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A. Robert Macleod
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Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Valentina Palermo, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey S. Revenko, A. Robert Macleod, Brandon Willis, Hongbo Cai, Joana Hauser, Claire Rooney, Sophie E. Willis, Philip Lloyd Martin, Anna Staniszewska, Helen Ambrose, Lyndsey Hanson, Chiara Cattaneo, Alessandra Tucci, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood
Blood (2021) 138 (18): 1705–1720.
https://doi.org/10.1182/blood.2020010572
Published: 2021
Includes: Supplemental data
Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Antonio Sacco, RN, Cinzia Federico, PhD, Katia Todoerti, PhD, Bachisio Ziccheddu, PhD, Arianna Giacomini, PhD, Cosetta Ravelli, PhD, Federica Maccarinelli, PhD, Giada Bianchi, MD, Angelo Belotti, Rossella Ribolla, MD, Vanessa Favasuli, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brandon Willis, PhD, Hongoo Cai, PhD, Joana Hauser, RN, Claire Rooney, PhD, Helen Ambrose, PhD, Anna Staniszewska, PhD, Lyndsey Hanson, PhD, Giuseppe Rossi, Roberto Ronca, PhD, Antonino Neri, MD, Stefania Mitola, PhD, Niccolò Bolli, MD PhD, Marco Presta, PhD, Michele Moschetta, MD PhD, Sarah Ross, PhD, Aldo M. Roccaro, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3104.
https://doi.org/10.1182/blood-2019-124391
Published: 2019
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 364.
https://doi.org/10.1182/blood.V130.Suppl_1.364.364
Published: 2017
Journal Articles

Therapeutic Targeting of Interferon Regulatory Factor 4 with Next Generation Antisense Oligonucleotides Produces Robust In Vivo Antitumor Activity in Preclinical Models of Multiple Myeloma

Tianyuan Zhou, PhD, Joanna Schmidt, Youngsoo Kim, PhD, A. Robert MacLeod, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3078.
https://doi.org/10.1182/blood.V130.Suppl_1.3078.3078
Published: 2017
Journal Articles

Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland
Journal: Blood
Blood (2017) 129 (18): 2547–2556.
https://doi.org/10.1182/blood-2016-11-753202
Published: 2017
Includes: Supplemental data
Journal Articles

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod
Journal: Blood
Blood (2011) 118 (19): 5302–5311.
https://doi.org/10.1182/blood-2011-05-355248
Published: 2011
Includes: Supplemental data
Journal Articles

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C. M. Meijers, Erik S. Stroes, Marcel Levi, Brett P. Monia
Journal: Blood
Blood (2010) 116 (22): 4684–4692.
https://doi.org/10.1182/blood-2010-04-277798
Published: 2010
Includes: Multimedia, Supplemental data