impact of Dynamic Changes of Genetic Risk Stratification in Multiple Myeloma

Huishou Fan, Jiahui Liu, Chenglu Yuan, Xue-Han Mao, MD, Xiaoqing LI, MD, Xin Du, Zengjun Li, Mu Hao, Yuting Yan, Shuhui Deng, MD, Chenxing Du, MD, Chengwen Li, Jiawei Zhao, Shuhua Yi, MD, Dehui Zou, MD, Yaozhong Zhao, Fenghuang Zhan, MD PhD, Yu-Tzu Tai, PhD, Jianxiang Wang, MD, Kenneth Anderson, MD, Lugui Qiu, MD, Gang An, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–3.
https://doi.org/10.1182/blood-2020-139345
Published: 2020
Journal Articles

A Novel CD138-Targeting Monoclonal Antibody Induces Potent Myeloma Killing and Further Synergizes with IMiDs or Bortezomib in in Vitro and In Vivo Preclinical Models of Human Multiple Myeloma

Tengteng Yu, MD, Bharat Chaganty, Liang Lin, PhD, Lijie Xing, MD, Boopathy Ramakrishnan, Kenneth Wen, Phillip A Hsieh, Andrew Wollacott, Karthik Viswanathan, Hedy Adari, Shih-Feng Cho, MD PhD, Yuyin Li, PhD, Wenjuan Yang, Hailin Chen, Yan Xu, MD, Gang An, Lugui Qiu, MD, Nikhil C. Munshi, MD, Gregory Babcock, Zach Shriver, James Myette, PhD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136824
Published: 2020