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Ronan Chaligné
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Journal Articles

Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTK C481S -Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia

Ramon Massoni-Badosa, Joshua S. Schiffman, Barun Pradhan, Rebecca M. Murray, Andrew H. Lipsky, Debra Van Egeren, Danny Luan, Shirley Chen, Ronan Chaligne, Kai Beattie, Alyssa Indart, Nada Chraiki, Neville Dusaj, Erica B. Bhavsar, Chelston Ang, Anna S. Nam, Federico Gaiti, Paulina Chamely, Nathaniel D. Omans, Preeti Trisal, Anita K. Gandhi, Kyu-Tae Kim, Rafael Schulman, Franco Izzo, Gavriel Mullokandov, Chingiz Underbayev, Jan A. Burger, Adrian Wiestner, Elisa Ten Hacken, John N. Allan, Jennifer A. Woyach, Richard R. Furman, Dan A. Landau
Journal: Blood
Blood (2024) 144 (Supplement 1): 4610.
https://doi.org/10.1182/blood-2024-205727
Published: 2024
Journal Articles

A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Biomarkers of Disease and May Delay Progression to Myeloma

Urvi A. Shah, Laura Lucia Cogrossi, Andriy Derkach, Francesca Castro, Teng Fei, Susan DeWolf, Juan-Jose Garces, Anna Policastro, Matteo Grioni, Sofia Sisti, Blaslov Jenna, Peter Adintori, Kinga K. Hosszu, Devin McAvoy, Mirae Baichoo, Justin Cross, Aishwarya Anuraj, Charlotte Pohl, Ruben Ramos, Jenny Paredes Sanchez, Brianna Gipson, Kylee H Maclachlan, Ana Gradissimo, Leonardo Boiocchi, Richard Koche, Ronan Chaligne, Torin Block, Neha Korde, Carlyn Rose Tan, Malin Hultcrantz, Hani Hassoun, Gunjan L. Shah, Michael Scordo, Oscar B Lahoud, David J. Chung, Heather J. Landau, Jonathan U. Peled, Nicola Clementi, Marta Chesi, P. Leif Bergsagel, Sham Mailankody, Michael Pollak, Anita D'Souza, Ola Landgren, Susan Chimonas, Sergio Giralt, Saad Z. Usmani, Neil M. Iyengar, Alexander M. Lesokhin, Matteo Bellone, Marcel R.M. van den Brink
Journal: Blood
Blood (2024) 144 (Supplement 1): 671.
https://doi.org/10.1182/blood-2024-202224
Published: 2024
Journal Articles

A Single-Cell Atlas of Classical Mantle Cell Lymphoma Reveals Paired Tumor-Immune Malignant States Correlating with Prognosis

Amira Marouf, Sneha Mitra, Irem Isgor, Ashlee Joseph, Jahan Rahman, Ya-Hui Lin, Meril Takizawa, Ronan Chaligne, Shenon Sethi, Ahmet Dogan, Sandrine Roulland, Gilles Salles, Christina Leslie, Anita Kumar, Santosha A. Vardhana
Journal: Blood
Blood (2024) 144 (Supplement 1): 234.
https://doi.org/10.1182/blood-2024-206805
Published: 2024
Journal Articles

Single-Cell Spatial Transcriptomics Identifies Lymphoid Aggregates with Location-Specific Alterations of Adaptive Immune Cells in Human MDS Bone Marrow

Robert Stanley, Beatrice Zhang, Kimon V Argyropoulos, Brianna Gipson, Kenyon Weis, Alexander M. Lewis, Zoe Katsamakis, Karen Zhao, Catherine Snopkowski, Matthew Zatzman, Ning Fan, Ronan Chaligne, Umesh Bhanot, Mikhail Roshal, Ahmet Dogan, Benjamin D. Greenbaum, Eytan M. Stein, Marcel R.M. van den Brink, Omar Abdel-Wahab, Susan Dewolf
Journal: Blood
Blood (2024) 144 (Supplement 1): 817.
https://doi.org/10.1182/blood-2024-203714
Published: 2024
Journal Articles

Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms

Won Jun Kim, Edie I. Crosse, Emma De Neef, Inaki Etxeberria, Erich Sabio, Eric Wang, Jan Philipp Bewersdorf, Sydney X. Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H. Winick, Alexander M. Lewis, Robert Stanley, Susan Dewolf, Brigita Meskauskaite Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey J. Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony F. Daniyan, Benjamin D. Greenbaum, Christopher A. Klebanoff, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2024) 144 (Supplement 1): 343.
https://doi.org/10.1182/blood-2024-198639
Published: 2024
Journal Articles

Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment

Susan DeWolf, Nicholas Ceglia, Matthew Zatzman, Brianna Gipson, Yuval Elhanati, Zoe Katsamakis, Hannah Lees, Kenyon Weis, Gustavo Yepes, Barbara Oliveira, Ana Figueiredo Longhini, Natalie Grier Smith, Katherine Nichols, Eliyahu Havasov, Karen Zhao, Brigita Meskauskaite, Ignas Masilionis, Alexander M. Lewis, Maria Adriana Cuibus, M. Kazim Pajwani, Simone A Minnie, Ronan Chaligne, Andri Leo L Lemarquis, Aaron D. Goldberg, Katharine C. Hsu, Eytan M. Stein, Benjamin D. Greenbaum, Omar Abdel-Wahab, Sohrab P. Shah, Marcel R.M. van den Brink
Journal: Blood
Blood (2024) 144 (Supplement 1): 637.
https://doi.org/10.1182/blood-2024-194037
Published: 2024
Journal Articles

Deconvoluting Clonal and Cellular Architecture in IDH -Mutant Acute Myeloid Leukemia

Maria Sirenko, Soobeom Lee, Zhengxi Sun, Ronan Chaligne, Georgios Asimomitis, Charlotte K Brierley, Elsa Bernard, Sheng F. Cai, Robert M Myers, Bettina Nadorp, Max F Levine, Dylan Domenico, Juan E Arango Ossa, Juan Santiago Medina Martinez, Kamal Menghrajani, Audrey Lasry, Alice Mims, Helee Desai, Andrea Laganson, Christopher Famulare, Minal Patel, Gerard Lozanski, Sanam Loghavi, Kelly L. Bolton, Aaron D. Viny, Mikhail Roshal, Ross L Levine, Eytan M. Stein, Dan A. Landau, Ann-Kathrin Eisfeld, Iannis Aifantis, Elli Papaemmanuil
Journal: Blood
Blood (2023) 142 (Supplement 1): 1591.
https://doi.org/10.1182/blood-2023-186322
Published: 2023
Journal Articles

N/KRAS -Mutant AML LSCs Originate from Committed Myelomonocytic Progenitors and Drive Clinical Resistance to Venetoclax

Junya Sango, Saul Carcamo, Nataly Cruz-Rodriguez, Maria Sirenko, Abhishek Maiti, Malgorzata Olszewska, Tiansu Wang, Gulay Bengu Ulukaya, Lewis Tomalin, Emmanuel Olivier, Manon Jaud, Ronan Chaligne, Hager Mansour, Deniz Demircioglu, Dan A. Landau, Elli Papaemmanuil, Courtney D. DiNardo, Dan Hasson, Marina Y. Konopleva, Eirini Papapetrou
Journal: Blood
Blood (2023) 142 (Supplement 1): 403.
https://doi.org/10.1182/blood-2023-187695
Published: 2023
Journal Articles

Comparison of Live Cell Enrichment Methods for Single-Cell Rnaseq

Brigita Meskauskaite Urben, Tobias Krause, Meril Takizawa, Catherine Snopkowski, Ignas Masilionis, Jan Remsik, Yollanda Parisotto, Chrysothemis Brown, Adrienne Boire, Dana Pe'er, Roshan Sharma, Ronan Chaligne
Journal: Blood
Blood (2023) 142 (Supplement 1): 7179.
https://doi.org/10.1182/blood-2023-190109
Published: 2023
Journal Articles

Single-Cell Multi-Omics Reveals That Pegylated Interferon-Alfa Treatment Differentially Redirects Mutated and Wildtype Hematopoietic Cell Differentiation Trajectories in CALR- mutated Essential Thrombocythemia (ET) Patients

Shira Rosenberg, Andrea Kubas-Meyer, Neelang Parghi, Nathaniel D. Omans, Neville Dusaj, Paulina Chamely, Eleni Mimitou, Amylou C. Dueck, Heidi E. Kosiorek, Rona Singer Weinberg, Peter Smibert, Ronan Chaligne, Dan A. Landau, Ronald Hoffman, Anna S Nam
Journal: Blood
Blood (2021) 138 (Supplement 1): 57.
https://doi.org/10.1182/blood-2021-150745
Published: 2021
Journal Articles

High Throughput Single-Cell Simultaneous Genotyping and Chromatin Accessibility Reveals Genotype to Phenotype Relationship in Human Myeloproliferation

Robert M. Myers, Franco Izzo, Tamara Prieto, Eleni Mimitou, Ramya Raviram, Ronan Chaligne, Ronald Hoffman, Maximilian Stahl, Omar Abdel-Wahab, Bridget Marcellino, Peter Smibert, Dan A. Landau
Journal: Blood
Blood (2021) 138 (Supplement 1): 678.
https://doi.org/10.1182/blood-2021-149226
Published: 2021
Journal Articles

Single-Cell Multi-Omics Defines the Cell-Type Specific Impact of SF3B1 Splicing Factor Mutations on Hematopoietic Differentiation in Human Clonal Hematopoiesis and Myelodysplastic Syndromes

Federico Gaiti, Allegra Hawkins, Paulina Chamely, Ariel Swett, Xiaoguang Dai, Lloyd Kluegel, Celine Chen, John Beaulaurier, Alex Drong, Scott Hickey, Tarek H Mouhieddine, Franco Izzo, Neville Dusaj, Ronan Chaligne, Sissel Juul, Daniel H Wiseman, Eoghan Harrington, Justin Taylor, Irene M. Ghobrial, Omar Abdel-Wahab, Dan A. Landau
Journal: Blood
Blood (2021) 138 (Supplement 1): 145.
https://doi.org/10.1182/blood-2021-147529
Published: 2021
Journal Articles

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Anna S Nam, MD, Neville Dusaj, MS, Franco Izzo, PhD, Rekha Murali, MS, Tarek H Mouhieddine, MD, Robert M Myers, Jesus Sotelo, Salima Benbarche, PhD, Federico Gaiti, PhD, Sabrin Tahri, MD MSc, Omar Abdel-Wahab, MD, Irene M. Ghobrial, MD, Ronan Chaligne, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-142574
Published: 2020
Journal Articles

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Andrew Lipsky, MD, Danny Luan, MPH, Shirley Chen, BSc, Ronan Chaligne, PhD, Neville Dusaj, MS, Erica B Bhavsar, BS, Chelston Ang, MS, Anna S Nam, MD, Federico Gaiti, PhD, Paulina Chamely, MSc, Nathaniel D. Omans, MS, Preeti Trisal, MS, Anita K Gandhi, PhD, Kyu-Tae Kim, PhD, Rafael Schulman, BS, Joshua S. Schiffman, PhD, Franco Izzo, PhD, Gregory Mullokandov, MD PhD, Chingiz Underbayev, MD PhD, Adrian Wiestner, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–42.
https://doi.org/10.1182/blood-2020-138374
Published: 2020
Journal Articles

Robust Discovery of Candidate DNA Methylation Cancer Drivers

Heng Pan, PhD, Loïc Renaud, MD MSc, Ronan Chaligne, PhD, Johannes Bloehdorn, MD, Eugen Tausch, MD, Daniel Mertens, PhD, Anna-Maria Fink, MD, Kirsten Fischer, MD, Chao Zhang, PhD, Doron Betel, PhD, Andreas Gnirke, Marcin Imielinski, Jerome Moreaux, PhD, Michael Hallek, Alexander Meissner, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Olivier Elemento, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-136830
Published: 2020
Journal Articles

High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations

Anna S Nam, MD, Kyu-Tae Kim, PhD, Ronan Chaligne, PhD, Franco Izzo, PhD, Chelston Ang, MS, Nathaniel Omans, MS, Alessandro Pastore, Justin Taylor, MD, Alicia Alonso, Wayne Tam, MD PhD, Ronald Hoffman, MD, Joseph Scandura, MDPhD, Raul Rabadan, PhD, Omar I Abdel-Wahab, MD, Peter Smibert, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 541.
https://doi.org/10.1182/blood-2018-99-119236
Published: 2018
Journal Articles

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Ronan Chaligne, PhD, Federico Gaiti, PhD, Franco Izzo, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Davide Risso, PhD, Rafael Schulman, BS, Ryan M Brand, Stanley C Lee, PhD, Asaf Poran, Kye-Tae Kim, PhD, Alessandro Pastore, Alicia Alonso, Andreas Gnirke, Catherine J. Wu, MD, Omar I Abdel-Wahab, MD, Alexander Meissner, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2018-99-115596
Published: 2018
Journal Articles

Single-Cell Joint Methylomics and Transcriptomics Define the Epigenetic Evolution and Lineage Histories of Chronic Lymphocytic Leukemia

Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Rafael Schulman, Kye-Tae Kim, PhD, Evan Biederstedt, Lili Wang, MD PhD, Martin J. Aryee, PhD, Andreas Gnirke, Catherine J. Wu, MD, Alexander Meissner, PhD, Dan A. Landau, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 55.
https://doi.org/10.1182/blood.V130.Suppl_1.55.55
Published: 2017
Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 559.
https://doi.org/10.1182/blood.V130.Suppl_1.559.559
Published: 2017
Journal Articles

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

Christian Pecquet, Judith Staerk, Ronan Chaligné, Valerie Goss, Kimberly A. Lee, Xiaowu Zhang, John Rush, Joanne Van Hees, Hélène A. Poirel, Jean-Marie Scheiff, William Vainchenker, Stéphane Giraudier, Roberto D. Polakiewicz, Stefan N. Constantinescu
Journal: Blood
Blood (2010) 115 (5): 1037–1048.
https://doi.org/10.1182/blood-2008-10-183558
Published: 2010