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Journal Articles

SUMO E3 Ligase ZMIZ1 Drives Leukemogenesis Via Transcriptional Deregulation in Acute Myeloid Leukemia

Fu Ziyu, Yun Tan, Xiaoguang Xu, Jie Xu, Sai-Juan Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4134.
https://doi.org/10.1182/blood-2023-187978
Published: 2023
Journal Articles

Recommendations on Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Combination of All- Trans Retinoic Acid and Arsenic Trioxide

Li Chen, Hongming Zhu, Fangyi Dong, Yan Li, Qifa Liu, Yu Hu, Yicheng Zhang, Jie Jin, Jianda Hu, Ting Liu, Depei Wu, Jieping Chen, Yongrong Lai, Jianxiang Wang, Juan Li, Jianyong Li, Xin Du, Xin Wang, Mingzhen Yang, Jinsong Yan, Guifang Ouyang, Li Liu, Ming Hou, Xiaojun Huang, Wen Jin, Yongmei Zhu, Jian Li, Kankan Wang, Zhu Chen, Sai-Juan Chen, Junmin Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 2946.
https://doi.org/10.1182/blood-2023-184433
Published: 2023
Journal Articles

Metabolomic Insights into the Pathogenesis and Prognostic Potential of Adult Acute Lymphoblastic Leukemia

Junyu Wang, Tuantuan Gui, Tong Yin, Yuting Dai, Jing Qiao, Jianfeng Li, Jie Xu, Yuanfang Liu, Yan Wang, Yun Tan, Bo Jiao, Yongmei Zhu, Zhu Chen, Wenlian Chen, Hai Fang, Jian Hou, Jian-Qing Mi, Jin Wang, Sai-Juan Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2971.
https://doi.org/10.1182/blood-2023-184328
Published: 2023
Journal Articles

Phase 2, Open-Label Study of Ciltacabtagene Autoleucel, an Anti-BCMA CAR-T Cell Therapy, in Chinese Patients with Relapsed/Refractory Multiple Myeloma (CARTIFAN-1): 26-Month Median Follow-up

Jian-Qing Mi, Wanhong Zhao, Hongmei Jing, Weijun Fu, Jianda Hu, Lijuan Chen, Yiwen Zhang, Dan Yao, Hui Li, Jordan M Schecter, Fan Yang, Huabin Sun, Sen Hong Zhuang, Da Xu, Tracy Luo, Xiaohu Fan, Ting Niu, Jie Jin, Sai-Juan Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 7542–7544.
https://doi.org/10.1182/blood-2022-159185
Published: 2022
Journal Articles

Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion

Ming Zhang, Hao Zhang, Zhihui Li, Ling Bai, Qianqian Wang, Jianfeng Li, Minghao Jiang, Qing Xue, Nuo Cheng, Weina Zhang, Dongdong Mao, Zhiming Chen, Jinyan Huang, Guoyu Meng, Zhu Chen, Sai-Juan Chen
Journal: Blood
Blood (2022) 140 (12): 1390–1407.
https://doi.org/10.1182/blood.2022016241
Published: 2022
Includes: Supplemental data
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS

CME
Bing-Yi Chen, Junhong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, Na Liu, Peng-Cheng Yu, Ping Liu, Li-Juan Zong, Jia-Ying Zhang, Ruo-Fei Dai, Fei Lan, Qiu-Hua Huang, Su-Jiang Zhang, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Lan Wang
Journal: Blood
Blood (2020) 135 (25): 2271–2285.
https://doi.org/10.1182/blood.2019001963
Published: 2020
Includes: Supplemental data
Journal Articles

Dynamic Analysis of Cytokine Profile for Cytokine Release Syndrome in Multiple Myeloma Patients after CAR-T Cell Therapy

Shuangshuang Yang, MD, Lijuan Chen, MD PhD, Jie Xu, MD PhD, Frank Xiao-Hu Fan, MD PhD, Sun Yan, PhD, Wen Wu, MD PhD, Yan Wang, MD, Jin Wang, MD PhD, Shiwei Jin, MD, Yuebo Zhou, Yuanfang Liu, MD PhD, Yan Zhuang, PhD, Wu Zhang, PhD, Jun-Min Li, Jian Hou, PhD MD, Jian-Yong Li, MD PhD, Zhu Chen, PhD, Jian-Qing Mi, MD PhD, Sai-Juan Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5617.
https://doi.org/10.1182/blood-2019-131799
Published: 2019
Journal Articles

Updated Phase 1 Results of a First-in-Human Open-Label Study of Lcar-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (Bcma)

Lijuan Chen, MD PhD, Jie Xu, MD PhD, Weijun Fu, Sr., MD PhD, Shiwei Jin, MD, Shuangshuang Yang, MD, Sun Yan, PhD, Wen Wu, MD PhD, Yuanfang Liu, MD PhD, Wu Zhang, PhD, Xiangqin Weng, Yan Wang, MD, Jin WANG, MD PhD, Xiaoyi Ding, Biao Li, Jiang Zhu, MD, Zhu Chen, PhD, Frank Xiao-Hu Fan, MD PhD, Jianyong Li, MD PhD, Jian Hou, PhD MD, Sai-Juan Chen, PhD, Jian-Qing Mi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1858.
https://doi.org/10.1182/blood-2019-130008
Published: 2019
Journal Articles

Differential Expression of CD49f Discriminates the Independently Emerged Hematopoietic Stem Cells and Erythroid-Biased Progenitors

Ai-Ning Xu, Dan Liu, Yu-Ting Dai, Fan Zhang, Jian Shen, MSc, Cheng-Long Hu, Chun-Hui Xu, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Peng-Fei Xu, Lan Wang, Lin Cheng, Jinyan Huang, PhD, Zhu Chen, PhD, Sai-Juan Chen, PhD, Xiao-Jian Sun, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3700.
https://doi.org/10.1182/blood-2019-130429
Published: 2019
Journal Articles

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

Clinical Trials & Observations
Miguel A. Sanz, Pierre Fenaux, Martin S. Tallman, Elihu H. Estey, Bob Löwenberg, Tomoki Naoe, Eva Lengfelder, Hartmut Döhner, Alan K. Burnett, Sai-Juan Chen, Vikram Mathews, Harry Iland, Eduardo Rego, Hagop Kantarjian, Lionel Adès, Giuseppe Avvisati, Pau Montesinos, Uwe Platzbecker, Farhad Ravandi, Nigel H. Russell, Francesco Lo-Coco
Journal: Blood
Blood (2019) 133 (15): 1630–1643.
https://doi.org/10.1182/blood-2019-01-894980
Published: 2019
Journal Articles

The Three E Proteins Define a Heterogeneity of the AML1-ETO-Containing Transcription Factor Complex (AETFC) and Differentially Regulate t(8;21) Leukemogenesis

Na Liu, Junhong Song, Yangyang Xie, Xiao-Lin Wang, Bowen Rong, Na Man, PhD, Meng-Meng Zhang, Qunling Zhang, MD PhD, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Chun-Hui Xu, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jinyan Huang, PhD, Qiu-Hua Huang, Fei Lan, Shuhong Shen, MD PhD, Stephen D. Nimer, MD, Zhu Chen, Sai-Juan Chen, Robert G. Roeder, Lan Wang, MD, Xiao-Jian Sun, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5247.
https://doi.org/10.1182/blood-2018-99-112372
Published: 2018
Journal Articles

Angiogenesis Induced By Aminoacyl-tRNA Synthetase Deficiency Is Dependent on Amino Acid Response (AAR) but Not Unfolded Protein Response (UPR) Pathways

Fan Zhang, Yi Chen, Yi Jin, Chun-Hui Xu, Dian-Jia Liu, Ai-Ning Xu, Yuan-Liang Zhang, Yin-Yin Xie, Jing-Yi Shi, Lan Wang, MD, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 77.
https://doi.org/10.1182/blood-2018-99-117909
Published: 2018
Journal Articles

In Vivo CRISPR/Cas9-Targeted Genome Editing Recovers Factor IX Expression Restoring Haemostasis in a Mouse Model

Qiang Wang, MD, Lin Zhang, PhD, Zhu Chen, PhD, Sai-Juan Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5562.
https://doi.org/10.1182/blood.V130.Suppl_1.5562.5562
Published: 2017
Journal Articles

Platelet-Targeted Gene Therapy of Hemophilia a Using Hematopoietic Stem Cells Derived from Genome-Edited Induced Pluripotent Stem Cells

Dawei Wang, Guowei Zhang, Junjie Gu, Xiaohu Shao, Xiaohong Pan, Shuxian Yao, Ying Jin, Qizhen Shi, MD PhD, Zhu Chen, PhD, Sai-Juan Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2063.
https://doi.org/10.1182/blood.V130.Suppl_1.2063.2063
Published: 2017
Journal Articles

Setd2 Is Critical for Maintaining Hematopoietic Homeostasis

Yuanliang Zhang, Jiewen Sun, Zhu Chen, PhD, Sai-Juan Chen, PhD, Xiaojian Sun, Qiuhua Huang
Journal: Blood
Blood (2017) 130 (Supplement 1): 2414.
https://doi.org/10.1182/blood.V130.Suppl_1.2414.2414
Published: 2017
Journal Articles

Identification of Novel Fusion Genes and Characterization of Transcriptome Features in T-Cell Acute Lymphoblastic Leukemia

Bing Chen, MD PhD, Jiang LU, PhD, Meng-Ling Zhong, Jian-Feng LI, Ben-Shang LI, MD, Li-Jun Peng, Yu-Ting Dai, Wei-Na Zhang, PhD, Su-Ning Chen, MD PhD, Jianda Hu, Prof MDPhD, De-pei Wu, MDPhD, Zhu Chen, Jing-Yan Tang, MD, Jin-yan Huang, PhD, Jian-Qing Mi, MD PhD, Sai-Juan Chen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2724.
https://doi.org/10.1182/blood.V130.Suppl_1.2724.2724
Published: 2017
Journal Articles

Effective Treatment of Relapsed/Refractory Multiple Myeloma Including Extramedullary Involvement By BCMA-Specific Chimeric Antigen Receptor-Modified T Cells

Jian-Qing Mi, MD PhD, Xiaohu (Frank) Fan, PhD, Jie Xu, PhDMD, Yuanfang Liu, MD PhD, Yan Zhuang, PhD, Shuangshuang Yang, Wu Zhang, PhD, Bing Chen, MD PhD, Yueying Wang, PhD, Xiangqin Weng, Junmin Li, Weijun Fu, MD, Hua Jiang, MD, Li Zhu, Zhu Chen, PhD, Sai-Juan Chen, PhD, Jian Hou, PhD MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3115.
https://doi.org/10.1182/blood.V130.Suppl_1.3115.3115
Published: 2017
Journal Articles

NPM1 Mutation Contributes to Hematological Dysfunction By Disrupting H3K79 Methylation

Jie Xu, MD, PhD, Wu Zhang, PhD, Xiaojing Yan, MD PhD, Chen Zhao, Jiang Zhu, MD PhD, Zhu Chen, Sai-Juan Chen, MD, PhD, Jiong Hu, Sr., Doctor
Journal: Blood
Blood (2016) 128 (22): 2702.
https://doi.org/10.1182/blood.V128.22.2702.2702
Published: 2016
Journal Articles

Functional Study of Novel Gene Fusions and Patterns of Epigenetic Regulator Mutations in Adult and Childhood B-Cell Acute Lymphoblastic Leukemia

Wei-Na Zhang, Ming Zhang, Jin-yan Huang, Zhu Chen, Sai-Juan Chen
Journal: Blood
Blood (2016) 128 (22): 4076.
https://doi.org/10.1182/blood.V128.22.4076.4076
Published: 2016