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Journal Articles

CYT-338 NK Cell Engager Mutispecific Antibody Engagement of NKp46 Activation Receptor Overcomes Anti-CD38 Mab Mediated Fratricide of NK Cells and Accords Enhanced Cancer Immunotherapy

Vishal Khairnar, Liang Lin, Hao-Ming Chang, Sourindra Maiti, Solgalim Diaz, Ofer Mandelboim, Tariq Mughal, Dan Chiche, Elisabetta Burchi, Armand Bensussan, Jean Kadouche, Ola Landgren, Dickran Kazandjian, Armin Rath, Daniel Teper, Wei Li, Antonio Arulanandam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6725.
https://doi.org/10.1182/blood-2023-190613
Published: 2023
Journal Articles

Biological Characterization and Differential Gene Expression Analysis of CYT-338 NK Cell Engager (NKE) Against CD38 Expressing Tumors Including Multiple Myeloma (MM)

Liang Lin, Hao-Ming Chang, Dennis Wu, Ben Titz, Amy Chen, Marshall Chao Ma, Preeti Ashok, David Zou, Nejmi Dilmac, Armand Bensussan, Jean Kadouche, Chorom Pak, Stanley Frankel, Daniel Teper, Wei Li, Antonio Arulanandam
Journal: Blood
Blood (2022) 140 (Supplement 1): 7068–7069.
https://doi.org/10.1182/blood-2022-170193
Published: 2022
Journal Articles

PHF19 Inhibits Multiple Myeloma Cell Response to Immunotherapy Via Promoting Immunosuppressive Microenvironment

Tengteng Yu, Mu Hao, Hailin Chen, Kenneth Wen, Tingjian Wang, Thomas C.M Smits, Mehmet K. Samur, Eugenio Morelli, Lijie Xing, Liang Lin, Jun Qi, Gang An, Nikhil C Munshi, Yu-Tzu Tai, Lugui Qiu, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 854–855.
https://doi.org/10.1182/blood-2022-159137
Published: 2022
Journal Articles

Γ-Secretase Inhibitors Enhance the Potency of BCMA-Targeting T Cell Engagers Against Multiple Myeloma Cells without Adverse Impact on T-Cell Activation and Differentiation

Hailin Chen, Tengteng Yu, Liang Lin, Lijie Xing, Shih-Feng Cho, Kenneth Wen, Kimberly Aardalen, Mike Daley, Haihui Lu, Adwait Oka, Joni Lam, Nikhil C Munshi, Kenneth C. Anderson, Yu-Tzu Tai
Journal: Blood
Blood (2022) 140 (Supplement 1): 9968–9969.
https://doi.org/10.1182/blood-2022-155553
Published: 2022
Journal Articles

A Novel CD138-Targeting Monoclonal Antibody Induces Potent Myeloma Killing and Further Synergizes with IMiDs or Bortezomib in in Vitro and In Vivo Preclinical Models of Human Multiple Myeloma

Tengteng Yu, MD, Bharat Chaganty, Liang Lin, PhD, Lijie Xing, MD, Boopathy Ramakrishnan, Kenneth Wen, Phillip A Hsieh, Andrew Wollacott, Karthik Viswanathan, Hedy Adari, Shih-Feng Cho, MD PhD, Yuyin Li, PhD, Wenjuan Yang, Hailin Chen, Yan Xu, MD, Gang An, Lugui Qiu, MD, Nikhil C. Munshi, MD, Gregory Babcock, Zach Shriver, James Myette, PhD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136824
Published: 2020
Journal Articles

Preclinical Evaluation of CD8+ Anti-Bcma mRNA CAR T-Cells for the Control of Human Multiple Myeloma

Liang Lin, PhD, Lijie Xing, MD, Shih-Feng Cho, MD PhD, Kenneth Wen, Phillip A Hsieh, Metin Kurtoglu, MD PhD, Yi Zhang, C Andrew Stewart, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1811.
https://doi.org/10.1182/blood-2019-121595
Published: 2019
Journal Articles

Anti-Bcma PBD MEDI2228 Combats Drug Resistance and Synergizes with Bortezomib and Inhibitors to DNA Damage Response in Multiple Myeloma

Lijie Xing, MD, Liang Lin, PhD, Tengteng Yu, MD PhD, Yuyin Li, PhD, Kenneth Wen, BS, Shih-Feng Cho, MD PhD, Phillip A Hsieh, Krista Kinneer, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1817.
https://doi.org/10.1182/blood-2019-127163
Published: 2019
Journal Articles

MEDI2228, a Novel Bcma Antibody-PBD Conjugate, Sensitizes Human Multiple Myeloma Cells to NK Cell-Mediated Cytotoxicity and Upregulates CD38 Expression in MM Cells

Lijie Xing, MD, Yuyin Li, PhD, Liang Lin, PhD, Tengteng Yu, MD PhD, Kenneth Wen, Shih-Feng Cho, MD PhD, Phillip A Hsieh, Krista Kinneer, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3096.
https://doi.org/10.1182/blood-2019-127135
Published: 2019
Journal Articles

Impacts of a Proliferation-Inducing Ligand on Current Therapeutic Monoclonal Antibody-Induced Cytotoxicity Against Human Multiple Myeloma Cells

Liang Lin, PhD, Shih-Feng Cho, MD PhD, Kenneth Wen, Tengteng Yu, MD PhD, Phillip A Hsieh, Yuyin Li, PhD, Gang An, MD, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3105.
https://doi.org/10.1182/blood-2019-130927
Published: 2019
Journal Articles

AMG 701 Potently Induces Anti-Multiple Myeloma (MM) Functions of T Cells and IMiDs Further Enhance Its Efficacy to Prevent MM Relapse In Vivo

Shih-Feng Cho, MD PhD, Liang Lin, PhD, Lijie Xing, MD, Kenneth Wen, Tengteng Yu, MD PhD, Phillip A Hsieh, Yuyin Li, PhD, Nikhil C. Munshi, MD, Joachim Wahl, PhD, Katja Matthes, Kenneth C. Anderson, MD, Tara Chapman-Arvedson, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 135.
https://doi.org/10.1182/blood-2019-128528
Published: 2019
Journal Articles

Syndecan-1 Is Critical in ARF6-Dependent Macropinocytosis Driven By KRAS Mutation in the Pathophysiology of Multiple Myeloma

Tengteng Yu, MD PhD, Liang Lin, PhD, Kenneth Wen, Lijie Xing, MD, Jiye Liu, PhD, Shih-Feng Cho, MD PhD, Phillip Hsieh, Ola Rizq, MD PhD, Yuyin Li, PhD, Liang Yu, Xiang Wu, Eugenio Morelli, MD, Yan Xu, MD, Gang An, MD, Nikhil C. Munshi, MD, Lugui Qiu, MD PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4371.
https://doi.org/10.1182/blood-2019-127454
Published: 2019
Journal Articles

APOBEC3B Induction Following DNA Damage Response Modulates the Survival and Treatment Response in Human Multiple Myeloma

Lijie Xing, MD, Jiye Liu, PhD, Yuyin Li, PhD, Liang Lin, PhD, Kenneth Wen, Shih-Feng Cho, MD PhD, Tengteng Yu, MD PhD, Gang An, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4381.
https://doi.org/10.1182/blood-2019-130297
Published: 2019
Journal Articles

APOBEC3B Is Induced By Activation of DNA Repair Pathway and Modulates the Survival and Treatment Response in Human Multiple Myeloma

Lijie Xing, MD, Jiye Liu, PhD, Liang Lin, PhD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip Hsieh, Gang An, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 407.
https://doi.org/10.1182/blood-2018-99-110317
Published: 2018
Journal Articles

An Immune Based, Anti-CD138 Targeting Antibody for the Treatment of Multiple Myeloma

Tengteng Yu, MD, Lijie Xing, MD, Liang Lin, PhD, Jiye Liu, PhD, Kenneth Wen, BS, Shih-Feng Cho, MD PhD, Phillip Hsieh, James Myette, Bharat Chaganty, Hedy Adari, Hamid Tissire, Ketan Deotale, Zach Shriver, Nikhil Munshi, MD, Yu-Tzu Tai, PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5617.
https://doi.org/10.1182/blood-2018-99-119112
Published: 2018
Journal Articles

Anti-BCMA BiTE ® AMG 701 Potently Induces Specific T Cell Lysis of Human Multiple Myeloma (MM) Cells and Immunomodulation in the Bone Marrow Microenvironment

Shih-Feng Cho, MD PhD, Liang Lin, PhD, Lijie Xing, MD, Jiye Liu, PhD, Tengteng Yu, MD, Kenneth Wen, BS, Phillip Hsieh, Nikhil Munshi, MD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 592.
https://doi.org/10.1182/blood-2018-99-118425
Published: 2018
Journal Articles

Genome-Wide CRISPR-Cas9 Screening Reveals a Role for TRAF2 in Resistance to IMiDs in Multiple Myeloma

Jiye Liu, PhD, Wenrong Zhou, PhD, Lijie Xing, MD, Liang Lin, PhD, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Teru Hideshima, MD PhD, Yong Cang, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1917.
https://doi.org/10.1182/blood-2018-99-111962
Published: 2018
Journal Articles

APRIL Is Significantly Elevated at All Stages of Multiple Myeloma (MM) and Interferes with Anti-Bcma Monoclonal Antibody-Mediated Cytolysis, Supporting the Clinical Evaluation of Bion-1301 As a Novel Therapeutic Approach in MM

Yu-Tzu Tai, PhD, John Dulos, PhD, Lars Guelen, Liang Lin, PhD, Lijie Xing, MD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip A Hsieh, Peter van Zandvoort, Bsc, Guido van de Wiel, Jos van de Crommert, Bsc, Bonny Lejeune, Hamid Namini, Hans Eenennaam, PhD, Andrea van Elsas, PhD, Paul Richardson, Nikhil Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3209.
https://doi.org/10.1182/blood-2018-99-117296
Published: 2018
Journal Articles

Dysregulated Translational Control Is a Central Feature of MM Mediated By 14-3-3ε Interactome Promoting Multiple Myeloma Cell Growth and Viability

Yan Xu, MD, Mariateresa Fulciniti, PhD, Matthew Ho, Mehmet Kemal Samur, PhD, Michael A Lopez, Na Li, MD, Giada Bianchi, MD, Raphael Szalat, MD, Jianhong Lin, MD MSc, Tommaso Perini, MD, Srikanth Talluri, PhD, Tengteng Yu, MD, Kenneth Wen, BS, Jiye Liu, PhD, Li Zhang, MD, Liang Lin, PhD, Lijie Xing, MD, Gang An, MD, Yu-Tzu Tai, PhD, Kenneth Anderson, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3176.
https://doi.org/10.1182/blood-2018-99-118994
Published: 2018
Journal Articles

A Proliferation Inducing Ligand (APRIL) Directly Impacts Immune Regulatory Subsets to Regulate Suppressive Multiple Myeloma Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Liang Lin, PhD, Lijie Xing, MD, Kenneth Wen, BS, Phillip Hsieh, An Gang, MD, Lugui Qiu, MD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3066.
https://doi.org/10.1182/blood.V130.Suppl_1.3066.3066
Published: 2017
Journal Articles

CD8+ Anti-BCMA mRNA CAR T-Cells Effectively Kill Human Multiple Myeloma Cells In Vitro and In Vivo

Liang Lin, PhD, Lijie Xing, MD, Chirag M Acharya, MBBS, Kenneth Wen, BS, Jiye Liu, PhD, Phillip Hsieh, Metin Kurtoglu, MD PhD, Jeffrey Holderness, MD, Murat Kalayoglu, MD PhD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3067.
https://doi.org/10.1182/blood.V130.Suppl_1.3067.3067
Published: 2017