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Flavia C. Leonardo
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Journal Articles

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Pamela L Brito, Erica M.F. Gotardo, Lucas F.S. Gushiken, Flavia C. Leonardo, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2023) 142 (Supplement 1): 1078.
https://doi.org/10.1182/blood-2023-189048
Published: 2023
Journal Articles

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Erica M.F. Gotardo, Lucas F.S. Gushiken, Pamela L Brito, Flavia C. Leonardo, Lidiane S. Torres, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2023) 142 (Supplement 1): 2487.
https://doi.org/10.1182/blood-2023-181895
Published: 2023
Journal Articles

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Erica M.F. Gotardo, Lidiane S. Torres, Lucas F.S. Gushiken, Pamela L. Brito, Flavia C. Leonardo, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Alessandra Vitaliti, Irmgard Förster, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2022) 140 (Supplement 1): 8230–8232.
https://doi.org/10.1182/blood-2022-159020
Published: 2022
Journal Articles

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Erica M.F. Gotardo, PhD, Pamela L. Brito, M.Sc., Hanan Chweih, M.Sc., Flavia C. Leonardo, PhD, Fernando Ferreira Costa, MD PhD, Nicola Conran, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2263.
https://doi.org/10.1182/blood-2019-131741
Published: 2019
Journal Articles

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Hanan Chweih, M.Sc., Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Pamela L. Brito, B.Sc, Guilherme G.O. Barbosa, PhD, Flavia Garcia, PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2354.
https://doi.org/10.1182/blood-2018-99-118633
Published: 2018
Journal Articles

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Mariana Gonçalves Oliveira, M.Sc., Edson Antunes, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2362.
https://doi.org/10.1182/blood-2018-99-118813
Published: 2018
Journal Articles

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Lidiane S. Torres, PhD, Lediana I. Miguel, M.Sc., Merav E. Shaul, PhD, Zvi G. Fridlender, MD PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2366.
https://doi.org/10.1182/blood-2018-99-118960
Published: 2018
Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3608.
https://doi.org/10.1182/blood-2018-99-118416
Published: 2018
Journal Articles

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

Lediana I. Miguel, M.Sc., Lidiane S. Torres, PhD, Wilson A. Ferreira, Jr., PhD, Fernanda C. Z. Fabris, B.Sc., Flavia C. Leonardo, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3610.
https://doi.org/10.1182/blood-2018-99-118974
Published: 2018
Journal Articles

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Hanan Chweih, BSc, Juliete A.F. Silva, PhD, Wilson A. Ferreira, Jr., PhD, Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Flavia C. Leonardo, PhD, Carla F Franco-Penteado, B.Sc. PhD, Fernando Ferreira Costa, PhD,MD, Nicola Conran, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 540.
https://doi.org/10.1182/blood.V130.Suppl_1.540.540
Published: 2017
Journal Articles

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

Fernanda F.C. Fabris, Flavia C. Leonardo, PhD, Rodolfo Cancado, MD, PhD, Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Kleber Yotsumoto Fertrin, MD, PhD, Sara Teresinha Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD, Camila B. Almeida, PhD
Journal: Blood
Blood (2016) 128 (22): 1257.
https://doi.org/10.1182/blood.V128.22.1257.1257
Published: 2016
Journal Articles

Inflammasome-Dependent IL-1β Release from Neutrophils in Human Sickle Cell Anemia

Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Fernando Vieira Pericole, MD, Cecilia Seguin, B.Sc., Flavia C. Leonardo, PhD, Sara T Olalla Saad, MD, PhD, Fernando F. Costa, MD PhD, Nicola Conran, PhD
Journal: Blood
Blood (2016) 128 (22): 854.
https://doi.org/10.1182/blood.V128.22.854.854
Published: 2016