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Volume 95, Issue 9

May 1 2000

In this Issue

PLENARY PAPERS
ERRATA
PERSPECTIVES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
PHOTOGRAPHS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
BRIEF REPORTS
CORRESPONDENCE
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PLENARY PAPERS

Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506

David Peters,Masahiro Tsuchida,Eric R. Manthei,Tausif Alam,Clifford S. Cho,Stuart J. Knechtle,Majed M. Hamawy

View Articletitled, Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506

Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells

Cristina Sanz,Adalberto Benito,Naohiro Inohara,Daryoush Ekhterae,Gabriel Nunez,Jose Luis Fernandez-Luna

View Articletitled, Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells

Role of SUMO-1–modified PML in nuclear body formation

Sue Zhong,Stefan Müller,Simona Ronchetti,Paul S. Freemont,Anne Dejean,Pier Paolo Pandolfi

View Articletitled, Role of SUMO-1–modified PML in nuclear body formation

ERRATA

Erratum in Tournamille et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92:2147-2156.

View Articletitled, Erratum in Tournamille et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92:2147-2156.

PERSPECTIVES

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
Clinical Trials & Observations

Geoffrey R. Hill,James L. M. Ferrara

View Articletitled, The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation

CHEMOKINES

HTLV-II down-regulates HIV-1 replication in IL-2–stimulated primary PBMC of coinfected individuals through expression of MIP-1α

Claudio Casoli,Elisa Vicenzi,Andrea Cimarelli,Giacomo Magnani,Paolo Ciancianaini,Ercole Cattaneo,PierPaolo Dall'Aglio,Guido Poli,Umberto Bertazzoni

View Articletitled, HTLV-II down-regulates HIV-1 replication in IL-2–stimulated primary PBMC of coinfected individuals through expression of MIP-1α

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy
Clinical Trials & Observations

Lutz Löning,Martin Zimmermann,Alfred Reiter,Peter Kaatsch,Günter Henze,Hansjörg Riehm,Martin Schrappe

View Articletitled, Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy

Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload
Clinical Trials & Observations

Massimo Franchini,Giorgio Gandini,Marzia de Gironcoli,Aurora Vassanelli,Caterina Borgna-Pignatti,Giuseppe Aprili

View Articletitled, Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
Clinical Trials & Observations

José Manuel Soria,Laura Almasy,Juan Carlos Souto,Isabel Tirado,Montserrat Borell,José Mateo,Susan Slifer,William Stone,John Blangero,Jordi Fontcuberta

View Articletitled, Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis

Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features
Clinical Trials & Observations

Francesca R. Mauro,Robert Foa,Raffaella Cerretti,Diana Giannarelli,Serelina Coluzzi,Franco Mandelli,Gabriella Girelli

View Articletitled, Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features

PHOTOGRAPHS

Photograph

View Articletitled, Photograph

GENE THERAPY

Improvement of erythropoiesis in β-thalassemic mice by continuous erythropoietin delivery from muscle

Delphine Bohl,Assumpció Bosch,Ana Cardona,Anna Salvetti,Jean Michel Heard

View Articletitled, Improvement of erythropoiesis in β-thalassemic mice by continuous erythropoietin delivery from muscle

Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin

Steven S. Fakharzadeh,Yue Zhang,Rita Sarkar,Haig H. Kazazian, Jr

View Articletitled, Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin

HEMATOPOIESIS

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α

Steven F. A. Weekx,Hans W. Snoeck,Fritz Offner,Magda De Smedt,Dirk R. Van Bockstaele,Griet Nijs,Marc Lenjou,Adriaan Moulijn,Inez Rodrigus,Zwi N. Berneman,Jean Plum

View Articletitled, Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α

Isolation and characterization of human CD34⁻Lin⁻ and CD34⁺Lin⁻ hematopoietic stem cells using cell surface markers AC133 and CD7

Lisa Gallacher,Barbara Murdoch,Dongmei M. Wu,Francis N. Karanu,Mike Keeney,Mickie Bhatia

View Articletitled, Isolation and characterization of human CD34−Lin− and CD34+Lin− hematopoietic stem cells using cell surface markers AC133 and CD7

Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors

Tatsuya Kinoshita,Kenichi Koike,Hadija Hemed Mwamtemi,Susumu Ito,Shuichi Ishida,Yozo Nakazawa,Yumi Kurokawa,Kazuo Sakashita,Tsukasa Higuchi,Kouichi Takeuchi,Nobukuni Sawai,Masaaki Shiohara,Takehiko Kamijo,Shigeyuki Kawa,Tetsuji Yamashita,Atsushi Komiyama

View Articletitled, Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors

Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells

Stephen J. Szilvassy,Todd E. Meyerrose,Barry Grimes

View Articletitled, Effects of cell cycle activation on the short-term engraftment properties of ex vivo expanded murine hematopoietic cells

REDK, a novel human regulatory erythroid kinase

Kenneth A. Lord,Caretha L. Creasy,Andrew G. King,Caroline King,Brian M. Burns,John C. Lee,Susan B. Dillon

View Articletitled, REDK, a novel human regulatory erythroid kinase

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

Kohshi Ohishi,Barbara Varnum-Finney,David Flowers,Claudio Anasetti,David Myerson,Irwin D. Bernstein

View Articletitled, Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis

Nico H. van Tilburg,Frits R. Rosendaal,Rogier M. Bertina

View Articletitled, Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis

IMMUNOBIOLOGY

Shortage of circulating naive CD8⁺ T cells provides new insights on immunodeficiency in aging

Francesco F. Fagnoni,Rosanna Vescovini,Giovanni Passeri,Giovanni Bologna,Mario Pedrazzoni,Giampaolo Lavagetto,Amos Casti,Claudio Franceschi,Mario Passeri,Paolo Sansoni

View Articletitled, Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

Role of IL-16 in delayed-type hypersensitivity reaction

Takayuki Yoshimoto,Chrong-Reen Wang,Toshihiko Yoneto,Akio Matsuzawa,William W. Cruikshank,Hideo Nariuchi

View Articletitled, Role of IL-16 in delayed-type hypersensitivity reaction

Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells

Janne Komi,Olli Lassila

View Articletitled, Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells

Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas

Nadia Guerra,Maryvonne Guillard,Eric Angevin,Hamid Echchakir,Bernard Escudier,Alessandro Moretta,Salem Chouaib,Anne Caignard

View Articletitled, Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas

Defensins are dominant HLA-DR-associated self-peptides from CD34⁻ peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia)

Thomas M. Halder,Martin Blüggel,Susanne Heinzel,Graham Pawelec,Helmut E. Meyer,Hubert Kalbacher

View Articletitled, Defensins are dominant HLA-DR-associated self-peptides from CD34− peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia)

NEOPLASIA

P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway

Monica Pallis,Nigel Russell

View Articletitled, P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway

Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells

Francesca Pica,Antonio Volpi,Annalucia Serafino,Marzia Fraschetti,Ornella Franzese,Enrico Garaci

View Articletitled, Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Robert C. Quackenbush,Gary W. Reuther,Juli P. Miller,Kevin D. Courtney,Warren S. Pear,Ann Marie Pendergast

View Articletitled, Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load

Wilhelmina M. Aarts,Richard J. Bende,Eric J. Steenbergen,Philip M. Kluin,Engelbert C. M. Ooms,Steven T. Pals,Carel J. M. van Noesel

View Articletitled, Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load

MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma

Frédéric Gilles,André Goy,Yvonne Remache,Peter Shue,Andrew D. Zelenetz

View Articletitled, MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma

Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN

Julia J. Scarisbrick,Alison J. Woolford,Robin Russell-Jones,Sean J. Whittaker

View Articletitled, Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN

PHAGOCYTES

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

Roberto Lorenzi,Paul M. Brickell,David R. Katz,Christine Kinnon,Adrian J. Thrasher

View Articletitled, Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia

Brigitte Kasper,Nicola Tidow,Dirk Grothues,Karl Welte

View Articletitled, Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia

Importance of L-selectin–dependent leukocyte–leukocyte interactions in human whole blood

Debra J. Mitchell,Pauline Li,Paul H. Reinhardt,Paul Kubes

View Articletitled, Importance of L-selectin–dependent leukocyte–leukocyte interactions in human whole blood

RED CELLS

Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H₂O₂

Pawel Lipiński,Jean-Claude Drapier,Leonor Oliveira,Hanna Retmańska,Barbara Sochanowicz,Marcin Kruszewski

View Articletitled, Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H2O2

Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta

Ralph M. Bohmer,Thomas A. Campbell,Diana W. Bianchi

View Articletitled, Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta

The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation

William Breuer,Aharon Ronson,Itzchak N. Slotki,Ayala Abramov,Chaim Hershko,Z. Ioav Cabantchik

View Articletitled, The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation

TRANSFUSION MEDICINE

Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans

Petra Jilma Stohlawetz,Larisa Dzirlo,Nicole Hergovich,Edith Lackner,Christa Mensik,Hans Georg Eichler,Eva Kabrna,Klaus Geissler,Bernd Jilma

View Articletitled, Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans

BRIEF REPORTS

Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications
Brief Report

TuDung T. Nguyen,Ann F. Mohrbacher,Yvonne C. Tsai,John Groffen,Nora Heisterkamp,Peter W. Nichols,Mimi C. Yu,Michael Lübbert,Peter A. Jones

View Articletitled, Quantitative measure of c-abl andp15 methylation in chronic myelogenous leukemia: biological implications

CORRESPONDENCE

Normal T, B, and NK cell counts in healthy donors at 1 year after blood stem cell harvesting

Jan Storek,Monja A. Dawson,David G. Maloney

View Articletitled, Normal T, B, and NK cell counts in healthy donors at 1 year after blood stem cell harvesting

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Donor lymphocyte infusions for CML: possible effects of age and mobilization
Clinical Trials & Observations

Vijay Reddy,Jan Moreb,Paulette Mehta

View Articletitled, Donor lymphocyte infusions for CML: possible effects of age and mobilization

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Benzene and multiple myeloma: appraisal of the scientific evidence

Daniel Thau Teitelbaum,Nachman Brautbar,Myron Mehlman,Joseph LaDou

View Articletitled, Benzene and multiple myeloma: appraisal of the scientific evidence

DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology?

Anni Aggerholm,Peter Hokland,Per Guldberg

View Articletitled, DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology?

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Issue Archive

Table of Contents

PLENARY PAPERS

ERRATA

PERSPECTIVES

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation Clinical Trials & Observations

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy Clinical Trials & Observations

Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload Clinical Trials & Observations

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis Clinical Trials & Observations

Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features Clinical Trials & Observations