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Issue Archive

Volume 126, Issue 10
September 3 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
mTOR: a new target in Erdheim-Chester disease?
Clinical Trials & Observations
Julien Haroche,Zahir Amoura
View Articletitled, mTOR: a new target in Erdheim-Chester disease?
INSIDE BLOOD COMMENTARY
Biomarker of sensitivity to PR-104 in leukemia
Simone Fulda
View Articletitled, Biomarker of sensitivity to PR-104 in leukemia
INSIDE BLOOD COMMENTARY
Expanding the peptidome for immunotherapy
Jacques Neefjes
View Articletitled, Expanding the peptidome for immunotherapy
INSIDE BLOOD COMMENTARY
Getting a handle on hereditary CEBPA mutations
Courtney D. DiNardo
View Articletitled, Getting a handle on hereditary <em>CEBPA</em> mutations
INSIDE BLOOD COMMENTARY
fVIII binds platelets + fibrin: no PS!
Kathleen P. Pratt
View Articletitled, fVIII binds platelets + fibrin: no PS!
INSIDE BLOOD COMMENTARY
A booster shot to cure hemoglobinopathies
Mark C. Walters,Tippi C. MacKenzie
View Articletitled, A booster shot to cure hemoglobinopathies

CLINICAL TRIALS AND OBSERVATIONS

Sirolimus plus prednisone for Erdheim-Chester disease: an open-label trial
Clinical Trials & Observations
Davide Gianfreda,Maria Nicastro,Maricla Galetti,Federico Alberici,Domenico Corradi,Gabriella Becchi,Giorgio Baldari,Massimo De Filippo,Stefania Ferretti,Gabriella Moroni,Rosario Foti,Marcella Di Gangi,Guido Jeannin,Raphael Saffroy,Jean-François Emile,Carlo Buzio,Augusto Vaglio
View Articletitled, Sirolimus plus prednisone for Erdheim-Chester disease: an open-label trial
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
Makiko Mochizuki-Kashio,Kazumasa Aoyama,Goro Sashida,Motohiko Oshima,Takahisa Tomioka,Tomoya Muto,Changshan Wang,Atsushi Iwama
View Articletitled, Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
Supplemental data

IMMUNOBIOLOGY

Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses
Joshua M. Moreau,Alexandra Berger,Megan E. Nelles,Michael Mielnik,Caren Furlonger,Selena Y. Cen,Rickvinder Besla,Clinton S. Robbins,Christopher J. Paige
View Articletitled, Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses

LYMPHOID NEOPLASIA

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Donya Moradi Manesh,Jad El-Hoss,Kathryn Evans,Jennifer Richmond,Cara E. Toscan,Lauryn S. Bracken,Ashlee Hedrick,Rosemary Sutton,Glenn M. Marshall,William R. Wilson,Raushan T. Kurmasheva,Catherine Billups,Peter J. Houghton,Malcolm A. Smith,Hernan Carol,Richard B. Lock
View Articletitled, AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Supplemental data
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy
Simon Walz,Juliane S. Stickel,Daniel Johannes Kowalewski,Heiko Schuster,Katja Weisel,Linus Backert,Stefan Kahn,Annika Nelde,Tatjana Stroh,Martin Handel,Oliver Kohlbacher,Lothar Kanz,Helmut Rainer Salih,Hans-Georg Rammensee,Stefan Stevanović
View Articletitled, The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy
Supplemental data

MYELOID NEOPLASIA

Disease evolution and outcomes in familial AML with germline CEBPA mutations
Kiran Tawana,Jun Wang,Aline Renneville,Csaba Bödör,Robert Hills,Chey Loveday,Aleksandar Savic,Frederik W. Van Delft,Jennifer Treleaven,Panayiotis Georgiades,Elizabeth Uglow,Norio Asou,Naokuni Uike,Maruša Debeljak,Janez Jazbec,Philip Ancliff,Rosemary Gale,Xavier Thomas,Valerie Mialou,Konstanze Döhner,Lars Bullinger,Beatrice Mueller,Thomas Pabst,Matthias Stelljes,Brigitte Schlegelberger,Eva Wozniak,Sameena Iqbal,Jessica Okosun,Shamzah Araf,Anne-Katrine Frank,Felicia B. Lauridsen,Bo Porse,Claus Nerlov,Carolyn Owen,Inderjeet Dokal,John Gribben,Matthew Smith,Claude Preudhomme,Claude Chelala,Jamie Cavenagh,Jude Fitzgibbon
View Articletitled, Disease evolution and outcomes in familial AML with germline <em>CEBPA</em> mutations
Supplemental data

PLATELETS AND THROMBOPOIESIS

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis
Madhu M. Ouseph,Yunjie Huang,Meenakshi Banerjee,Smita Joshi,Laura MacDonald,Yu Zhong,Huijuan Liu,Xianting Li,Binggang Xiang,Guoying Zhang,Masaaki Komatsu,Zhenyu Yue,Zhenyu Li,Brian Storrie,Sidney W. Whiteheart,Qing Jun Wang
View Articletitled, Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis
Supplemental data
Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies
Brief Report
Zhi-Jian Liu,James B. Bussel,Madhavi Lakkaraja,Francisca Ferrer-Marin,Cedric Ghevaert,Henry A. Feldman,Janice G. McFarland,Chaitanya Chavda,Martha Sola-Visner
View Articletitled, Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies
Supplemental data

THROMBOSIS AND HEMOSTASIS

Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine
Gary E. Gilbert,Valerie A. Novakovic,Jialan Shi,Jan Rasmussen,Steven W. Pipe
View Articletitled, Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine
Supplemental data
Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction
e-blood
Paul C. J Armstrong,Nicholas S. Kirkby,Melissa V. Chan,Michaela Finsterbusch,Nancy Hogg,Sussan Nourshargh,Timothy D. Warner
View Articletitled, Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction
Supplemental data

TRANSPLANTATION

Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants
William H. Peranteau,Satoshi Hayashi,Osheiza Abdulmalik,Qiukan Chen,Aziz Merchant,Toshio Asakura,Alan W. Flake
View Articletitled, Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants
Supplemental data

BLOOD WORK

Mantle cell lymphoma presenting as cardiac tamponade
Abhijeet Kumar,Soham Puvvada
View Articletitled, Mantle cell lymphoma presenting as cardiac tamponade
Rapid evolution of intracranial myeloid sarcoma in 4 weeks: images in blood
Philippe Prouet,Michael Martin
View Articletitled, Rapid evolution of intracranial myeloid sarcoma in 4 weeks: images in blood

CORRESPONDENCE

Ceritinib in patients with advanced anaplastic lymphoma kinase–rearranged anaplastic large-cell lymphoma
Clinical Trials & Observations
Heike Richly,Tae Min Kim,Martin Schuler,Dong-Wan Kim,Simon J. Harrison,Alice T. Shaw,Anthony L. Boral,Alejandro Yovine,Benjamin Solomon
View Articletitled, Ceritinib in patients with advanced anaplastic lymphoma kinase–rearranged anaplastic large-cell lymphoma
Association between ENPP1 K173Q and stroke in a newborn cohort of 395 Brazilian children with sickle cell anemia
André Rolim Belisário,Rahyssa Rodrigues Sales,Nayara Evelin Toledo,Cibele Velloso-Rodrigues,Célia Maria Silva,Marcos Borato Viana
View Articletitled, Association between <em>ENPP1</em> K173Q and stroke in a newborn cohort of 395 Brazilian children with sickle cell anemia

ERRATA

Chalandon Y, Thomas X, Hayette S, et al; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL). Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia. Blood. 2015;125(24):3711-3719.
View Articletitled, Chalandon Y, Thomas X, Hayette S, et al; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL). Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia. <em>Blood</em>. 2015;125(24):3711-3719.
Victora GD, Dominguez-Sola D, Holmes AB, Deroubaix S, Dalla-Favera R, Nussenzweig MC. Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood. 2012;120(11):2240-2248.
View Articletitled, Victora GD, Dominguez-Sola D, Holmes AB, Deroubaix S, Dalla-Favera R, Nussenzweig MC. Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. <em>Blood</em>. 2012;120(11):2240-2248.
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Cardiac complete response in AL amyloidosis has similar survival to matched general population
Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma
Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.
NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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