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Angel F Lopez
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Journal Articles

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

Kelly Lim, Monika Kutyna, Winnie Kan, Angel F. Lopez, Anna Brown, Agnes S. M. Yong, Steven W Lane, Chun Yew Fong, Timothy P Hughes, David T Yeung, David M Ross, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2024-202682
Published: 2024
Journal Articles

Transforming Growth Factor Beta 1/SMAD2 Signalling Axis Regulates Leukemia Stem Cell Marker CD123: Implications for Acute Myeloid Leukemia

Sepideh Azizi Taramsary, Joanna Woodcock, Denis Tvorogov, Angel F. Lopez, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 5723.
https://doi.org/10.1182/blood-2024-204191
Published: 2024
Journal Articles

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Denis Tvorogov, Chloe AL Thompson-Peach, Johannes Foßelteder, Mara Dottore, Frank Stomski, Kelly SY Lim, Suraiya A Onnesha, David M Ross, Andreas Reinisch, Daniel Thomas, Angel F. Lopez
Journal: Blood
Blood (2021) 138 (Supplement 1): 3597.
https://doi.org/10.1182/blood-2021-154332
Published: 2021
Journal Articles

Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Nadia El Khawanky, Bsc(Biomed), BHlthSc(Hons), Amy Hughes, PhD, Wenbo Yu, PhD, Sanaz Taromi, PhD, Jade Clarson, BSc, Angel F. Lopez, MD PhD, Michael P. Brown, MD PhD, Justus Duyster, MD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Deborah L. White, PhD FFSc (RCPA), Agnes S. M. Yong, MD PhD, Robert Zeiser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3904.
https://doi.org/10.1182/blood-2019-124684
Published: 2019
Journal Articles

Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Denis Tvorogov, PhD, Daniel Thomas, MD PhD, Nicholas P.D Liau, Mara Dottore, Emma F Barry, Maya Lathi, Winnie L Kan, PhD, Tim R Hercus, PhD, Frank Stomski, PhD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Vinay Tergaonkar, PhD, Michael W Parker, PhD, David M Ross, Jeffrey J Babon, PhD, Ravindra Majeti, MD PhD, Angel F. Lopez, MBBS,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1787.
https://doi.org/10.1182/blood-2018-99-115760
Published: 2018
Journal Articles

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw, Daniel Thomas, Andrew H. Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis, Stuart M. Pitson
Journal: Blood
Blood (2017) 129 (6): 771–782.
https://doi.org/10.1182/blood-2016-06-720433
Published: 2017
Includes: Supplemental data
Journal Articles

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Eva Nievergall, Hayley S. Ramshaw, Agnes S. M. Yong, Mark Biondo, Samantha J. Busfield, Gino Vairo, Angel F. Lopez, Timothy P. Hughes, Deborah L. White, Devendra K. Hiwase
Journal: Blood
Blood (2014) 123 (8): 1218–1228.
https://doi.org/10.1182/blood-2012-12-475194
Published: 2014
Includes: Supplemental data
Journal Articles

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Therese Vu, Claudia Bruedigam, Rebecca Austin, Catherine Paine-Kuhn, Hayley S. Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Geoff Hill, MD, Ann Mullally, MD, Steven W Lane, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2841.
https://doi.org/10.1182/blood.V122.21.2841.2841
Published: 2013
Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A. Powell, Francois Vergez, David H. Segal, Nhu-Y. N. Nguyen, Adele Baker, Tse-Chieh Teh, Emma F. Barry, Jean-Emmanuel Sarry, Erwin M. Lee, Tracy L. Nero, Anissa M. Jabbour, Giovanna Pomilio, Benjamin D. Green, Stéphane Manenti, Stefan P. Glaser, Michael W. Parker, Angel F. Lopez, Paul G. Ekert, Richard B. Lock, David C. S. Huang, Susie K. Nilsson, Christian Récher, Andrew H. Wei, Mark A. Guthridge
Journal: Blood
Blood (2013) 122 (5): 738–748.
https://doi.org/10.1182/blood-2012-08-447441
Published: 2013
Includes: Supplemental data
Journal Articles

Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment

Eva Nievergall, PhD, Deborah L. White, PhD, FFSc(RCPA), Agnes S.M. Yong, MD, PhD, Hayley S. Ramshaw, PhD, Samantha J. Busfield, PhD, Gino Vairo, PhD, Angel F. Lopez, MBBS, PhD, Timothy P. Hughes, MD, MBBS, Devendra K. Hiwase, MBBS, MD, PhD, FRACP, FRCPA
Journal: Blood
Blood (2012) 120 (21): 32.
https://doi.org/10.1182/blood.V120.21.32.32
Published: 2012
Journal Articles

CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells

Samantha J. Busfield, PhD, Mark Biondo, PhD, Mae Wong, PhD, Hayley S. Ramshaw, PhD, Erwin M Lee, PhD, Kirstee Martin, PhD, Souravi Ghosh, PhD, Hal Braley, Vesna Tomasetig, Con Panousis, PhD, Gino Vairo, PhD, Andrew W. Roberts, MBBS, PhD, Simon Z. He, MBBS, Naomi Sprigg, Daniel Thomas, MBBS, PhD, Mark DeWitte, VMD, Richard B. Lock, PhD, Angel F. Lopez, MBBS, PhD, Andrew Nash, PhD
Journal: Blood
Blood (2012) 120 (21): 3598.
https://doi.org/10.1182/blood.V120.21.3598.3598
Published: 2012
Journal Articles

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Kate A. Markey, Motoko Koyama, Rachel D. Kuns, Katie E. Lineburg, Yana A. Wilson, Stuart D. Olver, Neil C. Raffelt, Alistair L. J. Don, Antiopi Varelias, Renee J. Robb, Melody Cheong, Christian R. Engwerda, Raymond J. Steptoe, Hayley S. Ramshaw, Angel F. Lopez, Javier Vega-Ramos, Andrew M. Lew, Jose A. Villadangos, Geoffrey R. Hill, Kelli P. A. MacDonald
Journal: Blood
Blood (2012) 119 (24): 5918–5930.
https://doi.org/10.1182/blood-2011-12-398164
Published: 2012
Journal Articles

Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34 + CML Progenitors to Dasatinib-Induced Cell Death,

Eva Nievergall, Deborah L. White, PhD. FFSc(RCPA), Hayley Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Timothy P. Hughes, MD, MBBS, Devendra K Hiwase, MBBS, MD, PhD, FRACP, FRCPA
Journal: Blood
Blood (2011) 118 (21): 3745.
https://doi.org/10.1182/blood.V118.21.3745.3745
Published: 2011
Journal Articles

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Michelle Perugini, Anna L. Brown, Diana G. Salerno, Grant W. Booker, Cvetan Stojkoski, Timothy R. Hercus, Angel F. Lopez, Margaret L. Hibbs, Thomas J. Gonda, Richard J. D'Andrea
Journal: Blood
Blood (2010) 115 (16): 3346–3353.
https://doi.org/10.1182/blood-2009-08-235846
Published: 2010
Includes: Supplemental data
Journal Articles

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Jason A. Powell, Daniel Thomas, Emma F. Barry, Chung H. Kok, Barbara J. McClure, Anna Tsykin, L. Bik To, Anna Brown, Ian D. Lewis, Kirsten Herbert, Gregory J. Goodall, Terence P. Speed, Norio Asou, Bindya Jacob, Motomi Osato, David N. Haylock, Susan K. Nilsson, Richard J. D'Andrea, Angel F. Lopez, Mark A. Guthridge
Journal: Blood
Blood (2009) 114 (23): 4859–4870.
https://doi.org/10.1182/blood-2009-02-204818
Published: 2009
Includes: Supplemental data
Journal Articles

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Timothy R. Hercus, Daniel Thomas, Mark A. Guthridge, Paul G. Ekert, Jack King-Scott, Michael W. Parker, Angel F. Lopez
Journal: Blood
Blood (2009) 114 (7): 1289–1298.
https://doi.org/10.1182/blood-2008-12-164004
Published: 2009
Journal Articles

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

Claudine S. Bonder, Wai Y. Sun, Tyson Matthews, Carlos Cassano, Xiaochun Li, Hayley S. Ramshaw, Stuart M. Pitson, Angel F. Lopez, P. Toby Coates, Richard L. Proia, Mathew A. Vadas, Jennifer R. Gamble
Journal: Blood
Blood (2009) 113 (9): 2108–2117.
https://doi.org/10.1182/blood-2008-07-166942
Published: 2009
Includes: Supplemental data
Journal Articles

Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia

Daniel Thomas, MD, Joanna Woodcock, PhD, Jason A Powell, PhD, Emma F Barry, Angel F Lopez, Mark A Guthridge, PhD
Journal: Blood
Blood (2008) 112 (11): 3864.
https://doi.org/10.1182/blood.V112.11.3864.3864
Published: 2008
Journal Articles

A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

Fi-Tjen Mu, Robert K. Andrews, Jane F. Arthur, Adam D. Munday, Susan L. Cranmer, Shaun P. Jackson, Frank C. Stomski, Angel F. Lopez, Michael C. Berndt
Journal: Blood
Blood (2008) 111 (9): 4580–4587.
https://doi.org/10.1182/blood-2007-09-111096
Published: 2008
Journal Articles

The Shc-binding site of the β c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

Hayley S. Ramshaw, Mark A. Guthridge, Frank C. Stomski, Emma F. Barry, Lisa Ooms, Christina A. Mitchell, C. Glenn Begley, Angel F. Lopez
Journal: Blood
Blood (2007) 110 (10): 3582–3590.
https://doi.org/10.1182/blood-2007-01-070391
Published: 2007
Includes: Supplemental data