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Richard J. Rickles
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Journal Articles

Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies

Richard J. Rickles, Laura T. Pierce, Thomas P. Giordano, 3rd, Winnie F. Tam, Douglas W. McMillin, Jake Delmore, Jacob P. Laubach, Alexis A. Borisy, Paul G. Richardson, Margaret S. Lee
Journal: Blood
Blood (2010) 116 (4): 593–602.
https://doi.org/10.1182/blood-2009-11-252668
Published: 2010
Includes: Supplemental data
Journal Articles

A2A or Beta-2 Adrenergic Receptor Agonist Synergies Induce Distinct Patterns of Gene Expression Relevant to Multiple Myeloma Cell Survival.

Winnie F. Tam, PhD, Richard J Rickles, PhD, Thomas Giordano, Alexis Borisy, Margaret S. Lee, PhD
Journal: Blood
Blood (2009) 114 (22): 3831.
https://doi.org/10.1182/blood.V114.22.3831.3831
Published: 2009
Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.

Richard J. Rickles, PhD, Winnie F. Tam, PhD, Antoaneta Necheva, MSc, Thomas Giordano, Alexis A. Borisy, Margaret S. Lee, PhD
Journal: Blood
Blood (2009) 114 (22): 3762.
https://doi.org/10.1182/blood.V114.22.3762.3762
Published: 2009
Journal Articles

Adenosine A2A Receptor Agonism and PDE Inhibition: A Synergistic Multi-Target Mechanism Discovered through Systematic Combination Screening in Multiple Myeloma

Richard J Rickles, Ph.D., Laura Pierce, Thomas Giordano, Winnie F. Tam, Ph.D., Douglas W. McMillin, BSc, PhD, Kenneth C. Anderson, MD, Constantine Mitsiades, M.D., Ph.D., Margaret S Lee, Ph.D
Journal: Blood
Blood (2008) 112 (11): 847.
https://doi.org/10.1182/blood.V112.11.847.847
Published: 2008
Journal Articles

Preclinical Evaluation of CRx-501, a Potent Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Richard J Rickles, Ph.D., Laura Pierce, Thomas Giordano, William Avery, Melissa Farwell, David Crowe, Winnie F. Tam, Ph.D., Mei Chen, Ph.D., Vikram Kansra, PhD, Douglas W. McMillin, BSc, PhD, Kenneth C Anderson, MD, Constantine Mitsiades, M.D., Ph.D., Margaret S. Lee, PhD
Journal: Blood
Blood (2008) 112 (11): 252.
https://doi.org/10.1182/blood.V112.11.252.252
Published: 2008
Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Richard J. Rickles, Ph.D., Laura Pierce, Thomas Giordano, Winnie F. Tam, Ph.D., William Avery, Melissa Farwell, David Crowe, Mei Chen, Ph.D., Alexander Brown, Vikram Kansra, PhD, Steffan T. Nawrocki, PhD, Jennifer S Carew, Ph.D., Francis J Giles, MD, Margaret S Lee, PhD
Journal: Blood
Blood (2008) 112 (11): 384.
https://doi.org/10.1182/blood.V112.11.384.384
Published: 2008