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Journal Articles

Cereblon-Based Compounds for Induction of HbF

Aline Renata Pavan, Victor Gabriel de Faria Pastre, Carolina Lanaro, Dulcineia Albuquerque, Joshua P. Smalley, Urvashi Patel, John W. R. Schwabe, Shaun M. Cowley, James T. Hodgkinson, Jean Leandro Dos Santos, Fernando Ferreira Costa

Blood (2024) 144 (Supplement 1): 1109.

https://doi.org/10.1182/blood-2024-208177

Published: 2024

Journal Articles

Heme Reduces the Contraction of Corpus Cavernosum Smooth Muscle through the HO-CO-sGC-cGMP Pathway: Its Implications for Priapism in Sickle Cell Disease

Fabio H Silva, Dalila A Pereira, Fabiano B Calmasini, Fernando Ferreira Costa

Blood (2024) 144 (Supplement 1): 5300.

https://doi.org/10.1182/blood-2024-210862

Published: 2024

Journal Articles

Modulatory Effects of Voxelotor and 5-HMF on Hemoglobin Affinity, Heme-Heme Cooperativity and Bohr Effect - Prospecting the Use of These Compounds in Cases of Hypoxemia, Such As in the Acute Respiratory Distress Syndrome (ARDS)

Diogo Grangani Lopes, Thaís Traina Jorge, Fernando Ferreira Costa, Susan Elisabeth Jorge

Blood (2024) 144 (Supplement 1): 5603.

https://doi.org/10.1182/blood-2024-207797

Published: 2024

Journal Articles

Extracellular Vesicles from Sickle Cell Disease Patients with Acute Chest Syndrome Suggest Activation of Endothelial Cells and Coagulation

Cristiane Maria Souza, Irene Pereira dos Santos, Carolina Lanaro, Renata Sesti-Costa, Sara Teresinha Olalla Saad, Bruno D Benites, Fernando Ferreira Costa

Blood (2024) 144 (Supplement 1): 5284.

https://doi.org/10.1182/blood-2024-210018

Published: 2024

Journal Articles

Palliative Performance Scale (PPS), ECOG and Albumin Levels Can Predict Prognosis in Patients with Hematological Malignancies Followed at a Palliative Care Service

Lucas W. Weiss Santos, Viviane Catini Nishiyama, Fabiana Gomes de Oliveira Miranda Manoel, Mariana Munari Magnus, Fernando Ferreira Costa, Paula de Melo Campos

Blood (2024) 144 (Supplement 1): 7587.

https://doi.org/10.1182/blood-2024-209095

Published: 2024

Journal Articles

Novel Selective HDAC1/2 Inhibitor 2-Aminobenzamide Derivative Potently Induces Fetal Hemoglobin

Victor Gabriel de Faria Pastre, Aline Renata Pavan, Carolina Lanaro, Dulcineia Albuquerque, Rafael Consolin Chelucci, Leonardo Luiz Gomes Ferreira, Adriano D. Andricopulo, Jean Leandro Dos Santos, Fernando Ferreira Costa

Blood (2024) 144 (Supplement 1): 3868.

https://doi.org/10.1182/blood-2024-208290

Published: 2024

Journal Articles

Defining Mechanistic Responses to Different Vaso-Occlusive Triggers in Sickle Cell Disease: A Step Towards Personalized VOC Reversal Strategies

Lucas F.S. Gushiken, Sarah Liane Linguet, Erica M.F. Gotardo, Pamela L Brito, Flavia C. Leonardo, Laetitia Claer, Slim Azouzi, Caroline Le Van Kim, Fernando Ferreira Costa, Sandrine Laurance, Berengere Khoel, Nicola Conran

Blood (2024) 144 (Supplement 1): 2489.

https://doi.org/10.1182/blood-2024-193820

Published: 2024

Journal Articles

Impact and Aggravating Factors of Chronic Pain in Sickle Cell Disease: Results of the Analysis of Promis® Questionnaires and the Metabolomic Profile of Brazilian Adult Patients

Lucas Bibiano Oliveira Souza, Thaís Olalla Bonon Assis, Rogerio Olalla Torres Seber, Adriana da Silva Santos Duarte, Audrey Bastos, Bruno D Benites, Fernando Ferreira Costa, Sara Teresinha Olalla Saad

Blood (2024) 144 (Supplement 1): 3692.

https://doi.org/10.1182/blood-2024-205228

Published: 2024

Journal Articles

A Landscape of Dendritic Cells Development, Activation and Migration in Mouse Model of Sickle Cell Anemia

Matheus Ajeje Souza, Izabela Felice Paes, Sara Teresinha Olalla Saad, Fernando Ferreira Costa, Renata Sesti-Costa

Blood (2023) 142 (Supplement 1): 3856.

https://doi.org/10.1182/blood-2023-186181

Published: 2023

Journal Articles

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Erica M.F. Gotardo, Lucas F.S. Gushiken, Pamela L Brito, Flavia C. Leonardo, Lidiane S. Torres, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Fernando Ferreira Costa, Nicola Conran

Blood (2023) 142 (Supplement 1): 2487.

https://doi.org/10.1182/blood-2023-181895

Published: 2023

Journal Articles

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Pamela L Brito, Erica M.F. Gotardo, Lucas F.S. Gushiken, Flavia C. Leonardo, Fernando Ferreira Costa, Nicola Conran

Blood (2023) 142 (Supplement 1): 1078.

https://doi.org/10.1182/blood-2023-189048

Published: 2023

Journal Articles

Erythrophagocytosis Mediated By Circulating Monocytes Is Induced By Distinct Mechanisms Depending on the Disease

Marina Dorigatti Borges, Dulcineia Albuquerque, Carolina Lanaro, Sara Teresinha Olalla Saad, Katia B Pagnano, Renata Sesti-Costa, Fernando Ferreira Costa

Blood (2023) 142 (Supplement 1): 2454.

https://doi.org/10.1182/blood-2023-189370

Published: 2023

Journal Articles

The Proteomic Signature of Extracellular Vesicles from Sickle Cell Anemia Patients Provides Insights into Their Possible Role in the Pathophysiology of the Disease

Cristiane Maria de Souza, Sami Yokoo, Ana Carolina Lima Camargo, Romenia Ramos Domingues, Carolina Lanaro, Marina Dorigatti Borges, Renata Sesti-Costa, Sara Teresinha Olalla Saad, Adriana Franco Paes Leme, Fernando Ferreira Costa

Blood (2023) 142 (Supplement 1): 1120.

https://doi.org/10.1182/blood-2023-189371

Published: 2023

Journal Articles

Exploring Coagulation and Fibrinolysis Activation As Mechanisms of Sepsis-Related Tissue Damage in Patients with Severe Neutropenia and Thrombocytopenia Secondary to Hematological Malignancies

Letícia Queiroz da Silva, Stephany Cares Huber, Beatriz Martinelli, Camilla Maria de Alencar Saraiva, Silmara Aparecida De Lima Montalvão, Fernando Ferreira Costa, Erich Vinicius De Paula

Blood (2023) 142 (Supplement 1): 2608.

https://doi.org/10.1182/blood-2023-189004

Published: 2023

Journal Articles

Cognitive Assessment in Brazilian Adults with Sickle Cell Disease (SCD): The Burdens of Sociocultural Background and Correlations with Neuroimaging Findings

Pedro Junqueira Fleury Silva, Caroline Martins Silva, Brunno Machado de Campos, Paula De Melo Campos, Samuel de Souza Medina, Andreza Lamonica, Fernando Cendes, Fernando Ferreira Costa, Sara T Olalla Saad, Bruno Deltreggia Benites

Blood (2022) 140 (Supplement 1): 2576–2577.

https://doi.org/10.1182/blood-2022-166596

Published: 2022

Journal Articles

Treatment with Resveratrol Reverses Priapism in the Sickle Cell Mouse

Fabio H Silva, Carolina Oliveira Splendore, Fabiano B Calmasini, Fernando Ferreira Costa

Blood (2022) 140 (Supplement 1): 5379.

https://doi.org/10.1182/blood-2022-169850

Published: 2022

Journal Articles

The Association of Heterozygous β-Thalassemia and β-Spectrin Mutations May Result in a Phenotype of Severe Anemia

Guilherme Antonio de Paula Machado, Isabella Macedo Toni, Dulcinéia Martins Albuquerque, Kleber Yotsumoto Fertrin, Fernando Ferreira Costa, Paula De Melo Campos

Blood (2022) 140 (Supplement 1): 11068–11069.

https://doi.org/10.1182/blood-2022-167957

Published: 2022

Journal Articles

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Erica M.F. Gotardo, Lidiane S. Torres, Lucas F.S. Gushiken, Pamela L. Brito, Flavia C. Leonardo, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Alessandra Vitaliti, Irmgard Förster, Fernando Ferreira Costa, Nicola Conran

Blood (2022) 140 (Supplement 1): 8230–8232.

https://doi.org/10.1182/blood-2022-159020

Published: 2022

Journal Articles

Individual Red Blood Cell Fetal Hemoglobin Concentrations Determined By Imaging Flow Cytometry and the Number of F Cells Are Very Good Predictors of Clinical Response to Increased Level of HbF and Are Associated with Hemolysis, Tricuspid Regurgitant Jet Velocity, and Sickle Retinopathy in Adult Sickle Cell Disease Patients

Daniela Pinheiro Leonardo, Myriam Salazar-Terreros, Stephan Menzel, Carolina Lanaro, Dulcinéia Martins de Albuquerque, Sara T Olalla Saad, Kleber Yotsumoto Fertrin, Fernando Ferreira Costa

Blood (2022) 140 (Supplement 1): 2510–2511.

https://doi.org/10.1182/blood-2022-169182

Published: 2022

Journal Articles

Sphingomyelin and Phosphatidylserine Derived Compounds Found into RBCs of Two Unrelated Individuals with Idiopathic Erythrocytosis with Altered Hemoglobin (Hb) Function Properties and No Hemoglobinopathies - Preliminary Results

Susan Elisabeth Jorge, Monica PINHEIRO DE ALMEIDA Verissimo, Fernando Ferreira Costa, Maria de Fátima Sonati

Blood (2022) 140 (Supplement 1): 11052–11053.

https://doi.org/10.1182/blood-2022-170021

Published: 2022

NARROW

Cereblon-Based Compounds for Induction of HbF

Heme Reduces the Contraction of Corpus Cavernosum Smooth Muscle through the HO-CO-sGC-cGMP Pathway: Its Implications for Priapism in Sickle Cell Disease

Modulatory Effects of Voxelotor and 5-HMF on Hemoglobin Affinity, Heme-Heme Cooperativity and Bohr Effect - Prospecting the Use of These Compounds in Cases of Hypoxemia, Such As in the Acute Respiratory Distress Syndrome (ARDS)

Extracellular Vesicles from Sickle Cell Disease Patients with Acute Chest Syndrome Suggest Activation of Endothelial Cells and Coagulation

Palliative Performance Scale (PPS), ECOG and Albumin Levels Can Predict Prognosis in Patients with Hematological Malignancies Followed at a Palliative Care Service

Novel Selective HDAC1/2 Inhibitor 2-Aminobenzamide Derivative Potently Induces Fetal Hemoglobin

Defining Mechanistic Responses to Different Vaso-Occlusive Triggers in Sickle Cell Disease: A Step Towards Personalized VOC Reversal Strategies

Impact and Aggravating Factors of Chronic Pain in Sickle Cell Disease: Results of the Analysis of Promis® Questionnaires and the Metabolomic Profile of Brazilian Adult Patients

A Landscape of Dendritic Cells Development, Activation and Migration in Mouse Model of Sickle Cell Anemia

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Erythrophagocytosis Mediated By Circulating Monocytes Is Induced By Distinct Mechanisms Depending on the Disease

The Proteomic Signature of Extracellular Vesicles from Sickle Cell Anemia Patients Provides Insights into Their Possible Role in the Pathophysiology of the Disease

Exploring Coagulation and Fibrinolysis Activation As Mechanisms of Sepsis-Related Tissue Damage in Patients with Severe Neutropenia and Thrombocytopenia Secondary to Hematological Malignancies

Cognitive Assessment in Brazilian Adults with Sickle Cell Disease (SCD): The Burdens of Sociocultural Background and Correlations with Neuroimaging Findings

Treatment with Resveratrol Reverses Priapism in the Sickle Cell Mouse

The Association of Heterozygous β-Thalassemia and β-Spectrin Mutations May Result in a Phenotype of Severe Anemia

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Sphingomyelin and Phosphatidylserine Derived Compounds Found into RBCs of Two Unrelated Individuals with Idiopathic Erythrocytosis with Altered Hemoglobin (Hb) Function Properties and No Hemoglobinopathies - Preliminary Results

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American Society of Hematology

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ASH Publications

American Society of Hematology

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