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Journal Articles

High Plasma Levels of TGF-α and IL-6 at Diagnosis Predict Early Molecular Response Failure and Transformation in CML

Eva Nievergall, PhD, John Reynolds, PhD, Chung H Kok, PhD, Dale Watkins, PhD, Mark Biondo, PhD, Samantha J Busfield, PhD, Gino Vairo, PhD, David T Yeung, BSc, MBBS, FRACP, FRCPA, Angel Lopez, PhD, Devendra K Hiwase, MBBS, MD PhD FRACP, FRCPA, Deborah L White, PhD FFSc (RCPA), Timothy P Hughes, MD MBBS, FRACP, FRCPA
Journal: Blood
Blood (2014) 124 (21): 1788.
https://doi.org/10.1182/blood.V124.21.1788.1788
Published: 2014
Journal Articles

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Eva Nievergall, Hayley S. Ramshaw, Agnes S. M. Yong, Mark Biondo, Samantha J. Busfield, Gino Vairo, Angel F. Lopez, Timothy P. Hughes, Deborah L. White, Devendra K. Hiwase
Journal: Blood
Blood (2014) 123 (8): 1218–1228.
https://doi.org/10.1182/blood-2012-12-475194
Published: 2014
Includes: Supplemental data
Journal Articles

Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment

Eva Nievergall, PhD, Deborah L. White, PhD, FFSc(RCPA), Agnes S.M. Yong, MD, PhD, Hayley S. Ramshaw, PhD, Samantha J. Busfield, PhD, Gino Vairo, PhD, Angel F. Lopez, MBBS, PhD, Timothy P. Hughes, MD, MBBS, Devendra K. Hiwase, MBBS, MD, PhD, FRACP, FRCPA
Journal: Blood
Blood (2012) 120 (21): 32.
https://doi.org/10.1182/blood.V120.21.32.32
Published: 2012
Journal Articles

CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells

Samantha J. Busfield, PhD, Mark Biondo, PhD, Mae Wong, PhD, Hayley S. Ramshaw, PhD, Erwin M Lee, PhD, Kirstee Martin, PhD, Souravi Ghosh, PhD, Hal Braley, Vesna Tomasetig, Con Panousis, PhD, Gino Vairo, PhD, Andrew W. Roberts, MBBS, PhD, Simon Z. He, MBBS, Naomi Sprigg, Daniel Thomas, MBBS, PhD, Mark DeWitte, VMD, Richard B. Lock, PhD, Angel F. Lopez, MBBS, PhD, Andrew Nash, PhD
Journal: Blood
Blood (2012) 120 (21): 3598.
https://doi.org/10.1182/blood.V120.21.3598.3598
Published: 2012
Journal Articles

A Neutralizing Antibody (CSL362) Against the Interleukin-3 Receptor α-Chain Augments the Efficacy of a Cytarabine/Daunorubicin Induction-Type Therapy in Preclinical Xenograft Models of Acute Myelogenous Leukemia

Erwin M Lee, PhD, Dean Yee, PhD, Samantha J Busfield, PhD, Gino Vairo, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3599.
https://doi.org/10.1182/blood.V120.21.3599.3599
Published: 2012
Journal Articles

Pharmacodynamic Activity and Preclinical Safety of CSL362, a Novel Humanised, Affinity Matured Monoclonal Antibody Against Human Interleukin 3 Receptor

Eva Herzog, Samantha Busfield, PhD, Mark Biondo, PhD, Gino Vairo, Mark DeWitte, VMD, Ingo Pragst, Gerhard Dickneite, Prof. PhD, Andrew Nash, PhD, Sabine Zollner
Journal: Blood
Blood (2012) 120 (21): 1524.
https://doi.org/10.1182/blood.V120.21.1524.1524
Published: 2012
Journal Articles

CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.

Richard B. Lock, PhD, Liqing Jin, PhD, Erwin M. Lee, PhD, Hayley S. Ramshaw, PhD, Sam Busfield, PhD, Armando G. Peoppl, BSc, Lucy Wilkinson, BSc, Mark A. Guthridge, PhD, Andrew Boyd, PhD, David Gearing, PhD, Gino Vairo, PhD, Angel Lopez, MD, PhD, John E. Dick, PhD
Journal: Blood
Blood (2007) 110 (11): 161.
https://doi.org/10.1182/blood.V110.11.161.161
Published: 2007