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Volume 120, Issue 14
October 4 2012
Issue Cover

Table of Contents

Inside Blood

PLATELETS & THROMBOPOIESIS
It takes 2 to thrombopoies in the vascular niche
Eric Gars,Shahin Rafii
View Articletitled, It takes 2 to thrombopoies in the vascular niche
CLINICAL TRIALS
Carfilzomib in multiple myeloma: gold, silver, or bronze?
Donna E. Reece
View Articletitled, Carfilzomib in multiple myeloma: gold, silver, or bronze?
RED CELLS & IRON
HU for acute treatment of sickle VOC?
Wassim El Nemer
View Articletitled, HU for acute treatment of sickle VOC?
THROMBOSIS & HEMOSTASIS
Fragmenting the platelet to reduce metastasis
Jerry Ware
View Articletitled, Fragmenting the platelet to reduce metastasis
TRANSPLANTATION
α-1 antitrysin DAMPens GVHD
Pavan Reddy
View Articletitled, α-1 antitrysin DAMPens GVHD
TRANSPLANTATION
HLA factors in transplantation for nonmalignant hematologic disorders
Marcelo A. Fernandez-Viña
View Articletitled, HLA factors in transplantation for nonmalignant hematologic disorders

Blood Work

Blastic plasmacytoid dendritic cell neoplasm
Fanny Angelot-Delettre,Francine Garnache-Ottou
View Articletitled, Blastic plasmacytoid dendritic cell neoplasm
Reactive eosinophilia and thrombosis
Javier Munoz,Amr Hanbali
View Articletitled, Reactive eosinophilia and thrombosis

Plenary Paper

PLATELETS AND THROMBOPOIESIS
VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice
Simon C. Pitchford,Tracey Lodie,Sara M. Rankin
View Articletitled, VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice
Supplemental data

Review Article

Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
Edus H. Warren,Xinyi Cindy Zhang,Shuying Li,Wenhong Fan,Barry E. Storer,Jason W. Chien,Michael J. Boeckh,Lue Ping Zhao,Paul J. Martin,John A. Hansen
View Articletitled, Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT

How I Treat

How I treat relapsed childhood acute lymphoblastic leukemia
Franco Locatelli,Martin Schrappe,Maria Ester Bernardo,Sergio Rutella
View Articletitled, How I treat relapsed childhood acute lymphoblastic leukemia

Clinical Trials and Observations

A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
Clinical Trials & Observations
David S. Siegel,Thomas Martin,Michael Wang,Ravi Vij,Andrzej J. Jakubowiak,Sagar Lonial,Suzanne Trudel,Vishal Kukreti,Nizar Bahlis,Melissa Alsina,Asher Chanan-Khan,Francis Buadi,Frederic J. Reu,George Somlo,Jeffrey Zonder,Kevin Song,A. Keith Stewart,Edward Stadtmauer,Lori Kunkel,Sandra Wear,Alvin F. Wong,Robert Z. Orlowski,Sundar Jagannath
View Articletitled, A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
Supplemental data
Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disorders
Clinical Trials & Observations
John Horan,Tao Wang,Michael Haagenson,Stephen R. Spellman,Jason Dehn,Mary Eapen,Haydar Frangoul,Vikas Gupta,Gregory A. Hale,Carolyn K. Hurley,Susana Marino,Machteld Oudshoorn,Vijay Reddy,Peter Shaw,Stephanie J. Lee,Ann Woolfrey
View Articletitled, Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disorders

Immunobiology

Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination
Donald N. Forthal,Erin E. Gabriel,Angela Wang,Gary Landucci,Tran B. Phan
View Articletitled, Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination

Lymphoid Neoplasia

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
Christopher J. Ott,Nadja Kopp,Liat Bird,Ronald M. Paranal,Jun Qi,Teresa Bowman,Scott J. Rodig,Andrew L. Kung,James E. Bradner,David M. Weinstock
View Articletitled, BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
Supplemental data
Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2
Diederik van Bodegom,Jun Zhong,Nadja Kopp,Chaitali Dutta,Min-Sik Kim,Liat Bird,Oliver Weigert,Jeffrey Tyner,Akhilesh Pandey,Akinori Yoda,David M. Weinstock
View Articletitled, Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2
Supplemental data
IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas
Brief Report
Harvey A. Greisman,Zhengfei Lu,Albert G. Tsai,Timothy C. Greiner,Hye Son Yi,Michael R. Lieber
View Articletitled, IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas
Supplemental data

Myeloid Neoplasia

Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial
Clinical Trials & Observations
John A. Liu Yin,Michelle A. O'Brien,Robert K. Hills,Sarah B. Daly,Keith Wheatley,Alan K. Burnett
View Articletitled, Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays
e-blood
Eric K. Sackmann,Erwin Berthier,Edmond W.K. Young,Miriam A. Shelef,Sarah A. Wernimont,Anna Huttenlocher,David J. Beebe
View Articletitled, Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays
Supplemental data

Red Cells, Iron, and Erythropoiesis

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53
Sasidhar Vemula,Jianjian Shi,Raghuveer Singh Mali,Peilin Ma,Yan Liu,Philip Hanneman,Karl R. Koehler,Eri Hashino,Lei Wei,Reuben Kapur
View Articletitled, ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53
Supplemental data
Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
Camila Bononi Almeida,Christoph Scheiermann,Jung-Eun Jang,Colette Prophete,Fernando Ferreira Costa,Nicola Conran,Paul S. Frenette
View Articletitled, Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
Supplemental data

Thrombosis and Hemostasis

A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment
Wei Zhang,Suying Dang,Tao Hong,Jian Tang,Jing Fan,Dawei Bu,Yanjie Sun,Zhugang Wang,Thomas Wisniewski
View Articletitled, A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment
Supplemental data

Transplantation

Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
Todd V. Brennan,Liwen Lin,Xiaopei Huang,Diana M. Cardona,Zhiguo Li,Keith Dredge,Nelson J. Chao,Yiping Yang
View Articletitled, Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
Supplemental data
Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
Pawel Zerr,Katrin Palumbo-Zerr,Alfiya Distler,Michal Tomcik,Stefan Vollath,Luis E. Munoz,Christian Beyer,Clara Dees,Friederike Egberts,Ilaria Tinazzi,Francesco Del Galdo,Oliver Distler,Georg Schett,Bernd M. Spriewald,Jörg H. W. Distler
View Articletitled, Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease

Vascular Biology

SOCS3 is an endogenous inhibitor of pathologic angiogenesis
Brief Report
Andreas Stahl,Jean-Sebastian Joyal,Jing Chen,Przemyslaw Sapieha,Aimee M. Juan,Colman J. Hatton,Dorothy T. Pei,Christian G. Hurst,Molly R. Seaward,Nathan M. Krah,Roberta J. Dennison,Emily R. Greene,Elisa Boscolo,Dipak Panigrahy,Lois E. H. Smith
View Articletitled, SOCS3 is an endogenous inhibitor of pathologic angiogenesis
All Issues

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy
NGS-based stratification refines the risk stratification in T-ALL and identifies a Very High-Risk subgroup of patients
Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis
How I Treat Low-risk Polycythemia Vera Patients who Require Cytoreduction
How I manage major hemorrhage

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