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Issue Archive

Volume 114, Issue 27
December 24 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Neoplastic blood cells become pluripotent
Igor I. Slukvin
View Articletitled, Neoplastic blood cells become pluripotent
CLINICAL TRIALS
Increasing the punch of reduced-intensity transplants
Edward D. Ball
View Articletitled, Increasing the punch of reduced-intensity transplants
MYELOID NEOPLASIA
CCL2/CCR2: push/pull for migration
Giuseppe Avvisati
View Articletitled, CCL2/CCR2: push/pull for migration
PLATELETS & THROMBOPOIESIS
Getting in shape with RanBP10
Robert Flaumenhaft
View Articletitled, Getting in shape with RanBP10

PLENARY PAPERS

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
Florence C. Guibal,Meritxell Alberich-Jorda,Hideyo Hirai,Alexander Ebralidze,Elena Levantini,Annalisa Di Ruscio,Pu Zhang,Barbara A. Santana-Lemos,Donna Neuberg,Amy J. Wagers,Eduardo M. Rego,Daniel G. Tenen
View Articletitled, Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
Supplemental data

PERSPECTIVES

Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?
Susan Branford,Junia V. Melo,Timothy P. Hughes
View Articletitled, Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

HOW I TREAT

How I treat multiple myeloma in younger patients
A. Keith Stewart,Paul G. Richardson,Jesus F. San-Miguel
View Articletitled, How I treat multiple myeloma in younger patients

CLINICAL TRIALS AND OBSERVATIONS

Allogeneic hematopoietic cell transplantation after conditioning with 131I–anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome
Clinical Trials & Observations
John M. Pagel,Theodore A. Gooley,Joseph Rajendran,Darrell R. Fisher,Wendy A. Wilson,Brenda M. Sandmaier,Dana C. Matthews,H. Joachim Deeg,Ajay K. Gopal,Paul J. Martin,Rainer F. Storb,Oliver W. Press,Frederick R. Appelbaum
View Articletitled, Allogeneic hematopoietic cell transplantation after conditioning with <sup>131</sup>I–anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome

GENE THERAPY

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
Scott E. James,Nural N. Orgun,Thomas F. Tedder,Mark J. Shlomchik,Michael C. Jensen,Yukang Lin,Philip D. Greenberg,Oliver W. Press
View Articletitled, Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
Xiang Li,Shunji Jia,Shaohe Wang,Yuemeng Wang,Anming Meng
View Articletitled, Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
Supplemental data
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
Zhaohui Ye,Huichun Zhan,Prashant Mali,Sarah Dowey,Donna M. Williams,Yoon-Young Jang,Chi V. Dang,Jerry L. Spivak,Alison R. Moliterno,Linzhao Cheng
View Articletitled, Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
Supplemental data

IMMUNOBIOLOGY

Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
Stephan Blüml,Gordin Zupkovitz,Stefanie Kirchberger,Maria Seyerl,Valery N. Bochkov,Karl Stuhlmeier,Otto Majdic,Gerhard J. Zlabinger,Christian Seiser,Johannes Stöckl
View Articletitled, Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids

LYMPHOID NEOPLASIA

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
Dominique J. P. M. Stumpel,Pauline Schneider,Eddy H. J. van Roon,Judith M. Boer,Paola de Lorenzo,Maria G. Valsecchi,Renee X. de Menezes,Rob Pieters,Ronald W. Stam
View Articletitled, Specific promoter methylation identifies different subgroups of <em>MLL</em>-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
Supplemental data

MYELOID NEOPLASIA

Comprehensive genomic screens identify a role for PLZF-RARα as a positive regulator of cell proliferation via direct regulation of c-MYC
Kim L. Rice,Itsaso Hormaeche,Sergei Doulatov,Jared M. Flatow,David Grimwade,Ken I. Mills,Magdalena Leiva,Julien Ablain,Charuta Ambardekar,Melanie J. McConnell,John E. Dick,Jonathan D. Licht
View Articletitled, Comprehensive genomic screens identify a role for PLZF-RARα as a positive regulator of cell proliferation via direct regulation of c-MYC
Supplemental data
Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome
Maaike Luesink,Jeroen L. A. Pennings,Willemijn M. Wissink,Peter C. M. Linssen,Petra Muus,Rolph Pfundt,Theo J. M. de Witte,Bert A. van der Reijden,Joop H. Jansen
View Articletitled, Chemokine induction by all-<em>trans</em> retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
Anne-Marit Sponaas,Ana Paula Freitas do Rosario,Cecile Voisine,Beatris Mastelic,Joanne Thompson,Sandra Koernig,William Jarra,Laurent Renia,Marjorie Mauduit,Alexandre J. Potocnik,Jean Langhorne
View Articletitled, Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
Supplemental data

PLATELETS AND THROMBOPOIESIS

The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation
Stefan Kunert,Imke Meyer,Silke Fleischhauer,Martin Wannack,Janine Fiedler,Ramesh A. Shivdasani,Harald Schulze
View Articletitled, The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
Jose A. Guerrero,Mark Kyei,Susan Russell,Junling Liu,T. Kent Gartner,Brian Storrie,Jerry Ware
View Articletitled, Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
Supplemental data

VASCULAR BIOLOGY

EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2α–mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2
Faten Bougatef,Cathy Quemener,Sabrina Kellouche,Benyoussef Naïmi,Marie-Pierre Podgorniak,Guy Millot,Eric E. Gabison,Fabien Calvo,Christine Dosquet,Céleste Lebbé,Suzanne Menashi,Samia Mourah
View Articletitled, EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2α–mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2
Supplemental data
Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
Enjing Jin,Ju Liu,Jun-ichi Suehiro,Lei Yuan,Yoshiaki Okada,Vesna Nikolova-Krstevski,Kiichiro Yano,Lauren Janes,David Beeler,Katherine C. Spokes,Dan Li,Erzsébet Regan,Shou-Ching Shih,Peter Oettgen,Takashi Minami,William C. Aird
View Articletitled, Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
Supplemental data

CORRESPONDENCE

Complement: help or hindrance?
Stephen A. Beers,Mark S. Cragg,Martin J. Glennie
View Articletitled, Complement: help or hindrance?
Response: Complement in antibody therapy for lymphoma: both a help and a hindrance?
George J. Weiner
View Articletitled, Response: Complement in antibody therapy for lymphoma: both a help and a hindrance?
Birth order and outcome after HLA–identical sibling donor transplantation
Alois Gratwohl,Bernd Doehler,Martin Stern,Christoph Bucher,Jakob Passweg,Gerhard Opelz
View Articletitled, Birth order and outcome after HLA–identical sibling donor transplantation
All Issues

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