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Merja Heinäniemi
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Journal Articles

Unraveling Clonal Evolution and Mechanisms of Treatment Resistance in Murine KMT2A -Rearranged Leukemia with Subclonal FLT3 N676K

Ton Falques-Costa, Mattias Pilheden, Andrea Hanel, Qirui Zhang, Louise Ahlgren, Helena Sturesson, Lars Ronnstrand, Julhash Uddin Kazi, Merja Heinäniemi, Axel Hyrenius Wittsten, Anna K. Hagstroem-Andersson
Journal: Blood
Blood (2023) 142 (Supplement 1): 5918.
https://doi.org/10.1182/blood-2023-180636
Published: 2023
Journal Articles

Pax5 Heterozygosity Affects B-Cell Differentiation and Generates a Deregulated Precursor Population in the Bone Marrow

Franziska Auer, Mina Morcos, Mikko Sipola, Sanni Moisio, Anna Viitasalo, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2768.
https://doi.org/10.1182/blood-2023-184384
Published: 2023
Journal Articles

Genomic Determinants of Therapy Response in ETV6::RUNX1 Leukemia

Laura Oksa, Sanni Moisio, Khurram Maqbool, Hassan Foroughi-Asl, Roger Kramer, Atte Nikkilä, Kaisa Vepsäläinen, Jesus Duque-Afonso, Julia Hauer, Jessica Nordlund, Valtteri Wirta, Olli Lohi, Merja Heinäniemi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2970.
https://doi.org/10.1182/blood-2023-188691
Published: 2023
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

Vera H Jepsen, Daniel Hein, Daniel Picard, Tobias Lautwein, Rabea Wagener, Nan Qin, Annika Filip, Merja Heinäniemi, Arndt Borkhardt, Ute Fischer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3469–3470.
https://doi.org/10.1182/blood-2022-163564
Published: 2022
Journal Articles

Mechanistic Study of Wee1 Kinase Inhibition with AZD1775 Exposes Drug Targetable Vulnerabilities in Acute B-Lymphoblastic Leukemia

Alena Malyukova, Mari Lahnalampi, Ton Falqués, Petri Pölönen, Mikko Sipola, Juha Mehtonen, Susanna Teppo, Johanna Viiliäinen, Olli Lohi, Anna Hagstroem-Andersson, Merja Heinäniemi, Olle Sangfelt
Journal: Blood
Blood (2022) 140 (Supplement 1): 11576.
https://doi.org/10.1182/blood-2022-168684
Published: 2022
Journal Articles

Genetic and Pharmacological Inhibition of BTK Increases Dasatinib Sensitivity in Vitro and In Vivo Including CNS-Infiltrating E2A-PBX1 + /Pre-BCR + ALL Cells

Gaia Gentile, Teresa Poggio, Antonella Catalano, Minna Voutilainen, Marta Andrade-Martinez, Tobias Ma, Roman Sankowski, Lina Goncarenko, Stefan Tholen, Kyuho Han, David Morgens, Marco Prinz, Michael Luebbert, Peter Bronsert, Michael Bassik, Michael Cleary, Oliver Schilling, Merja Heinäniemi, Jesus Duque Afonso
Journal: Blood
Blood (2022) 140 (Supplement 1): 503–504.
https://doi.org/10.1182/blood-2022-162699
Published: 2022
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Identification and Interpretation of Clinically Relevant Somatic Variants from Whole-Genome Sequencing Data

Khurram Maqbool, Hassan Hassan Foroughi-Asl, Ashwini Ashwini Jeggari, Vadym Ivanchuk, Jesper Eisfeldt, Annick Renevey, Keyvan Elhami, Chiara Rasi, Daniel Nilsson, Merja Heinäniemi, Olli Lohi, Valtteri Wirta
Journal: Blood
Blood (2022) 140 (Supplement 1): 13003–13004.
https://doi.org/10.1182/blood-2022-163295
Published: 2022
Journal Articles

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia

Saara Laukkanen, Alexandra Veloso, Chuan Yan, Laura Oksa, Eric J. Alpert, Daniel Do, Noora Hyvärinen, Karin McCarthy, Abhinav Adhikari, Qiqi Yang, Sowmya Iyer, Sara P. Garcia, Annukka Pello, Tanja Ruokoranta, Sanni Moisio, Sadiksha Adhikari, Jeffrey A. Yoder, Kayleigh Gallagher, Lauren Whelton, James R. Allen, Alex H. Jin, Siebe Loontiens, Merja Heinäniemi, Michelle Kelliher, Caroline A. Heckman, Olli Lohi, David M. Langenau
Journal: Blood
Blood (2022) 140 (17): 1891–1906.
https://doi.org/10.1182/blood.2021015106
Published: 2022
Includes: Supplemental data
Journal Articles

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Anne Schedel, Ulrike Anne Friedrich, Rabea Wagener, Juha Mehtonen, Claudia Saitta, Triantafyllia Brozou, Pia Michler, Carolin Walter, Peter Horak, Nagarajan Paramasivam, Grazia Fazio, Stefan Fröhling, Martin Dugas, Daniela Richter, Hanno Glimm, Merja Heinäniemi, Rolf Jessberger, Giovanni Cazzaniga, Arndt Borkhardt, Julia Hauer, Franziska Auer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3358.
https://doi.org/10.1182/blood-2021-150284
Published: 2021
Journal Articles

Pax5 Heterozygosity Delays BCR Expression in Preb-II Cells and Generates a Preleukemic Population

Franziska Auer, Juha Mehtonen, Mikko Sipola, Mina Morcos, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1140.
https://doi.org/10.1182/blood-2021-150144
Published: 2021
Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Immunogenomic Landscape of Hematological Malignancies

Olli Dufva, Petri Pölönen, MSc, Oscar Brück, MD, Mikko A Keränen, MD PhD, Juha Mehtonen, MSc, Sanna M. Siitonen, MD PhD, Suvi-Katri Leivonen, PhD, Leo Meriranta, MS, Sirpa Leppa, MD Prof, Matti Nykter, Olli Lohi, MD PhD, Merja Heinäniemi, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2596.
https://doi.org/10.1182/blood-2018-99-118335
Published: 2018
Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1440.
https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440
Published: 2017
Journal Articles

Genome-Wide Analysis of the Regulatory Landscape in Different Pre-B-ALL Subtypes

Mari Lahnalampi, MSc, Juha Mehtonen, MSc, Susanna Teppo, MSc, Saara Laukkanen, MSc, Laura Oksa, MSc, Markus Muschen, MD, Olli Lohi, MD PhD, Merja Heinäniemi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3807.
https://doi.org/10.1182/blood.V130.Suppl_1.3807.3807
Published: 2017
Journal Articles

Pan-Hematopoietic Cancer Gene Expression Analysis Identifies Immunologically Active Acute Myeloid Leukemia Subtypes

Olli Dufva, Petri Pölönen, Mikko A Keränen, MD PhD, Thomas Liuksiala, Jake Lin, Juha Mehtonen, MSc, Sergei Häyrynen, Kirsi Granberg, PhD, Matti Nykter, PhD, Olli Lohi, Merja Heinäniemi, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1725.
https://doi.org/10.1182/blood.V128.22.1725.1725
Published: 2016
Journal Articles

In Silico and Ex Vivo Drug Screening Identifies Dasatinib as a Potential Targeted Therapy for T-ALL

Saara Laukkanen, Petri Pölönen, Toni Grönroos, Heikki Kuusanmäki, MSc, Caroline A Heckman, PhD, Mika Kontro, Merja Heinäniemi, Olli Lohi
Journal: Blood
Blood (2016) 128 (22): 4029.
https://doi.org/10.1182/blood.V128.22.4029.4029
Published: 2016
Journal Articles

Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments

Susanna Teppo, MSc, Juha Mehtonen, MSc, Samuli Eldfors, MSc, Caroline A Heckman, PhD, Markus Müschen, MD PhD, Merja Heinäniemi, PhD, Olli Lohi
Journal: Blood
Blood (2016) 128 (22): 4077.
https://doi.org/10.1182/blood.V128.22.4077.4077
Published: 2016