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Issue Archive

Volume 120, Issue 7
August 16 2012
Issue Cover

Table of Contents

Inside Blood

IMMUNOBIOLOGY
Notch and PI3K: how is the road traveled?
Will Bailis,Warren S. Pear
View Articletitled, Notch and PI3K: how is the road traveled?
IMMUNOBIOLOGY
Leaky gut, clotting, and vasculopathy in SIV
Peter W. Hunt
View Articletitled, Leaky gut, clotting, and vasculopathy in SIV
INSIDE BLOOD
CCR1 blockade and myeloma bone disease
Michael Sebag
View Articletitled, CCR1 blockade and myeloma bone disease
PHAGOCYTES & GRANULOCYTES
Has Ly6G finally found a job?
Michael J. Hickey
View Articletitled, Has Ly6G finally found a job?
THROMBOSIS & HEMOSTASIS
Thrombophilia screening: whom to test?
Aisha Bruce,M. Patricia Massicotte
View Articletitled, Thrombophilia screening: whom to test?

Blood Work

Meningeal myelomatosis
Saiyed Anwer,Alexander Sternberg
View Articletitled, Meningeal myelomatosis

Plenary paper

IMMUNOBIOLOGY
Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates
Ivona Pandrea,Elaine Cornell,Cara Wilson,Ruy M. Ribeiro,Dongzhu Ma,Jan Kristoff,Cuiling Xu,George S. Haret-Richter,Anita Trichel,Cristian Apetrei,Alan Landay,Russell Tracy
View Articletitled, Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

Perspectives

Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors
Vikas Gupta,Parameswaran Hari,Ronald Hoffman
View Articletitled, Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors

Review Article

NFAT control of innate immunity
Jan Fric,Teresa Zelante,Alicia Y. W. Wong,Alexandra Mertes,Hong-Bing Yu,Paola Ricciardi-Castagnoli
View Articletitled, NFAT control of innate immunity

How I Treat

How I treat newly diagnosed chronic phase CML
Jorge Cortes,Hagop Kantarjian
View Articletitled, How I treat newly diagnosed chronic phase CML

Clinical Trials and Observations

Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS
Clinical Trials & Observations
H. Joachim Deeg,Bart L. Scott,Min Fang,Howard M. Shulman,Boglarka Gyurkocza,David Myerson,John M. Pagel,Uwe Platzbecker,Aravind Ramakrishnan,Jerald P. Radich,Brenda M. Sandmaier,Mohamed Sorror,Derek L. Stirewalt,Wendy A. Wilson,Rainer Storb,Frederick R. Appelbaum,Ted Gooley
View Articletitled, Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS
Supplemental data
Correlation of blood counts with vascular complications in essential thrombocythemia: analysis of the prospective PT1 cohort
Brief Report
Peter J. Campbell,Cathy MacLean,Philip A. Beer,Georgina Buck,Keith Wheatley,Jean-Jacques Kiladjian,Cecily Forsyth,Claire N. Harrison,Anthony R. Green
View Articletitled, Correlation of blood counts with vascular complications in essential thrombocythemia: analysis of the prospective PT1 cohort
Brentuximab vedotin for relapsed or refractory CD30+ hematologic malignancies: the German Hodgkin Study Group experience
Brief Report
Achim Rothe,Stephanie Sasse,Helen Goergen,Dennis A. Eichenauer,Andreas Lohri,Ulrich Jäger,Christopher Bangard,Boris Böll,Michael von Bergwelt Baildon,Sebastian Theurich,Peter Borchmann,Andreas Engert
View Articletitled, Brentuximab vedotin for relapsed or refractory CD30<sup>+</sup> hematologic malignancies: the German Hodgkin Study Group experience

Immunobiology

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
Bart Everts,Eyal Amiel,Gerritje J. W. van der Windt,Tori C. Freitas,Robert Chott,Kevin E. Yarasheski,Erika L. Pearce,Edward J. Pearce
View Articletitled, Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
Supplemental data
The race for the prize: T-cell trafficking strategies for optimal surveillance
Minyi Lee,Judith N. Mandl,Ronald N. Germain,Andrew J. Yates
View Articletitled, The race for the prize: T-cell trafficking strategies for optimal surveillance
Supplemental data

Lymphoid Neoplasia

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
Alan G. Ramsay,Andrew J. Clear,Rewas Fatah,John G. Gribben
View Articletitled, Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
Supplemental data
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes
Gladys W. Wong,Gisele C. Knowles,Tak W. Mak,Adolfo A. Ferrando,Juan Carlos Zúñiga-Pflücker
View Articletitled, HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes
Supplemental data
CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
Daniel J. Dairaghi,Babatunde O. Oyajobi,Anjana Gupta,Brandon McCluskey,Shichang Miao,Jay P. Powers,Lisa C. Seitz,Yu Wang,Yibin Zeng,Penglie Zhang,Thomas J. Schall,Juan C. Jaen
View Articletitled, CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
Supplemental data
S1PR1 is an effective target to block STAT3 signaling in activated B cell–like diffuse large B-cell lymphoma
Yong Liu,Jiehui Deng,Lin Wang,Heehyoung Lee,Brian Armstrong,Anna Scuto,Claudia Kowolik,Lawrence M. Weiss,Stephen Forman,Hua Yu
View Articletitled, S1PR1 is an effective target to block STAT3 signaling in activated B cell–like diffuse large B-cell lymphoma
Supplemental data
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters
Brief Report
François Lemonnier,Lucile Couronné,Marie Parrens,Jean-Philippe Jaïs,Marion Travert,Laurence Lamant,Olivier Tournillac,Therese Rousset,Bettina Fabiani,Rob A. Cairns,Tak Mak,Christian Bastard,Olivier A. Bernard,Laurence de Leval,Philippe Gaulard
View Articletitled, Recurrent <em>TET2</em> mutations in peripheral T-cell lymphomas correlate with T<sub>FH</sub>-like features and adverse clinical parameters
Supplemental data

Myeloid Neoplasia

Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML
Miao-Chia Lo,Luke F. Peterson,Ming Yan,Xiuli Cong,Fulai Jin,Wei-Jong Shia,Shinobu Matsuura,Eun-Young Ahn,Yukiko Komeno,Minh Ly,Hans B. Ommen,I-Ming Chen,Peter Hokland,Cheryl L. Willman,Bing Ren,Dong-Er Zhang
View Articletitled, Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML
Supplemental data
Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
Brief Report
Sayoko Doisaki,Hideki Muramatsu,Akira Shimada,Yoshiyuki Takahashi,Makiko Mori-Ezaki,Masanori Sato,Hiroyuki Kawaguchi,Akitoshi Kinoshita,Manabu Sotomatsu,Yasuhide Hayashi,Yoko Furukawa-Hibi,Kiyofumi Yamada,Hideaki Hoshino,Hitoshi Kiyoi,Nao Yoshida,Hirotoshi Sakaguchi,Atsushi Narita,Xinan Wang,Olfat Ismael,Yinyan Xu,Nobuhiro Nishio,Makito Tanaka,Asahito Hama,Kenichi Koike,Seiji Kojima
View Articletitled, Somatic mosaicism for oncogenic <em>NRAS</em> mutations in juvenile myelomonocytic leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Ly6G ligation blocks recruitment of neutrophils via a β2-integrin–dependent mechanism
Jun-Xia Wang,Angela M. Bair,Sandra L. King,Ruslan Shnayder,Ya-Fang Huang,Chi-Chang Shieh,Roy J. Soberman,Robert C. Fuhlbrigge,Peter A. Nigrovic
View Articletitled, Ly6G ligation blocks recruitment of neutrophils via a β2-integrin–dependent mechanism
Supplemental data

Platelets and Thrombopoiesis

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia
Kazunobu Kiyomizu,Hirokazu Kashiwagi,Tsuyoshi Nakazawa,Seiji Tadokoro,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama
View Articletitled, Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia
Supplemental data

Thrombosis and Hemostasis

Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study
Clinical Trials & Observations
Susanne Holzhauer,Neil A. Goldenberg,Ralf Junker,Christine Heller,Monika Stoll,Daniela Manner,Rolf Mesters,Anne Krümpel,Michael Stach,Ulrike Nowak-Göttl
View Articletitled, Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study

Vascular Biology

Pericytes promote selective vessel regression to regulate vascular patterning
Nicole Simonavicius,Matthew Ashenden,Antoinette van Weverwijk,Siân Lax,David L. Huso,Christopher D. Buckley,Ivo J. Huijbers,Helen Yarwood,Clare M. Isacke
View Articletitled, Pericytes promote selective vessel regression to regulate vascular patterning
Supplemental data

Correspondence

Circulating microparticles do not all share biophysical light scatter properties with immune complexes when analyzed by flow cytometry
Philip Hexley,Chad T. Robinson,Andrew R. Osterburg,George F. Babcock
View Articletitled, Circulating microparticles do not all share biophysical light scatter properties with immune complexes when analyzed by flow cytometry
Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/PCM1-JAK2–positive chronic eosinophilic leukemia
Els Lierman,Dominik Selleslag,Sanne Smits,Johan Billiet,Peter Vandenberghe
View Articletitled, Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/<em>PCM1-JAK2</em>–positive chronic eosinophilic leukemia
Treatment with bosentan in a patient with thalassemia intermedia and pulmonary arterial hypertension
Anastasia Anthi,Iraklis Tsangaris,Eftichia S. Hamodraka,John Lekakis,Apostolos Armaganidis,Stylianos E. Orfanos
View Articletitled, Treatment with bosentan in a patient with thalassemia intermedia and pulmonary arterial hypertension

Retraction

Linger RMA, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK. Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia. Blood. 2009;114(13):2678–2687.
View Articletitled, Linger RMA, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK. Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia. <em>Blood</em>. 2009;114(13):<span class="related-article">2678–2687</span>.
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