Jean-Paul Fermand,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Frank Bridoux,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Robert A. Kyle,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Efstathios Kastritis,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Brendan M. Weiss,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Mark A. Cook,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Mark T. Drayson,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Angela Dispenzieri,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,Nelson Leung,on behalf of the International Kidney and Monoclonal Gammopathy Research Group

View Articletitled, How I treat monoclonal gammopathy of renal significance (MGRS)

LYMPHOID NEOPLASIA

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Bruno Paiva,Teresa Paino,Jose-Maria Sayagues,Mercedes Garayoa,Laura San-Segundo,Montserrat Martín,Ines Mota,María-Luz Sanchez,Paloma Bárcena,Irene Aires-Mejia,Luis Corchete,Cristina Jimenez,Ramon Garcia-Sanz,Norma C. Gutierrez,Enrique M. Ocio,Maria-Victoria Mateos,Maria-Belen Vidriales,Alberto Orfao,Jesús F. San Miguel

View Articletitled, Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Supplemental data

Indolent T-cell lymphoproliferative disease of the gastrointestinal tract

Anamarija M. Perry,Roger A. Warnke,Qinglong Hu,Philippe Gaulard,Christiane Copie-Bergman,Serhan Alkan,Huan-You Wang,Jason X. Cheng,Chris M. Bacon,Jan Delabie,Erik Ranheim,Can Kucuk,XiaoZhou Hu,Dennis D. Weisenburger,Elaine S. Jaffe,Wing C. Chan

View Articletitled, Indolent T-cell lymphoproliferative disease of the gastrointestinal tract

Supplemental data

MYELOID NEOPLASIA

Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia

Eric I. Zimmerman,David C. Turner,Jassada Buaboonnam,Shuiying Hu,Shelley Orwick,Michael S. Roberts,Laura J. Janke,Abhijit Ramachandran,Clinton F. Stewart,Hiroto Inaba,Sharyn D. Baker

View Articletitled, Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia

Supplemental data

Clinical and biological implications of driver mutations in myelodysplastic syndromes
CME

Elli Papaemmanuil,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Moritz Gerstung,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Luca Malcovati,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Sudhir Tauro,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Gunes Gundem,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Peter Van Loo,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Chris J. Yoon,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Peter Ellis,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,David C. Wedge,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Andrea Pellagatti,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Adam Shlien,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Michael John Groves,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Simon A. Forbes,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Keiran Raine,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Jon Hinton,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Laura J. Mudie,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Stuart McLaren,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Claire Hardy,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Calli Latimer,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Matteo G. Della Porta,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Sarah O’Meara,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Ilaria Ambaglio,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Anna Galli,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Adam P. Butler,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Gunilla Walldin,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Jon W. Teague,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Lynn Quek,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Alex Sternberg,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Carlo Gambacorti-Passerini,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Nicholas C. P. Cross,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Anthony R. Green,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Jacqueline Boultwood,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Paresh Vyas,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Eva Hellstrom-Lindberg,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,David Bowen,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Mario Cazzola,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Michael R. Stratton,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium,Peter J. Campbell,on behalf of the Chronic Myeloid Disorders working group of the International Cancer Genome Consortium

View Articletitled, Clinical and biological implications of driver mutations in myelodysplastic syndromes

Supplemental data

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition
Brief Report

Angela G. Fleischman,Julia E. Maxson,Samuel B. Luty,Anupriya Agarwal,Lacey R. Royer,Melissa L. Abel,Jason D. MacManiman,Marc M. Loriaux,Brian J. Druker,Jeffrey W. Tyner

View Articletitled, The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition

Supplemental data

PLATELETS AND THROMBOPOIESIS

Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation

Hua-Chen Chan,Liang-Yin Ke,Chih-Sheng Chu,An-Sheng Lee,Ming-Yi Shen,Miguel A. Cruz,Jing-Fang Hsu,Kai-Hung Cheng,Hsiu-Chuan Bonnie Chan,Jonathan Lu,Wen-Ter Lai,Tatsuya Sawamura,Sheng-Hsiung Sheu,Jeng-Hsien Yen,Chu-Huang Chen

View Articletitled, Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation

Supplemental data

Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin

Lu Wang,Yi Wu,Junsong Zhou,Syed S. Ahmad,Bulent Mutus,Natalio Garbi,Günter Hämmerling,Junling Liu,David W. Essex

View Articletitled, Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin

Supplemental data

TRANSPLANTATION

Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

Joseph Pidala,Tao Wang,Michael Haagenson,Stephen R. Spellman,Medhat Askar,Minoo Battiwalla,Lee Ann Baxter-Lowe,Menachem Bitan,Marcelo Fernandez-Viña,Manish Gandhi,Ann A. Jakubowski,Martin Maiers,Susana R. Marino,Steven G. E. Marsh,Machteld Oudshoorn,Jeanne Palmer,Vinod K. Prasad,Vijay Reddy,Olle Ringden,Wael Saber,Stella Santarone,Kirk R. Schultz,Michelle Setterholm,Elizabeth Trachtenberg,E. Victoria Turner,Ann E. Woolfrey,Stephanie J. Lee,Claudio Anasetti

View Articletitled, Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

Supplemental data

Mast cells suppress murine GVHD in a mechanism independent of CD4⁺CD25⁺ regulatory T cells

Dennis B. Leveson-Gower,Emanuela I. Sega,Janet Kalesnikoff,Mareike Florek,Yuqiong Pan,Antonio Pierini,Stephen J. Galli,Robert S. Negrin

View Articletitled, Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells

Supplemental data

VASCULAR BIOLOGY

Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D

Kar Wai Tan,Shu Zhen Chong,Fiona H. S. Wong,Maximilien Evrard,Sandra Min-Li Tan,Jo Keeble,D. M. Kemeny,Lai Guan Ng,Jean-Pierre Abastado,Véronique Angeli

View Articletitled, Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D

Supplemental data

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling

Christopher W. Wilson,Leon H. Parker,Christopher J. Hall,Tanya Smyczek,Judy Mak,Ailey Crow,George Posthuma,Ann De Mazière,Meredith Sagolla,Cecile Chalouni,Philip Vitorino,Merone Roose-Girma,Søren Warming,Judith Klumperman,Philip S. Crosier,Weilan Ye

View Articletitled, Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling

Supplemental data

CORRESPONDENCE

Human B-1 cells are not preplasmablasts: analysis of microarray data and other issues

Wentian Li,Franak Batliwalla,Thomas L. Rothstein

View Articletitled, Human B-1 cells are not preplasmablasts: analysis of microarray data and other issues

Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20⁺CD27⁺CD43⁺ cells

Kris Covens,Bert Verbinnen,Marc Jacquemin,Xavier Bossuyt

View Articletitled, Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20+CD27+CD43+ cells

Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia

Jean Grisouard,Mario Ojeda-Uribe,Renate Looser,Hui Hao-Shen,Pontus Lundberg,Adrian Duek,Eric Jeandidier,Axel Karow,Radek C. Skoda

View Articletitled, Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia

Platelet secretion defect in a patient with stromal interaction molecule 1 deficiency

Lea Nakamura,Kirstin Sandrock-Lang,Carsten Speckmann,Thomas Vraetz,Martina Bührlen,Stephan Ehl,Johan W. M. Heemskerk,Barbara Zieger

View Articletitled, Platelet secretion defect in a patient with stromal interaction molecule 1 deficiency

HbC disorders

Martin H. Steinberg,David H. K. Chui

View Articletitled, HbC disorders

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

High-throughput targeted gene resequencing in MDS
CME

View Articletitled, High-throughput targeted gene resequencing in MDS

Cover Image

Cover Image

The image shows the cranial vasculature (green) and red blood cells (red) from a 48-hour-old zebrafish embryo injected with rasip1 anti-sense morpholino oligonucleotide. Circulating red blood cells can be seen within the lumen of blood vessels. Accumulation of extravascular red blood cells indicates hemorrhage due to vascular instability. See the article by Wilson et al on page 3678.
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