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Issue Archive

Volume 116, Issue 4
July 29 2010
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
I don't know how to treat amyloidosis
Morie A. Gertz
View Articletitled, I don't know how to treat amyloidosis
INSIDE BLOOD
Angiopoietin-2 in CLL
Jan A. Burger
View Articletitled, Angiopoietin-2 in CLL
INSIDE BLOOD
Want fries with that? Antimyeloma drug combos
Aaron D. Schimmer
View Articletitled, Want fries with that? Antimyeloma drug combos
PHAGOCYTES & GRANULOCYTES
A day (or 5) in a neutrophil's life
Scott I. Simon,Min-Ho Kim
View Articletitled, A day (or 5) in a neutrophil's life
VASCULAR BIOLOGY
Inside bloody lymphatics
Gabriela D'Amico,Kari Alitalo
View Articletitled, Inside bloody lymphatics

Perspectives

Am“B”valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis
Olivier Thaunat,Emmanuel Morelon,Thierry Defrance
View Articletitled, Am“B”valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis

Clinical Trials and Observations

Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement
Clinical Trials & Observations
Sascha Dietrich,Stefan O. Schönland,Axel Benner,Tilmann Bochtler,Arnt V. Kristen,Jörg Beimler,Ernst Hund,Markus Zorn,Hartmut Goldschmidt,Antony D. Ho,Ute Hegenbart
View Articletitled, Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement

Hematopoiesis and Stem Cells

Endothelial protein C receptor–expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
Hiroko Iwasaki,Fumio Arai,Yoshiaki Kubota,Maria Dahl,Toshio Suda
View Articletitled, Endothelial protein C receptor–expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
Supplemental data
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Hiroko Iwasaki,Yuka Nakamura,Yumiko Gomei,Toshio Suda
View Articletitled, Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
Supplemental data

Immunobiology

Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
Gerty Schreibelt,Daniel Benitez-Ribas,Danita Schuurhuis,Annechien J. A. Lambeck,Maaike van Hout-Kuijer,Niels Schaft,Cornelis J. A. Punt,Carl G. Figdor,Gosse J. Adema,I. Jolanda M. de Vries
View Articletitled, Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
Supplemental data
Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15
Lazar Vujanovic,David E. Szymkowski,Sean Alber,Simon C. Watkins,Nikola L. Vujanovic,Lisa H. Butterfield
View Articletitled, Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15
Supplemental data

Lymphoid Neoplasia

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
Rossana Maffei,Silvia Martinelli,Rita Santachiara,Davide Rossi,Carla Guarnotta,Elisa Sozzi,Antonella Zucchetto,Gian Matteo Rigolin,Stefania Fiorcari,Ilaria Castelli,Marcella Fontana,Valeria Coluccio,Giovanna Leonardi,Patrizia Zucchini,Claudio Tripodo,Antonio Cuneo,Valter Gattei,Giovanni Del Poeta,Francesco Forconi,Gianluca Gaidano,Giuseppe Torelli,Roberto Marasca
View Articletitled, Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
Supplemental data
Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies
Richard J. Rickles,Laura T. Pierce,Thomas P. Giordano, 3rd,Winnie F. Tam,Douglas W. McMillin,Jake Delmore,Jacob P. Laubach,Alexis A. Borisy,Paul G. Richardson,Margaret S. Lee
View Articletitled, Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies
Supplemental data

Myeloid Neoplasia

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity
Christian Wichmann,Yvonne Becker,Linping Chen-Wichmann,Vitali Vogel,Anna Vojtkova,Julia Herglotz,Sandra Moore,Joachim Koch,Jörn Lausen,Werner Mäntele,Holger Gohlke,Manuel Grez
View Articletitled, Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity
Supplemental data
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
Brief Report
Felicitas Thol,Frederik Damm,Katharina Wagner,Gudrun Göhring,Brigitte Schlegelberger,Dieter Hoelzer,Michael Lübbert,Wolfgang Heit,Lothar Kanz,Günter Schlimok,Aruna Raghavachar,Walter Fiedler,Hartmut Kirchner,Gerhard Heil,Michael Heuser,Jürgen Krauter,Arnold Ganser
View Articletitled, Prognostic impact of <em>IDH2</em> mutations in cytogenetically normal acute myeloid leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
Yoshihiro Kuwano,Oliver Spelten,Hong Zhang,Klaus Ley,Alexander Zarbock
View Articletitled, Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
Supplemental data
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
Brief Report
Janesh Pillay,Ineke den Braber,Nienke Vrisekoop,Lydia M. Kwast,Rob J. de Boer,José A. M. Borghans,Kiki Tesselaar,Leo Koenderman
View Articletitled, In vivo labeling with <sup>2</sup>H<sub>2</sub>O reveals a human neutrophil lifespan of 5.4 days
Supplemental data

Red Cells, Iron, and Erythropoiesis

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores
Clinical Trials & Observations
John C. Wood,Barinder P. Kang,Alexis Thompson,Patricia Giardina,Paul Harmatz,Tara Glynos,Carole Paley,Thomas D. Coates
View Articletitled, The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis
Brief Report
Wen Chen,Harry A. Dailey,Barry H. Paw
View Articletitled, Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis
Supplemental data

Thrombosis and Hemostasis

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men
Clinical Trials & Observations
Mirjam E. Meltzer,Carine J. M. Doggen,Philip G. de Groot,Frits R. Rosendaal,Ton Lisman
View Articletitled, Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis
Clinical Trials & Observations
Ioannis Kourtzelis,Maciej M. Markiewski,Michael Doumas,Stavros Rafail,Konstantinos Kambas,Ioannis Mitroulis,Stelios Panagoutsos,Ploumis Passadakis,Vasilios Vargemezis,Paola Magotti,Hongchang Qu,Tom Eirik Mollnes,Konstantinos Ritis,John D. Lambris
View Articletitled, Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis
Supplemental data
Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor
Thomas A. J. McKinnon,Elizabeth C. Goode,Graeme M. Birdsey,Agata A. Nowak,Alain C. K. Chan,David A. Lane,Michael A. Laffan
View Articletitled, Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor

Transplantation

Successful engraftment after reduced-intensity umbilical cord blood transplantation for myelofibrosis
Brief Report
Shinsuke Takagi,Yasunori Ota,Naoyuki Uchida,Koichi Takahashi,Kazuya Ishiwata,Masanori Tsuji,Hisashi Yamamoto,Yuki Asano-Mori,Naofumi Matsuno,Kazuhiro Masuoka,Atsushi Wake,Shigesaburo Miyakoshi,Kenichi Ohashi,Shuichi Taniguchi
View Articletitled, Successful engraftment after reduced-intensity umbilical cord blood transplantation for myelofibrosis

Vascular Biology

Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
Leigh Coultas,Erica Nieuwenhuis,Gregory A. Anderson,Jorge Cabezas,Andras Nagy,R. Mark Henkelman,Chi-Chung Hui,Janet Rossant
View Articletitled, Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms
Supplemental data
Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling
Cara C. Bertozzi,Alec A. Schmaier,Patricia Mericko,Paul R. Hess,Zhiying Zou,Mei Chen,Chiu-Yu Chen,Bin Xu,Min-min Lu,Diane Zhou,Eric Sebzda,Matthew T. Santore,Demetri J. Merianos,Matthias Stadtfeld,Alan W. Flake,Thomas Graf,Radek Skoda,Jonathan S. Maltzman,Gary A. Koretzky,Mark L. Kahn
View Articletitled, Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling
Supplemental data

Errata

Enzler T, Kater AP, Zhang W, et al. Chronic lymphocytic leukemia of Eμ-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009;114(20):4469–4476.
View Articletitled, Enzler T, Kater AP, Zhang W, et al. Chronic lymphocytic leukemia of Eμ-<em>TCL1</em> transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. <em>Blood</em>. 2009;114(20):<span class="related-article">4469–4476</span>.
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