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The mouse model for cystinosis accumulates excess cystine in every tissue compartment and reproduces most of the multi-systemic tissue injury seen in affected individuals. Transplantation with wild-type bone marrow cells from GFP-expressing animals results in significant reductions of cystine content in all tissues. Confocal microscopy revealed a large quantity of transplanted bone marrow–derived cells in all organs tested. The spleen shown in this photomicrograph demonstrated the most GFP-positive cells (green) of any tissue and the majority of these cells were von Willebrand factor (blue)– and F-actin (red)–positive, consistent with reticulo-endothelial cells known to accumulate cystine. See the article by Syres et al on page 2542.