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Volume 123, Issue 4
January 23 2014
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
TPO signal for stem cell genomic integrity
Atsushi Hirao
View Articletitled, TPO signal for stem cell genomic integrity
INSIDE BLOOD
Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis
Dirk P. Dittmer
View Articletitled, Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
Severe congenital neutropenia: new lane for ELANE
Niels Borregaard
View Articletitled, Severe congenital neutropenia: new lane for <em>ELANE</em>
PLATELETS & THROMBOPOIESIS
Core fucosylation and IgG function in NAIT
Richard H. Aster
View Articletitled, Core fucosylation and IgG function in NAIT
RED CELLS, IRON, & ERYTHROPOIESIS
“Packaging” of fetal hemoglobin in sickle cell anemia
George R. Buchanan
View Articletitled, “Packaging” of fetal hemoglobin in sickle cell anemia
RED CELLS, IRON, & ERYTHROPOIESIS
Long noncoding RNAs in erythropoiesis
Patrick G. Gallagher
View Articletitled, Long noncoding RNAs in erythropoiesis
THROMBOSIS & HEMOSTASIS
PAI at breakfast (whether you like it or not)
Martin E. Young
View Articletitled, PAI at breakfast (whether you like it or not)

BLOOD WORK

Iron-laden macrophage in autoimmune disease
Rebecca L. King,Mitchell J. Weiss
View Articletitled, Iron-laden macrophage in autoimmune disease
Graft-versus-leukemia in the bone marrow
Clara P.W. Klerk,King H. Lam
View Articletitled, Graft-versus-leukemia in the bone marrow

PLENARY PAPER

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
Rick Kapur,Iwan Kustiawan,Anne Vestrheim,Carolien A. M. Koeleman,Remco Visser,Helga K. Einarsdottir,Leendert Porcelijn,Dave Jackson,Belinda Kumpel,André M. Deelder,Dennis Blank,Björn Skogen,Mette Kjaer Killie,Terje E. Michaelsen,Masja de Haas,Theo Rispens,C. Ellen van der Schoot,Manfred Wuhrer,Gestur Vidarsson
View Articletitled, A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
Supplemental data

PERSPECTIVES

Fetal hemoglobin in sickle cell anemia: a glass half full?
Martin H. Steinberg,David H. K. Chui,George J. Dover,Paola Sebastiani,Abdulrahman Alsultan
View Articletitled, Fetal hemoglobin in sickle cell anemia: a glass half full?

REVIEW ARTICLE

Primary testicular lymphoma
Chan Y. Cheah,Andrew Wirth,John F. Seymour
View Articletitled, Primary testicular lymphoma

CLINICAL TRIALS AND OBSERVATIONS

Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION)
Clinical Trials & Observations
Elias Jabbour,Hagop M. Kantarjian,Giuseppe Saglio,Juan Luis Steegmann,Neil P. Shah,Concepción Boqué,Charles Chuah,Carolina Pavlovsky,Jiří Mayer,Jorge Cortes,Michele Baccarani,Dong-Wook Kim,M. Brigid Bradley-Garelik,Hesham Mohamed,Mark Wildgust,Andreas Hochhaus
View Articletitled, Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION)
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish
Lei Li,Di Chen,Jia Li,Xiaojing Wang,Nan Wang,Chengqi Xu,Qing K. Wang
View Articletitled, <em>Aggf1</em> acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish
Supplemental data
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1
Bérengère de Laval,Patrycja Pawlikowska,Daniela Barbieri,Corinne Besnard-Guerin,Alba Cico,Rajiv Kumar,Murielle Gaudry,Véronique Baud,Françoise Porteu
View Articletitled, Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1
Supplemental data

IMMUNOBIOLOGY

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation
Eric Keil,David Finkenstädt,Christian Wufka,Mirko Trilling,Pia Liebfried,Birgit Strobl,Mathias Müller,Klaus Pfeffer
View Articletitled, Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation
Supplemental data

LYMPHOID NEOPLASIA

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma
Kamonwan Fish,Jia Chen,Richard Longnecker
View Articletitled, Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma
Supplemental data

MYELOID NEOPLASIA

Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice
Jiapeng Wang,Zhaomin Li,Yongzheng He,Feng Pan,Shi Chen,Steven Rhodes,Lihn Nguyen,Jin Yuan,Li Jiang,Xianlin Yang,Ophelia Weeks,Ziyue Liu,Jiehao Zhou,Hongyu Ni,Chen-Leng Cai,Mingjiang Xu,Feng-Chun Yang
View Articletitled, Loss of <em>Asxl1</em> leads to myelodysplastic syndrome–like disease in mice
Supplemental data
Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML
George S. Laszlo,Chelsea J. Gudgeon,Kimberly H. Harrington,Justine Dell’Aringa,Kathryn J. Newhall,Gary D. Means,Angus M. Sinclair,Roman Kischel,Stanley R. Frankel,Roland B. Walter
View Articletitled, Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms
Timothy Tidwell,Jeremy Wechsler,Ramesh C. Nayak,Lisa Trump,Stephen J. Salipante,Jerry C. Cheng,Jean Donadieu,Taly Glaubach,Seth J. Corey,H. Leighton Grimes,Carolyn Lutzko,Jose A. Cancelas,Marshall S. Horwitz
View Articletitled, Neutropenia-associated <em>ELANE</em> mutations disrupting translation initiation produce novel neutrophil elastase isoforms
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation
Juan R. Alvarez-Dominguez,Wenqian Hu,Bingbing Yuan,Jiahai Shi,Staphany S. Park,Austin A. Gromatzky,Alexander van Oudenaarden,Harvey F. Lodish
View Articletitled, Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation
Supplemental data

THROMBOSIS AND HEMOSTASIS

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites
Jamil A. Haque,Matthew G. McDonald,John D. Kulman,Allan E. Rettie
View Articletitled, A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites
Supplemental data
Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle
Brief Report
Frank A. J. L. Scheer,Steven A. Shea
View Articletitled, Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

CORRESPONDENCE

Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells
Debanjana Chatterjee,Dejene Milkessa Tufa,Heike Baehre,Ralf Hass,Reinhold Ernst Schmidt,Roland Jacobs
View Articletitled, Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells
Supplemental data
The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia
Annette Hildegard Schmitt-Graeff,Philipp Erben,Juliane Schwaab,Beate Vollmer-Kary,Georgia Metzgeroth,Karl Sotlar,Hans-Peter Horny,Hans-H Kreipe,Paul Fisch,Andreas Reiter
View Articletitled, The <em>FIP1L1-PDGFRA</em> fusion gene and the <em>KIT</em> D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia
Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis
David N. Douda,Lily Yip,Meraj A. Khan,Hartmut Grasemann,Nades Palaniyar
View Articletitled, Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis
  • Cover Image

    Cover Image

    issue cover

    The image shows the localization of Jak1 (blue) and a mutant Jak2 (green), which lacks the pseudokinase (JH2) and the kinase (JH1) domain. The Jak2 JH2-domain is necessary for maintaining the scaffold function of Jak2 and the physiological localization of Jak1 and Jak2. These results demonstrate that Jak2, independent of its kinase function, significantly shapes the subcellular localization of Jak1 highlighting the role of Jak2 as scaffold protein for the assembly of the IFN-γ receptor complex. See the article by Keil et al on page 520.

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