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Pamela L. Brito
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Journal Articles

Defining Mechanistic Responses to Different Vaso-Occlusive Triggers in Sickle Cell Disease: A Step Towards Personalized VOC Reversal Strategies

Lucas F.S. Gushiken, Sarah Liane Linguet, Erica M.F. Gotardo, Pamela L Brito, Flavia C. Leonardo, Laetitia Claer, Slim Azouzi, Caroline Le Van Kim, Fernando Ferreira Costa, Sandrine Laurance, Berengere Khoel, Nicola Conran
Journal: Blood
Blood (2024) 144 (Supplement 1): 2489.
https://doi.org/10.1182/blood-2024-193820
Published: 2024
Journal Articles

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Erica M.F. Gotardo, Lucas F.S. Gushiken, Pamela L Brito, Flavia C. Leonardo, Lidiane S. Torres, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2023) 142 (Supplement 1): 2487.
https://doi.org/10.1182/blood-2023-181895
Published: 2023
Journal Articles

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Pamela L Brito, Erica M.F. Gotardo, Lucas F.S. Gushiken, Flavia C. Leonardo, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2023) 142 (Supplement 1): 1078.
https://doi.org/10.1182/blood-2023-189048
Published: 2023
Journal Articles

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Erica M.F. Gotardo, Lidiane S. Torres, Lucas F.S. Gushiken, Pamela L. Brito, Flavia C. Leonardo, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Alessandra Vitaliti, Irmgard Förster, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2022) 140 (Supplement 1): 8230–8232.
https://doi.org/10.1182/blood-2022-159020
Published: 2022
Journal Articles

Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice

Lidiane S. Torres, Erica M.F. Gotardo, Flávia Costa Leonardo, Pamela L. Brito, Irmgard Förster, Jiri Kovarik, Fernando Ferreira Costa, Nicola Conran
Journal: Blood
Blood (2021) 138 (Supplement 1): 856.
https://doi.org/10.1182/blood-2021-147436
Published: 2021
Journal Articles

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Erica M.F. Gotardo, PhD, Pamela L. Brito, M.Sc., Hanan Chweih, M.Sc., Flavia C. Leonardo, PhD, Fernando Ferreira Costa, MD PhD, Nicola Conran, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2263.
https://doi.org/10.1182/blood-2019-131741
Published: 2019
Journal Articles

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Hanan Chweih, M.Sc., Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Pamela L. Brito, B.Sc, Guilherme G.O. Barbosa, PhD, Flavia Garcia, PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2354.
https://doi.org/10.1182/blood-2018-99-118633
Published: 2018
Journal Articles

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Mariana Gonçalves Oliveira, M.Sc., Edson Antunes, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2362.
https://doi.org/10.1182/blood-2018-99-118813
Published: 2018
Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3608.
https://doi.org/10.1182/blood-2018-99-118416
Published: 2018
Journal Articles

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Hanan Chweih, BSc, Juliete A.F. Silva, PhD, Wilson A. Ferreira, Jr., PhD, Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Flavia C. Leonardo, PhD, Carla F Franco-Penteado, B.Sc. PhD, Fernando Ferreira Costa, PhD,MD, Nicola Conran, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 540.
https://doi.org/10.1182/blood.V130.Suppl_1.540.540
Published: 2017