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Issue Archive

Volume 122, Issue 23
November 28 2013
Issue Cover

Table of Contents

INSIDE BLOOD

RED CELLS, IRON, & ERYTHROPOIESIS
The TRIMming on an erythroid repressor complex
Margaret H. Baron
View Articletitled, The TRIMming on an erythroid repressor complex
INSIDE BLOOD
No immunosurveillance in human IL-10R deficiency
Martin Oft
View Articletitled, No immunosurveillance in human IL-10R deficiency
MYELOID NEOPLASIA
Clearing the path for MPN therapy monitoring
Ruben A. Mesa
View Articletitled, Clearing the path for MPN therapy monitoring
PLATELETS & THROMBOPOIESIS
Causal role for JAK2 V617F in thrombosis
Angela G. Fleischman,Jeffrey W. Tyner
View Articletitled, Causal role for JAK2 V617F in thrombosis
THROMBOSIS & HEMOSTASIS
Bad (or good) things come in small packages
Lubica Rauova,Douglas B. Cines
View Articletitled, Bad (or good) things come in small packages
VASCULAR BIOLOGY
CXCL1 excess stops neutrophils in their tracks
Francis W. Luscinskas
View Articletitled, CXCL1 excess stops neutrophils in their tracks

BLOOD WORK

Atypical lymphocytosis, cold agglutinin hemolytic anemia, and monoclonal gammopathy in an HIV patient with marrow involvement by diffuse large B-cell lymphoma
Mingyi Chen,Mehrdad Abedi
View Articletitled, Atypical lymphocytosis, cold agglutinin hemolytic anemia, and monoclonal gammopathy in an HIV patient with marrow involvement by diffuse large B-cell lymphoma
HHV-8–positive but EBV-negative primary effusion lymphoma
Joo Y. Song,Elaine S. Jaffe
View Articletitled, HHV-8–positive but EBV-negative primary effusion lymphoma

PLENARY PAPER

A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
Bénédicte Neven,Emilie Mamessier,Julie Bruneau,Sophie Kaltenbach,Daniel Kotlarz,Felipe Suarez,Julien Masliah-Planchon,Katy Billot,Danielle Canioni,Pierre Frange,Isabelle Radford-Weiss,Vahid Asnafi,Dhaarini Murugan,Christine Bole,Patrick Nitschke,Olivier Goulet,Jean-Laurent Casanova,Stéphane Blanche,Capucine Picard,Olivier Hermine,Frederic Rieux-Laucat,Nicole Brousse,Frederic Davi,Véronique Baud,Christoph Klein,Bertrand Nadel,Frank Ruemmele,Alain Fischer
View Articletitled, A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
Supplemental data

REVIEW ARTICLE

Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies
Michael Hallek
View Articletitled, Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies
von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy
David Lillicrap
View Articletitled, von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy

REVIEW SERIES

The biology and clinical impact of genetic lesions in myeloid malignancies
R. Coleman Lindsley,Benjamin L. Ebert
View Articletitled, The biology and clinical impact of genetic lesions in myeloid malignancies

HOW I TREAT

How I treat severe combined immunodeficiency
H. Bobby Gaspar,Waseem Qasim,E. Graham Davies,Kanchan Rao,Persis J. Amrolia,Paul Veys
View Articletitled, How I treat severe combined immunodeficiency

LYMPHOID NEOPLASIA

Persistence of minimal residual disease in bone marrow predicts outcome in follicular lymphomas treated with a rituximab-intensive program
Clinical Trials & Observations
Marco Ladetto,Chiara Lobetti-Bodoni,Barbara Mantoan,Manuela Ceccarelli,Carola Boccomini,Elisa Genuardi,Annalisa Chiappella,Luca Baldini,Giuseppe Rossi,Alessandro Pulsoni,Francesco Di Raimondo,Luigi Rigacci,Antonello Pinto,Sara Galimberti,Alessia Bari,Delia Rota-Scalabrini,Angela Ferrari,Francesco Zaja,Andrea Gallamini,Giorgina Specchia,Pellegrino Musto,Francesca Gaia Rossi,Enrica Gamba,Andrea Evangelista,Umberto Vitolo,for the Fondazione Italiana Linfomi
View Articletitled, Persistence of minimal residual disease in bone marrow predicts outcome in follicular lymphomas treated with a rituximab-intensive program
Supplemental data

MYELOID NEOPLASIA

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression
Bastien Laperrousaz,Sandrine Jeanpierre,Karen Sagorny,Thibault Voeltzel,Sophie Ramas,Bastien Kaniewski,Martine Ffrench,Stéphanie Salesse,Franck E. Nicolini,Véronique Maguer-Satta
View Articletitled, Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression
Supplemental data
Eradicating acute myeloid leukemia in a MllPTD/wt:Flt3ITD/wt murine model: a path to novel therapeutic approaches for human disease
Kelsie M. Bernot,John S. Nemer,Ramasamy Santhanam,Shujun Liu,Nicholas A. Zorko,Susan P. Whitman,Kathryn E. Dickerson,Mengzi Zhang,Xiaojuan Yang,Kathleen K. McConnell,Elshafa H. Ahmed,Maura R. Muñoz,Ronald F. Siebenaler,Gabriel G. Marcucci,Bethany L. Mundy-Bosse,Daniel L. Brook,Sabrina Garman,Adrienne M. Dorrance,Xiaoli Zhang,Jianying Zhang,Robert J. Lee,William Blum,Michael A. Caligiuri,Guido Marcucci
View Articletitled, Eradicating acute myeloid leukemia in a <em>Mll</em><sup>PTD/wt</sup>:<em>Flt3</em><sup>ITD/wt</sup> murine model: a path to novel therapeutic approaches for human disease
JAK2 p.V617F detection and allele burden measurement in peripheral blood and bone marrow aspirates in patients with myeloproliferative neoplasms
Brief Report
Koichi Takahashi,Keyur P. Patel,Hagop Kantarjian,Rajyalakshmi Luthra,Sherry Pierce,Jorge Cortes,Srdan Verstovsek
View Articletitled, <em>JAK2</em> p.V617F detection and allele burden measurement in peripheral blood and bone marrow aspirates in patients with myeloproliferative neoplasms

PLATELETS AND THROMBOPOIESIS

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia
Catherine M. Hobbs,Harriet Manning,Cavan Bennett,Louella Vasquez,Sonia Severin,Lauren Brain,Alexandra Mazharian,Jose A. Guerrero,Juan Li,Nicole Soranzo,Anthony R. Green,Steve P. Watson,Cedric Ghevaert
View Articletitled, JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

TRIM28 is essential for erythroblast differentiation in the mouse
Tomonori Hosoya,Mary Clifford,Régine Losson,Osamu Tanabe,James Douglas Engel
View Articletitled, TRIM28 is essential for erythroblast differentiation in the mouse
Supplemental data

THROMBOSIS AND HEMOSTASIS

Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway
Venkaiah Betapudi,George Lominadze,Linda Hsi,Belinda Willard,Meifang Wu,Keith R. McCrae
View Articletitled, Anti-β<sub>2</sub>GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway
Supplemental data
Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII
Lars Faxälv,Niklas Boknäs,Jakob O. Ström,Pentti Tengvall,Elvar Theodorsson,Sofia Ramström,Tomas L. Lindahl
View Articletitled, Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII
Supplemental data
Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation
Francesca Nuzzo,Claudia Radu,Marco Baralle,Luca Spiezia,Tilman M. Hackeng,Paolo Simioni,Elisabetta Castoldi
View Articletitled, Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a <em>F5</em> deep-intronic splicing mutation
Supplemental data

VASCULAR BIOLOGY

Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice
Longbiao Yao,Tadayuki Yago,Bojing Shao,Zhenghui Liu,Robert Silasi-Mansat,Hendra Setiadi,Florea Lupu,Rodger P. McEver
View Articletitled, Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice
Supplemental data

CORRESPONDENCE

Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?
Annkristin Heine,Peter Brossart,Dominik Wolf
View Articletitled, Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?
MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK- and B-cell counts
Abdulrahman Alsultan,Hanan E. Shamseldin,Mohamed Elfaki Osman,Mansour Aljabri,Fowzan S. Alkuraya
View Articletitled, <em>MYSM1</em> is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK- and B-cell counts
Supplemental data
Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus
Vijay G. Sankaran,Mugdha Joshi,Akshat Agrawal,Klaus Schmitz-Abe,Meghan C. Towne,Nicholas Marinakis,Kyriacos Markianos,Gerard T. Berry,Pankaj B. Agrawal
View Articletitled, Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus
Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII–mediated coagulation
Katrin Faye Nickel,Henri M. Spronk,Nicola J. Mutch,Thomas Renné
View Articletitled, Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII–mediated coagulation
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