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Journal Articles

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Andreas Agathangelidis, Nikos Darzentas, Anastasia Hadzidimitriou, Xavier Brochet, Fiona Murray, Xiao-Jie Yan, Zadie Davis, Ellen J. van Gastel-Mol, Cristina Tresoldi, Charles C. Chu, Nicola Cahill, Veronique Giudicelli, Boris Tichy, Lone Bredo Pedersen, Letizia Foroni, Lisa Bonello, Agnieszka Janus, Karin Smedby, Achilles Anagnostopoulos, Helene Merle-Beral, Nikolaos Laoutaris, Gunnar Juliusson, Paola Francia di Celle, Sarka Pospisilova, Jesper Jurlander, Christian Geisler, Athanasios Tsaftaris, Marie-Paule Lefranc, Anton W. Langerak, David Graham Oscier, Nicholas Chiorazzi, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2012) 119 (19): 4467–4475.
https://doi.org/10.1182/blood-2011-11-393694
Published: 2012
Includes: Supplemental data
Journal Articles

The Composition of the B Cell Receptor Repertoire In 7428 Cases of Chronic Lymphocytic Leukemia: One Third Stereotyped, Two Thirds Heterogeneous - What Does This Mean?

Andreas Agathaggelidis, Nikos Darzentas, Anastasia Hadzidimitriou, Xavier Brochet, Fiona Murray, Xiao-Jie Yan, Zadie Davis, Ellen van Gastel, Cristina Tresoldi, Charles C Chu, PhD, Nicola Cahill, Veronique Giudicelli, Boris Tichy, Lone Bredo Pedersen, Letizia Foroni, Paola Francia di Celle, Agnieszka Janus, Karin Smedby, Achilles Anagnostopoulos, Helene Merle-Beral, Nikolaos Laoutaris, Gunnar Juliusson, Sarka Pospisilova, Jesper Jurlander, Athanasios Tsaftaris, Marie-Paule Lefranc, Anton W. Langerak, David Graham Oscier, Nicholas Chiorazzi, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2010) 116 (21): 43.
https://doi.org/10.1182/blood.V116.21.43.43
Published: 2010
Journal Articles

Toll-Like Receptor Signaling Pathway In Chronic Lymphocytic Leukemia: Distinct Gene Expression Profiles of Potential Pathogenetic Significance In Specific Subsets of Patients

Eleni Arvaniti, Stavroula Ntoufa, Nikos Papakonstantinou, Tasoula Touloumenidou, Nikolaos Laoutaris, Achilles Anagnostopoulos, Kleoniki Lamnisou, Federico Caligaris-Cappio, M.D., Kostas Stamatopoulos, Paolo Ghia, Marta Muzio, Chrysoula Belessi
Journal: Blood
Blood (2010) 116 (21): 44.
https://doi.org/10.1182/blood.V116.21.44.44
Published: 2010
Journal Articles

Insight Into HCDR3 Restrictions in CLL by Analysis of Incomplete IGHD-IGHJ Rearrangements: Further Evidence that Somatic Selection Shapes the Expressed CLL Immunoglobulin Repertoire.

Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Georgios Bourikas, Helene Merle-Beral, Achilles Anagnostopoulos, Nikolaos Laoutaris, Monika Bruggemann, Frederic Davi, Kostas Stamatopoulos, Chrysoula Belessi
Journal: Blood
Blood (2009) 114 (22): 2346.
https://doi.org/10.1182/blood.V114.22.2346.2346
Published: 2009
Journal Articles

Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia

Anastasia Hadzidimitriou, Nikos Darzentas, Fiona Murray, Tanja Smilevska, Eleni Arvaniti, Cristina Tresoldi, Athanasios Tsaftaris, Nikolaos Laoutaris, Achilles Anagnostopoulos, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos, Chrysoula Belessi
Journal: Blood
Blood (2009) 113 (2): 403–411.
https://doi.org/10.1182/blood-2008-07-166868
Published: 2009
Includes: Supplemental data
Journal Articles

A Different Ontogenesis for CLL Cases Carrying Stereotyped Antigen Receptors: Molecular and Computational Evidence

Nikos Darzentas, Anastasia Hadzidimitriou, Fiona Murray, Katerina Hatzi, Par Josefsson, Nikolaos Laoutaris, Carol Moreno, Achilles Anagnostopoulos, Jesper Jurlander, Athanasios Tsaftaris, Nicholas Chiorazzi, Chrysoula Belessi, Paolo Ghia, Richard Rosenquist, Frederic Davi, Kostas Stamatopoulos
Journal: Blood
Blood (2008) 112 (11): 777.
https://doi.org/10.1182/blood.V112.11.777.777
Published: 2008
Journal Articles

Evidence for the Significant Role of Immunoglobulin Light Chains in Antigen Recognition and Selection in Chronic Lymphocytic Leukemia

Anastasia Hadzidimitriou, Nikos Darzentas, Fiona Murray, Tanja Smilevska, Eleni Arvaniti, Cristina Tresoldi, Athanasios Tsaftaris, Nikolaos Laoutaris, Achilles Anagnostopoulos, Frederic Davi, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos, Chrysoula Belessi
Journal: Blood
Blood (2008) 112 (11): 780.
https://doi.org/10.1182/blood.V112.11.780.780
Published: 2008
Journal Articles

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

Fiona Murray, Nikos Darzentas, Anastasia Hadzidimitriou, Gerard Tobin, Myriam Boudjogra, Cristina Scielzo, Nikolaos Laoutaris, Karin Karlsson, Fanny Baran-Marzsak, Athanasios Tsaftaris, Carol Moreno, Achilles Anagnostopoulos, Federico Caligaris-Cappio, Dominique Vaur, Christos Ouzounis, Chrysoula Belessi, Paolo Ghia, Fred Davi, Richard Rosenquist, Kostas Stamatopoulos
Journal: Blood
Blood (2008) 111 (3): 1524–1533.
https://doi.org/10.1182/blood-2007-07-099564
Published: 2008
Includes: Supplemental data
Journal Articles

Over 20% of Patients with Chronic Lymphocytic Leukemia Carry Stereotyped Receptors: Pathogenetic Implications and Clinical Correlations.

Kostas Stamatopoulos, Chrysoula Belessi, Carol Moreno, Myriam Boudjograh, Giuseppe Guida, Tatjana Smilevska, Lynda Belhoul, Stefania Stella, Niki Stavroyianni, Marta Crespo, Anastasia Hadzidimitriou, Laurent Sutton, Francesc Bosch, Nikolaos Laoutaris, Achilles Anagnostopoulos, Emili Montserrat, Athanasios Fassas, Guillaume Dighiero, Federico Caligaris-Cappio, Helene Merle-Beral, Paolo Ghia, Frederic Davi
Journal: Blood
Blood (2006) 108 (11): 26.
https://doi.org/10.1182/blood.V108.11.26.26
Published: 2006
Journal Articles

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations

Clinical Trials & Observations
Kostas Stamatopoulos, Chrysoula Belessi, Carol Moreno, Myriam Boudjograh, Giuseppe Guida, Tatjana Smilevska, Lynda Belhoul, Stefania Stella, Niki Stavroyianni, Marta Crespo, Anastasia Hadzidimitriou, Laurent Sutton, Francesc Bosch, Nikolaos Laoutaris, Achilles Anagnostopoulos, Emili Montserrat, Athanasios Fassas, Guillaume Dighiero, Federico Caligaris-Cappio, Hélène Merle-Béral, Paolo Ghia, Frédéric Davi
Journal: Blood
Blood (2006) 109 (1): 259–270.
https://doi.org/10.1182/blood-2006-03-012948
Published: 2006
Includes: Supplemental data
Journal Articles

Somatic Mutation Analysis of Immunoglobulin (IG) Genes in Chronic Lymphocytic Leukemia (CLL) and Comparison to Normal and Autoreactive IG Sequences Reveals CLL-Biased Patterns for Selected IG Genes.

Kostas Stamatopoulos, Chrysoula Belessi, Thanassis Andreou, Anastasia Hadzidimitriou, Niki Stavroyianni, Tanja Smilevska, Fotini Marantidou, Nikolaos Laoutaris, Achilles Anagnostopoulos, George Nikiforidis, Athanasios Fassas
Journal: Blood
Blood (2005) 106 (11): 1185.
https://doi.org/10.1182/blood.V106.11.1185.1185
Published: 2005
Journal Articles

Nucleotide Insertions and Deletions in Chronic Lymphocytic Leukemia. A CLL Specific Deletion among IGHV3-21 Expressing Cases with Stereotyped Receptors.

Chrysoula Belessi, Frédéric Davi, Kostas Stamatopoulos, Massimo Degano, Thanassis Andreou, Carol Moreno, Hélène Merle-Beral, Marta Crespo, Nikolaos Laoutaris, Emili Montserrat, Federico Caligaris-Cappio, Achilles Anagnostopoulos, Paolo Ghia
Journal: Blood
Blood (2005) 106 (11): 2100.
https://doi.org/10.1182/blood.V106.11.2100.2100
Published: 2005
Journal Articles

Splenic Marginal-Zone Lymphoma: One or More Entities? A Histological, Immunohistochemical and Molecular Study of 41 Cases.

Theodora Papadaki, Kostas Stamatopoulos, Chrysoula Belessi, Evi Pouliou, Aikaterini Parasi, Nikolaos Laoutaris, Athanasios Fassas, Achilles Anagnostopoulos, Dimitra Anagnostou
Journal: Blood
Blood (2005) 106 (11): 4671.
https://doi.org/10.1182/blood.V106.11.4671.4671
Published: 2005
Journal Articles

Evidence for Differential Regulation of Transferrin Receptor 1 in Normal vs. Malignant B Cells.

Ioanna Chiotoglou, Tatjana Smilevska, Kostas Stamatopoulos, Maria Samara, Sophia Likousi, Chrysoula Belessi, Nikolaos Laoutaris, Athanasios Fassas, Nikolaos Stathakis, Panagoula Kollia
Journal: Blood
Blood (2005) 106 (11): 3722.
https://doi.org/10.1182/blood.V106.11.3722.3722
Published: 2005
Journal Articles

Immunoglobulin light chain repertoire in chronic lymphocytic leukemia

Kostas Stamatopoulos, Chrysoula Belessi, Anastasia Hadzidimitriou, Tatjana Smilevska, Evangelia Kalagiakou, Katerina Hatzi, Niki Stavroyianni, Anastasia Athanasiadou, Aliki Tsompanakou, Theodora Papadaki, Garyfallia Kokkini, George Paterakis, Riad Saloum, Nikolaos Laoutaris, Achilles Anagnostopoulos, Athanasios Fassas
Journal: Blood
Blood (2005) 106 (10): 3575–3583.
https://doi.org/10.1182/blood-2005-04-1511
Published: 2005
Includes: Supplemental data
Journal Articles

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

Clinical Trials & Observations
Paolo Ghia, Kostas Stamatopoulos, Chrysoula Belessi, Carol Moreno, Stefania Stella, Giuseppe Guida, Ariane Michel, Marta Crespo, Nikolaos Laoutaris, Emili Montserrat, Achilles Anagnostopoulos, Guillaume Dighiero, Athanasios Fassas, Federico Caligaris-Cappio, Frédéric Davi
Journal: Blood
Blood (2005) 105 (4): 1678–1685.
https://doi.org/10.1182/blood-2004-07-2606
Published: 2005
Journal Articles

IG Heavy and Light Chain Variable Genes in Chronic Lymphocytic Leukemia Exhibit Distinct Somatic Mutation Patterns and a Comparable Imprint of Antigen Selection.

Kostas Stamatopoulos, Chrysoula Belessi, Anastasia Hadzidimitriou, Katerina Hatzi, Niki Stavroyianni, Evangelia Kalagiakou, Theodora Papadaki, Fotini Marantidou, Eleni Manioudaki, Anastasia Athanasiadou, Vassiliki Douka, Ioanna Athanasiadou, Varvara Tachynopoulou, Riad Saloum, Nikolaos Laoutaris, Athanasios Fassas, Achilles Anagnostopoulos
Journal: Blood
Blood (2004) 104 (11): 1921.
https://doi.org/10.1182/blood.V104.11.1921.1921
Published: 2004
Journal Articles

Analysis of Non-Expressed IGK Locus Rearrangements in Chronic Lymphocytic Leukemia Indicates a Role for Secondary Rearrangements in Shaping the Expressed Immunoglobulin Repertoire.

Chrysoula Belessi, Kostas Stamatopoulos, Katerina Hatzi, Anastasia Hadzidimitriou, Fotini Marantidou, Tatjana Smilevska, Niki Stavroyianni, Anastasia Athanasiadou, Evangelia Kalagiakou, Garyfallia Kokkini, Christos Georgopoulos, George Paterakis, Riad Saloum, Athanasios Fassas, Achilles Anagnostopoulos, Nikolaos Laoutaris
Journal: Blood
Blood (2004) 104 (11): 972.
https://doi.org/10.1182/blood.V104.11.972.972
Published: 2004
Journal Articles

Immunoglobulin Light Chain Repertoire in Chronic Lymphocytic Leukemia (CLL): Recognition of Subsets with “CLL-Specific” CDR3 Regions and Associations with Heavy Chains.

Kostas Stamatopoulos, Chrysoula Belessi, Anastasia Hadzidimitriou, Evangelia Kalagiakou, Tatjana Smilevska, Niki Stavroyianni, Anastasia Athanasiadou, Aliki Tsompanakou, Theodora Papadaki, Garyfallia Kokkini, George Paterakis, Kalliopi Valianatou, Vassiliki Douka, Riad Saloum, Nikolaos Laoutaris, Achilles Anagnostopoulos, Athanasios Fassas
Journal: Blood
Blood (2004) 104 (11): 769.
https://doi.org/10.1182/blood.V104.11.769.769
Published: 2004
Journal Articles

Pathogenetic Implications from the Analysis of Immunoglobulin Genes in Chronic Lymphocytic Leukemia of Mediterranean Ancestry: The Lesson of the IGHV3-21 Gene.

Paolo Ghia, MD, PhD, Kostas Stamatopoulos, MD, Chrysoula Belessi, MD, Carol Moreno, MD, Stefania Stella, PhD, Giuseppe Guida, MD, Ariane Michel, PhD, Marta Crespo, PhD, Nikolaos Laoutaris, MD, Emili Montserrat, MD, Achilles Anagnostopoulos, MD, Guillaume Dighiero, MD, Athanasios Fassas, MD, Federico Caligaris-Cappio, MD, Frederic Davi, PhD
Journal: Blood
Blood (2004) 104 (11): 771.
https://doi.org/10.1182/blood.V104.11.771.771
Published: 2004