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Issue Archive

Volume 113, Issue 2
January 8 2009
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
TLR-mediated immune activation in HIV
J. Judy Chang,Marcus Altfeld
View Articletitled, TLR-mediated immune activation in HIV
RED CELLS & IRON
Ironing out complementary medicine
Robert T. Means, Jr
View Articletitled, Ironing out complementary medicine
TRANSPLANTATION
Graft-versus-host disease: proteomics comes of age
Gerard Socié
View Articletitled, Graft-versus-host disease: proteomics comes of age

PLENARY PAPERS

A biomarker panel for acute graft-versus-host disease
Sophie Paczesny,Oleg I. Krijanovski,Thomas M. Braun,Sung W. Choi,Shawn G. Clouthier,Rork Kuick,David E. Misek,Kenneth R. Cooke,Carrie L. Kitko,Angela Weyand,Daniel Bickley,Dawn Jones,Joel Whitfield,Pavan Reddy,John E. Levine,Samir M. Hanash,James L. M. Ferrara
View Articletitled, A biomarker panel for acute graft-versus-host disease
Supplemental data

PERSPECTIVE

Is allergic disease curable or transferable with allogeneic hematopoietic cell transplantation?
Faisal Khan,Teal S. Hallstrand,Michelle N. Geddes,William R. Henderson, Jr,Jan Storek
View Articletitled, Is allergic disease curable or transferable with allogeneic hematopoietic cell transplantation?

REVIEW ARTICLES

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects
Bas J. Wouters,Bob Löwenberg,Ruud Delwel
View Articletitled, A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

CLINICAL TRIALS AND OBSERVATIONS

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
Clinical Trials & Observations
Susan M. O'Brien,David F. Claxton,Michael Crump,Stefan Faderl,Thomas Kipps,Michael J. Keating,Jean Viallet,Bruce D. Cheson
View Articletitled, Phase I study of obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
Thyroid function following hematopoietic cell transplantation in children: 30 years' experience
Brief Report
Jean E. Sanders,Paul A. Hoffmeister,Ann E. Woolfrey,Paul A. Carpenter,Barry E. Storer,Rainer F. Storb,Frederick R. Appelbaum
View Articletitled, Thyroid function following hematopoietic cell transplantation in children: 30 years' experience

HEMATOPOIESIS AND STEM CELLS

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements
Hong-Yan Du,Elena Pumbo,Jennifer Ivanovich,Ping An,Richard T. Maziarz,Ulrike M. Reiss,Deborah Chirnomas,Akiko Shimamura,Adrianna Vlachos,Jeffrey M. Lipton,Rakesh K. Goyal,Frederick Goldman,David B. Wilson,Philip J. Mason,Monica Bessler
View Articletitled, <em>TERC</em> and <em>TERT</em> gene mutations in patients with bone marrow failure and the significance of telomere length measurements
Supplemental data
Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation
Richa Bedi,Jian Du,Arun K. Sharma,Ignatius Gomes,Steven J. Ackerman
View Articletitled, Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation
Supplemental data

IMMUNOBIOLOGY

Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins
Jovanka Bestebroer,Kok P. M. van Kessel,Hafida Azouagh,Annemiek M. Walenkamp,Ingrid G. J. Boer,Roland A. Romijn,Jos A. G. van Strijp,Carla J. C. de Haas
View Articletitled, Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins
Supplemental data
Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function
Ramon Urrea Moreno,Juana Gil,Carmen Rodriguez-Sainz,Elena Cela,Victor LaFay,Brian Oloizia,Andrew B. Herr,Janos Sumegi,Michael B. Jordan,Kimberly A. Risma
View Articletitled, Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function
Supplemental data
Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction
Aurore Brémond,Ophélie Meynet,Karim Mahiddine,Sylvie Coito,Mélanie Tichet,Katia Scotlandi,Jean-Philippe Breittmayer,Pierre Gounon,Paul A. Gleeson,Alain Bernard,Ghislaine Bernard
View Articletitled, Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction
Supplemental data
NKp80 defines and stimulates a reactive subset of CD8 T cells
Sabrina Kuttruff,Sven Koch,Alexandra Kelp,Graham Pawelec,Hans-Georg Rammensee,Alexander Steinle
View Articletitled, NKp80 defines and stimulates a reactive subset of CD8 T cells
NKT-cell help to B lymphocytes can occur independently of cognate interaction
Elena Tonti,Grazia Galli,Carmine Malzone,Sergio Abrignani,Giulia Casorati,Paolo Dellabona
View Articletitled, NKT-cell help to B lymphocytes can occur independently of cognate interaction
Supplemental data
Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
Stefan Baenziger,Mathias Heikenwalder,Pål Johansen,Erika Schlaepfer,Ursula Hofer,Regina C. Miller,Simone Diemand,Kenya Honda,Thomas M. Kundig,Adriano Aguzzi,Roberto F. Speck
View Articletitled, Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
Supplemental data
Distinct roles of helper T-cell subsets in a systemic autoimmune disease
Katrina K. Hoyer,Wilson F. Kuswanto,Eugenio Gallo,Abul K. Abbas
View Articletitled, Distinct roles of helper T-cell subsets in a systemic autoimmune disease
Supplemental data

LYMPHOID NEOPLASIA

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes
Mika Inomata,Hiroyuki Tagawa,Yong-Mei Guo,Yoshihiro Kameoka,Naoto Takahashi,Kenichi Sawada
View Articletitled, MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
Anastasia Hadzidimitriou,Nikos Darzentas,Fiona Murray,Tanja Smilevska,Eleni Arvaniti,Cristina Tresoldi,Athanasios Tsaftaris,Nikolaos Laoutaris,Achilles Anagnostopoulos,Frederic Davi,Paolo Ghia,Richard Rosenquist,Kostas Stamatopoulos,Chrysoula Belessi
View Articletitled, Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia
Anne Saumet,Guillaume Vetter,Manuella Bouttier,Elodie Portales-Casamar,Wyeth W. Wasserman,Thomas Maurin,Bernard Mari,Pascal Barbry,Laurent Vallar,Evelyne Friederich,Khalil Arar,Bruno Cassinat,Christine Chomienne,Charles-Henri Lecellier
View Articletitled, Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia
Supplemental data
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
Xingming Deng,Fengqin Gao,W. Stratford May
View Articletitled, Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2
Rong L. He,Jian Zhou,Crystal Z. Hanson,Jia Chen,Ni Cheng,Richard D. Ye
View Articletitled, Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2
Supplemental data
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
Wei Xia,Andrew R. Hilgenbrink,Eric L. Matteson,Michael B. Lockwood,Ji-Xin Cheng,Philip S. Low
View Articletitled, A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
Supplemental data

PLATELETS AND THROMBOPOIESIS

Group IVA cytosolic phospholipase A2 (cPLA2α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets
Nicolas Prévost,John V. Mitsios,Hisashi Kato,John E. Burke,Edward A. Dennis,Takao Shimizu,Sanford J. Shattil
View Articletitled, Group IVA cytosolic phospholipase A<sub>2</sub> (cPLA<sub>2</sub>α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets
Supplemental data
Mutation of the β1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly
Brief Report
Shinji Kunishima,Ryoji Kobayashi,Tomohiko J. Itoh,Motohiro Hamaguchi,Hidehiko Saito
View Articletitled, Mutation of the β1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
Yan Jiao,John Wilkinson, IV,Xiumin Di,Wei Wang,Heather Hatcher,Nancy D. Kock,Ralph D'Agostino, Jr,Mary Ann Knovich,Frank M. Torti,Suzy V. Torti
View Articletitled, Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
Supplemental data

THROMBOSIS AND HEMOSTASIS

Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells
Yuko Suzuki,Hideo Mogami,Hayato Ihara,Tetsumei Urano
View Articletitled, Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells
Supplemental data

TRANSPLANTATION

CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses
Nirupama D. Verma,Karren M. Plain,Masaru Nomura,Giang T. Tran,Catherine Robinson,Rochelle Boyd,Suzanne J. Hodgkinson,Bruce M. Hall
View Articletitled, CD4<sup>+</sup>CD25<sup>+</sup> T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses

VASCULAR BIOLOGY

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Guillaume Carmona,Stephan Göttig,Alessia Orlandi,Jürgen Scheele,Tobias Bäuerle,Manfred Jugold,Fabian Kiessling,Reinhard Henschler,Andreas M. Zeiher,Stefanie Dimmeler,Emmanouil Chavakis
View Articletitled, Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Supplemental data

CORRESPONDENCE

Dasatinib induces a response in chronic lymphocytic leukemia
Vincenzo Pitini,Carmela Arrigo,Giuseppe Altavilla
View Articletitled, Dasatinib induces a response in chronic lymphocytic leukemia
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