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Journal Articles

A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)

Blood (2021) 138 (Supplement 1): 740.

https://doi.org/10.1182/blood-2021-146268

Published: 2021

Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Blood (2021) 138 (18): 1705–1720.

https://doi.org/10.1182/blood.2020010572

Published: 2021

Includes: Supplemental data

Journal Articles

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial

Blood (2021) 137 (17): 2360–2372.

https://doi.org/10.1182/blood.2020005885

Published: 2021

Includes: Supplemental data

Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Blood (2019) 134 (Supplement_1): 3104.

https://doi.org/10.1182/blood-2019-124391

Published: 2019

Journal Articles

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Blood (2018) 132 (Supplement 1): 55.

https://doi.org/10.1182/blood-2018-99-113916

Published: 2018

Journal Articles

Dual Conditional Loss of BLIMP-1 and p53 in B-Cells Drives B-Cell Lymphomagenesis

Antonio Sacco, BS, Yawara Kawano, MD PhD, Michele Moschetta, MD, Jihye Park, PhD, Oksana Zavidij, PhD, Michaela Reagan, PhD, Yuji Mishima, PhD, Elizabeth A. Morgan, MD, Satoshi Takagi, PhD, Salomon Manier, MD, Luisa Imberti, MD, Giuseppe Rossi, MD, Kwok Wong, MD, Ruben D. Carrasco, MD PhD, Irene M. Ghobrial, MD, Aldo M. Roccaro, MD PhD

Blood (2016) 128 (22): 4169.

https://doi.org/10.1182/blood.V128.22.4169.4169

Published: 2016

Journal Articles

In Vivo Analysis of Clonal Evolution of Multiple Myeloma

Yuji Mishima, PhD, Jiantao Shi, PhD, Michele Moschetta, MD, Yujia Shen, PhD, Salomon Manier, MD, Aldo M. Roccaro, MD PhD, Francois Mercier, MD FRCPC, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Shokichi Tsukamoto, MD PhD, Ilyas Sahin, Antonio Sacco, BS, Kiyohiko Hatake, MD PhD, Franziska Michor, PhD, David T. Scadden, MD, Irene M. Ghobrial, MD

Blood (2016) 128 (22): 799.

https://doi.org/10.1182/blood.V128.22.799.799

Published: 2016

Journal Articles

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Michele Moschetta, Mike Y. Zhong, Xiaoyan Feng, Michele Cea, Antonia Cagnetta, Kenneth Wen, Hans van Eenennaam, Andrea van Elsas, Lugui Qiu, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Blood (2016) 127 (25): 3225–3236.

https://doi.org/10.1182/blood-2016-01-691162

Published: 2016

Includes: Supplemental data

Journal Articles

Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia

Blood (2016) 127 (21): 2598–2606.

https://doi.org/10.1182/blood-2015-11-680199

Published: 2016

Includes: Supplemental data

Journal Articles

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MDPhD, Michele Moschetta, MD, Mike Zhong, BS, Xiaoyan Feng, MD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 1810.

https://doi.org/10.1182/blood.V126.23.1810.1810

Published: 2015

Journal Articles

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

Yawara Kawano, MDPhD, Michele Moschetta, MD, Katsutoshi Kokubun, PhD, Pavlo Lukyanchykov, MD, Esilida Sula Karreci, MD, Salomon Manier, MD, Shokichi Tsukamoto, MD PhD, Satoshi Takagi, PhD, Jiantao Shi, Michaela R. Reagan, PhD, Daisy Huynh, BS, MS, Antonio Sacco, BS, David M. Dorfman, MD PhD, Marta Chesi, PhD, Peter Leif Bergsagel, MD PhD, Aldo M Roccaro, MD PhD, Jamil Azzi, MD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 502.

https://doi.org/10.1182/blood.V126.23.502.502

Published: 2015

Journal Articles

A New Model for Studying the Dissemination of Myeloma Cells throughout the Bone Marrow Using Embryonic Zebrafish

Aldo M Roccaro, MD PhD, Antonio Sacco, BS, Dongdong Ma, MD PhD, Jiantao Shi, Yuji Mishima, PhD, Michele Moschetta, MD, Robert I. Handin, MD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 915.

https://doi.org/10.1182/blood.V126.23.915.915

Published: 2015

Journal Articles

Platelets/Megakaryocytes Are Critical Regulators of Tumor Progression in Multiple Myeloma

Satoshi Takagi, PhD, Shokichi Tsukamoto, MD PhD, Yawara Kawano, MDPhD, Michele Moschetta, MD, Yuji Mishima, PhD, Katsutoshi Kokubun, PhD, Salomon Manier, MD, Karma Salem, MD, Daisy Huynh, BS, MS, Antonio Sacco, BS, Aldo M Roccaro, MD PhD, Kelly Elizabeth Johnson, PhD, Elisabeth M. Battinelli, MD PhD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 1793.

https://doi.org/10.1182/blood.V126.23.1793.1793

Published: 2015

Journal Articles

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

Salomon Manier, MD, John Powers, PhD, Antonio Sacco, BS, Siobhan Glavey, MD, Daisy Huynh, BS, MS, Michaela R. Reagan, PhD, Karma Salem, MD, Michele Moschetta, MD, Yuji Mishima, PhD, Xavier Leleu, MD PhD, Aldo M Roccaro, MD PhD, George Q. Daley, MD PhD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 1755.

https://doi.org/10.1182/blood.V126.23.1755.1755

Published: 2015

Journal Articles

Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix

Siobhan Glavey, MD, Alexandra Naba, PhD, Salomon Manier, MD, Manuela Gambella, Alberto Rocci, MD, Antonio Sacco, BS, John M. Asara, PhD, Michele Moschetta, MD, Michaela R. Reagan, PhD, Yuji Mishima, PhD, Yawara Kawano, MD PhD, Aldo M Roccaro, MD PhD, Antonio Palumbo, MD, Richard O. Hynes, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2051.

https://doi.org/10.1182/blood.V124.21.2051.2051

Published: 2014

Journal Articles

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM

Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michele Moschetta, MD, Wenjing Zhang, MD, Patricia Maiso, PhD, Antonio Sacco, BS, Yosra Aljawai, MS, Ilyas Sahin, MD, Michaela R. Reagan, PhD, Jennifer E. Ring, Winnie F. Tam, PhD, Qunli Xu, PhD, Jonathan A. Pachter, PhD, Aldo M Roccaro, MD PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2101.

https://doi.org/10.1182/blood.V124.21.2101.2101

Published: 2014

Journal Articles

Prognostic Value of Circulating Exosomal microRNAs in 112 Patients with Multiple Myeloma

Salomon Manier, MD, Herve Avet-Loiseau, Federico Campigotto, MS, Siobhan Glavey, MD, Karma Salem, MD, Daisy Huynh, MPS, Erica N Boswell, BS, Antonio Sacco, BS, Yuji Mishima, PhD, Michele Moschetta, MD, Michaela R. Reagan, PhD, Yawara Kawano, MDPhD, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Philippe Moreau, MD, Thierry Facon, MD, Xavier Leleu, MD PhD, Edie A. Weller, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2056.

https://doi.org/10.1182/blood.V124.21.2056.2056

Published: 2014

Journal Articles

Novel CXCR4-Targeted Therapy to Inhibit Multiple Myeloma Bone Dissemination

Aldo M Roccaro, MD PhD, Antonio Sacco, BS, Michele Moschetta, MD, Yuji Mishima, PhD, Patricia Maiso, PhD, Daisy Huynh, MPS, Marco Chiarini, MSc, Pina M. Cardarelli, PhD, Lewis Cohen, MD MS, Michelle Kuhne, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 4709.

https://doi.org/10.1182/blood.V124.21.4709.4709

Published: 2014

Journal Articles

Multiple Myeloma Cells Express Functional E-Selectin Ligands Which Can be Inhibited Both in-Vitro and in-Vivo Leading to Prolongation of Survival in a Murine Transplant Model

Alessandro Natoni, PhD, Michele Moschetta, MD, Siobhan Glavey, MD, Ping Wu, MBBS, MSc, Gareth J. Morgan, MD PhD, Lokesh Joshi, PhD, John L. Magnani, PhD, Irene M. Ghobrial, MD, Michael E O'Dwyer, MD FRCPI, FRCPath

Blood (2014) 124 (21): 4718.

https://doi.org/10.1182/blood.V124.21.4718.4718

Published: 2014

Journal Articles

Early Trafficking of Bone Marrow Derived-Endothelial Progenitor Cells Promotes Multiple Myeloma Progression

Michele Moschetta, MD, Yuji Mishima, PhD, Yawara Kawano, MD PhD, Yosra Aljawai, MS, Bruno Paiva, PhD, Luis Palomera, MD, Arianna Calcinotto, Unitt L. Christine, BSc, Ilyas Sahin, MD, Antonio Sacco, BS, Siobhan Glavey, MD, Michaela R. Reagan, PhD, Salomon Manier, MD, Peter Leif Bergsagel, MD PhD, Marta Chesi, PhD, Matteo Bellone, MD, Aldo M Roccaro, MD PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 4719.

https://doi.org/10.1182/blood.V124.21.4719.4719

Published: 2014

NARROW

A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Dual Conditional Loss of BLIMP-1 and p53 in B-Cells Drives B-Cell Lymphomagenesis

In Vivo Analysis of Clonal Evolution of Multiple Myeloma

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

A New Model for Studying the Dissemination of Myeloma Cells throughout the Bone Marrow Using Embryonic Zebrafish

Platelets/Megakaryocytes Are Critical Regulators of Tumor Progression in Multiple Myeloma

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM

Prognostic Value of Circulating Exosomal microRNAs in 112 Patients with Multiple Myeloma

Novel CXCR4-Targeted Therapy to Inhibit Multiple Myeloma Bone Dissemination

Multiple Myeloma Cells Express Functional E-Selectin Ligands Which Can be Inhibited Both in-Vitro and in-Vivo Leading to Prolongation of Survival in a Murine Transplant Model

Early Trafficking of Bone Marrow Derived-Endothelial Progenitor Cells Promotes Multiple Myeloma Progression

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American Society of Hematology

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American Society of Hematology

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