Issue Archive

Molecular models of human ADAMTS13 domains are fitted into an envelope determined by small angle X-ray scattering and colored as follows: metalloprotease (M, orange); disintegrin-like (D, yellow); thrombospondin-1 (T1, green); Cys-rich (C, sky blue); spacer (S, lavender); T2, T4, T5, T7, and T8 (green); T3 and T6 (yellow); linkers between T4 and T5 (T4L) and between T8 and CUBs (T8L, gray); CUB1 (red); and CUB2 (brick red). The intervening nonessential T domains extend like a hairpin away from the core MDTCS and T7-CUB domains with a hinge between T4 and T5 that allows close packing of T domains. Two studies in this issue independently report critical insights into the structure and function of ADAMTS13. For the source of this issue's cover image, see the article by Zhu et al on page 1909.