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Journal Articles

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A - and NPM1 -altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L. Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P. Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David M. Wilson, Ricardo Attar, Yusri Elsayed, Eric S. Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (11): 1206–1220.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A -r and NPM1c AML

Wallace Bourgeois, Jevon A. Cutler, Brandon J. Aubrey, Daniela V. Wenge, Florian Perner, Cynthia Martucci, Jill A. Henrich, Kelly Klega, Radosław P. Nowak, Katherine A. Donovan, Meaghan Boileau, Yanhe Wen, Charlie Hatton, Athina A. Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A. Pollard, Jennifer A. Perry, Adam S. Sperling, Benjamin L. Ebert, Gerard M. McGeehan, Brian D. Crompton, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2024) 143 (15): 1513–1527.
https://doi.org/10.1182/blood.2023021105
Published: 2024
Includes: Supplemental data
Journal Articles

UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability

Jonathan M Tsai, Jacob D Aguirre, Jared Brown, Vivian Focht, Yen-Der Li, Georg Kempf, Lukas Kater, Pius Galli, Simone Cavadini, Brittany E Sandoval, Charles Zou, Justine Rutter, Katherine Donovan, Quinlan Sievers, Paul Park, Jevon A. Cutler, Charlie Hatton, Elizabeth Ener, Micah T Sperling, Mikolaj Slabicki, Peter G. Miller, Roger Belizaire, Adam S. Sperling, Scott A. Armstrong, Eric S. Fischer, Nicolas Thomä, Benjamin L. Ebert
Journal: Blood
Blood (2022) 140 (Supplement 1): 2968–2969.
https://doi.org/10.1182/blood-2022-167615
Published: 2022
Journal Articles

Dysregulated Humoral and Cellular Response to Sars-Cov-2 Vaccination in Patients with MGUS and SMM

Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Shohreh Varmeh, Daniel Heilpern-Mallory, Michael P. Agius, Nang Kham Su, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna V. Justis, Radoslaw P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric S. Fischer, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7158–7159.
https://doi.org/10.1182/blood-2022-167212
Published: 2022
Journal Articles

Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1

Wenchao Wu, Geoffrey M. Nelson, Raphael Koch, Katherine A. Donovan, Radosław P. Nowak, Tayla B. Heavican-Foral, Ajit J. Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E. Stevenson, Marcus Kenneth Jones, Samuel Y. Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L. Donaldson, Patrick R. Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S. Fischer, Karen Adelman, David M. Weinstock
Journal: Blood
Blood (2022) 139 (13): 2024–2037.
https://doi.org/10.1182/blood.2021014701
Published: 2022
Includes: Supplemental data
Journal Articles

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1 -Rearranged and NPM1 -Mutant AML

Wallace Bourgeois, Brandon J. Aubrey, Jevon A. Cutler, Katherine A. Donovan, Charles Hatton, Alexandra C. P. Theall, Radoslaw P. Nowak, Gerard M. McGeehan, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2021) 138 (Supplement 1): 208.
https://doi.org/10.1182/blood-2021-150971
Published: 2021
Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 406.
https://doi.org/10.1182/blood-2019-123573
Published: 2019
Journal Articles

Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

Dennis Dobrovolsky, Eric S. Wang, Sara Morrow, Catharine Leahy, Tyler Faust, Radosław P. Nowak, Katherine A. Donovan, Guang Yang, Zhengnian Li, Eric S. Fischer, Steven P. Treon, David M. Weinstock, Nathanael S. Gray
Journal: Blood
Blood (2019) 133 (9): 952–961.
https://doi.org/10.1182/blood-2018-07-862953
Published: 2019
Includes: Supplemental data
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4 CRBN activity

Quinlan L. Sievers, Jessica A. Gasser, Glenn S. Cowley, Eric S. Fischer, Benjamin L. Ebert
Journal: Blood
Blood (2018) 132 (12): 1293–1303.
https://doi.org/10.1182/blood-2018-01-821769
Published: 2018
Includes: Supplemental data
Journal Articles

The Safety and Activity of BMS-906024, a Gamma Secretase Inhibitor (GSI) with Anti-Notch Activity, in Patients with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL): Initial Results of a Phase 1 Trial

Patrick A. Zweidler-McKay, MDPhD, Daniel J. DeAngelo, MDPhD, Dan Douer, MD, Hervé Dombret, MD, Oliver G. Ottmann, MD, Norbert Vey, MD, Deborah A. Thomas, MD, Lili Zhu, MSc, Fei Huang, PhD, Gaurav Bajaj, PhD, Bruce S. Fischer, MD
Journal: Blood
Blood (2014) 124 (21): 968.
https://doi.org/10.1182/blood.V124.21.968.968
Published: 2014
Journal Articles

A new Rac-ket in red cells

Velia M. Fowler, Robert S. Fischer
Journal: Blood
Blood (2006) 108 (12): 3633–3634.
https://doi.org/10.1182/blood-2006-09-046870
Published: 2006
Journal Articles

Human mononuclear cells express 12-LX: coordinated mRNA regulation with 5-LX and FLAP genes

WE Kaminski, E Jendraschak, K Baumann, R Kiefl, S Fischer, AJ Marcus, MJ Broekman, C von Schacky
Journal: Blood
Blood (1996) 87 (1): 331–340.
https://doi.org/10.1182/blood.V87.1.331.331
Published: 1996
Journal Articles

Heterogeneity of the T-cell receptor delta gene indicating subclone formation in acute precursor B-cell leukemias

DW Ghali, S Panzer, S Fischer, A Argyriou-Tirita, OA Haas, H Kovar, H Gadner, ER Panzer-Grumayer
Journal: Blood
Blood (1995) 85 (10): 2795–2801.
https://doi.org/10.1182/blood.V85.10.2795.bloodjournal85102795
Published: 1995
Journal Articles

High pp60c-src level in human platelet dense bodies

F Rendu, M Lebret, S Danielian, R Fagard, S Levy-Toledano, S Fischer
Journal: Blood
Blood (1989) 73 (6): 1545–1551.
https://doi.org/10.1182/blood.V73.6.1545.1545
Published: 1989
Journal Articles

Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias

JP Piau, J Delaunay, S Fischer, M Tortolero, G Schapira
Journal: Blood
Blood (1980) 56 (6): 963–968.
https://doi.org/10.1182/blood.V56.6.963.963
Published: 1980
Journal Articles

Studies in the Pathogenesis of Autoerythrocyte Sensitization Syndrome

GEORGE S. GROCH, Captain, M.C., U.S.A.R., STUART C. FINCH, M.D., WILLIAM ROGOWAY, M.D., DAVID S. FISCHER, M.D.
Journal: Blood
Blood (1966) 28 (1): 19–33.
https://doi.org/10.1182/blood.V28.1.19.19
Published: 1966
Journal Articles

Separation and Properties of Urinary Hemopoietine

G. HODGSON, S. FISCHER, M. PERRETTA, I. ESKUCHE, G. ARAYA, M. DINAMARCA
Journal: Blood
Blood (1960) 16 (4): 1398–1410.
https://doi.org/10.1182/blood.V16.4.1398.1398
Published: 1960
Journal Articles

Inability of Haptoglobin to Bind Myoglobin

JAMSHID JAVID, DAVID S. FISCHER, THEODORE H. SPAET
Journal: Blood
Blood (1959) 14 (6): 683–687.
https://doi.org/10.1182/blood.V14.6.683.683
Published: 1959