Page 1 | Search Results | Blood | American Society of Hematology

1-13 of 13

Sort by

Sort Order Select

Journal Articles

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Melissa A. Fischer, PhD, Sharon Friedlander, PhD, Leah Hogdal, PhD, Pia Arrate, Hua Chang, PhD, Trinayan Kashyap, MS, Christian Argueta, PhD, Boris Klebanov, MA, MS, William Senapedis, PhD, Erkan Baloglu, PhD MBA, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael R. Savona, MD

Blood (2016) 128 (22): 3949.

https://doi.org/10.1182/blood.V128.22.3949.3949

Published: 2016

Journal Articles

Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Christian Argueta, PhD, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD, William Senapedis, PhD

Blood (2016) 128 (22): 5660.

https://doi.org/10.1182/blood.V128.22.5660.5660

Published: 2016

Journal Articles

Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma

Christian Argueta, PhD, Hua Chang, PhD, Trinayan Kashyap, MS, Sivan Elloul, PhD, Sharon Friedlander, PhD, Margaret S. Lee, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA, William Senapedis, PhD, Erkan Baloglu, PhD MBA

Blood (2016) 128 (22): 3298.

https://doi.org/10.1182/blood.V128.22.3298.3298

Published: 2016

Journal Articles

Development of a Pharmacodynamic Assay for XPO1 Occupancy Using Fluorescence Cross Correlation Spectroscopy (FCCS)

Marsha L. Crochiere, PhD, Stefan Hannus, PhD, Kerrin Hansen, Frank Becker, PhD, Joel Ellis, PhD, Margaret S. Lee, PhD, Yosef Landesman, PhD

Blood (2015) 126 (23): 2487.

https://doi.org/10.1182/blood.V126.23.2487.2487

Published: 2015

Journal Articles

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Margaret S. Lee, PhD, Yosef Landesman, PhD

Blood (2015) 126 (23): 3683.

https://doi.org/10.1182/blood.V126.23.3683.3683

Published: 2015

Journal Articles

ATL313, A Potent, and Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Richard Rickles, PhD, Mahesh Padval, PhD, Thomas Giordanno, Jayson M Rieger, PhD, MBA, Margaret S Lee, PhD

Blood (2010) 116 (21): 2990.

https://doi.org/10.1182/blood.V116.21.2990.2990

Published: 2010

Journal Articles

Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies

Richard J. Rickles, Laura T. Pierce, Thomas P. Giordano, 3rd, Winnie F. Tam, Douglas W. McMillin, Jake Delmore, Jacob P. Laubach, Alexis A. Borisy, Paul G. Richardson, Margaret S. Lee

Blood (2010) 116 (4): 593–602.

https://doi.org/10.1182/blood-2009-11-252668

Published: 2010

Includes: Supplemental data

Journal Articles

A2A or Beta-2 Adrenergic Receptor Agonist Synergies Induce Distinct Patterns of Gene Expression Relevant to Multiple Myeloma Cell Survival.

Winnie F. Tam, PhD, Richard J Rickles, PhD, Thomas Giordano, Alexis Borisy, Margaret S. Lee, PhD

Blood (2009) 114 (22): 3831.

https://doi.org/10.1182/blood.V114.22.3831.3831

Published: 2009

Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.

Richard J. Rickles, PhD, Winnie F. Tam, PhD, Antoaneta Necheva, MSc, Thomas Giordano, Alexis A. Borisy, Margaret S. Lee, PhD

Blood (2009) 114 (22): 3762.

https://doi.org/10.1182/blood.V114.22.3762.3762

Published: 2009

Journal Articles

Preclinical Evaluation of CRx-501, a Potent Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Richard J Rickles, Ph.D., Laura Pierce, Thomas Giordano, William Avery, Melissa Farwell, David Crowe, Winnie F. Tam, Ph.D., Mei Chen, Ph.D., Vikram Kansra, PhD, Douglas W. McMillin, BSc, PhD, Kenneth C Anderson, MD, Constantine Mitsiades, M.D., Ph.D., Margaret S. Lee, PhD

Blood (2008) 112 (11): 252.

https://doi.org/10.1182/blood.V112.11.252.252

Published: 2008

Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Richard J. Rickles, Ph.D., Laura Pierce, Thomas Giordano, Winnie F. Tam, Ph.D., William Avery, Melissa Farwell, David Crowe, Mei Chen, Ph.D., Alexander Brown, Vikram Kansra, PhD, Steffan T. Nawrocki, PhD, Jennifer S Carew, Ph.D., Francis J Giles, MD, Margaret S Lee, PhD

Blood (2008) 112 (11): 384.

https://doi.org/10.1182/blood.V112.11.384.384

Published: 2008

Journal Articles

Synergistic Activity of Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Myeloma Cells in the Context of Tumor-Stromal Interactions

Douglas W. McMillin, PhD, Richard Rickles, Joseph Negri, Jake Delmore, Melissa G. Ooi, MD, Melissa Farwell, David Crowe, Mei Chen, William Avery, Vikram Kansra, PhD, Kenneth C. Anderson, MD, Margaret S. Lee, PhD, Constantine S. Mitsiades, MD, PhD

Blood (2008) 112 (11): 2663.

https://doi.org/10.1182/blood.V112.11.2663.2663

Published: 2008

Journal Articles

Adenosine A2A Receptor Agonism and PDE Inhibition: A Synergistic Multi-Target Mechanism Discovered through Systematic Combination Screening in Multiple Myeloma

Richard J Rickles, Ph.D., Laura Pierce, Thomas Giordano, Winnie F. Tam, Ph.D., Douglas W. McMillin, BSc, PhD, Kenneth C. Anderson, MD, Constantine Mitsiades, M.D., Ph.D., Margaret S Lee, Ph.D

Blood (2008) 112 (11): 847.

https://doi.org/10.1182/blood.V112.11.847.847

Published: 2008

NARROW

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells

Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma

Development of a Pharmacodynamic Assay for XPO1 Occupancy Using Fluorescence Cross Correlation Spectroscopy (FCCS)

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)

ATL313, A Potent, and Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies

A2A or Beta-2 Adrenergic Receptor Agonist Synergies Induce Distinct Patterns of Gene Expression Relevant to Multiple Myeloma Cell Survival.

Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.

Preclinical Evaluation of CRx-501, a Potent Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Synergistic Activity of Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Myeloma Cells in the Context of Tumor-Stromal Interactions

Adenosine A2A Receptor Agonism and PDE Inhibition: A Synergistic Multi-Target Mechanism Discovered through Systematic Combination Screening in Multiple Myeloma

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only