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Issue Archive

Volume 3, Issue 20
October 22 2019
Issue Cover

Table of Contents

STIMULUS REPORTS

Five-year outcomes of the S1106 study of R-hyper-CVAD vs R-bendamustine in transplant-eligible patients with mantle cell lymphoma
Manali Kamdar,Hongli Li,Robert W. Chen,Lisa M. Rimsza,Michael L. Leblanc,Timothy S. Fenske,Thomas C. Shea,Paul M. Barr,Tycel J. Phillips,John P. Leonard,Brad S. Kahl,Jonathan W. Friedberg,Sonali M. Smith
View Articletitled, Five-year outcomes of the S1106 study of R-hyper-CVAD vs R-bendamustine in transplant-eligible patients with mantle cell lymphoma
Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies
Ray Zhang,Brian F. Duffy,Vinzenz Lange,Charles S. Eby,Chang Liu
View Articletitled, Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies

REVIEW ARTICLE

Role of the coagulation system in the pathogenesis of sickle cell disease
Md Nasimuzzaman,Punam Malik
View Articletitled, Role of the coagulation system in the pathogenesis of sickle cell disease

CLINICAL TRIALS AND OBSERVATIONS

Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia
Clinical Trials & Observations
Amanda C. Winters,Jonathan A. Gutman,Enkhtsetseg Purev,Molly Nakic,Jennifer Tobin,Stephanie Chase,Jeff Kaiser,Lindsey Lyle,Chelsey Boggs,Keri Halsema,Jeffrey T. Schowinsky,Julie Rosser,Mark D. Ewalt,Bradford Siegele,Vishal Rana,Steven Schuster,Diana Abbott,Brett M. Stevens,Craig T. Jordan,Clayton Smith,Daniel A. Pollyea
View Articletitled, Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia
Supplemental data
Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease
Clinical Trials & Observations
Lauren C. Bylsma,Anne Gulbech Ording,Adam Rosenthal,Buket Öztürk,Jon P. Fryzek,Jaime Morales Arias,Alexander Röth,Sigbjørn Berentsen
View Articletitled, Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease
Supplemental data
Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation
Clinical Trials & Observations
Andrea S. Henden,Antiopi Varelias,Justine Leach,Elise Sturgeon,Judy Avery,Jessica Kelly,Stuart Olver,Luke Samson,Gunter Hartel,Simon Durrant,Jason Butler,Anthony J. Morton,Ashish Misra,Siok-Keen Tey,Elango Subramoniapillai,Cameron Curley,Glen Kennedy,Geoffrey R. Hill
View Articletitled, Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation
Supplemental data
Molecular response with blinatumomab in relapsed/refractory B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations
Nicola Gökbuget,Hagop M. Kantarjian,Monika Brüggemann,Anthony S. Stein,Ralf C. Bargou,Hervé Dombret,Adele K. Fielding,Leonard Heffner,Françoise Rigal-Huguet,Mark Litzow,Susan O’Brien,Gerhard Zugmaier,Shan Gao,Dirk Nagorsen,Stephen J. Forman,Max S. Topp
View Articletitled, Molecular response with blinatumomab in relapsed/refractory B-cell precursor acute lymphoblastic leukemia
Supplemental data

HEALTH SERVICES AND OUTCOMES

Racial disparities in treatment patterns and outcomes among patients with multiple myeloma: a SEER-Medicare analysis
Sikander Ailawadhi,Kejal Parikh,Safiya Abouzaid,Zhou Zhou,Wenxi Tang,Zoe Clancy,Claudia Cheung,Zheng-Yi Zhou,Jipan Xie
View Articletitled, Racial disparities in treatment patterns and outcomes among patients with multiple myeloma: a SEER-Medicare analysis

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Generation and function of progenitor T cells from StemRegenin-1–expanded CD34+ human hematopoietic progenitor cells
Jastaranpreet Singh,Edward L. Y. Chen,Yan Xing,Heather E. Stefanski,Bruce R. Blazar,Juan Carlos Zúñiga-Pflücker
View Articletitled, Generation and function of progenitor T cells from StemRegenin-1–expanded CD34<sup>+</sup> human hematopoietic progenitor cells
Supplemental data
Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway
Kaycee B. Moshofsky,Hyun J. Cho,Guanming Wu,Kyle A. Romine,Matthew T. Newman,Yoko Kosaka,Shannon K. McWeeney,Evan F. Lind
View Articletitled, Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

LYMPHOID NEOPLASIA

Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1–derived peptides overcomes drug resistance
Elodie Pramil,Linda Herbi Bastian,Thomas Denèfle,Fariba Nemati,Malina Xiao,Eva Lardé,Karim Maloum,Damien Roos-Weil,Elise Chapiro,Magali Le Garff-Tavernier,Frédéric Davi,Didier Decaudin,Marika Sarfati,Florence Nguyen-Khac,Hélène Merle-Béral,Philippe Karoyan,Santos A. Susin
View Articletitled, Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1–derived peptides overcomes drug resistance
Supplemental data
Primary treatment of light-chain amyloidosis with bortezomib, lenalidomide, and dexamethasone
Efstathios Kastritis,Ioanna Dialoupi,Maria Gavriatopoulou,Maria Roussou,Nikolaos Kanellias,Despina Fotiou,Ioannis Ntanasis-Stathopoulos,Elektra Papadopoulou,Dimitrios C. Ziogas,Kimon Stamatelopoulos,Efstathios Manios,Argyrios Ntalianis,Evangelos Eleutherakis-Papaiakovou,Asimina Papanikolaou,Magdalini Migkou,Aristea-Maria Papanota,Harikleia Gakiopoulou,Erasmia Psimenou,Maria Irini Tselegkidi,Ourania Tsitsilonis,Ioannis Kostopoulos,Evangelos Terpos,Meletios A. Dimopoulos
View Articletitled, Primary treatment of light-chain amyloidosis with bortezomib, lenalidomide, and dexamethasone
Supplemental data
Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma
Anna Stelling,Cheuk-Ting Wu,Katrin Bertram,Hind Hashwah,Alexandre P. A. Theocharides,Markus G. Manz,Alexandar Tzankov,Anne Müller
View Articletitled, Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma
Supplemental data
Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
Jessica I. Hoell,Sebastian Ginzel,Michaela Kuhlen,Andreas Kloetgen,Michael Gombert,Ute Fischer,Daniel Hein,Salih Demir,Martin Stanulla,Martin Schrappe,Udo zur Stadt,Peter Bader,Florian Babor,Friedhelm Schuster,Brigitte Strahm,Julia Alten,Anja Moericke,Gabriele Escherich,Arend von Stackelberg,Ralf Thiele,Alice C. McHardy,Christina Peters,Beat Bornhauser,Jean-Pierre Bourquin,Stefan Krause,Juergen Enczmann,Lüder Hinrich Meyer,Cornelia Eckert,Arndt Borkhardt,Roland Meisel
View Articletitled, Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
Supplemental data

MYELOID NEOPLASIA

The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations
Anca Franzini,Anthony D. Pomicter,Dongqing Yan,Jamshid S. Khorashad,Srinivas K. Tantravahi,Hein Than,Jonathan M. Ahmann,Thomas O’Hare,Michael W. Deininger
View Articletitled, The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations
Supplemental data
ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants
Xi Luo,Simone Feurstein,Shruthi Mohan,Christopher C. Porter,Sarah A. Jackson,Sioban Keel,Michael Chicka,Anna L. Brown,Chimene Kesserwan,Anupriya Agarwal,Minjie Luo,Zejuan Li,Justyne E. Ross,Panagiotis Baliakas,Daniel Pineda-Alvarez,Courtney D. DiNardo,Alison A. Bertuch,Nikita Mehta,Tom Vulliamy,Ying Wang,Kim E. Nichols,Luca Malcovati,Michael F. Walsh,Lesley H. Rawlings,Shannon K. McWeeney,Jean Soulier,Anna Raimbault,Mark J. Routbort,Liying Zhang,Gabriella Ryan,Nancy A. Speck,Sharon E. Plon,David Wu,Lucy A. Godley
View Articletitled, ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline <em>RUNX1</em> variants
Supplemental data
Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia
Paul Milne,Charlotte Wilhelm-Benartzi,Michael R. Grunwald,Venetia Bigley,Richard Dillon,Sylvie D. Freeman,Kathleen Gallagher,Amy Publicover,Sarah Pagan,Helen Marr,Gail L. Jones,Anne M. Dickinson,Angela Grech,Alan K. Burnett,Nigel H. Russell,Mark Levis,Steven Knapper,Matthew Collin
View Articletitled, Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia
Supplemental data
Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern
Gerbrig Berger,Mylene Gerritsen,Guoqiang Yi,Theresia N. Koorenhof-Scheele,Leonie I. Kroeze,Marian Stevens-Kroef,Kenichi Yoshida,Yuichi Shiraishi,Eva van den Berg,Hein Schepers,Geert Huls,André B. Mulder,Seishi Ogawa,Joost H. A. Martens,Joop H. Jansen,Edo Vellenga
View Articletitled, Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern
Supplemental data
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia
Norio Shiba,Kenichi Yoshida,Yusuke Hara,Genki Yamato,Yuichi Shiraishi,Hidemasa Matsuo,Yusuke Okuno,Kenichi Chiba,Hiroko Tanaka,Taeko Kaburagi,Masanobu Takeuchi,Kentaro Ohki,Masashi Sanada,Jun Okubo,Daisuke Tomizawa,Tomohiko Taki,Akira Shimada,Manabu Sotomatsu,Keizo Horibe,Takashi Taga,Souichi Adachi,Akio Tawa,Satoru Miyano,Seishi Ogawa,Yasuhide Hayashi
View Articletitled, Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice
Toshiaki Shirai,Alexey S. Revenko,Justin Tibbitts,Anh T. P. Ngo,Annachiara Mitrugno,Laura D. Healy,Jennifer Johnson,Erik I. Tucker,Monica T. Hinds,Lisa M. Coussens,Owen J. T. McCarty,Brett P. Monia,András Gruber
View Articletitled, Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice
Supplemental data
Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets
Elisabeth M. Battinelli,Jonathan N. Thon,Ross Okazaki,Christian G. Peters,Prakrith Vijey,Adrian R. Wilkie,Leila J. Noetzli,Robert Flaumenhaft,Joseph E. Italiano, Jr
View Articletitled, Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

BCL2L1 is associated with γ-globin gene expression
Yan Dai,Elmutaz M. Shaikho,Jessica Perez,Carolyn A. Wilson,Lesley Y. Liu,Mitchell R. White,John J. Farrell,David H. K. Chui,Paola Sebastiani,Martin H. Steinberg
View Articletitled, <em>BCL2L1</em> is associated with γ-globin gene expression

THROMBOSIS AND HEMOSTASIS

Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice
Weiqing Jing,Juan Chen,Yuanhua Cai,Yingyu Chen,Jocelyn A. Schroeder,Bryon D. Johnson,Weiguo Cui,Qizhen Shi
View Articletitled, Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice
Supplemental data

TRANSPLANTATION

Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy
Mazyar Shadman,Jordan Gauthier,Kevin A. Hay,Jenna M. Voutsinas,Filippo Milano,Ang Li,Alexandre V. Hirayama,Mohamed L. Sorror,Sindhu Cherian,Xueyan Chen,Ryan D. Cassaday,Brian G. Till,Ajay K. Gopal,Brenda M. Sandmaier,David G. Maloney,Cameron J. Turtle
View Articletitled, Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy
Similar outcomes of alemtuzumab-based hematopoietic cell transplantation for SAA patients older or younger than 50 years
Vipul Sharad Sheth,Victoria Potter,Shreyans A. Gandhi,Austin Gladston Kulasekararaj,Hugues de Lavallade,Petra Muus,Antonio Pagliuca,Carmel F. M. Rice,Varun Mehra,Francesco Grimaldi,Shafqat Inam,Linda D. Barber,Ghulam J. Mufti,Judith C. Marsh
View Articletitled, Similar outcomes of alemtuzumab-based hematopoietic cell transplantation for SAA patients older or younger than 50 years
Supplemental data
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia
Nelli Bejanyan,Soyoung Kim,Kyle M. Hebert,Natasha Kekre,Hisham Abdel-Azim,Ibrahim Ahmed,Mahmoud Aljurf,Sherif M. Badawy,Amer Beitinjaneh,Jaap Jan Boelens,Miguel Angel Diaz,Christopher C. Dvorak,Shahinaz Gadalla,James Gajewski,Robert Peter Gale,Siddhartha Ganguly,Andrew R. Gennery,Biju George,Usama Gergis,David Gómez-Almaguer,Marta Gonzalez Vicent,Hasan Hashem,Rammurti T. Kamble,Kimberly A. Kasow,Hillard M. Lazarus,Vikram Mathews,Paul J. Orchard,Michael Pulsipher,Olle Ringden,Kirk Schultz,Pierre Teira,Ann E. Woolfrey,Blachy Dávila Saldaña,Bipin Savani,Jacek Winiarski,Jean Yared,Daniel J. Weisdorf,Joseph H. Antin,Mary Eapen
View Articletitled, Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia
Supplemental data

COMMENTARY

Response to meta-analysis of leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera
Lukas Ronner,John Mascarenhas,Erin L. Moshier
View Articletitled, Response to meta-analysis of leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera
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