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Issue Archive

Volume 3, Issue 22
November 26 2019
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORTS

Larotrectinib in TRK fusion–positive pediatric B-cell acute lymphoblastic leukemia
Clinical Trials & Observations
Denis M. Schewe,Lennart Lenk,Fotini Vogiatzi,Dorothee Winterberg,Annika V. Rademacher,Swantje Buchmann,Dahlia Henry,Anke K. Bergmann,Gunnar Cario,Michael C. Cox
View Articletitled, Larotrectinib in TRK fusion–positive pediatric B-cell acute lymphoblastic leukemia
Supplemental data
Paroxysmal cold hemoglobinuria successfully treated with complement inhibition
Clinical Trials & Observations
Sarah A. Lau-Braunhut,Hannah Stone,Griffin Collins,Sigbjørn Berentsen,Benjamin S. Braun,Matt S. Zinter
View Articletitled, Paroxysmal cold hemoglobinuria successfully treated with complement inhibition

STIMULUS REPORT

Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia
Clinical Trials & Observations
Gabriela M. Baerlocher,Monika Haubitz,Thomas R. Braschler,Claudio Brunold,Bart Burington,Elisabeth Oppliger Leibundgut,Ning Go
View Articletitled, Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia

REVIEW ARTICLES

Opportunities for immunotherapy in childhood acute myeloid leukemia
Adam J. Lamble,Sarah K. Tasian
View Articletitled, Opportunities for immunotherapy in childhood acute myeloid leukemia
Clonal dynamics in chronic lymphocytic leukemia
Catherine Gutierrez,Catherine J. Wu
View Articletitled, Clonal dynamics in chronic lymphocytic leukemia
Managing the competing risks of thrombosis, bleeding, and anticoagulation in patients with malignancy
Hanny Al-Samkari,Jean M. Connors
View Articletitled, Managing the competing risks of thrombosis, bleeding, and anticoagulation in patients with malignancy
Updated international consensus report on the investigation and management of primary immune thrombocytopenia
Drew Provan,Donald M. Arnold,James B. Bussel,Beng H. Chong,Nichola Cooper,Terry Gernsheimer,Waleed Ghanima,Bertrand Godeau,Tomás José González-López,John Grainger,Ming Hou,Caroline Kruse,Vickie McDonald,Marc Michel,Adrian C. Newland,Sue Pavord,Francesco Rodeghiero,Marie Scully,Yoshiaki Tomiyama,Raymond S. Wong,Francesco Zaja,David J. Kuter
View Articletitled, Updated international consensus report on the investigation and management of primary immune thrombocytopenia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity
Clinical Trials & Observations
Franziska Schramm,Udo zur Stadt,Martin Zimmermann,Norbert Jorch,Arnulf Pekrun,Arndt Borkhardt,Thomas Imschweiler,Holger Christiansen,Jörg Faber,Irene Schmid,Tobias Feuchtinger,Gerhard Beron,Monique L. den Boer,Rob Pieters,Martin A. Horstmann,Gritta E. Janka-Schaub,Gabriele Escherich
View Articletitled, Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity
Supplemental data
BST-236, a novel cytarabine prodrug for patients with acute leukemia unfit for standard induction: a phase 1/2a study
Clinical Trials & Observations
Tsila Zuckerman,Ron Ram,Luiza Akria,Maya Koren-Michowitz,Ron Hoffman,Israel Henig,Noa Lavi,Yishai Ofran,Netanel A. Horowitz,Olga Nudelman,Sigal Tavor,Shay Yeganeh,Stela Gengrinovitch,Liat Flaishon,Shoshi Tessler,Ruth Ben Yakar,Jacob M. Rowe
View Articletitled, BST-236, a novel cytarabine prodrug for patients with acute leukemia unfit for standard induction: a phase 1/2a study
Supplemental data

HEALTH SERVICES AND OUTCOMES

Trends and factors affecting the US adult hematology workforce: a mixed methods study
Deva Sharma,Natalie Wallace,Erik A. Levinsohn,Ariela L. Marshall,Karen Kayoumi,Johanna Madero,Morgan Homer,Robby Reynolds,Janet Hafler,Nikolai A. Podoltsev,Alfred Ian Lee
View Articletitled, Trends and factors affecting the US adult hematology workforce: a mixed methods study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis
Velayoudame Parthibane,Diwash Acharya,Sargur Madabushi Srideshikan,Jing Lin,Dru G. Myerscough,Thiruvaimozhi Abimannan,Nagampalli Vijaykrishna,Daniel Blankenberg,Lavanya Bondada,Kimberly D. Klarmann,Stephen D. Fox,Thorkell Andresson,Lino Tessarollo,Usha Acharya,Jonathan R. Keller,Jairaj K. Acharya
View Articletitled, <em>Sptlc1</em> is essential for myeloid differentiation and hematopoietic homeostasis
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice
Séverine Bézie,Béatrice Charreau,Nadège Vimond,Juliette Lasselin,Nathalie Gérard,Véronique Nerrière-Daguin,Frédérique Bellier-Waast,Franck Duteille,Ignacio Anegon,Carole Guillonneau
View Articletitled, Human CD8<sup>+</sup> Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice
Supplemental data
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy
Vinodh Pillai,Kavitha Muralidharan,Wenzhao Meng,Asen Bagashev,Derek A. Oldridge,Jaclyn Rosenthal,John Van Arnam,Jos J. Melenhorst,Diwakar Mohan,Amanda M. DiNofia,Minjie Luo,Sindhu Cherian,Jonathan R. Fromm,Gerald Wertheim,Andrei Thomas-Tikhonenko,Michele Paessler,Carl H. June,Eline T. Luning Prak,Vijay G. Bhoj,Stephan A. Grupp,Shannon L. Maude,Susan R. Rheingold
View Articletitled, CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy
Supplemental data
Durable preservation of antiviral antibodies after CD19-directed chimeric antigen receptor T-cell immunotherapy
Joshua A. Hill,Elizabeth M. Krantz,Kevin A. Hay,Sayan Dasgupta,Terry Stevens-Ayers,Rachel A. Bender Ignacio,Merav Bar,Joyce Maalouf,Sindhu Cherian,Xueyan Chen,Greg Pepper,Stanley R. Riddell,David G. Maloney,Michael J. Boeckh,Cameron J. Turtle
View Articletitled, Durable preservation of antiviral antibodies after CD19-directed chimeric antigen receptor T-cell immunotherapy
Supplemental data
CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML
Bérengère Salomé,Alejandra Gomez-Cadena,Romain Loyon,Madeleine Suffiotti,Valentina Salvestrini,Tania Wyss,Giulia Vanoni,Dan Fu Ruan,Marianna Rossi,Alessandra Tozzo,Paolo Tentorio,Elena Bruni,Carsten Riether,Eva-Maria Jacobsen,Peter Jandus,Curdin Conrad,Manfred Hoenig,Ansgar Schulz,Katarzyna Michaud,Matteo Giovanni Della Porta,Silvia Salvatore,Ping-Chih Ho,David Gfeller,Adrian Ochsenbein,Domenico Mavilio,Antonio Curti,Emanuela Marcenaro,Alexander Steinle,Amir Horowitz,Pedro Romero,Sara Trabanelli,Camilla Jandus
View Articletitled, CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML
Supplemental data

LYMPHOID NEOPLASIA

TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC
Stacy Grieve,Gabriel Wajnberg,Miranda Lees,Simi Chacko,Jackson Weir,Nicolas Crapoulet,Tony Reiman
View Articletitled, TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC
Supplemental data

MYELOID NEOPLASIA

The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
Lucia Mazzacurati,Robert J. Collins,Garima Pandey,Que T. Lambert-Showers,Narmin E. Amin,Ling Zhang,Matthew C. Stubbs,Pearlie K. Epling-Burnette,Holly K. Koblish,Gary W. Reuther
View Articletitled, The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
Supplemental data
Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis
Kathy L. McGraw,Chia-Ho Cheng,Y. Ann Chen,Hsin-An Hou,Björn Nilsson,Giulio Genovese,Thomas Cluzeau,Andrea Pellagatti,Bartlomiej P. Przychodzen,Mar Mallo,Leonor Arenillas,Azim Mohamedali,Lionel Adès,David A. Sallman,Eric Padron,Lubomir Sokol,Chimene Moreilhon,Sophie Raynaud,Hwei-Fang Tien,Jacqueline Boultwood,Benjamin L. Ebert,Francesc Sole,Pierre Fenaux,Ghulam J. Mufti,Jaroslaw P. Maciejewski,Peter A. Kanetsky,Alan F. List
View Articletitled, Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis
Supplemental data
LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML
Neil Beeharry,Sean Landrette,Sophia Gayle,Marylens Hernandez,Jeff E. Grotzke,Peter R. Young,Paul Beckett,Xuan Zhang,Bing Z. Carter,Michael Andreeff,Stephanie Halene,Tian Xu,Jonathan Rothberg,Henri Lichenstein
View Articletitled, LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML
Supplemental data
Risk of disease transformation and second primary solid tumors in patients with myeloproliferative neoplasms
Junshik Hong,Ju Hyun Lee,Ja Min Byun,Ji Yun Lee,Youngil Koh,Dong-Yeop Shin,Jeong-Ok Lee,Sang Mee Hwang,Hyoung Soo Choi,Inho Kim,Sung-Soo Yoon,Soo-Mee Bang
View Articletitled, Risk of disease transformation and second primary solid tumors in patients with myeloproliferative neoplasms
Supplemental data
The ParaHox gene Cdx4 induces acute erythroid leukemia in mice
Silvia Thoene,Tamoghna Mandal,Naidu M. Vegi,Leticia Quintanilla-Martinez,Reinhild Rösler,Sebastian Wiese,Klaus H. Metzeler,Tobias Herold,Torsten Haferlach,Konstanze Döhner,Hartmut Döhner,Luisa Schwarzmüller,Ursula Klingmüller,Christian Buske,Vijay P. S. Rawat,Michaela Feuring-Buske
View Articletitled, The ParaHox gene <em>Cdx4</em> induces acute erythroid leukemia in mice
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair
Cathelijn E. M. Aarts,Ida H. Hiemstra,Eelke P. Béguin,Arjan J. Hoogendijk,Souhailla Bouchmal,Michel van Houdt,Anton T. J. Tool,Erik Mul,Machiel H. Jansen,Hans Janssen,Floris P. J. van Alphen,Jan-Paul de Boer,Charlotte L. Zuur,Alexander B. Meijer,Timo K. van den Berg,Taco W. Kuijpers
View Articletitled, Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair
Supplemental data

PLATELETS AND THROMBOPOIESIS

Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance
Marie A. Hollenhorst,Hanny Al-Samkari,David J. Kuter
View Articletitled, Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance
Supplemental data
Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis
Stephen P. Holly,Nidhi Gera,Putianqi Wang,Alexander Wilson,Ziqiang Guan,Ling Lin,Brian Cooley,Hammodah R. Alfar,Ruchi G. Patil,Raymond Piatt,Tina M. Leisner,Wolfgang Bergmeier,Rinku Majumder,Leslie V. Parise
View Articletitled, Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis
Supplemental data

THROMBOSIS AND HEMOSTASIS

Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains
Clinical Trials & Observations
Amit Prabhakar,Tathagata Chatterjee,Nitin Bajaj,Tarun Tyagi,Anita Sahu,Neha Gupta,Babita Kumari,Velu Nair,Bhuvnesh Kumar,Mohammad Zahid Ashraf
View Articletitled, Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains
Supplemental data

TRANSPLANTATION

Results from a multidisciplinary clinic guided by geriatric assessment before stem cell transplantation in older adults
Clinical Trials & Observations
Benjamin A. Derman,Keriann Kordas,Jean Ridgeway,Selina Chow,William Dale,Sang Mee Lee,Elingel Aguada,Andrzej J. Jakubowiak,Jagoda Jasielec,Justin Kline,Satyajit Kosuri,Richard A. Larson,Hongtao Liu,Mylove Mortel,Olatoyosi Odenike,Jennifer Pisano,Peter Riedell,Wendy Stock,Michael R. Bishop,Andrew S. Artz
View Articletitled, Results from a multidisciplinary clinic guided by geriatric assessment before stem cell transplantation in older adults
Supplemental data
Missed diagnosis and misdiagnosis of infectious diseases in hematopoietic cell transplant recipients: an autopsy study
Ashrit Multani,Libby S. Allard,Tamna Wangjam,R. Alejandro Sica,David J. Epstein,Andrew R. Rezvani,Dora Y. Ho
View Articletitled, Missed diagnosis and misdiagnosis of infectious diseases in hematopoietic cell transplant recipients: an autopsy study
Using a machine learning algorithm to predict acute graft-versus-host disease following allogeneic transplantation
Clinical Trials & Observations
Yasuyuki Arai,Tadakazu Kondo,Kyoko Fuse,Yasuhiko Shibasaki,Masayoshi Masuko,Junichi Sugita,Takanori Teshima,Naoyuki Uchida,Takahiro Fukuda,Kazuhiko Kakihana,Yukiyasu Ozawa,Tetsuya Eto,Masatsugu Tanaka,Kazuhiro Ikegame,Takehiko Mori,Koji Iwato,Tatsuo Ichinohe,Yoshinobu Kanda,Yoshiko Atsuta
View Articletitled, Using a machine learning algorithm to predict acute graft-versus-host disease following allogeneic transplantation
Supplemental data
Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft-versus-host disease
Mette D. Hazenberg,Nienke J. E. Haverkate,Yannouck F. van Lier,Hergen Spits,Lisette Krabbendam,Willem A. Bemelman,Christianne J. Buskens,Bianca Blom,Medya M. Shikhagaie
View Articletitled, Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft-versus-host disease
Supplemental data

COMMENTARY

Erythroid differentiation of myeloblast induced by gilteritinib in relapsed FLT3-ITD–positive acute myeloid leukemia
Hyun Don Yun,Sunita Nathan,Melissa Larson,Mohammad J. Hussain,Deborah A. Katz,Ankur Varma,Ira Miller,Celalettin Ustun
View Articletitled, Erythroid differentiation of myeloblast induced by gilteritinib in relapsed <em>FLT3</em>-<em>ITD</em>–positive acute myeloid leukemia
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