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Journal Articles

Targeting B- and T-cell lymphomas with anti-CXCR5 CAR T cell therapy

Free
Jinsheng Weng, Eunyoung Lee, Federico Mario Aletti, Cuong Le, Karan Chohan, Abdur Rehman, Xiaoyun Cheng, Jingjing Cao, Sridevi Patchva, Fuliang Chu, Yongfu Tang, Lubna Rehman, Kamini Singh, Matthew D. Richard, Chun-Yen Lin, Faezeh Darbaniyan, Kumudha Balakrishnan, Neeraj Saini, Michael R Green, Swami Iyer, Francisco Vega, Jingwei Liu, Rafael Casellas, Sattva Neelapu
Journal: Blood
Blood (2025) 146 (Supplement 1): 3709.
https://doi.org/10.1182/blood-2025-3709
Published: 2025
Journal Articles

Integrative profiling of t-follicular helper cells heterogeneity and tumor microenvironment signatures in angioimmunoblastic T cell lymphoma

Free
Tania Sainz, Vakul Mohanty, Yuchen Pan, Xuehong Gui, Vishal Sahu, Anna Casasent, Akshay Basi, Claudia Kettlun, Christopher Pacheco, Ashley Wilson, Juan Andres Donoso, Aniruddha Mundhada, Jared Henderson, Yago Nieto, Jared Burks, Michael R Green, Ken Chen, Francisco Vega
Journal: Blood
Blood (2025) 146 (Supplement 1): 555.
https://doi.org/10.1182/blood-2025-555
Published: 2025
Journal Articles

primary analysis of the smart stop trial: Lenalidomide, tafasitamab, rituximab, and acalabrutinib alone and with combination chemotherapy in newly diagnosed diffuse large B-cell lymphoma

Free
Jason Westin, Luis Fayad, Raphael Steiner, Sairah Ahmed, Preetesh Jain, Luis Malpica, Ranjit Nair, Sattva Neelapu, Jared Henderson, Frederick Hagemeister, Maria Rodriguez, Chijioke Nze, Fateeha Furqan, Ayushi Chauhan, Mark Hamilton, Anath Lionel, Francisco Vega, Jisha Tom, Isak Durmic, Gita Masand, Rhanna Wilson, Cara Blyth, Christopher Flowers, Michael R Green, Dai Chihara
Journal: Blood
Blood (2025) 146 (Supplement 1): 477.
https://doi.org/10.1182/blood-2025-477
Published: 2025
Journal Articles

KIR3DL2-directed CAR T cell therapy for T cell malignancies

Free
Federico Mario Aletti, Jinsheng Weng, Cuong Le, Xiaoyun Cheng, Jingjing Cao, Sridevi Patchva, Yongfu Tang, Abdur Rehman, Lubna Rehman, Kamini Singh, Matthew D. Richard, Chun-Yen Lin, Faezeh Darbaniyan, Kumudha Balakrishnan, Neeraj Saini, Fuliang Chu, Michael R Green, Francisco Vega, Swami Iyer, Jingwei Liu, Rafael Casellas, Sattva Neelapu
Journal: Blood
Blood (2025) 146 (Supplement 1): 7621.
https://doi.org/10.1182/blood-2025-7621
Published: 2025
Journal Articles

Germline variants and their role in the pathogenesis of immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) in adult lymphoma patients

Free
Anath Lionel, Cuong Le, Jianlong Liao, Sushanth Gouni, Xubin Li, Faezeh Darbaniyan, Jared Henderson, Ajlan Al Zaki, Federico Mario Aletti, Christen Dillard, Krina Patel, Amy Ayers, Misha Hawkins, Frederick Hagemeister, Maria Rodriguez, Hun Lee, Luis Fayad, Ranjit Nair, Luis Malpica, Chijioke Nze, Preetesh Jain, Michael Wang, Elizabeth Shpall, Partow Kebriaei, Swami Iyer, Dai Chihara, Paolo Strati, Jason Westin, Christopher Flowers, Sairah Ahmed, Linghua Wang, Michael R Green, Sattva Neelapu
Journal: Blood
Blood (2025) 146 (Supplement 1): 806.
https://doi.org/10.1182/blood-2025-806
Published: 2025
Journal Articles

Long-term clinical outcomes from the smart start trial: Rituximab, lenalidomide and ibrutinib in patients with newly diagnosed large B-cell lymphoma

Free
Eduardo Edelman Saul, Karan Chohan, Richard Davis, F. B. Hagemeister, Raphael Steiner, Luis Fayad, Sairah Ahmed, Maria Rodriguez, Swami Iyer, Ranjit Nair, Francisco Vega, Dai Chihara, Paolo Strati, Preetesh Jain, Luis Malpica, Chijioke Nze, Fateeha Furqan, Ayushi Chauhan, Mark Hamilton, Jared Henderson, Anath Lionel, Christopher Flowers, Sattva Neelapu, Michael R Green, Jason Westin
Journal: Blood
Blood (2025) 146 (Supplement 1): 3691.
https://doi.org/10.1182/blood-2025-3691
Published: 2025
Journal Articles

Genome-wide analysis defines genetic determinants of MPN subtypes and identifies a sex-specific association at CDH22/CD40

Open Access
William J Tapper, Ahmed A.Z. Dawoud, Joannah Score, Andrew J Chase, E. Joanna Baxter, Joanne Ewing, Louise Wallis, Paola Guglielmelli, Dolors Colomer, Beatriz Bellosillo, Monste Gomez, Juan Carlos Hernandez-Boluda, Carlos Besses, Francisco Cervantes, Steffen Koschmieder, Anthony R Green, Andreas Reiter, Alessandro M. Vannucchi, Claire N. Harrison, Nicholas C.P. Cross
Journal: Blood
Blood blood.2025028489.
https://doi.org/10.1182/blood.2025028489
Published: 2025
Includes: Supplemental data
Journal Articles

Blunted CD40-responsive enhancer activation in CREBBP -mutant lymphomas can be restored by enforced CD4 T-cell engagement

Open Access
Haopeng Yang, Wenchao Zhang, Vida Ravanmehr, Guiling Cui, Kevin Bowman, Ruidong Chen, Jared M. Henderson, Shyanne Lockman, Estela Rojas, Ashley Wilson, Sydney Parsons, Ariel Mechaly, Leslie Regad, Ahmed Haouz, Christopher R. Flowers, Sattva Neelapu, Loretta Nastoupil, R. Eric Davis, Qing Deng, Fernando Rodrigues-Lima, Michael R. Green
Journal: Blood
Blood (2025) 146 (2): 191–205.
https://doi.org/10.1182/blood.2024026664
Published: 2025
Includes: Supplemental data
Journal Articles

Atezolizumab Combined with Venetoclax and Obinutuzumab for Frontline CLL

Free
Patrick K. Reville, Sogand Sajedi, Alessandra Ferrajoli, Jan A. Burger, Michael J. Keating, Naveen Garg, Qing Deng, Michael R. Green, Hussein A. Abbas, William G. Wierda, Nitin Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1014.
https://doi.org/10.1182/blood-2024-206306
Published: 2024
Journal Articles

Phase II Trial of Axicabagene Ciloleucel and Glofitamab As Second-Line Therapy for Patients with Relapsed or Refractory Large B-Cell Lymphoma

Free
Kunhwa Kim, Dai Chihara, Luis E. Fayad, Sattva S. Neelapu, Sairah Ahmed, Frederick Hagemeister, Chijioke Nze, Swaminathan P Iyer, Preetesh Jain, Michael Wang, Paolo Strati, Fateeha Furqan, Ayushi Chauhan, Michael R. Green, Christopher R. Flowers, Jason R. Westin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4511.1.
https://doi.org/10.1182/blood-2024-205196
Published: 2024
Journal Articles

Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

Free
Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori Kregar, C. Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Stanley Ng, George S Vassiliou, Kate Gowers, Sam Janes, Matt Hoare, Anthony R Green, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Inigo Martincorena, Michael Stratton, Jyoti Nangalia, Tim H.H. Coorens, Peter Campbell
Journal: Blood
Blood (2024) 144 (Supplement 1): 2673.
https://doi.org/10.1182/blood-2024-208773
Published: 2024
Journal Articles

Comprehensive Characterization and Validation of the Tumor Microenvironment in Patients with Relapsed/Refractory Large B-Cell Lymphoma Identifies Subgroups with Greatest Benefit from CD19 CAR T-Cell Therapy

Free
Xubin Li, Kartik Singhal, Qing Deng, Dai Chihara, David A Russler-Germain, Usama Hussein, Jennifer Ann Foltz, Jared Henderson, Ashley Wilson, Evelyn Schmidt, Imran A. Nizamuddin, Tommy Dinh, Ryan Sun, Akhil Kesaraju, Laura K. Hilton, David W. Scott, Francisco Vega, Christopher R. Flowers, Obi Griffith, Todd A Fehniger, Malachi Griffith, Michael R. Green
Journal: Blood
Blood (2024) 144 (Supplement 1): 643.
https://doi.org/10.1182/blood-2024-204166
Published: 2024
Journal Articles

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle

Free
Carys S. Johnson, Matthew Williams, Kendig Sham, Serena Belluschi, Wenjuan Ma, Xiaonan Wang, Winnie W. Y. Lau, Kerstin B. Kaufmann, Gabriela Krivdova, Emily F. Calderbank, Nicole Mende, Jessica McLeod, Giovanna Mantica, Juan Li, Charlotte Grey-Wilson, Michael Drakopoulos, Shaaezmeen Basheer, Shubhankar Sinha, Evangelia Diamanti, Christina Basford, Nicola K. Wilson, Steven J. Howe, John E. Dick, Berthold Göttgens, Anthony R. Green, Natalie Francis, Elisa Laurenti
Journal: Blood
Blood (2024) 144 (7): 729–741.
https://doi.org/10.1182/blood.2023021426
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes in Patients with Relapsed Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Treated with CAR-T Cell Therapies or Salvage Chemotherapy - a Single-Institution Experience

Free
Ranjit Nair, Iyanuoluwa Ogundipe, Jillian Gunther, L. Jeffrey Medeiros, Preetesh Jain, Loretta J. Nastoupil, Chelsea Camille Pinnix, Luis Malpica, Sairah Ahmed, Roberto Miranda, Luis Fayad, Raphael E Steiner, Frederick Hagemeister, Hun Ju Lee, Maria Alma Rodriguez, Paolo Strati, Dai Chihara, Michael Wang, Yago Nieto, Jeremy Ramdial, Ajlan Al Zaki, Chijioke Nze, Michael R. Green, Bouthaina S. Dabaja, Jie Xu, Beenu Thakral, Sattva S. Neelapu, Francisco Vega, Christopher R. Flowers, Penny Fang, Jason Westin, Lei Feng, Swami P. Iyer
Journal: Blood
Blood (2023) 142 (Supplement 1): 6327.
https://doi.org/10.1182/blood-2023-191096
Published: 2023
Journal Articles

Polygenic Germline Risk of Common Haematological Traits Drives Clonal Selection on JAK2 V617F and Development of Myeloproliferative Neoplasms

Free
Jyoti Nangalia, Jing Guo, Klaudia Walter, Pedro Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George Vassiliou, Dragana Vuckovic, Nicole Soranzo
Journal: Blood
Blood (2023) 142 (Supplement 1): 863.
https://doi.org/10.1182/blood-2023-189551
Published: 2023
Journal Articles

Initial Clinical Results and Immune Correlates of a Phase 2 Study of Daratumumab, Bortezomib, Dexamethasone Followed By a Proteasome Inhibitor in -Class Transition ( i CT) to Daratumumab, Ixazomib, Dexamethasone in Relapsed Refractory Multiple Myeloma

Free
Hans C. Lee, June Li, Heather Lin, Astrid D. Murga, Gabriela M Rodriguez, Mostafa E. Mohamed, Jared Henderson, Sarah Rodriguez, Melody R. Becnel, Donna M. Weber, Swami P. Iyer, Gregory P. Kaufman, Sheeba K. Thomas, Elisabet E. Manasanch, Krina K. Patel, Stephen J. Noga, Michael R. Green, Robert Z. Orlowski, Cara L Haymaker
Journal: Blood
Blood (2023) 142 (Supplement 1): 4760.
https://doi.org/10.1182/blood-2023-188201
Published: 2023
Journal Articles

Smart Stop: Lenalidomide, Tafasitamab, Rituximab, and Acalabrutinib Alone and with Combination Chemotherapy for the Treatment of Newly Diagnosed Diffuse Large B-Cell Lymphoma

Free
Jason Westin, Raphael E Steiner, Dai Chihara, Sairah Ahmed, Preetesh Jain, Luis Malpica, Swami P. Iyer, Luis Fayad, Ranjit Nair, Loretta J. Nastoupil, Sattva S. Neelapu, Jared Henderson, Maria Alma Rodriguez, F. B. Hagemeister, Francisco Vega, Brittani Pulsifer, Jisha Tom, Isak Durmic, Gita Masand, Lei Feng, Michael R. Green, Christopher R. Flowers, Paolo Strati
Journal: Blood
Blood (2023) 142 (Supplement 1): 856.
https://doi.org/10.1182/blood-2023-180381
Published: 2023
Journal Articles

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Free
Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Christopher Ly, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Nicole Vaugh, Natalia Baran, Qing Deng, Jairo Matthews, Preethi Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Y. Konopleva, Andy Futreal, Sean M. Post, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2796.
https://doi.org/10.1182/blood-2023-175010
Published: 2023
Journal Articles

SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Key Transcription Factors in B Cells and Restricts Aggressive Lymphoma

Free
Darko Barisic, Christopher Chin, Cem Meydan, Matthew Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Min Xia, Christian Steidl, David W. Scott, Andrew P. Weng, Christopher Mason, Michael R. Green, Ari M Melnick
Journal: Blood
Blood (2023) 142 (Supplement 1): 718.
https://doi.org/10.1182/blood-2023-190494
Published: 2023
Journal Articles

Iron homeostasis governs erythroid phenotype in polycythemia vera

Free
Cavan Bennett, Victoria E. Jackson, Anne Pettikiriarachchi, Thomas Hayman, Ute Schaeper, Gemma Moir-Meyer, Katherine Fielding, Ricardo Ataide, Danielle Clucas, Andrew Baldi, Alexandra L. Garnham, Connie S. N. Li-Wai-Suen, Stephen J. Loughran, E. Joanna Baxter, Anthony R. Green, Warren S. Alexander, Melanie Bahlo, Kate Burbury, Ashley P. Ng, Sant-Rayn Pasricha
Journal: Blood
Blood (2023) 141 (26): 3199–3214.
https://doi.org/10.1182/blood.2022016779
Published: 2023
Includes: Supplemental data