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Issue Archive

Volume 124, Issue 25
December 11 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Hypoxic exosomes promote angiogenesis
Guo-Chang Fan
View Articletitled, Hypoxic exosomes promote angiogenesis
INSIDE BLOOD COMMENTARY
Platelets: balancing the septic triad
Jerry Ware,Steven R. Post
View Articletitled, Platelets: balancing the septic triad
INSIDE BLOOD COMMENTARY
GVHD prophylaxis made safe, easy, and inexpensive
Olle Ringdén
View Articletitled, GVHD prophylaxis made safe, easy, and inexpensive

PLENARY PAPER

IMMUNOBIOLOGY
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity
Francesca S. Gazzaniga,Elizabeth H. Blackburn
View Articletitled, An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity
Supplemental data

HOW I TREAT

How I treat splanchnic vein thrombosis
Walter Ageno,Francesco Dentali,Alessandro Squizzato
View Articletitled, How I treat splanchnic vein thrombosis

CLINICAL TRIALS AND OBSERVATIONS

Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures
Clinical Trials & Observations
David Garcia,John H. Alexander,Lars Wallentin,Daniel M. Wojdyla,Laine Thomas,Michael Hanna,Sana M. Al-Khatib,Paul Dorian,Jack Ansell,Patrick Commerford,Greg Flaker,Fernando Lanas,Dragos Vinereanu,Denis Xavier,Elaine M. Hylek,Claes Held,Freek W. A. Verheugt,Christopher B. Granger,Renato D. Lopes
View Articletitled, Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures

HEMATOPOIESIS AND STEM CELLS

IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation
Fan-ching Lin,Megan Karwan,Bahara Saleh,Deborah L. Hodge,Tim Chan,Kimberly C. Boelte,Jonathan R. Keller,Howard A. Young
View Articletitled, IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation
Supplemental data

IMMUNOBIOLOGY

Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages
Sietse Q. Nagelkerke,Gillian Dekkers,Iwan Kustiawan,Fleur S. van de Bovenkamp,Judy Geissler,Rosina Plomp,Manfred Wuhrer,Gestur Vidarsson,Theo Rispens,Timo K. van den Berg,Taco W. Kuijpers
View Articletitled, Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages
Supplemental data
Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
Jason S. Weinstein,Kimberly Lezon-Geyda,Yelena Maksimova,Samuel Craft,Yaoping Zhang,Mack Su,Vincent P. Schulz,Joseph Craft,Patrick G. Gallagher
View Articletitled, Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
Supplemental data

LYMPHOID NEOPLASIA

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV
Marcelo J. Murai,Jonathan Pollock,Shihan He,Hongzhi Miao,Trupta Purohit,Adam Yokom,Jay L. Hess,Andrew G. Muntean,Jolanta Grembecka,Tomasz Cierpicki
View Articletitled, The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV
Supplemental data
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs,Filip Matthijssens,Steven Goossens,Inge Van de Walle,Katia Ruggero,Charles E. de Bock,Sandrine Degryse,Kirsten Canté-Barrett,Delphine Briot,Emmanuelle Clappier,Tim Lammens,Barbara De Moerloose,Yves Benoit,Bruce Poppe,Jules P. Meijerink,Jan Cools,Jean Soulier,Terence H. Rabbitts,Tom Taghon,Frank Speleman,Pieter Van Vlierberghe
View Articletitled, ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Supplemental data
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
Tomohiro Umezu,Hiroko Tadokoro,Kenko Azuma,Seiichiro Yoshizawa,Kazuma Ohyashiki,Junko H. Ohyashiki
View Articletitled, Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
Supplemental data
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase
James J. Steinhardt,Raymond J. Peroutka,Krystyna Mazan-Mamczarz,Qing Chen,Simone Houng,Carol Robles,Rolf N. Barth,Joseph DuBose,Brandon Bruns,Ronald Tesoriero,Deborah Stein,Raymond Fang,Nader Hanna,Jason Pasley,Carlos Rodriguez,Mark D. Kligman,Matthew Bradley,Joseph Rabin,Stacy Shackelford,Bojie Dai,Ari L. Landon,Thomas Scalea,Ferenc Livak,Ronald B. Gartenhaus
View Articletitled, Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase
Supplemental data
A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders
Brief Report
Thirunavukkarasu Velusamy,Mark J. Kiel,Anagh A. Sahasrabuddhe,Delphine Rolland,Catherine A. Dixon,Nathanael G. Bailey,Bryan L. Betz,Noah A. Brown,Alexandra C. Hristov,Ryan A. Wilcox,Roberto N. Miranda,L. Jeffrey Medeiros,Yoon K. Jeon,Kedar V. Inamdar,Megan S. Lim,Kojo S. J. Elenitoba-Johnson
View Articletitled, A novel recurrent <em>NPM1-TYK2</em> gene fusion in cutaneous CD30-positive lymphoproliferative disorders
Supplemental data

MYELOID NEOPLASIA

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
Adeline Vitaliano-Prunier,Juliane Halftermeyer,Julien Ablain,Aurélien de Reynies,Laurent Peres,Morgane Le Bras,Daniel Metzger,Hugues de Thé
View Articletitled, Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
Supplemental data

PLATELETS AND THROMBOPOIESIS

Thrombocytopenia impairs host defense in gram-negative pneumonia–derived sepsis in mice
Sacha F. de Stoppelaar,Cornelis van ’t Veer,Theodora A. M. Claushuis,Bregje J. A. Albersen,Joris J. T. H. Roelofs,Tom van der Poll
View Articletitled, Thrombocytopenia impairs host defense in gram-negative pneumonia–derived sepsis in mice
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors
Elena Bibikova,Min-Young Youn,Nadia Danilova,Yukako Ono-Uruga,Yoan Konto-Ghiorghi,Rachel Ochoa,Anupama Narla,Bertil Glader,Shuo Lin,Kathleen M. Sakamoto
View Articletitled, TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors
Supplemental data

THROMBOSIS AND HEMOSTASIS

Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis
Jianchung Chen,Hairu Zhou,Alexander Diacovo,X. Long Zheng,Jonas Emsley,Thomas G. Diacovo
View Articletitled, Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis
Supplemental data
Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome
Vera M. Ripoll,Anastasia Lambrianides,Silvia S. Pierangeli,Katie Poulton,Yiannis Ioannou,Wendy E. Heywood,Kevin Mills,David S. Latchman,David A. Isenberg,Anisur Rahman,Ian P. Giles
View Articletitled, Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome
Supplemental data

TRANSPLANTATION

Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS
Christopher G. Kanakry,Hua-Ling Tsai,Javier Bolaños-Meade,B. Douglas Smith,Ivana Gojo,Jennifer A. Kanakry,Yvette L. Kasamon,Douglas E. Gladstone,William Matsui,Ivan Borrello,Carol Ann Huff,Lode J. Swinnen,Jonathan D. Powell,Keith W. Pratz,Amy E. DeZern,Margaret M. Showel,Michael A. McDevitt,Robert A. Brodsky,Mark J. Levis,Richard F. Ambinder,Ephraim J. Fuchs,Gary L. Rosner,Richard J. Jones,Leo Luznik
View Articletitled, Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS
Supplemental data

BLOOD WORK

Auer rods in a patient with chronic myelomonocytic leukemia type 2
Zhaodong Xu,Luke Shier
View Articletitled, Auer rods in a patient with chronic myelomonocytic leukemia type 2

CORRESPONDENCE

Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling
Clinical Trials & Observations
Julie R. McMullen,Esther J. H. Boey,Jenny Y. Y. Ooi,John F. Seymour,Michael J. Keating,Constantine S. Tam
View Articletitled, Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling
Supplemental data
Ibrutinib-naïve chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
Rosella Famà,Riccardo Bomben,Silvia Rasi,Michele Dal Bo,Carmela Ciardullo,Sara Monti,Francesca Rossi,Tiziana D’Agaro,Antonella Zucchetto,Valter Gattei,Gianluca Gaidano,Davide Rossi
View Articletitled, Ibrutinib-naïve chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
Supplemental data
Acute megakaryocytic leukemia is associated with worse outcomes than other types of acute myeloid leukemia
Smith Giri,Ranjan Pathak,Philippe Prouet,Bojia Li,Mike G. Martin
View Articletitled, Acute megakaryocytic leukemia is associated with worse outcomes than other types of acute myeloid leukemia
All Issues

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