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Journal Articles

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging

Open Access
Wen-Yan Cheng, Xiao Yi, Zhen-Yi Wang, Jian-Feng Li, Jun-Yi Zhang, Rui-Hong Zhang, Qian-Qian Zhang, Xiang-Qin Weng, Ting Huang, Yong-Mei Zhu, Chao Wang, Wei Yin, Jia-Nan Zhang, Hui-Yi Wu, Jun-Min Li, Hong-Ming Zhu, Li Chen, Wen-Fang Wang, Yu-Ting Dai, Chen-Xu Gao, Xuan Liu, Shan Wang, Sheng-Yue Wang, Bo Jiao, Zhu Chen, Hai Fang, Tong Yin, Yang Shen, Sai-Juan Chen
Journal: Blood
Blood (2025) 146 (22): 2681–2695.
https://doi.org/10.1182/blood.2024027692
Published: 2025
Includes: Supplemental data
Journal Articles

Simvastatin targets the cholesterol–bile acid axis to improve ALL survival by remodeling the metabolic microenvironment

Free
Junyu Wang, Bo Jiao, Tuantuan Gui, Xuan Liu, Shan-Shan Guo, Cheng Wang, Weiyang Liu, Li-Jun Peng, Jiayi Ren, Ming Zhang, Yun Tan, Duohui Jing, Jian-Qing Mi, Tong Yin, Hai Fang, Sai-Juan Chen, JIN WANG
Journal: Blood
Blood (2025) 146 (Supplement 1): 3362.
https://doi.org/10.1182/blood-2025-3362
Published: 2025
Journal Articles

The efficacy and safety of venetoclax and azacitidine combined with granulocyte-colony stimulating factor in the treatment of Acute Myeloid Leukemia

Free
Xiaotian Yang, Juan Chen, Ziyi Hao, Yejun Si, Xingxia Zhang, Guoqiang Lin, Bing Zhang, Li Wang, Yan Wan, Sailan Huang, Huiran Jiang, Yanming Zhang
Journal: Blood
Blood (2025) 146 (Supplement 1): 6970.
https://doi.org/10.1182/blood-2025-6970
Published: 2025
Journal Articles

The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis

Available to Purchase
Wenting Zhao, Peina Wang, Zhengxun Liu, Dongyuan Zhang, Yi Xia, Teng Xu, Fei Wang, Mingyang Cui, Xu Zhang, Shuaishuai Zhou, Zhixi Wei, Min Ma, Sitong Wan, Jingyi Qi, Zhengyang Zhang, Juan Chen, Libing Liu, Yinhua Zhu, Junjie Luo, Yongting Luo, Peng An
Journal: Blood
Blood (2025) 146 (14): 1722–1736.
https://doi.org/10.1182/blood.2025028454
Published: 2025
Includes: Supplemental data
Journal Articles

The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice

Available to Purchase
Weiqing Jing, Jocelyn A. Schroeder, Saurabh Kumar, Juan Chen, Yuanhua Cai, Lynn M. Malec, Alexander L. Dent, Weiguo Cui, Qizhen Shi
Journal: Blood
Blood (2025) 146 (8): 998–1010.
https://doi.org/10.1182/blood.2025029470
Published: 2025
Includes: Supplemental data
Journal Articles

VA Combined with Mbucy Conditioning Regimen Followed By Allo-HSCT Can Improve Survival of High-Risk AML Patients: A Prospective, Single-Center, Single-Arm Clinical Trial

Free
Wei Cui, Xiaoqian Chen, Qingya Cui, Zheng Li, Sifan Chen, Mengyun Li, Xuekai Li, Juan Chen, Yan Yu, Depei Wu, Xiaowen Tang
Journal: Blood
Blood (2024) 144 (Supplement 1): 3493.
https://doi.org/10.1182/blood-2024-207083
Published: 2024
Journal Articles

Safety and Efficacy of VA Combined with Modified BuCy Conditioning Regimen Followed By Allo-HSCT for High-Risk or Refractory/Relapsed Acute Lymphoblastic Leukemia : A Prospective, Single-Center, Single-Arm Clinical Trial

Free
Xiaoqian Chen, Wei Cui, Qingya Cui, Zheng Li, Sifan Chen, Mengyun Li, Xuekai Li, Juan Chen, Yan Yu, Xin Zhang, Depei Wu, Xiaowen Tang
Journal: Blood
Blood (2024) 144 (Supplement 1): 270.
https://doi.org/10.1182/blood-2024-209163
Published: 2024
Journal Articles

Bird Regimen Followed By Anti-BCMA CAR T-Cell Immunotherapy As First-Line Therapy for Newly Diagnosed Multiple Myeloma: A Prospective, Single-Arm, Phase 3 Trial

Free
Yue Zhou, Juan Chen, Qingya Cui, Haiping Dai, Zheng Li, Jia Yin, Wei Cui, Mengyun Li, Xuekai Li, Xin Zhang, Feiran Gong, Xiaming Zhu, Liqing Kang, Lei Yu, Depei Wu, Xiaowen Tang
Journal: Blood
Blood (2024) 144 (Supplement 1): 3384.
https://doi.org/10.1182/blood-2024-199119
Published: 2024
Journal Articles

Chemotherapy-Free Induction with Venetoclax and Azacitidine, Followed By Tandem CD19/CD22 CAR-T Cell Therapy As First-Line Treatment in Newly Diagnosed High-Risk Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Prospective, Single-Center, Single-Arm, Phase 2 Trial

Free
Mengyun Li, Qingya Cui, Xuekai Li, Wei Cui, Xiaoqian Chen, Yan Yu, Juan Chen, Xin Zhang, Liqing Kang, Lei Yu, Depei Wu, Xiaowen Tang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4197.
https://doi.org/10.1182/blood-2024-207017
Published: 2024
Journal Articles

How to Improve the Efficacy of Venetoclax and Azacitidine（VA）for Newly Diagnosed Acute Myeloid Leukemia？a Prospective, Single-Center, Single-Arm, Phase 2 Trial for New Diagnosed AML

Free
Xuekai Li, Mengyun Li, Wei Cui, Xiaoqian Chen, Yan Yu, Juan Chen, Xin Zhang, Qingya Cui, Depei Wu, Xiaowen Tang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4284.
https://doi.org/10.1182/blood-2024-208981
Published: 2024
Journal Articles

SUMO E3 Ligase ZMIZ1 Drives Leukemogenesis Via Transcriptional Deregulation in Acute Myeloid Leukemia

Free
Fu Ziyu, Yun Tan, Xiaoguang Xu, Jie Xu, Sai-Juan Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4134.
https://doi.org/10.1182/blood-2023-187978
Published: 2023
Journal Articles

Metabolomic Insights into the Pathogenesis and Prognostic Potential of Adult Acute Lymphoblastic Leukemia

Free
Junyu Wang, Tuantuan Gui, Tong Yin, Yuting Dai, Jing Qiao, Jianfeng Li, Jie Xu, Yuanfang Liu, Yan Wang, Yun Tan, Bo Jiao, Yongmei Zhu, Zhu Chen, Wenlian Chen, Hai Fang, Jian Hou, Jian-Qing Mi, Jin Wang, Sai-Juan Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2971.
https://doi.org/10.1182/blood-2023-184328
Published: 2023
Journal Articles

The Tfh/Tfr Pathway Is Pivotal in FVIII Inhibitor Development in Mice

Free
Weiqing Jing, Jocelyn Schroeder, Juan Chen, Yuanhua Cai, Saurabh Kumar, Alexander Dent, Qizhen Shi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3971.
https://doi.org/10.1182/blood-2023-180998
Published: 2023
Journal Articles

Recommendations on Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Combination of All- Trans Retinoic Acid and Arsenic Trioxide

Free
Li Chen, Hongming Zhu, Fangyi Dong, Yan Li, Qifa Liu, Yu Hu, Yicheng Zhang, Jie Jin, Jianda Hu, Ting Liu, Depei Wu, Jieping Chen, Yongrong Lai, Jianxiang Wang, Juan Li, Jianyong Li, Xin Du, Xin Wang, Mingzhen Yang, Jinsong Yan, Guifang Ouyang, Li Liu, Ming Hou, Xiaojun Huang, Wen Jin, Yongmei Zhu, Jian Li, Kankan Wang, Zhu Chen, Sai-Juan Chen, Junmin Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 2946.
https://doi.org/10.1182/blood-2023-184433
Published: 2023
Journal Articles

Phase 2, Open-Label Study of Ciltacabtagene Autoleucel, an Anti-BCMA CAR-T Cell Therapy, in Chinese Patients with Relapsed/Refractory Multiple Myeloma (CARTIFAN-1): 26-Month Median Follow-up

Free
Jian-Qing Mi, Wanhong Zhao, Hongmei Jing, Weijun Fu, Jianda Hu, Lijuan Chen, Yiwen Zhang, Dan Yao, Hui Li, Jordan M Schecter, Fan Yang, Huabin Sun, Sen Hong Zhuang, Da Xu, Tracy Luo, Xiaohu Fan, Ting Niu, Jie Jin, Sai-Juan Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 7542–7544.
https://doi.org/10.1182/blood-2022-159185
Published: 2022
Journal Articles

Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion

Open Access
Ming Zhang, Hao Zhang, Zhihui Li, Ling Bai, Qianqian Wang, Jianfeng Li, Minghao Jiang, Qing Xue, Nuo Cheng, Weina Zhang, Dongdong Mao, Zhiming Chen, Jinyan Huang, Guoyu Meng, Zhu Chen, Sai-Juan Chen
Journal: Blood
Blood (2022) 140 (12): 1390–1407.
https://doi.org/10.1182/blood.2022016241
Published: 2022
Includes: Supplemental data
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Free
Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

Platelet-Targeted Gene Therapy Induces Robust Immune Tolerance Even in a Primed Model Via Peripheral Clonal Deletion of CD4 and CD8 T Cells and Expansion of Treg Cells

Free
Jing Li, MD PhD, Juan Chen, PhD, Jocelyn A. Schroeder, Qizhen Shi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2.
https://doi.org/10.1182/blood-2020-140851
Published: 2020
Journal Articles

SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS

Free
CME
Bing-Yi Chen, Junhong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, Na Liu, Peng-Cheng Yu, Ping Liu, Li-Juan Zong, Jia-Ying Zhang, Ruo-Fei Dai, Fei Lan, Qiu-Hua Huang, Su-Jiang Zhang, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Lan Wang
Journal: Blood
Blood (2020) 135 (25): 2271–2285.
https://doi.org/10.1182/blood.2019001963
Published: 2020
Includes: Supplemental data
Journal Articles

Induction of Activated T Follicular Helper Cells Is Critical for Anti-FVIII Inhibitor Development in Hemophilia a Mice

Free
Weiqing Jing, MD PhD, Juan Chen, PhD, Yuanhua Cai, MD, Yingyu Chen, PhD, Jocelyn A. Schroeder, Weiguo Cui, MD PhD, Qizhen Shi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 92.
https://doi.org/10.1182/blood-2019-123777
Published: 2019