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Issue Archive

Volume 116, Issue 13
September 30 2010
Issue Cover

Table of Contents

Inside blood

CLINICAL TRIALS
You should see the other guy
Morie A. Gertz
View Articletitled, You should see the other guy
MYELOID NEOPLASIA
A new oncoprotein catabolism pathway
Valérie Lallemand-Breitenbach,Hugues de Thé
View Articletitled, A new oncoprotein catabolism pathway
PLATELETS & THROMBOPOIESIS
Arterial thrombosis: going, gone!
Elizabeth E. Gardiner,Michael C. Berndt
View Articletitled, Arterial thrombosis: going, gone!
PLATELETS & THROMBOPOIESIS
Shedding light on endomitosis
Amy E. Geddis
View Articletitled, Shedding light on endomitosis

Review Article

A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia
Clinical Trials & Observations
Denise Niewerth,Ursula Creutzig,Marc B. Bierings,Gertjan J. L. Kaspers
View Articletitled, A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia

How I Treat

How I treat elderly patients with myeloma
Jayesh Mehta,Michele Cavo,Seema Singhal
View Articletitled, How I treat elderly patients with myeloma
Supplemental data

Clinical Trials and Observations

Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
Clinical Trials & Observations
Bruno C. Medeiros,Megan Othus,Min Fang,Diane Roulston,Frederick R. Appelbaum
View Articletitled, Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
Supplemental data

Hematopoiesis and Stem Cells

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process
Larissa Lordier,Yunhua Chang,Abdelali Jalil,Frédéric Aurade,Loïc Garçon,Yann Lécluse,Frédéric Larbret,Toshiyuki Kawashima,Toshio Kitamura,Jérôme Larghero,Najet Debili,William Vainchenker
View Articletitled, Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process
Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties
Miranda Buitenhuis,Edwin van der Linden,Laurien H. Ulfman,Frans M. Hofhuis,Marc B. Bierings,Paul J. Coffer
View Articletitled, Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties
Supplemental data

Immunobiology

Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly
Clinical Trials & Observations
Ales Janda,Petr Sedlacek,Manfred Hönig,Wilhelm Friedrich,Martin Champagne,Tadashi Matsumoto,Alain Fischer,Benedicte Neven,Audrey Contet,Danielle Bensoussan,Pierre Bordigoni,David Loeb,William Savage,Nada Jabado,Francisco A. Bonilla,Mary A. Slatter,E. Graham Davies,Andrew R. Gennery
View Articletitled, Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly
Supplemental data
Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders
Kimberley Jones,Jamie P. Nourse,Leanne Morrison,Do Nguyen-Van,Denis J. Moss,Scott R. Burrows,Maher K. Gandhi
View Articletitled, Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders
High-resolution mapping of prostaglandin E2–dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells
Nikolaus G. Oberprieler,Simone Lemeer,Maria E. Kalland,Knut M. Torgersen,Albert J. R. Heck,Kjetil Taskén
View Articletitled, High-resolution mapping of prostaglandin E<sub>2</sub>–dependent signaling networks identifies a constitutively active PKA signaling node in CD8<sup>+</sup>CD45RO<sup>+</sup> T cells
Supplemental data
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance
Tomohiro Fukaya,Hideaki Takagi,Yumiko Sato,Kaori Sato,Kawori Eizumi,Honami Taya,Tahiro Shin,Lieping Chen,Chen Dong,Miyuki Azuma,Hideo Yagita,Bernard Malissen,Katsuaki Sato
View Articletitled, Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells in the establishment of oral tolerance
Supplemental data
Targeting of DEC-205 on human dendritic cells results in efficient MHC class II–restricted antigen presentation
Katrin Birkholz,Michael Schwenkert,Christian Kellner,Stefanie Gross,Georg Fey,Beatrice Schuler-Thurner,Gerold Schuler,Niels Schaft,Jan Dörrie
View Articletitled, Targeting of DEC-205 on human dendritic cells results in efficient MHC class II–restricted antigen presentation
Supplemental data

Lymphoid Neoplasia

A population-based study of cardiac morbidity among Hodgkin lymphoma patients with preexisting heart disease
Brief Report
Sten Myrehaug,Melania Pintilie,Lingsong Yun,Michael Crump,Richard W. Tsang,Ralph M. Meyer,Jonathan Sussman,Eric Yu,David C. Hodgson
View Articletitled, A population-based study of cardiac morbidity among Hodgkin lymphoma patients with preexisting heart disease
Radioimmunodetection of amyloid deposits in patients with AL amyloidosis
Brief Report
Jonathan S. Wall,Stephen J. Kennel,Alan C. Stuckey,Misty J. Long,David W. Townsend,Gary T. Smith,Karen J. Wells,Yitong Fu,Michael G. Stabin,Deborah T. Weiss,Alan Solomon
View Articletitled, Radioimmunodetection of amyloid deposits in patients with AL amyloidosis
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
Don M. Benson, Jr,Courtney E. Bakan,Anjali Mishra,Craig C. Hofmeister,Yvonne Efebera,Brian Becknell,Robert A. Baiocchi,Jianying Zhang,Jianhua Yu,Megan K. Smith,Carli N. Greenfield,Pierluigi Porcu,Steven M. Devine,Rinat Rotem-Yehudar,Gerard Lozanski,John C. Byrd,Michael A. Caligiuri
View Articletitled, The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
Supplemental data

Myeloid Neoplasia

Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia
Clinical Trials & Observations
Francesco Buccisano,Luca Maurillo,Alessandra Spagnoli,Maria Ilaria Del Principe,Daniela Fraboni,Paola Panetta,Tiziana Ottone,Maria Irno Consalvo,Serena Lavorgna,Pietro Bulian,Emanuele Ammatuna,Daniela F. Angelini,Adamo Diamantini,Selenia Campagna,Licia Ottaviani,Chiara Sarlo,Valter Gattei,Giovanni Del Poeta,William Arcese,Sergio Amadori,Francesco Lo Coco,Adriano Venditti
View Articletitled, Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia
Supplemental data
The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes
Xiang Li,A. Mario Marcondes,Theodore A. Gooley,H. Joachim Deeg
View Articletitled, The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes
Supplemental data
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome
Thomas Prebet,Anne-Catherine Lhoumeau,Christine Arnoulet,Anaïs Aulas,Sylvie Marchetto,Stéphane Audebert,Francesca Puppo,Christian Chabannon,Danielle Sainty,Marie-Josée Santoni,Michael Sebbagh,Virginia Summerour,Yannick Huon,Won-Sik Shin,Seung-Taek Lee,Benjamin Esterni,Norbert Vey,Jean-Paul Borg
View Articletitled, The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome
Supplemental data
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Pauline Isakson,Magnar Bjørås,Stig Ove Bøe,Anne Simonsen
View Articletitled, Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Supplemental data
NUP98-MLL fusion in human acute myeloblastic leukemia
Brief Report
Sophie Kaltenbach,Gwendoline Soler,Carole Barin,Carine Gervais,Olivier A. Bernard,Virginie Penard-Lacronique,Serge P. Romana
View Articletitled, <em>NUP98-MLL</em> fusion in human acute myeloblastic leukemia
Proteomic cell surface phenotyping of differentiating acute myeloid leukemia cells
e-blood
Andreas Hofmann,Bertran Gerrits,Alexander Schmidt,Thomas Bock,Damaris Bausch-Fluck,Rudolf Aebersold,Bernd Wollscheid
View Articletitled, Proteomic cell surface phenotyping of differentiating acute myeloid leukemia cells
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis
Oonagh Shannon,Victoria Rydengård,Artur Schmidtchen,Matthias Mörgelin,Per Alm,Ole E. Sørensen,Lars Björck
View Articletitled, Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis

Platelets and Thrombopoiesis

Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus
Wei Zhang,Yong-Sheng Li,Michael A. Nardi,Suying Dang,Jing Yang,Yong Ji,Zongdong Li,Simon Karpatkin,Thomas Wisniewski
View Articletitled, Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus
Supplemental data

Red Cells, Iron, and Erythropoiesis

Multiple functions of Ldb1 required for β-globin activation during erythroid differentiation
Sang-Hyun Song,AeRi Kim,Tobias Ragoczy,M. A. Bender,Mark Groudine,Ann Dean
View Articletitled, Multiple functions of Ldb1 required for β-globin activation during erythroid differentiation
Supplemental data

Vascular Biology

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
Helen Sheldon,Emily Heikamp,Helen Turley,Rebecca Dragovic,Peter Thomas,Chern Ein Oon,Russell Leek,Mariola Edelmann,Benedikt Kessler,Richard C. A. Sainson,Ian Sargent,Ji-Liang Li,Adrian L. Harris
View Articletitled, New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
Supplemental data
Prox1 expression is negatively regulated by miR-181 in endothelial cells
Jan Kazenwadel,Michael Z. Michael,Natasha L. Harvey
View Articletitled, <em>Prox1</em> expression is negatively regulated by <em>miR-181</em> in endothelial cells
Supplemental data

Errata

Lenhoff S, Hjorth M, Holmberg E, et al. Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study. Blood. 2000;95(1):7–11.
View Articletitled, Lenhoff S, Hjorth M, Holmberg E, et al. Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study. <em>Blood</em>. 2000;95(1):<span class="related-article">7–11</span>.
Loke P, Favre D, Hunt PW, et al. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood. 2010;115(15):e20–e32.
View Articletitled, Loke P, Favre D, Hunt PW, et al. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. <em>Blood</em>. 2010;115(15):<span class="related-article">e20–e32</span>.
Bordon V, Gennery AR, Slatter MA, et al. Clinical and immunologic outcome of patients with cartilage hair hypoplasia after hematopoietic stem cell transplantation. Blood. 2010;116(1):27–35.
View Articletitled, Bordon V, Gennery AR, Slatter MA, et al. Clinical and immunologic outcome of patients with cartilage hair hypoplasia after hematopoietic stem cell transplantation. <em>Blood</em>. 2010;116(1):<span class="related-article">27–35</span>.
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