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Volume 92, Issue 5

September 1 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

REVIEW ARTICLES

Immune Reconstitution and Immunotherapy After Autologous Hematopoietic Stem Cell Transplantation

Thierry Guillaume,Daniel B. Rubinstein,Michel Symann

View Articletitled, Immune Reconstitution and Immunotherapy After Autologous Hematopoietic Stem Cell Transplantation

RAPID COMMUNICATIONS

The Prolactin Receptor Rescues EpoR^−/− Erythroid Progenitors and Replaces EpoR in a Synergistic Interaction With c-kit

Merav Socolovsky,Amy E.J. Fallon,Harvey F. Lodish

View Articletitled, The Prolactin Receptor Rescues EpoR−/− Erythroid Progenitors and Replaces EpoR in a Synergistic Interaction With c-kit

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

Zhu-Gang Wang,Roberta Rivi,Laurent Delva,Andrea König,David A. Scheinberg,Carlo Gambacorti-Passerini,Janice L. Gabrilove,Raymond P. Warrell, Jr,Pier Paolo Pandolfi

View Articletitled, Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

Philip Jones,Gill May,Lyn Healy,John Brown,Gerald Hoyne,Sylvie Delassus,Tariq Enver

View Articletitled, Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

Control of Erythropoietin Delivery by Doxycycline in Mice After Intramuscular Injection of Adeno-Associated Vector

Delphine Bohl,Anna Salvetti,Philippe Moullier,Jean Michel Heard

View Articletitled, Control of Erythropoietin Delivery by Doxycycline in Mice After Intramuscular Injection of Adeno-Associated Vector

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

A Double-Blind Randomized Comparison of Combined Aspirin and Ticlopidine Therapy Versus Aspirin or Ticlopidine Alone on Experimental Arterial Thrombogenesis in Humans

Jean-Pierre Bossavy,Claire Thalamas,Luc Sagnard,André Barret,Kjell Sakariassen,Bernard Boneu,Yves Cadroy

View Articletitled, A Double-Blind Randomized Comparison of Combined Aspirin and Ticlopidine Therapy Versus Aspirin or Ticlopidine Alone on Experimental Arterial Thrombogenesis in Humans

Heparin-Induced Thrombocytopenia: New Insights Into the Impact of the FcγRIIa-R-H131 Polymorphism

Lena E. Carlsson,Sentot Santoso,Gudrun Baurichter,Hartmut Kroll,Stephanie Papenberg,Petra Eichler,Nomdo A.C. Westerdaal,Volker Kiefel,Jan G.J. van de Winkel,Andreas Greinacher

View Articletitled, Heparin-Induced Thrombocytopenia: New Insights Into the Impact of the FcγRIIa-R-H131 Polymorphism

A Randomized Phase-II Study of BB-10010 (Macrophage Inflammatory Protein- 1) in Patients With Advanced Breast Cancer Receiving 5-Fluorouracil, Adriamycin, and Cyclophosphamide Chemotherapy

Mark J. Clemons,Ernest Marshall,Jan Dürig,Ken Watanabe,Anthony Howell,David Miles,Helena Earl,Julie Kiernan,Audrey Griffiths,K. Towlson,P. DeTakats,Nydia G. Testa,Mark Dougal,Michael G. Hunter,L. Michael Wood,Lloyd G. Czaplewski,Andrew Millar,T. Michael Dexter,Brian I. Lord

View Articletitled, A Randomized Phase-II Study of BB-10010 (Macrophage Inflammatory Protein- 1) in Patients With Advanced Breast Cancer Receiving 5-Fluorouracil, Adriamycin, and Cyclophosphamide Chemotherapy

Long-Term Follow-Up of the Italian Trial of Interferon- Versus Conventional Chemotherapy in Chronic Myeloid Leukemia

The Italian Cooperative Study Group on Chronic Myeloid Leukemia*

View Articletitled, Long-Term Follow-Up of the Italian Trial of Interferon- Versus Conventional Chemotherapy in Chronic Myeloid Leukemia

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

Cliona M. Rooney,Colton A. Smith,Catherine Y.C. Ng,Susan K. Loftin,John W. Sixbey,Yanjun Gan,Deo-Kumar Srivastava,Laura C. Bowman,Robert A. Krance,Malcolm K. Brenner,Helen E. Heslop

View Articletitled, Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

A Randomized Controlled Trial of Filgrastim During Remission Induction and Consolidation Chemotherapy for Adults With Acute Lymphoblastic Leukemia: CALGB Study 9111

Richard A. Larson,Richard K. Dodge,Charles A. Linker,Richard M. Stone,Bayard L. Powell,Edward J. Lee,Philip Schulman,Frederick R. Davey,Stanley R. Frankel,Clara D. Bloomfield,Stephen L. George,Charles A. Schiffer

View Articletitled, A Randomized Controlled Trial of Filgrastim During Remission Induction and Consolidation Chemotherapy for Adults With Acute Lymphoblastic Leukemia: CALGB Study 9111

HEMATOPOIESIS

Retroviral Marking of Canine Bone Marrow: Long-Term, High-Level Expression of Human Interleukin-2 Receptor Common Gamma Chain in Canine Lymphocytes

Todd Whitwam,Mark E. Haskins,Paula S. Henthorn,Jennifer N. Kraszewski,Sandra E. Kleiman,Nancy E. Seidel,David M. Bodine,Jennifer M. Puck

View Articletitled, Retroviral Marking of Canine Bone Marrow: Long-Term, High-Level Expression of Human Interleukin-2 Receptor Common Gamma Chain in Canine Lymphocytes

Neutrophils Deficient in PU.1 Do Not Terminally Differentiate or Become Functionally Competent

Karen L. Anderson,Kent A. Smith,Frederic Pio,Bruce E. Torbett,Richard A. Maki

View Articletitled, Neutrophils Deficient in PU.1 Do Not Terminally Differentiate or Become Functionally Competent

A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow–Repopulating Cells

Karen J. Neelis,Trudi P. Visser,Wati Dimjati,G. Roger Thomas,Paul J. Fielder,Duane Bloedow,Dan L. Eaton,Gerard Wagemaker

View Articletitled, A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow–Repopulating Cells

Proliferation in Monocyte-Derived Dendritic Cell Cultures Is Caused by Progenitor Cells Capable of Myeloid Differentiation

Lois L. Cavanagh,Russell J. Saal,Karen L. Grimmett,Ranjeny Thomas

View Articletitled, Proliferation in Monocyte-Derived Dendritic Cell Cultures Is Caused by Progenitor Cells Capable of Myeloid Differentiation

Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes

Patrick Lecine,Jean-Luc Villeval,Paresh Vyas,Bethany Swencki,Yuhui Xu,Ramesh A. Shivdasani

View Articletitled, Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex

John P. Sheehan,Hao-Chang Lan

View Articletitled, Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex

Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1

Sriram Neelamegham,Andrew D. Taylor,Alan R. Burns,C. Wayne Smith,Scott I. Simon

View Articletitled, Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1

Severe Factor VII Deficiency Due to a Mutation Disrupting an Sp1 Binding Site in the Factor VII Promoter

Josephine A. Carew,Eleanor S. Pollak,Katherine A. High,Kenneth A. Bauer

View Articletitled, Severe Factor VII Deficiency Due to a Mutation Disrupting an Sp1 Binding Site in the Factor VII Promoter

Molecular Mechanisms of FVII Deficiency: Expression of Mutations Clustered in the IVS7 Donor Splice Site of Factor VII Gene

M. Pinotti,R. Toso,R. Redaelli,M. Berrettini,G. Marchetti,F. Bernardi

View Articletitled, Molecular Mechanisms of FVII Deficiency: Expression of Mutations Clustered in the IVS7 Donor Splice Site of Factor VII Gene

Antiphospholipid Antibodies Accelerate Plasma Coagulation by Inhibiting Annexin-V Binding to Phospholipids: A “Lupus Procoagulant” Phenomenon

Jacob H. Rand,Xiao-Xuan Wu,Harry A.M. Andree,J.B. Alexander Ross,Elena Rusinova,Mayra G. Gascon-Lema,Cesare Calandri,Peter C. Harpel

View Articletitled, Antiphospholipid Antibodies Accelerate Plasma Coagulation by Inhibiting Annexin-V Binding to Phospholipids: A “Lupus Procoagulant” Phenomenon

IMMUNOBIOLOGY

Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation

Bo Nilsson,Rolf Larsson,Jaan Hong,Graciela Elgue,Kristina Nilsson Ekdahl,Arvind Sahu,John D. Lambris

View Articletitled, Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation

A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

Hiroshi Sakamoto,Hideo Yasukawa,Masaaki Masuhara,Shyu Tanimura,Atsuo Sasaki,Kentaro Yuge,Motoaki Ohtsubo,Akira Ohtsuka,Takasi Fujita,Tsunetaka Ohta,Yusuke Furukawa,Satsuki Iwase,Hisashi Yamada,Akihiko Yoshimura

View Articletitled, A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

CD80-Transfected Acute Myeloid Leukemia Cells Induce Primary Allogeneic T-Cell Responses Directed at Patient Specific Minor Histocompatibility Antigens and Leukemia-Associated Antigens

Tuna Mutis,Ellen Schrama,Cornelis J.M. Melief,Els Goulmy

View Articletitled, CD80-Transfected Acute Myeloid Leukemia Cells Induce Primary Allogeneic T-Cell Responses Directed at Patient Specific Minor Histocompatibility Antigens and Leukemia-Associated Antigens

Human Herpesvirus 7 Infection Induces Profound Cell Cycle Perturbations Coupled to Disregulation of cdc2 and Cyclin B and Polyploidization of CD4⁺ T Cells

Paola Secchiero,Lucia Bertolaso,Luca Casareto,Davide Gibellini,Marco Vitale,Kristi Bemis,Arrigo Aleotti,Silvano Capitani,Genoveffa Franchini,Robert C. Gallo,Giorgio Zauli

View Articletitled, Human Herpesvirus 7 Infection Induces Profound Cell Cycle Perturbations Coupled to Disregulation of cdc2 and Cyclin B and Polyploidization of CD4+ T Cells

SLP-76-Cbl-Grb2-Shc Interactions in FcγRI Signaling

Julie Chu,Yenbou Liu,Gary A. Koretzky,Donald L. Durden

View Articletitled, SLP-76-Cbl-Grb2-Shc Interactions in FcγRI Signaling

Expression of Proteins Controlling Transbilayer Movement of Plasma Membrane Phospholipids in the B Lymphocytes From a Patient With Scott Syndrome

Quansheng Zhou,Peter J. Sims,Therese Wiedmer

View Articletitled, Expression of Proteins Controlling Transbilayer Movement of Plasma Membrane Phospholipids in the B Lymphocytes From a Patient With Scott Syndrome

Retinoic Acid Inhibits CD40 + Interleukin-4–Mediated IgE Production In Vitro

M. Worm,J.M. Krah,R.A. Manz,B.M. Henz

View Articletitled, Retinoic Acid Inhibits CD40 + Interleukin-4–Mediated IgE Production In Vitro

NEOPLASIA

Antisense to the Epstein-Barr Virus (EBV)-Encoded Latent Membrane Protein 1 (LMP-1) Suppresses LMP-1 and Bcl-2 Expression and Promotes Apoptosis in EBV-Immortalized B Cells

Jamie L. Kenney,Mary E. Guinness,Tyler Curiel,Jill Lacy

View Articletitled, Antisense to the Epstein-Barr Virus (EBV)-Encoded Latent Membrane Protein 1 (LMP-1) Suppresses LMP-1 and Bcl-2 Expression and Promotes Apoptosis in EBV-Immortalized B Cells

Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy Donors

Susanne Schnittger,Bernhard Wörmann,Wolfgang Hiddemann,Frank Griesinger

View Articletitled, Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy Donors

Consistent Fusion of ZNF198 to the Fibroblast Growth Factor Receptor-1 in the t(8;13)(p11;q12) Myeloproliferative Syndrome

Andreas Reiter,Jastinder Sohal,Shashikant Kulkarni,Andrew Chase,Donald H.C. Macdonald,Ricardo C.T. Aguiar,Cristina Gonçalves,Jesus M. Hernandez,Barbara A. Jennings,John M. Goldman,Nicholas C.P. Cross

View Articletitled, Consistent Fusion of ZNF198 to the Fibroblast Growth Factor Receptor-1 in the t(8;13)(p11;q12) Myeloproliferative Syndrome

Multicolor Spectral Karyotyping Identifies New Recurring Breakpoints and Translocations in Multiple Myeloma

Pulivarthi H. Rao,Juan C. Cigudosa,Yi Ning,Marı́a J. Calasanz,Shinsuke Iida,Shinichi Tagawa,Joseph Michaeli,Bernard Klein,Riccardo Dalla-Favera,Suresh C. Jhanwar,Thomas Ried,R.S.K. Chaganti

View Articletitled, Multicolor Spectral Karyotyping Identifies New Recurring Breakpoints and Translocations in Multiple Myeloma

Anti-Estrogens Induce Apoptosis of Multiple Myeloma Cells

Steven P. Treon,Gerrard Teoh,Mitsuyoshi Urashima,Atsushi Ogata,Dharminder Chauhan,Iain J. Webb,Kenneth C. Anderson

View Articletitled, Anti-Estrogens Induce Apoptosis of Multiple Myeloma Cells

Targeting of PML/RAR Is Lethal to Retinoic Acid–Resistant Promyelocytic Leukemia Cells

Kathryn Nason-Burchenal,Janet Allopenna,Agnes Bègue,Dominique Stéhelin,Ethan Dmitrovsky,Patrick Martin

View Articletitled, Targeting of PML/RAR Is Lethal to Retinoic Acid–Resistant Promyelocytic Leukemia Cells

Phosphorylation of BCL-2 After Exposure of Human Leukemic Cells to Retinoic Acid

Z.-B. Hu,M.D. Minden,E.A. McCulloch

View Articletitled, Phosphorylation of BCL-2 After Exposure of Human Leukemic Cells to Retinoic Acid

RED CELLS

Rh50 Glycoprotein Gene and Rh_null Disease: A Silent Splice Donor Is trans to a Gly₂₇₉→Glu Missense Mutation in the Conserved Transmembrane Segment

Cheng-Han Huang,Zhi Liu,Guangjie Cheng,Ying Chen

View Articletitled, Rh50 Glycoprotein Gene and Rhnull Disease: A Silent Splice Donor Is trans to a Gly279→Glu Missense Mutation in the Conserved Transmembrane Segment

Targeted Inactivation of Murine Band 3 (AE1) Gene Produces a Hypercoagulable State Causing Widespread Thrombosis In Vivo

Hani Hassoun,Ying Wang,John Vassiliadis,Mohini Lutchman,Jiri Palek,Leo Aish,Irene S. Aish,Shih-Chun Liu,Athar H. Chishti

View Articletitled, Targeted Inactivation of Murine Band 3 (AE1) Gene Produces a Hypercoagulable State Causing Widespread Thrombosis In Vivo

Anemia in Children With Cancer Is Associated With Decreased Erythropoietic Activity and Not With Inadequate Erythropoietin Production

Francis Corazza,Yves Beguin,Pierre Bergmann,Marie André,Alina Ferster,Christine Devalck,Pierre Fondu,Marc Buyse,Eric Sariban

View Articletitled, Anemia in Children With Cancer Is Associated With Decreased Erythropoietic Activity and Not With Inadequate Erythropoietin Production

Lymphocyte Subset Analysis and Glycosylphosphatidylinositol Phenotype in Patients With Paroxysmal Nocturnal Hemoglobinuria

Stephen. J. Richards,Derek. R. Norfolk,David M. Swirsky,Peter Hillmen

View Articletitled, Lymphocyte Subset Analysis and Glycosylphosphatidylinositol Phenotype in Patients With Paroxysmal Nocturnal Hemoglobinuria

An Assessment of Dried Blood-Spot Technology for Identifying Iron Deficiency

James D. Cook,Carol H. Flowers,Barry S. Skikne

View Articletitled, An Assessment of Dried Blood-Spot Technology for Identifying Iron Deficiency

The Plasmodium falciparum–CD36 Interaction Is Modified by a Single Amino Acid Substitution in CD36

Lena Serghides,Ian Crandall,Eric Hull,Kevin C. Kain

View Articletitled, The Plasmodium falciparum–CD36 Interaction Is Modified by a Single Amino Acid Substitution in CD36

TRANSPLANTATION

Comparative Analysis of Autografting in Chronic Myelogenous Leukemia: Effects of Priming Regimen and Marrow or Blood Origin of Stem Cells

Catherine M. Verfaillie,Ravi Bhatia,Michael Steinbuch,Todd DeFor,Betsy Hirsch,Jeffrey S. Miller,Daniel Weisdorf,Philip B. McGlave

View Articletitled, Comparative Analysis of Autografting in Chronic Myelogenous Leukemia: Effects of Priming Regimen and Marrow or Blood Origin of Stem Cells

Allogeneic Bone Marrow Transplantation for Low-Grade Lymphoma

Koen van Besien,Kathleen A. Sobocinski,Philip A. Rowlings,Sandra C. Murphy,James O. Armitage,Michael R. Bishop,Ok-kyong Chaekal,Robert Peter Gale,John P. Klein,Hillard M. Lazarus,Philip L. McCarthy, Jr,John M.M. Raemaekers,Josy Reiffers,Gordon L. Phillips,Anton V.M.B. Schattenberg,Leo F. Verdonck,Julie M. Vose,Mary M. Horowitz

View Articletitled, Allogeneic Bone Marrow Transplantation for Low-Grade Lymphoma

CORRESPONDENCE

Leukemic Transformation in Polycythemia Vera

T.C. Pearson,A.R. Green,Georgina Harrisoni,on behalf of the MPD(UK) Study Group

View Articletitled, Leukemic Transformation in Polycythemia Vera

Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia

John H. Kersey

View Articletitled, Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia

Factor V Leiden Mutation and Budd-Chiari Syndrome

Dipika Mohanty,Shrimati Shetty,T.S. Narayanan,Philip Abraham

View Articletitled, Factor V Leiden Mutation and Budd-Chiari Syndrome

The RhD⁻ Trait in a White Patient With the RhCCee Phenotype Attributed to a Four-Nucleotide Deletion in theRHD Gene

K.T. Andrews,L.C. Wolter,A. Saul,C.A. Hyland

View Articletitled, The RhD− Trait in a White Patient With the RhCCee Phenotype Attributed to a Four-Nucleotide Deletion in theRHD Gene

The 20210A Allele of the Prothrombin Gene Is Frequent in Young Women With Unexplained Spinal Cord Infarction

Eric Mercier,Isabelle Quere,Chantal Campello,Pierre Mares,Jean-Christophe Gris

View Articletitled, The 20210A Allele of the Prothrombin Gene Is Frequent in Young Women With Unexplained Spinal Cord Infarction

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Cardiac complete response in AL amyloidosis has similar survival to matched general population

Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma

Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.

NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS