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Issue Archive

Volume 130, Issue 7
August 17 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Inherited thrombocytopenia and Occam’s razor
Clinical Trials & Observations
Jeffrey M. Lipton
View Articletitled, Inherited thrombocytopenia and Occam’s razor
INSIDE BLOOD COMMENTARY
Splicing together the origins of MDS-RS
Sara E. Meyer
View Articletitled, Splicing together the origins of MDS-RS
INSIDE BLOOD COMMENTARY
Accept the complement (blockade)
Stella M. Davies
View Articletitled, Accept the complement (blockade)
INSIDE BLOOD COMMENTARY
Innately interesting interactions
Krishna V. Komanduri
View Articletitled, Innately interesting interactions

PLENARY PAPER

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity
Robert Pick,Daniela Begandt,Thomas J. Stocker,Melanie Salvermoser,Sarah Thome,Ralph T. Böttcher,Eloi Montanez,Ute Harrison,Ignasi Forné,Alexander G. Khandoga,Raffaele Coletti,Ludwig T. Weckbach,Doris Brechtefeld,Rainer Haas,Axel Imhof,Steffen Massberg,Markus Sperandio,Barbara Walzog
View Articletitled, Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity
Supplemental data

PERSPECTIVE

Patient-reported outcomes in hematology: is it time to focus more on them in clinical trials and hematology practice?
Clinical Trials & Observations
Fabio Efficace,Gianluca Gaidano,Francesco Lo-Coco
View Articletitled, Patient-reported outcomes in hematology: is it time to focus more on them in clinical trials and hematology practice?

HOW I TREAT

How I treat patients with aggressive lymphoma at high risk of CNS relapse
Clinical Trials & Observations
Collin K. Chin,Chan Yoon Cheah
View Articletitled, How I treat patients with aggressive lymphoma at high risk of CNS relapse

CLINICAL TRIALS AND OBSERVATIONS

Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin
Clinical Trials & Observations
Aaron Seo,Miri Ben-Harosh,Mehtap Sirin,Jerry Stein,Orly Dgany,Joseph Kaplelushnik,Manfred Hoenig,Ulrich Pannicke,Myriam Lorenz,Klaus Schwarz,Clemens Stockklausner,Tom Walsh,Suleyman Gulsuner,Ming K. Lee,Anoop Sendamarai,Marilyn Sanchez-Bonilla,Mary-Claire King,Holger Cario,Andreas E. Kulozik,Klaus-Michael Debatin,Ansgar Schulz,Hannah Tamary,Akiko Shimamura
View Articletitled, Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in <em>thrombopoietin</em>
Supplemental data

HEMATOPOIESIS AND STEM CELLS

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
CME
Teresa Mortera-Blanco,Marios Dimitriou,Petter S. Woll,Mohsen Karimi,Edda Elvarsdottir,Simona Conte,Magnus Tobiasson,Monika Jansson,Iyadh Douagi,Matahi Moarii,Leonie Saft,Elli Papaemmanuil,Sten Eirik W. Jacobsen,Eva Hellström-Lindberg
View Articletitled, <em>SF3B1</em>-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults
Clinical Trials & Observations
Monica Konar,Dan M. Granoff
View Articletitled, Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults
Supplemental data

LYMPHOID NEOPLASIA

Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis
Clinical Trials & Observations Brief Report
Gregory P. Kaufman,Stanley L. Schrier,Richard A. Lafayette,Sally Arai,Ronald M. Witteles,Michaela Liedtke
View Articletitled, Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis
Supplemental data
The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment
Brief Report
Shan Lin,Roger T. Luo,Mahesh Shrestha,Michael J. Thirman,James C. Mulloy
View Articletitled, The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment
Supplemental data

MYELOID NEOPLASIA

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis
Saori Katayama,Mikiko Suzuki,Ayaka Yamaoka,Nadine Keleku-Lukwete,Fumiki Katsuoka,Akihito Otsuki,Shigeo Kure,James Douglas Engel,Masayuki Yamamoto
View Articletitled, GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis
Supplemental data
Hmga2 promotes the development of myelofibrosis in Jak2V617F knockin mice by enhancing TGF-β1 and Cxcl12 pathways
Avik Dutta,Robert E. Hutchison,Golam Mohi
View Articletitled, Hmga2 promotes the development of myelofibrosis in Jak2<sup>V617F</sup> knockin mice by enhancing TGF-β1 and Cxcl12 pathways
Supplemental data

TRANSPLANTATION

Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease
Jarrod A. Dudakov,Anna M. Mertelsmann,Margaret H. O’Connor,Robert R. Jenq,Enrico Velardi,Lauren F. Young,Odette M. Smith,Richard L. Boyd,Marcel R. M. van den Brink,Alan M. Hanash
View Articletitled, Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease

LETTERS TO BLOOD

Gemtuzumab ozogamicin in infants with AML: results from the Children’s Oncology Group trials AAML03P1 and AAML0531
Clinical Trials & Observations
Erin M. Guest,Richard Aplenc,Lillian Sung,Susana C. Raimondi,Betsy A. Hirsch,Todd A. Alonzo,Robert B. Gerbing,Yi-Cheng Jim Wang,Samir B. Kahwash,Amy Heerema-McKenney,Soheil Meshinchi,Alan S. Gamis
View Articletitled, Gemtuzumab ozogamicin in infants with AML: results from the Children’s Oncology Group trials AAML03P1 and AAML0531
Supplemental data
Cytarabine dose in the consolidation treatment of AML: a systematic review and meta-analysis
Clinical Trials & Observations
Kinkini N. Magina,Gudrun Pregartner,Armin Zebisch,Albert Wölfler,Peter Neumeister,Hildegard T. Greinix,Andrea Berghold,Heinz Sill
View Articletitled, Cytarabine dose in the consolidation treatment of AML: a systematic review and meta-analysis
Supplemental data
Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors
Da-Yun Jin,Brian O. Ingram,Darrel W. Stafford,Jian-Ke Tie
View Articletitled, Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors
Supplemental data

BLOOD WORK

Incidental brown adipose tissue in bone marrow biopsy
Jennifer Chapman,Francisco Vega
View Articletitled, Incidental brown adipose tissue in bone marrow biopsy
Relapse of an acute leukemia of mixed lineage as an isolated orbital mass
Xiao Yi Zhou,Amir Behdad
View Articletitled, Relapse of an acute leukemia of mixed lineage as an isolated orbital mass

ERRATUM

Putti MC, Pizzi M, Bertozzi I, et al. Bone marrow histology for the diagnosis of essential thrombocythemia in children: a multicenter Italian study. Blood. 2017;129(22):3040-3042.
View Articletitled, Putti MC, Pizzi M, Bertozzi I, et al. Bone marrow histology for the diagnosis of essential thrombocythemia in children: a multicenter Italian study. <em>Blood.</em> 2017;129(22):3040-3042.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

SF3B1 mutation arises at the multipotent HSC level
CME
View Articletitled, <em>SF3B1</em> mutation arises at the multipotent HSC level
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