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Issue Archive

Volume 122, Issue 22
November 21 2013
Issue Cover

Table of Contents

INSIDE BLOOD

MYELOID NEOPLASIA
Emergence of crenolanib for FLT3-mutant AML
Amir T. Fathi
View Articletitled, Emergence of crenolanib for FLT3-mutant AML
INSIDE BLOOD
T-cell LPD of the GIT: first do no harm
Jonathan Said
View Articletitled, T-cell LPD of the GIT: first do no harm
MYELOID NEOPLASIA
The importance of subclonal genetic events in MDS
Rafael Bejar,Omar Abdel-Wahab
View Articletitled, The importance of subclonal genetic events in MDS
PLATELETS & THROMBOPOIESIS
Bad cholesterol breaking really bad
Timothy C. Nichols
View Articletitled, Bad cholesterol breaking really bad
PLATELETS & THROMBOPOIESIS
Platelets using proteins creatively
Jonathan M. Gibbins
View Articletitled, Platelets using proteins creatively
TRANSPLANTATION
A closer look at permissive HLA mismatch
Andrea Bacigalupo
View Articletitled, A closer look at permissive HLA mismatch
TRANSPLANTATION
Mast cells and GVHD: old cells with a new role
Hans-Jochem Kolb
View Articletitled, Mast cells and GVHD: old cells with a new role

BLOOD WORK

Auer on the top!
Biswadip Hazarika
View Articletitled, Auer on the top!
Circulating proplatelet
Anne-Sophie Bourrel,Sylvain Clauser
View Articletitled, Circulating proplatelet

REVIEW ARTICLE

Management of the refractory aplastic anemia patient: what are the options?
Judith C. W. Marsh,Austin G. Kulasekararaj
View Articletitled, Management of the refractory aplastic anemia patient: what are the options?
Molecular approaches for improved clotting factors for hemophilia
Randal J. Kaufman,Jerry S. Powell
View Articletitled, Molecular approaches for improved clotting factors for hemophilia

REVIEW SERIES

Applications of high-throughput DNA sequencing to benign hematology
Vijay G. Sankaran,Patrick G. Gallagher
View Articletitled, Applications of high-throughput DNA sequencing to benign hematology

HOW I TREAT

How I treat monoclonal gammopathy of renal significance (MGRS)
Jean-Paul Fermand,Frank Bridoux,Robert A. Kyle,Efstathios Kastritis,Brendan M. Weiss,Mark A. Cook,Mark T. Drayson,Angela Dispenzieri,Nelson Leung,on behalf of the International Kidney and Monoclonal Gammopathy Research Group
View Articletitled, How I treat monoclonal gammopathy of renal significance (MGRS)

LYMPHOID NEOPLASIA

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile
Bruno Paiva,Teresa Paino,Jose-Maria Sayagues,Mercedes Garayoa,Laura San-Segundo,Montserrat Martín,Ines Mota,María-Luz Sanchez,Paloma Bárcena,Irene Aires-Mejia,Luis Corchete,Cristina Jimenez,Ramon Garcia-Sanz,Norma C. Gutierrez,Enrique M. Ocio,Maria-Victoria Mateos,Maria-Belen Vidriales,Alberto Orfao,Jesús F. San Miguel
View Articletitled, Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile
Supplemental data
Indolent T-cell lymphoproliferative disease of the gastrointestinal tract
Anamarija M. Perry,Roger A. Warnke,Qinglong Hu,Philippe Gaulard,Christiane Copie-Bergman,Serhan Alkan,Huan-You Wang,Jason X. Cheng,Chris M. Bacon,Jan Delabie,Erik Ranheim,Can Kucuk,XiaoZhou Hu,Dennis D. Weisenburger,Elaine S. Jaffe,Wing C. Chan
View Articletitled, Indolent T-cell lymphoproliferative disease of the gastrointestinal tract
Supplemental data

MYELOID NEOPLASIA

Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia
Eric I. Zimmerman,David C. Turner,Jassada Buaboonnam,Shuiying Hu,Shelley Orwick,Michael S. Roberts,Laura J. Janke,Abhijit Ramachandran,Clinton F. Stewart,Hiroto Inaba,Sharyn D. Baker
View Articletitled, Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia
Supplemental data
Clinical and biological implications of driver mutations in myelodysplastic syndromes
CME
Elli Papaemmanuil,Moritz Gerstung,Luca Malcovati,Sudhir Tauro,Gunes Gundem,Peter Van Loo,Chris J. Yoon,Peter Ellis,David C. Wedge,Andrea Pellagatti,Adam Shlien,Michael John Groves,Simon A. Forbes,Keiran Raine,Jon Hinton,Laura J. Mudie,Stuart McLaren,Claire Hardy,Calli Latimer,Matteo G. Della Porta,Sarah O’Meara,Ilaria Ambaglio,Anna Galli,Adam P. Butler,Gunilla Walldin,Jon W. Teague,Lynn Quek,Alex Sternberg,Carlo Gambacorti-Passerini,Nicholas C. P. Cross,Anthony R. Green,Jacqueline Boultwood,Paresh Vyas,Eva Hellstrom-Lindberg,David Bowen,Mario Cazzola,Michael R. Stratton,Peter J. Campbell,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium
View Articletitled, Clinical and biological implications of driver mutations in myelodysplastic syndromes
Supplemental data
The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition
Brief Report
Angela G. Fleischman,Julia E. Maxson,Samuel B. Luty,Anupriya Agarwal,Lacey R. Royer,Melissa L. Abel,Jason D. MacManiman,Marc M. Loriaux,Brian J. Druker,Jeffrey W. Tyner
View Articletitled, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition
Supplemental data

PLATELETS AND THROMBOPOIESIS

Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation
Hua-Chen Chan,Liang-Yin Ke,Chih-Sheng Chu,An-Sheng Lee,Ming-Yi Shen,Miguel A. Cruz,Jing-Fang Hsu,Kai-Hung Cheng,Hsiu-Chuan Bonnie Chan,Jonathan Lu,Wen-Ter Lai,Tatsuya Sawamura,Sheng-Hsiung Sheu,Jeng-Hsien Yen,Chu-Huang Chen
View Articletitled, Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation
Supplemental data
Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin
Lu Wang,Yi Wu,Junsong Zhou,Syed S. Ahmad,Bulent Mutus,Natalio Garbi,Günter Hämmerling,Junling Liu,David W. Essex
View Articletitled, Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin
Supplemental data

TRANSPLANTATION

Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality
Joseph Pidala,Tao Wang,Michael Haagenson,Stephen R. Spellman,Medhat Askar,Minoo Battiwalla,Lee Ann Baxter-Lowe,Menachem Bitan,Marcelo Fernandez-Viña,Manish Gandhi,Ann A. Jakubowski,Martin Maiers,Susana R. Marino,Steven G. E. Marsh,Machteld Oudshoorn,Jeanne Palmer,Vinod K. Prasad,Vijay Reddy,Olle Ringden,Wael Saber,Stella Santarone,Kirk R. Schultz,Michelle Setterholm,Elizabeth Trachtenberg,E. Victoria Turner,Ann E. Woolfrey,Stephanie J. Lee,Claudio Anasetti
View Articletitled, Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality
Supplemental data
Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells
Dennis B. Leveson-Gower,Emanuela I. Sega,Janet Kalesnikoff,Mareike Florek,Yuqiong Pan,Antonio Pierini,Stephen J. Galli,Robert S. Negrin
View Articletitled, Mast cells suppress murine GVHD in a mechanism independent of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells
Supplemental data

VASCULAR BIOLOGY

Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D
Kar Wai Tan,Shu Zhen Chong,Fiona H. S. Wong,Maximilien Evrard,Sandra Min-Li Tan,Jo Keeble,D. M. Kemeny,Lai Guan Ng,Jean-Pierre Abastado,Véronique Angeli
View Articletitled, Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D
Supplemental data
Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling
Christopher W. Wilson,Leon H. Parker,Christopher J. Hall,Tanya Smyczek,Judy Mak,Ailey Crow,George Posthuma,Ann De Mazière,Meredith Sagolla,Cecile Chalouni,Philip Vitorino,Merone Roose-Girma,Søren Warming,Judith Klumperman,Philip S. Crosier,Weilan Ye
View Articletitled, <em>Rasip1</em> regulates vertebrate vascular endothelial junction stability through <em>Epac1</em>-<em>Rap1</em> signaling
Supplemental data

CORRESPONDENCE

Human B-1 cells are not preplasmablasts: analysis of microarray data and other issues
Wentian Li,Franak Batliwalla,Thomas L. Rothstein
View Articletitled, Human B-1 cells are not preplasmablasts: analysis of microarray data and other issues
Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20+CD27+CD43+ cells
Kris Covens,Bert Verbinnen,Marc Jacquemin,Xavier Bossuyt
View Articletitled, Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup> cells
Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia
Jean Grisouard,Mario Ojeda-Uribe,Renate Looser,Hui Hao-Shen,Pontus Lundberg,Adrian Duek,Eric Jeandidier,Axel Karow,Radek C. Skoda
View Articletitled, Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia
Platelet secretion defect in a patient with stromal interaction molecule 1 deficiency
Lea Nakamura,Kirstin Sandrock-Lang,Carsten Speckmann,Thomas Vraetz,Martina Bührlen,Stephan Ehl,Johan W. M. Heemskerk,Barbara Zieger
View Articletitled, Platelet secretion defect in a patient with stromal interaction molecule 1 deficiency
HbC disorders
Martin H. Steinberg,David H. K. Chui
View Articletitled, HbC disorders

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

High-throughput targeted gene resequencing in MDS
CME
View Articletitled, High-throughput targeted gene resequencing in MDS
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