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Issue Archive

Volume 123, Issue 9
February 27 2014
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Monoclonal B-cell lymphocytosis in donors
Maryalice Stetler-Stevenson
View Articletitled, Monoclonal B-cell lymphocytosis in donors
CLINICAL TRIALS & OBSERVATIONS
Otlertuzumab more than a TRU(E) toddler in CLL?
Clinical Trials & Observations
Clemens-Martin Wendtner
View Articletitled, <em>Otler</em>tuzumab more than a TRU(E) <em>toddler</em> in CLL?
CLINICAL TRIALS & OBSERVATIONS
Optimizing tolerability of TKI therapy in CML
Clinical Trials & Observations
Andreas Hochhaus
View Articletitled, Optimizing tolerability of TKI therapy in CML
INSIDE BLOOD
Honing in on the (epi)genetic basis of AITL
Sonali M. Smith
View Articletitled, Honing in on the (epi)genetic basis of AITL
INSIDE BLOOD
Oncolytic virotherapy for ALL: MSCs to the rescue
Edwin M. Horwitz
View Articletitled, Oncolytic virotherapy for ALL: MSCs to the rescue
TRANSFUSION MEDICINE
Iron-related adverse effects from stored blood
Lawrence Tim Goodnough
View Articletitled, Iron-related adverse effects from stored blood
TRANSPLANTATION
Reversing CD8+ T-cell exhaustion with DLI
Paul J. Martin
View Articletitled, Reversing CD8<sup>+</sup> T-cell exhaustion with DLI

BLOOD WORK

Relapsed nodular sclerosis Hodgkin lymphoma and therapy-related myeloid sarcoma in a mediastinal mass
Michele Paessler,John Choi
View Articletitled, Relapsed nodular sclerosis Hodgkin lymphoma and therapy-related myeloid sarcoma in a mediastinal mass
Giant multilobated mastocytes (promastocytes) in the setting of a refractory acute myeloid leukemia with myelodysplasia-related changes and monosomal karyotype
Francisco Jose Ortuño,Lourdes Florensa
View Articletitled, Giant multilobated mastocytes (promastocytes) in the setting of a refractory acute myeloid leukemia with myelodysplasia-related changes and monosomal karyotype

PLENARY PAPER

A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
Brief Report
Oreofe Odejide,Oliver Weigert,Andrew A. Lane,Dan Toscano,Matthew A. Lunning,Nadja Kopp,Sunhee Kim,Diederik van Bodegom,Sudha Bolla,Jonathan H. Schatz,Julie Teruya-Feldstein,Ephraim Hochberg,Abner Louissaint,David Dorfman,Kristen Stevenson,Scott J. Rodig,Pier Paolo Piccaluga,Eric Jacobsen,Stefano A. Pileri,Nancy L. Harris,Simone Ferrero,Giorgio Inghirami,Steven M. Horwitz,David M. Weinstock
View Articletitled, A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
Supplemental data

BLOOD SPOTLIGHT

Cardiovascular risk in patients with hemophilia
Pieter W. Kamphuisen,Hugo ten Cate
View Articletitled, Cardiovascular risk in patients with hemophilia

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 study evaluating the safety and tolerability of otlertuzumab, an anti-CD37 mono-specific ADAPTIR therapeutic protein in chronic lymphocytic leukemia
Clinical Trials & Observations
John C. Byrd,John M. Pagel,Farrukh T. Awan,Andres Forero,Ian W. Flinn,Delva P. Deauna-Limayo,Stephen E. Spurgeon,Leslie A. Andritsos,Ajay K. Gopal,John P. Leonard,Amy J. Eisenfeld,Jeannette E. Bannink,Scott C. Stromatt,Richard R. Furman
View Articletitled, A phase 1 study evaluating the safety and tolerability of otlertuzumab, an anti-CD37 mono-specific ADAPTIR therapeutic protein in chronic lymphocytic leukemia
Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
Clinical Trials & Observations
Hagop M. Kantarjian,Jorge E. Cortes,Dong-Wook Kim,H. Jean Khoury,Tim H. Brümmendorf,Kimmo Porkka,Giovanni Martinelli,Simon Durrant,Eric Leip,Virginia Kelly,Kathleen Turnbull,Nadine Besson,Carlo Gambacorti-Passerini
View Articletitled, Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
Supplemental data

LYMPHOID NEOPLASIA

Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding
Youn K. Shim,Jane M. Rachel,Paolo Ghia,Jeff Boren,Fatima Abbasi,Antonis Dagklis,Geri Venable,Jiyeon Kang,Heba Degheidy,Fred V. Plapp,Robert F. Vogt,Jay E. Menitove,Gerald E. Marti
View Articletitled, Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding
Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity
Anna Castleton,Aditi Dey,Brendan Beaton,Bella Patel,Anne Aucher,Daniel M. Davis,Adele K. Fielding
View Articletitled, Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity
Supplemental data
Robust isolation of malignant plasma cells in multiple myeloma
Brief Report
Ildikó Frigyesi,Jörgen Adolfsson,Mina Ali,Mikael Kronborg Christophersen,Ellinor Johnsson,Ingemar Turesson,Urban Gullberg,Markus Hansson,Björn Nilsson
View Articletitled, Robust isolation of malignant plasma cells in multiple myeloma
Supplemental data

MYELOID NEOPLASIA

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors
Michael Bots,Inge Verbrugge,Benjamin P. Martin,Jessica M. Salmon,Margherita Ghisi,Adele Baker,Kym Stanley,Jake Shortt,Gert J. Ossenkoppele,Johannes Zuber,Amy R. Rappaport,Peter Atadja,Scott W. Lowe,Ricky W. Johnstone
View Articletitled, Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors
Supplemental data
Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib
Timothy P. Hughes,Giuseppe Saglio,Hagop M. Kantarjian,François Guilhot,Dietger Niederwieser,Gianantonio Rosti,Chiaki Nakaseko,Carmino Antonio De Souza,Matt E. Kalaycio,Stephan Meier,Xiaolin Fan,Hans D. Menssen,Richard A. Larson,Andreas Hochhaus
View Articletitled, Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib
Supplemental data
Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche
Daniela S. Krause,Katherine Lazarides,Juliana B. Lewis,Ulrich H. von Andrian,Richard A. Van Etten
View Articletitled, Selectins and their ligands are required for homing and engraftment of BCR-ABL1<sup>+</sup> leukemic stem cells in the bone marrow niche
Supplemental data

PLATELETS AND THROMBOPOIESIS

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors
Caroline Marty,Cécile Saint-Martin,Christian Pecquet,Sarah Grosjean,Joseph Saliba,Céline Mouton,Emilie Leroy,Ashot S. Harutyunyan,Jean-François Abgrall,Rémi Favier,Aurélie Toussaint,Eric Solary,Robert Kralovics,Stefan N. Constantinescu,Albert Najman,William Vainchenker,Isabelle Plo,Christine Bellanné-Chantelot
View Articletitled, Germ-line <em>JAK2</em> mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1
Xi Li,Yi-Chien Lu,Kezhi Dai,Ingrid Torregroza,Timothy Hla,Todd Evans
View Articletitled, Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of <em>gata1</em>
Supplemental data

THROMBOSIS AND HEMOSTASIS

Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c–Src complex
Meghna U. Naik,Jeffrey L. Caplan,Ulhas P. Naik
View Articletitled, Junctional adhesion molecule-A suppresses platelet integrin α<sub>IIb</sub>β<sub>3</sub> signaling by recruiting Csk to the integrin-c–Src complex

TRANSFUSION MEDICINE

Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia
Irene Cortés-Puch,Dong Wang,Junfeng Sun,Steven B. Solomon,Kenneth E. Remy,Melinda Fernandez,Jing Feng,Tamir Kanias,Landon Bellavia,Derek Sinchar,Andreas Perlegas,Michael A. Solomon,Walter E. Kelley,Mark A. Popovsky,Mark T. Gladwin,Daniel B. Kim-Shapiro,Harvey G. Klein,Charles Natanson
View Articletitled, Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia
Supplemental data

TRANSPLANTATION

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion
Pavan Bachireddy,Ursula Hainz,Michael Rooney,Olga Pozdnyakova,Julie Aldridge,Wandi Zhang,Xiaoyun Liao,F. Stephen Hodi,Karyn O’Connell,W. Nicholas Haining,Natalie R. Goldstein,Christine M. Canning,Robert J. Soiffer,Jerome Ritz,Nir Hacohen,Edwin P. Alyea, III,Haesook T. Kim,Catherine J. Wu
View Articletitled, Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion
Supplemental data

CORRESPONDENCE

Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor
Fouzia Amirache,Camille Lévy,Caroline Costa,Philippe-Emmanuel Mangeot,Bruce E. Torbett,Cathy X. Wang,Didier Nègre,François-Loïc Cosset,Els Verhoeyen
View Articletitled, Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor
Supplemental data
Statin and aspirin use is associated with improved outcome of FCR therapy in relapsed/refractory chronic lymphocytic leukemia
Young Kwang Chae,Long Trinh,Preetesh Jain,Xuemei Wang,Uri Rozovski,William G. Wierda,Michael J. Keating,Zeev Estrov
View Articletitled, Statin and aspirin use is associated with improved outcome of FCR therapy in relapsed/refractory chronic lymphocytic leukemia
Mutations in GATA2 are rare in juvenile myelomonocytic leukemia
Elliot Stieglitz,Y. Lucy Liu,Peter D. Emanuel,Robert P. Castleberry,Todd M. Cooper,Kevin M. Shannon,Mignon L. Loh
View Articletitled, Mutations in <em>GATA2</em> are rare in juvenile myelomonocytic leukemia
Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?
Mladen V. Tzvetkov,Tina Seitz,Kristin Bokelmann,Thomas Mueller,Jürgen Brockmöller,Hermann Koepsell
View Articletitled, Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?
Heckathorn disease revisited
Sucha Nand,Kevin Barton,Richard Schultz,Mary Klein,Ameet Kini
View Articletitled, Heckathorn disease revisited

ERRATA

Kurowska M, Goudin N, Nehme NT, et al. Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. Blood. 2012;119(17):3879-3889.
View Articletitled, Kurowska M, Goudin N, Nehme NT, et al. Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. <em>Blood</em>. 2012;119(17):<span class="related-article">3879-3889</span>.
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