The recent paper by Bergsagel et al raised questions of scope, content, and provenance.1 Goldstein and Shalat have addressed many of the issues of scope and content in their review, and a response to their letter has been received from the authors of the paper.2 We will not address those issues again. However, the issue of the article's provenance has not been addressed, and it is to that provenance we now turn.

When the Bergsagel review was published, one of us wrote to the editor to ask what the source of funding for this paper might have been. The editor responded at that time that since Blood did not have a policy that required financial disclosure, he had no information on the source or sources of funding for the paper. He recommended that we write the authors to obtain this information. Two letters to the authors went unanswered. Further inquiry to the editor provided welcome assurance that Blood's editorial policy had been changed [New policy follows the response to this letter—Ed]. Blood will require financial disclosure in the future. However, the policy could not fairly be applied retroactively. Because the provenance of the Bergsagel paper remained at issue, the editor invited a letter to encourage the authors to provide the financial support information.

In the interim, we have learned that the Bergsagel paper was prepared in support of litigation in which the causality of multiple myeloma by benzene was at issue.3 Two of the authors have published a series of papers for this purpose over the past years.4-7One is an employee of a major petrochemical company, and the other an epidemiologist whose work on behalf of the petrochemical industries is well known. In a sworn deposition in the litigation at issue, Professor Bergsagel testified as follows: Q.  What precipitated Dr Wong contacting you to co-author an article, if you know? R.  Yes I do know. We were both retained as expert witnesses by James Galbraith of Galveston, Texas in a litigation case of Donald Ballard versus Amoco. That case never came to trial. But Mr Galbraith wanted us to collaborate with three other hematologists and create a consensus statement, and so we began the article as a consensus statement for that case. Q.  Did Mr Galbraith ask you to publish your consensus statement? R.  Well the case was settled before we got the consensus statement published. And I asked him if he would mind if we were to develop this statement into an article that could be published in a hematology journal, and he encouraged me to do that. Q. And Mr Galbraith represented? R. He represented Amoco. Q. A petroleum company? R. That's correct.8 

Clearly, the current paper was litigation-driven. While this provenance does not in and of itself invalidate the authors' findings, which will stand or fall on their internal consistency and conclusions, it does raise questions of fairness, which should be addressed by the authors themselves. Scientific testimony in court is offered on behalf of one side or another, and it does not represent consensus, but rather the opinion of the expert or experts involved. That opinion testimony is subject to the trial protections of cross-examination. However, the publication of a review article in a journal does not undergo such cross-examination. Without vigorous debate, subsequent letters and responses, and the editor's good will and desire for fairness, as in this instance, such a litigation-support document that was prepared to further a particular point of view, published in a respected peer-reviewed journal like Blood, might improperly enter the literature as authoritative. Salting the literature in this fashion does not help to further scientific knowledge.

We applaud the willingness of Bergsagel et al to enter into the courtroom debate on the hematopoietic consequences of benzene exposure. We hope that, if they continue to participate in this process and continue to write about it, they will make their editors, reviewers, and readers aware of the provenance of their work.

Teitelbaum et al question the provenance of our recent review article on benzene exposure and multiple myeloma.1-1 Since their comments were addressed primarily to 2 of the authors, the undersigned have consulted the others, and they have agreed that it would be appropriate for us to respond.

Teitelbaum et al are correct in stating that we were retained as experts in a legal case involving benzene exposure and multiple myeloma (Fannin vs Norfolk and Western Railway Co). However, we have been engaged in research on multiple myeloma and benzene and have published on the subject long before our involvement in the Fannin case. Furthermore, what Teitelbaum et al do not reveal in their letter is the fact that they are very active in working with attorneys in litigation themselves. Similarly, both Goldstein and Shalat work with attorneys in litigation matters as well.

As to the provenance of the review article, although individually we have previously published articles on different aspects (clinical vs epidemiological) of benzene and multiple myeloma, we felt there was a need for a more comprehensive review paper on the subject. Many new scientific investigations (particularly epidemiological studies) on benzene and multiple myeloma have been published during the last 2 decades, but the results have not been summarized in any review. This lack of an up-to-date review was clear to us while we were reviewing the literature 4 or 5 years ago. In spite of the recent studies, some “experts” still base their opinions solely on outdated case reports. Mr Galbraith (an attorney) suggested that we might consider writing a comprehensive review. We agreed that such a review was needed. To ensure the scientific quality of our review, we enlisted several other scientists in hematology, oncology, and epidemiology as coauthors. Our review represented a consensus of all the authors of the article. Furthermore, the article was also subjected to the rigorous peer-review process required by Blood. The review was based on our own research over the years as well as our assessment of the pertinent literature over the last 2 decades. The preparation of the review was not funded by any party. Even the cost of the reprints was paid by us personally.

In our review1-1 and our response to Goldstein and Shalat,1-2 our assessment of the relationship between benzene exposure and multiple myeloma was based on scientific data (in particular, recent epidemiological studies). Neither Goldstein and Shalat1-3 nor Teitelbaum et al have offered any scientific data to counter our argument. In particular, they have not offered even one epidemiological study that demonstrates a causal relationship between benzene exposure and multiple myeloma. Causation assessment of chronic diseases such as multiple myeloma, whether in the medical or legal context, should be based on scientific data. Likewise, expert opinions should be based on the most up-to-date scientific data as well.

References

1-1
Bergsagel
 
DE
Wong
 
O
Bergsagel
 
PL
et al
Benzene and multiple myeloma: appraisal of the scientific evidence.
Blood
94
1999
1174
1182
1-2
Bergsagel
 
DE
Wong
 
O
Bergsagel
 
PL
et al
Benzene and multiple myeloma: scientific evidence [letter].
Blood.
95
2000
1513
1514
1-3
Goldstein
 
BD
Shalat
 
SL
The causal relationship between benzene exposure and multiple myeloma [letter].
Blood.
95
2000
1512
1513

Note: Prior to receiving Teitelbaum et al's letter and Bergsagel et al's response, the Editorial Board of Bloodinitiated a new policy requiring disclosure of any significant financial interests in subjects covered in the text of published papers in the Journal. This policy is stated in the Author Guide of this and other issues of Blood. However, this disclosure policy was not in place at the time of writing of the review “Benzene and multiple myeloma,” which has prompted the above exchange of letters.—Editor

1
Bergsagel
 
DE
Wong
 
O
Bergsagel
 
PL
et al
Benzene and multiple myeloma: Appraisal of the scientific evidence.
Blood.
94
1999
1174
1182
2
Goldstein
 
BD
Shalat
 
SL
The causal relationship between benzene exposure and multiple myeloma [letter].
Blood.
95
2000
1512
1513
3
Fannin v. Norfolk & Western Railway Co, USDC ND Ohio: Case No. 5:93-CV-2594 (1997).
4
Wong
 
O
Raabe
 
GK
Acute myeloid and monocytic leukaemia and benzene exposure in petroleum distribution workers in the United Kingdom [letter].
Occup Environ Med.
55
1998
360
361
5
Wong
 
O
Raabe
 
GK
Multiple myeloma and benzene exposure in a multina-tional cohort of more than 250,000 petroleum workers.
Regul Toxicol Pharmacol.
26
1997
188
199
6
Wong
 
O
Trent
 
L
Harris
 
F
Nested case-control study of leukaemia, multiple myeloma, and kidney cancer in a cohort of petroleum workers exposed to gasoline.
Occup Environ Med.
56
1999
217
221
7
Raabe
 
GK
Collingwood
 
KW
Wong
 
O
An updated mortality study of workers at a petroleum refinery in Beaumont, Texas.
Am J Ind Med.
33
1998
61
81
8
Fannin v. Norfolk & Western Railway Co, USDC ND Ohio: Case No. 5:93-CV-2594 at 12(22) (1997).
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