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Volume 124, Issue 18
October 30 2014
Issue Cover

Table of Contents

EDITORIAL

Introduction to the Review Series on “Bone Marrow Failure”
David Bodine,Nancy Berliner
View Articletitled, Introduction to the Review Series on “Bone Marrow Failure”

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
A new mutant at the end: TPP1, telomeres, and BMF
Alison A. Bertuch
View Articletitled, A new mutant at the end: TPP1, telomeres, and BMF
INSIDE BLOOD COMMENTARY
Cyclophosphamide in severe aplastic anemia?
Clinical Trials & Observations
Régis Peffault de Latour
View Articletitled, Cyclophosphamide in severe aplastic anemia?
INSIDE BLOOD COMMENTARY
Cellular thrust and parry in the leukemic niche
Youmna Kfoury,David T. Scadden
View Articletitled, Cellular thrust and parry in the leukemic niche
INSIDE BLOOD COMMENTARY
Resolvin(g) innate immunodeficiencies?
Annalisa Chiocchetti
View Articletitled, Resolvin(g) innate immunodeficiencies?
INSIDE BLOOD COMMENTARY
Transfer RNA and syndromic sideroblastic anemia
Achille Iolascon
View Articletitled, Transfer RNA and syndromic sideroblastic anemia
INSIDE BLOOD COMMENTARY
Postpartum venous thromboembolic risk: one size may not fit all
Hilary S. Gammill
View Articletitled, Postpartum venous thromboembolic risk: one size may not fit all

PLENARY PAPER

Hematopoiesis and Stem Cells
Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1
Yiran Guo,Melissa Kartawinata,Jiankang Li,Hilda A. Pickett,Juliana Teo,Tatjana Kilo,Pasquale M. Barbaro,Brendan Keating,Yulan Chen,Lifeng Tian,Ahmad Al-Odaib,Roger R. Reddel,John Christodoulou,Xun Xu,Hakon Hakonarson,Tracy M. Bryan
View Articletitled, Inherited bone marrow failure associated with germline mutation of <em>ACD</em>, the gene encoding telomere protein TPP1
Supplemental data

REVIEW SERIES

Bone marrow failure and the telomeropathies
Clinical Trials & Observations
Danielle M. Townsley,Bogdan Dumitriu,Neal S. Young
View Articletitled, Bone marrow failure and the telomeropathies

REVIEW SERIES

Marrow failure: a window into ribosome biology
Davide Ruggero,Akiko Shimamura
View Articletitled, Marrow failure: a window into ribosome biology

REVIEW SERIES

Recent developments in myelodysplastic syndromes
Clinical Trials & Observations
Rafael Bejar,David P. Steensma
View Articletitled, Recent developments in myelodysplastic syndromes

REVIEW SERIES

Paroxysmal nocturnal hemoglobinuria
Clinical Trials & Observations
Robert A. Brodsky
View Articletitled, Paroxysmal nocturnal hemoglobinuria

REVIEW SERIES

Stress and DNA repair biology of the Fanconi anemia pathway
Simonne Longerich,Jian Li,Yong Xiong,Patrick Sung,Gary M. Kupfer
View Articletitled, Stress and DNA repair biology of the Fanconi anemia pathway

CLINICAL TRIALS AND OBSERVATIONS

Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution
Clinical Trials & Observations Brief Report
Phillip Scheinberg,Danielle Townsley,Bogdan Dumitriu,Priscila Scheinberg,Barbara Weinstein,Maithili Daphtary,Olga Rios,Colin O. Wu,Neal S. Young
View Articletitled, Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution
Supplemental data

IMMUNOBIOLOGY

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
Andras Heczey,Daofeng Liu,Gengwen Tian,Amy N. Courtney,Jie Wei,Ekaterina Marinova,Xiuhua Gao,Linjie Guo,Eric Yvon,John Hicks,Hao Liu,Gianpietro Dotti,Leonid S. Metelitsa
View Articletitled, Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
Supplemental data

MYELOID NEOPLASIA

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts
Maria Krevvata,Barbara C. Silva,John S. Manavalan,Marta Galan-Diez,Aruna Kode,Brya Grace Matthews,David Park,Chiyuan A. Zhang,Naomi Galili,Thomas L. Nickolas,David W. Dempster,William Dougall,Julie Teruya-Feldstein,Aris N. Economides,Ivo Kalajzic,Azra Raza,Ellin Berman,Siddhartha Mukherjee,Govind Bhagat,Stavroula Kousteni
View Articletitled, Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap−/− mice
Wan-Chen Hsieh,Ya-Ting Chuang,I-Hsuan Chiang,Shu-Ching Hsu,Shi-Chuen Miaw,Ming-Zong Lai
View Articletitled, Inability to resolve specific infection generates innate immunodeficiency syndrome in <em>Xiap</em><sup><em>−/−</em></sup> mice
Supplemental data

PLATELETS AND THROMBOPOIESIS

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia
Sylvain Audia,Marzia Rossato,Kim Santegoets,Sanne Spijkers,Catharina Wichers,Cornelis Bekker,Andries Bloem,Louis Boon,Thijs Flinsenberg,Ewoud Compeer,Theo van den Broek,Olivier Facy,Pablo Ortega-Deballon,Sabine Berthier,Vanessa Leguy-Seguin,Laurent Martin,Marion Ciudad,Maxime Samson,Malika Trad,Bernard Lorcerie,Nona Janikashvili,Philippe Saas,Bernard Bonnotte,Timothy R. D. J. Radstake
View Articletitled, Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)
Brief Report
Pranesh K. Chakraborty,Klaus Schmitz-Abe,Erin K. Kennedy,Hapsatou Mamady,Turaya Naas,Danielle Durie,Dean R. Campagna,Ashley Lau,Anoop K. Sendamarai,Daniel H. Wiseman,Alison May,Stephen Jolles,Philip Connor,Colin Powell,Matthew M. Heeney,Patricia-Jane Giardina,Robert J. Klaassen,Caroline Kannengiesser,Isabelle Thuret,Alexis A. Thompson,Laura Marques,Stephen Hughes,Denise K. Bonney,Sylvia S. Bottomley,Robert F. Wynn,Ronald M. Laxer,Caterina P. Minniti,John Moppett,Victoria Bordon,Michael Geraghty,Paul B. M. Joyce,Kyriacos Markianos,Adam D. Rudner,Martin Holcik,Mark D. Fleming
View Articletitled, Mutations in <em>TRNT1</em> cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)
Supplemental data

THROMBOSIS AND HEMOSTASIS

Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England
Clinical Trials & Observations
Alyshah Abdul Sultan,Matthew J. Grainge,Joe West,Kate M. Fleming,Catherine Nelson-Piercy,Laila J. Tata
View Articletitled, Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England
Supplemental data

TRANSPLANTATION

α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics
A. Mario Marcondes,Ekapun Karoopongse,Marina Lesnikova,Daciana Margineantu,Tobias Welte,Charles A. Dinarello,David Hockenbery,Sabina Janciauskiene,H. Joachim Deeg
View Articletitled, α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics
Supplemental data

BLOOD WORK

Bipolar staining of gram-negative bacillus in cerebrospinal fluid
Clinical Trials & Observations
Lori D. Racsa,Eileen M. Burd
View Articletitled, Bipolar staining of gram-negative bacillus in cerebrospinal fluid

ERRATA

Li K, Blum Y, Verma A, et al. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. Blood. 2010;115(1):133-139.
View Articletitled, Li K, Blum Y, Verma A, et al. A noncoding antisense RNA in <em>tie-1</em> locus regulates <em>tie-1</em> function in vivo. <em>Blood</em>. 2010;115(1):133-139.
Chen W-L, Wang J-H, Zhao A-H, et al. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood. 2014;124(10):1645-1654.
View Articletitled, Chen W-L, Wang J-H, Zhao A-H, et al. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. <em>Blood</em>. 2014;124(10):1645-1654.
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