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Margaret M. Showel
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Journal Articles

Allogeneic Blood or Marrow Transplantation (AlloBMT) with High-Dose Post-Transplantation Cyclophosphamide (PTCy) for Acute Lymphoblastic Leukemia (ALL) in Patients Aged ≥ 55: Best Results in B ALL in First Remission (CR1) with Reduced-Intensity Conditioning (RIC)

Jonathan Allen Webster, Madison C. Reed, Hua-Ling Tsai, Alexander J. Ambinder, Tania Jain, Amy E. DeZern, Mark J. Levis, Margaret M. Showel, Gabrielle T. Prince, Christopher S. Hourigan, Javier Bolaños-Meade, Lukasz P. Gondek, Gabriel Ghiaur, William Brian Dalton, Suman Paul, Ephraim J. Fuchs, Christian B. Gocke, Abbas Abbas Ali, Douglas E. Gladstone, Carol Ann Huff, Ivan M. Borrello, Lode J. Swinnen, Nina D. Wagner-Johnston, Richard F. Ambinder, Leo Luznik, Ivana Gojo, B. Douglas Douglas Smith, Ravi Varadhan, Richard J. Jones, Philip H. Imus
Journal: Blood
Blood (2022) 140 (Supplement 1): 4813–4815.
https://doi.org/10.1182/blood-2022-171038
Published: 2022
Journal Articles

Nonmyeloablative Allogeneic Transplantation in First Remission for Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia with Post-Transplantation Cyclophosphamide: Outcomes By Receipt of Pre-Transplant Blinatumomab

Jonathan Webster, B. Douglas Smith, Amy E. DeZern, Alexander J. Ambinder, Mark Levis, Margaret M. Showel, Gabrielle T. Prince, Lukasz P. Gondek, Gabriel Ghiaur, William Brian Dalton, Christopher S. Hourigan, Tania Jain, Douglas E Gladstone, Leo Luznik, Philip H. Imus, Javier Bolanos-Meade, Ephraim J. Fuchs, Christian B. Gocke, Abbas Abbas Ali, Carol Ann Huff, Ivan M. Borrello, Lode J. Swinnen, Nina D. Wagner-Johnston, Richard F. Ambinder, Richard J. Jones, Ivana Gojo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1846.
https://doi.org/10.1182/blood-2021-153750
Published: 2021
Journal Articles

Allogeneic Transplantation for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Post-Transplantation Cyclophosphamide: Assessing the Importance of Conditioning Regimen, Donor Choice, and Tyrosine Kinase Inhibitor Use

Jonathan Webster, MD, Leo Luznik, MD, Hua-Ling Tsai, ScM, Philip H. Imus, MD, Amy E. DeZern, MD, Keith W. Pratz, MD, Mark Levis, MD PhD, Ivana Gojo, MD, Margaret M. Showel, MD, Gabrielle T. Prince, MD, Javier Bolanos-Meade, MD, Lukasz P. Gondek, MDPhD, Gabriel Ghiaur, MD PhD, William Brian Dalton, MD PhD, Tania Jain, MD, Ephraim J. Fuchs, MD MBA, Douglas E Gladstone, MD, Christian B. Gocke, MD PhD, Abbas Abbas Ali, MD, Carol Ann Huff, MD, Ivan M. Borrello, MD, Lode J. Swinnen, MB ChB, Nina D. Wagner-Johnston, Richard F. Ambinder, MD, Richard J. Jones, MD, B. Douglas Smith, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-141294
Published: 2020
Journal Articles

Reduced-Intensity Induction with Dasatinib Vs. Hypercvad + 2 nd Generation TKIs with MRD-Guided Follow-up Therapy Leads to Comparable Rates of MRD-Negative Remission While Reducing Transfusions and Neutropenia in Ph+ ALL

Jonathan Webster, MD, Hua-Ling Tsai, ScM, Eric Gehrie, Tania Jain, MD, Christopher S. Hourigan, MDDPhil, William Brian Dalton, MD PhD, Gabrielle T. Prince, MD, Lukasz P. Gondek, MDPhD, Gabriel Ghiaur, MD PhD, Amy E. DeZern, MD, Margaret M. Showel, MD, Ivana Gojo, MD, Douglas E Gladstone, MD, Philip H. Imus, MD, Javier Bolanos-Meade, MD, Leo Luznik, MD, Ephraim J. Fuchs, MD MBA, Christian B. Gocke, MD PhD, Abbas Abbas Ali, MD, Carol Ann Huff, MD, Ivan M. Borrello, MD, Lode J. Swinnen, MB ChB, Nina D. Wagner-Johnston, Richard F. Ambinder, MD, Richard J. Jones, MD, B. Douglas Smith, MD, Mark Levis, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–44.
https://doi.org/10.1182/blood-2020-141264
Published: 2020
Journal Articles

Allogeneic Blood or Marrow Transplantation (BMT) with Post-Transplantation Cyclophosphamide (PTCy) Based Graft Versus Host Disease (GVHD) Prophylaxis for Myelodysplastic Syndrome/ Myeloproliferative Neoplasm-Overlap Syndromes (MDS/MPN)

Theodoros Karantanos, MDPhD, Hua-Ling Tsai, ScM, Lukasz P. Gondek, MDPhD, Mark Levis, MD PhD, Margaret M. Showel, MD, Amy E. DeZern, MD, Ivana Gojo, MD, Ravi Varadhan, PhD, Richard J. Jones, MD, Tania Jain, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
https://doi.org/10.1182/blood-2020-138671
Published: 2020
Journal Articles

Coagulopathy, Hypoxemia, and Mortality Outcomes in Newly Diagnosed Acute Myeloid Leukemia with Hyperleukocytosis Treated with Large Volume Leukapheresis

Bryan Hambley, MD, Eric Gehrie, Jonathan Webster, MD, Margaret M. Showel, MD, Lukasz P. Gondek, MD PhD, William Brian Dalton, MD PhD, Gabrielle T. Prince, MD, Douglas E Gladstone, MD, Ivana Gojo, MD, Gabriel Ghiaur, MD PhD, Keith W. Pratz, MD, B. Douglas Smith, MD, Amy E. DeZern, MD, Mark J. Levis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3841.
https://doi.org/10.1182/blood-2019-123229
Published: 2019
Journal Articles

Effective Immunomodulation with Pomalidomide Beginning at Early Lymphocyte Recovery during Induction Timed Sequential Therapy (TST) for Acute Myeloid Leukemia (AML) and High-Risk Myelodysplasia (HR-MDS)

Joshua F Zeidner, MD, Hanna Knaus, MD, Amer M. Zeidan, MBBS, MHS, Amanda Blackford, Raul Montiel-Esparza, MD, Gabrielle T. Prince, MD, Lukasz P. Gondek, MD PhD, Gabriel Ghiaur, MD PhD, Margaret M. Showel, MD, Amy E. DeZern, MD, Keith W. Pratz, MD, B. Douglas Smith, MD, Mark J. Levis, MD, Matthew C Foster, MD, Catherine C. Coombs, MD, Howard Streicher, MD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 335.
https://doi.org/10.1182/blood-2018-99-114961
Published: 2018
Journal Articles

The Fountain of Youth: Outcomes of Nonmyeloablative (NMA), HLA-Haploidentical Related (Haplo) Bone Marrow Transplantation (BMT) with Post-Transplantation Cyclophosphamide (PTCy) Best with Younger Donors Regardless of Relationship to Patient

Clio E Franklin, MBBS, BSc, MRCP, Margaret M. Showel, MD, Hua-Ling Tsai, ScM, Ravi Varadhan, PhD, Shannon R. McCurdy, MD, Douglas E. Gladstone, MD, Richard J. Jones, MD, Amy E. DeZern, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 849.
https://doi.org/10.1182/blood.V130.Suppl_1.849.849
Published: 2017
Journal Articles

FLT3 ITD AML Outcomes Are Impacted By Exposure to One Cycle of Cytarabine Based Consolidation, Pre- and Post-Transplant TKI Therapy, and Presence of Minimal Residual Disease (MRD) Prior to Allogeneic Blood or Marrow Transplant

Melanie Rebechi, Amy E. DeZern, MD, Amanda Kagan, MD, B. Douglas Smith, MD, Ivana Gojo, MD, Margaret M. Showel, MD, Gabrielle T. Prince, MD, Gabriel Ghiaur, MD PhD, Lukasz P. Gondek, MD PhD, William Matsui, MD, Ephraim J. Fuchs, MD MBA, Leo Luznik, MD, Shannon R. McCurdy, MD, Carol Ann Huff, MD, Lode J. Swinnen, Ivan M. Borrello, MD, Douglas E. Gladstone, MD, Javier Bolanos-Meade, MD, Richard F Ambinder, MD, Richard J. Jones, MD, Mark J. Levis, MD, Keith Pratz, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2593.
https://doi.org/10.1182/blood.V130.Suppl_1.2593.2593
Published: 2017
Journal Articles

Immunoglobulin Heavy Chain Variable Region (IgHV) Unmutated, but Not Mutated, Chronic Lymphocytic Leukemia (CLL) Arises in a CD34+ Progenitor

Brandy Perkins, Margaret M. Showel, MD, Laura Schoch, MS, NP, Philip Imus, MD, Gabriel Ghiaur, MD PhD, Douglas E. Gladstone, MD, Richard J. Jones, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1709.
https://doi.org/10.1182/blood.V130.Suppl_1.1709.1709
Published: 2017
Journal Articles

The Selective Anti Leukemic Effect of BL-8040, a Peptidic CXCR4 Antagonist, Is Mediated By Induction of Leukemic Blast Mobilization, Differentiation and Apoptosis: Results of Correlative Studies from a Ph2a Trial in Acute Myeloid Leukemia

Gautam Borthakur, MD, Martin S. Tallman, MD, Yishai Ofran, MD, James M. Foran, MD, Geoffrey L Uy, MD, John F DiPersio, MD PhD, Arnon Nagler, Jacob M. Rowe, MD, Margaret M. Showel, MD, Jessica Altman, MD, Ahmed Al-Rawi, Rui-Yu Wang, MD PhD, Amnon Peled, PhD, Michal Abraham, PhD, Yaron Pereg, PhD, Abi Vainstein, MD, Galia Oberkovitz, PhD, Tzipi Lustig, DVM, Arnon Aharon, MD, Carlos E. Bueso-Ramos, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2745.
https://doi.org/10.1182/blood.V128.22.2745.2745
Published: 2016
Journal Articles

Structural Chromosomal Changes Are Common Manifestation of FLT3 ITD Relapse and Presence of Chromosomal Progression Is Independent of Normal Karyotype at Diagnosis

Melanie Rebechi, BS, Wesley Hand, B. Douglas Smith, MD, Ivana Gojo, MD, Margaret M. Showel, MD, Gabrielle T Prince, MD, Douglas Gladstone, MD, Shannon R. McCurdy, MD, Gabriel Ghiaur, MD PhD, Lukasz P Gondek, MD PhD, Amy E. DeZern, MD MHS, Mark J. Levis, MD PhD, Keith W. Pratz, MD
Journal: Blood
Blood (2016) 128 (22): 2868.
https://doi.org/10.1182/blood.V128.22.2868.2868
Published: 2016
Journal Articles

Checkpoint Inhibitor Therapy and Graft Versus Host Disease in Allogeneic Bone Marrow Transplant Recipients of Haploidentical and Matched Products with Post-Transplant Cyclophosphamide.

Laura K Schoch, MS, CRNP, Ivan Borrello, MD, Ephraim J. Fuchs, MD, Javier Bolanos-Meade, MD, Jeffrey Sean Huo, MD PhD, Ivana Gojo, MD, Nina Wagner-Johnston, MD, Gabrielle T Prince, MD, Shannon R. McCurdy, MD, B. Douglas Smith, MD, Amy E. DeZern, MD MHS, Margaret M. Showel, MD, David Loeb, MD PhD, Aziza T. Shad, MD, Richard J Jones, MD, Richard F. Ambinder, MD PhD, Douglas Gladstone, MD
Journal: Blood
Blood (2016) 128 (22): 4571.
https://doi.org/10.1182/blood.V128.22.4571.4571
Published: 2016
Journal Articles

Phase 1 Study of Pomalidomide Given at the Time of Early Lymphocyte Recovery after Induction Timed Sequential Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS)

Joshua F. Zeidner, MD, Raul Montiel-Esparza, MD, Hanna A. Knaus, MD, Sofia Berglund, MD PhD, Amer M. Zeidan, MBBS, MHS, Shannon R. McCurdy, MD, Gabrielle T Prince, MD, Lukasz P Gondek, MD PhD, Gabriel Ghiaur, MD PhD, Margaret M. Showel, MD, Amy E. DeZern, MD MHS, Keith W. Pratz, MD, B. Douglas Smith, MD, Mark J. Levis, MD PhD, Matthew C Foster, MD, Katarzyna Jamieson, MD, Hendrik W. Van Deventer, MD, Howard Streicher, MD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2016) 128 (22): 2820.
https://doi.org/10.1182/blood.V128.22.2820.2820
Published: 2016
Journal Articles

Liberal Vs. Restrictive Transfusion Thresholds in Leukemia Patients: A Feasibility Pilot Study

Amy E. DeZern, MD MHS, Katherine Williams, Karen E. King, MD, Wesley Hand, Mark J. Levis, MD PhD, B Doug Smith, MD, Ivana Gojo, MD, Keith W. Pratz, MD, Lukasz P Gondek, MD PhD, Gabrielle T. Prince, MD, Gabriel Ghiaur, MD PhD, Margaret M. Showel, MD, Douglas Gladstone, MD, Steve Frank, Paul M. Ness, MD
Journal: Blood
Blood (2015) 126 (23): 771.
https://doi.org/10.1182/blood.V126.23.771.771
Published: 2015
Journal Articles

Related Nonmyeloablative Haploidentical (mini-haplo) Blood or Marrow Transplantation (BMT) with High-Dose Post-Transplant Cyclophosphmade (PTCy) for Acute Myeloid Leukemia (AML): Donor Age Impacts Outcome

Margaret M. Showel, MD, Ephraim J. Fuchs, Ravi Varadhan, PhD, Mark J. Levis, MD PhD, Richard J. Jones, Sr., MD
Journal: Blood
Blood (2015) 126 (23): 151.
https://doi.org/10.1182/blood.V126.23.151.151
Published: 2015
Journal Articles

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Leukemias

Ivana Gojo, MD, Jan H. Beumer, PharmD, PhD, Keith Pratz, MD, Jiuping Ji, Lihua Wang, PhD, Michelle A. Rudek, PharmD, PhD, Michael A. McDevitt, MD PhD, Maria R. Baer, MD, Amanda Blackford, ScM, B. Douglas Smith, MD, Steven D. Gore, MD, Hetty E. Carraway, MD MBA, Margaret M. Showel, MD, Mark J. Levis, MD PhD, Amy E. DeZern, MD MHS, Douglas Gladstone, MD, Tania Jain, MD, Jackie Greer, RN, Marie Pouquet, PharmD, Ali-walbi Ismail, PharmD, MS, James Herman, MD, Weijie Poh, PhD, Larry Karnitz, PhD, Scott H. Kaufmann, MD PhD, Alice Chen, MD, Judith E Karp, MD
Journal: Blood
Blood (2015) 126 (23): 1361.
https://doi.org/10.1182/blood.V126.23.1361.1361
Published: 2015
Journal Articles

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

Clinical Trials & Observations
Shannon R. McCurdy, Jennifer A. Kanakry, Margaret M. Showel, Hua-Ling Tsai, Javier Bolaños-Meade, Gary L. Rosner, Christopher G. Kanakry, Karlo Perica, Heather J. Symons, Robert A. Brodsky, Douglas E. Gladstone, Carol Ann Huff, Keith W. Pratz, Gabrielle T. Prince, Amy E. Dezern, Ivana Gojo, William H. Matsui, Ivan Borrello, Michael A. McDevitt, Lode J. Swinnen, B. Douglas Smith, Mark J. Levis, Richard F. Ambinder, Leo Luznik, Richard J. Jones, Ephraim J. Fuchs, Yvette L. Kasamon
Journal: Blood
Blood (2015) 125 (19): 3024–3031.
https://doi.org/10.1182/blood-2015-01-623991
Published: 2015
Includes: Supplemental data
Journal Articles

Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS

Christopher G. Kanakry, Hua-Ling Tsai, Javier Bolaños-Meade, B. Douglas Smith, Ivana Gojo, Jennifer A. Kanakry, Yvette L. Kasamon, Douglas E. Gladstone, William Matsui, Ivan Borrello, Carol Ann Huff, Lode J. Swinnen, Jonathan D. Powell, Keith W. Pratz, Amy E. DeZern, Margaret M. Showel, Michael A. McDevitt, Robert A. Brodsky, Mark J. Levis, Richard F. Ambinder, Ephraim J. Fuchs, Gary L. Rosner, Richard J. Jones, Leo Luznik
Journal: Blood
Blood (2014) 124 (25): 3817–3827.
https://doi.org/10.1182/blood-2014-07-587477
Published: 2014
Includes: Supplemental data
Journal Articles

Nonmyeloablative HLA-Haploidentical (NMA Haplo) BMT with High-Dose Posttransplantation Cyclophosphamide (PTCy) Is Associated with Similar Outcomes to Matched BMT When Stratified By Disease Risk Index (DRI)

Shannon R. McCurdy, Jennifer A. Kanakry, Margaret M. Showel, Hua-Ling Tsai, Javier Bolaños-Meade, Christopher G. Kanakry, Douglas E. Gladstone, Leo Luznik, Carol Ann Huff, Lode J. Swinnen, Richard F. Ambinder, Richard J. Jones, Ephraim J. Fuchs, Yvette L. Kasamon
Journal: Blood
Blood (2014) 124 (21): 680.
https://doi.org/10.1182/blood.V124.21.680.680
Published: 2014