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Journal Articles

Targeting cereblon in AML

Steven Grant
Journal: Blood
Blood (2021) 137 (5): 584–586.
https://doi.org/10.1182/blood.2020009827
Published: 2021
Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission

Andrew H. Wei, MBBS, FRACP, FRCPA, PhD, Hartmut Döhner, MD, Christopher Pocock, MBBS, Pau Montesinos, MD PhD, Boris Afanasyev, MD DSci, Hervé Dombret, MD, Farhad Ravandi, MD, Hamid Sayar, MD MSc, Jun Ho Jang, MD PhD, Kimmo Porkka, MD, Dominik Selleslag, MD, Irwindeep Sandhu, MD, Mehmet Turgut, MD, Valentina Giai, MD, Yishai Ofran, MD, Merih Kizil Cakar, MD, Aida Botelho de Sousa, MD, Justyna Rybka, MD PhD, Chiara Frairia, MD, Lorenza Borin, MD, Germana Beltrami, MD, Jaroslav Cermak, MD PhD, Gert J. Ossenkoppele, MD PhD, Ignazia La Torre, MD, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, CL Beach, PharmD, Gail J. Roboz, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-3.
https://doi.org/10.1182/blood-2019-132405
Published: 2019
Journal Articles

Late Effects Are Important Considerations in Initial Hodgkin Lymphoma Treatment Decision-Making According to Survivors

Anita J Kumar, MDMS, Rachel Murphy-Banks, MA, Ruth Ann Weidner, MBA, MRP, Susan K Parsons, MD MRP
Journal: Blood
Blood (2019) 134 (Supplement_1): 2137.
https://doi.org/10.1182/blood-2019-124481
Published: 2019
Journal Articles

Polymorphisms in Inflammatory Genes Modulate the Occurrence of Clinical Complications in Patients with Sickle Cell Disease

Karina Tozatto-Maio, MD, Robert Girot, MD PhD, Indou Deme Ly, MD, Vanderson Rocha, MD PhD, Ana Cristina Silva Pinto, MD PhD, Ibrahima Diagne, Prof, Yahia Benzerara, Francisco Fernandes, Carla Luana Dinardo, MD PhD, Simone Kashima, PhD, Itaua Leston Araujo, MSc, PhD, Chantal Kenzey, Guilherme Henrique Hencklain Fonseca, MD, Evandra Strazza Rodrigues, PhD, Fernanda Volt, MSc, Luciana Ribeiro Jarduli, PhD, Annalisa Ruggeri, MD, Christina Mary Mariaselvam, PhD, Sandra Fatima Menosi Gualandro, MD PhD, Hanadi Elayoubi, MD, Renato Cunha, MD PhD, Barbara Cappelli, MD, Julia Pavan, PhD, Belinda Pinto Simões, MD PhD, Eliane Gluckman, MD PhD, Ryad Tamouza, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4825.
https://doi.org/10.1182/blood-2019-124218
Published: 2019
Journal Articles

Hereditary Hemolytic Anemias Other Than Thalassemia: Single Center Experience

Gul Nihal Ozdemir, MD, Mehmet Akif Kilic, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4855.
https://doi.org/10.1182/blood-2019-121702
Published: 2019
Journal Articles

Hydroxyurea Pharmacokinetic Profiles in Children Treated for Extreme Thrombocytosis after Total Pancreatectomy with Islet Cell Autotransplant Demonstrate Poor Absorption

Alexander A Boucher, MD, Min Dong, PhD, Anu Marahatta, PhD, Adriane Hausfeld, Thad A. Howard, MS, Jaimie D Nathan, MD, Alexander A. Vinks, PharmD, PhD FCP, Patrick T. McGann, MD, Russell E. Ware, MD PhD, Lori Luchtman-Jones, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4893.
https://doi.org/10.1182/blood-2019-127378
Published: 2019
Journal Articles

The Unforeseen Medical and Business Challenges Found When Integrating Abstracted Data from Disparate EHR Systems While Building the Curecloud Direct-to-Patient Multiple Myeloma Registry

Steven E. Labkoff, MD, Shaadi Mehr, PhD, Christopher Williams, Daniel Auclair, Paul A. Giusti, MBA, Kathy E. Giusti, MBA, Stuart L. Goldberg, MD, Kevin M Keogh, Andrew J. Belli, MPH, Andrew D Norden, MDMPH MBA
Journal: Blood
Blood (2019) 134 (Supplement_1): 4736.
https://doi.org/10.1182/blood-2019-130276
Published: 2019
Journal Articles

The Effects of Utilization of Individualized Pain Plans in Treatment of Vaso-Occlusive Crises in the Emergency Department

Sherraine Griffin, MD, Payal Desai, MD, Eric Adkins, MD MSc, Michael G (MD) Purcell, MD, Luca Delatore, MD, Ying Huang, MS, MA, Melanie Heinlein, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4682.
https://doi.org/10.1182/blood-2019-126991
Published: 2019
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Genomic Landscape Including Novel Mutational Drivers in Relapsed/Refractory Diffuse Large B Cell Lymphoma

Kerstin Wenzl, PhD, Maria Ortiz, Nicholas Stong, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Hamid Nikbakht, PhD, Matthew Stokes, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantinos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, Thomas M. Habermann, MD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Anne J Novak, PhD, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 919.
https://doi.org/10.1182/blood-2019-123694
Published: 2019
Journal Articles

Clustering of Transcriptomic Signatures in Newly Diagnosed Diffuse Large B-Cell Lymphoma Identifies Two High-Risk Subgroups Which Increase in Prevalence at Relapse

Maria Ortiz, Kerstin Wenzl, PhD, Matthew Stokes, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Alexander Ratushny, PhD, Mark McConnell, PhD, Samuel A Danziger, PhD, Nicholas Stong, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantimos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Thomas M. Habermann, MD, Anita K Gandhi, Anne J Novak, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 923.
https://doi.org/10.1182/blood-2019-122756
Published: 2019
Journal Articles

Targeting B-Cell Maturation Antigen (BCMA) with CC-93269, a 2+1 T Cell Engager, Elicits Significant Apoptosis in Diffuse Large B-Cell Lymphoma Preclinical Models

Patrick R. Hagner, PhD, Michelle Waldman, MS, Falon D. Gray, DVM, DACVP, Renee Yura, PhD, Sarah Hersey, MS, MBA, Henry Chan, PhD, Mingjun Zhang, PhD, Isaac Boss, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 1580.
https://doi.org/10.1182/blood-2019-126115
Published: 2019
Journal Articles

A Phase I Study of CC-90002, a Monoclonal Antibody Targeting CD47, in Patients with Relapsed and/or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS): Final Results

Amer M. Zeidan, MBBS, MHS, Daniel J. DeAngelo, MD PhD, Jeanne M. Palmer, Christopher S. Seet, MD PhD, Martin S. Tallman, MD, Xin Wei, PhD, Ying Fei Li, PhD, Nanette Hock, RN, MSN, Michael R. Burgess, Kristen Hege, Wendy Stock, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1320.
https://doi.org/10.1182/blood-2019-125363
Published: 2019
Journal Articles

MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), As Monotherapy or "Add-on" to Ruxolitinib, in Patients with Refractory or Intolerant Advanced Myelofibrosis

John Mascarenhas, MD, Marina Kremyanskaya, Ronald Hoffman, MD, Prithviraj Bose, MD, Moshe Talpaz, MD, Claire N Harrison, Professor, Vikas Gupta, MD FRCP, FRCPath, Brian Leber, MD, Shireen Sirhan, MD, Sujan Kabir, MD, Adrian Senderowicz, MD, James Shao, MS, Jennifer Mertz, PhD, Patrick Trojer, PhD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 670.
https://doi.org/10.1182/blood-2019-127119
Published: 2019
Journal Articles

Frequent Impaired Overall Neurocognitive and Executive Function in Children Ages 1-12 Years of Age with Sickle Cell Anemia in Uganda

Amelia Boehme, PhD MSPH, Paul Bangirana, MS, PhD, Annet Birabwa, MS, Deogratias Munube, MD, Ezekiel Mupere, MMed, MS, PhD, Robert Opoka, MMED, Philip Kasirye, MMED, Philip LaRussa, MD, Nancy S. Green, MD, Richard Idro, MMED, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1015.
https://doi.org/10.1182/blood-2019-131509
Published: 2019
Journal Articles

Defining Germline Predisposition to Dnmt3a -Mutant Clonal Hematopoiesis (CH)

Logan Sari Schwartz, BS, Kristina Mujica, Rebecca Bell, BA, Matthew Loberg, BA, Jennifer Trowbridge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1198.
https://doi.org/10.1182/blood-2019-124530
Published: 2019
Journal Articles

Can Monosomy 7 be Targeted By Next Generation Cereblon-Modulating Agents?

Vera Adema, PhD, Cassandra M Kerr, MS, Wencke Walter, PhD, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, MD, Sunisa Kongkiatkamon, Christina A. Snider, BA, Milo Co, Rainey Magdalena, Arda Durmaz, Manja Meggendorfer, PhD, Aziz Nazha, MD, Jacob Scott, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Torsten Haferlach, MD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1270.
https://doi.org/10.1182/blood-2019-128967
Published: 2019
Journal Articles

Implication of Inherited Genetic Variants Associated with Follicular Lymphoma Susceptibility in the Prognosis of Patients Treated By Immunochemotherapy in PRIMA Study

Herve Ghesquieres, MD PhD, Youenn Drouet, PhD, Sarah Huet, PharmD PhD, Guillaume Cartron, Marie-Helene Delfau, MD PhD, Fritz Offner, MD, Pauline Brice, Luc Xerri, MD PhD, Reda Bouabdallah, Gilles A. Salles, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2780.
https://doi.org/10.1182/blood-2019-130357
Published: 2019
Journal Articles

Pharmacodynamic Responses to CC-90009, a Novel Cereblon E3 Ligase Modulator, in a Phase I Dose-Escalation Study in Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Jinhong Fan, Hongbin Wang, Suzana Couto, Tsun-Wen Sheena Yao, Geoffrey L. Uy, MD, Amer M. Zeidan, MBBS, MHS, Mark D. Minden, Pau Montesinos, Daniel J. DeAngelo, Jessica K. Altman, Jamie Koprivnikar, MD, Paresh Vyas, MD PhD, Yngvar Fløisand, María Belén Vidriales, Bjørn Tore Gjertsen, Tonia J. Buchholz, Michael Pourdehnad, Daniel W. Pierce
Journal: Blood
Blood (2019) 134 (Supplement_1): 2547.
https://doi.org/10.1182/blood-2019-124291
Published: 2019