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Journal Articles

Regulation of VWF Cleavage Is Mediated By Coupling ADAMTS13 D- and C- Domain Binding Sites

Joshua Muia, J. Cameron Barton, Kathryn L Smith, Karen Vanhoorelbeke, Veera V Manukonda, Anna Platt, Frida Miranda
Journal: Blood
Blood (2022) 140 (Supplement 1): 5580–5581.
https://doi.org/10.1182/blood-2022-168339
Published: 2022
Journal Articles

Adjuvant low-dose rituximab and plasma exchange for acquired TTP

Jeffrey I. Zwicker, Joshua Muia, Leili Dolatshahi, Lisa A. Westfield, Patricia Nieters, Anita Rodrigues, Ayad Hamdan, Ana G. Antun, Ara Metjian, J. Evan Sadler
Journal: Blood
Blood (2019) 134 (13): 1106–1109.
https://doi.org/10.1182/blood.2019000795
Published: 2019
Includes: Supplemental data
Journal Articles

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Joshua Muia, Jian Zhu, Suellen C. Greco, Karen Vanhoorelbeke, Garima Gupta, Lisa A. Westfield, J. Evan Sadler
Journal: Blood
Blood (2019) 133 (17): 1899–1908.
https://doi.org/10.1182/blood-2018-11-886275
Published: 2019
Includes: Supplemental data
Journal Articles

Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Jian Zhu, Joshua Muia, Garima Gupta, Lisa A. Westfield, Karen Vanhoorelbeke, Niraj H. Tolia, J. Evan Sadler
Journal: Blood
Blood (2019) 133 (17): 1909–1918.
https://doi.org/10.1182/blood-2018-11-886309
Published: 2019
Includes: Supplemental data
Journal Articles

Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency — Results of the ART Study

J. Evan Sadler, MD PhD, Joshua Muia, PhD, Leili Dolatshahi, MD, Lisa A. Westfield, MA, Patricia Nieters, RN, BSN, Anita Rodrigues, BA, Ana G. Antun, MD, Ara Metjian, MD, Jeffrey I. Zwicker, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 374.
https://doi.org/10.1182/blood-2018-99-113677
Published: 2018
Journal Articles

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

Joshua Muia, PhD, Jian Zhu, PhD, Suellen Greco, DVM, Karen Vanhoorelbeke, PhD, Louis Deforche, PhD, Lisa Westfield, Garima Tyagi, PhD, J. Evan Sadler, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1385.
https://doi.org/10.1182/blood.V128.22.1385.1385
Published: 2016
Journal Articles

The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering

Jian Zhu, PhD, Joshua Muia, PhD, Louis Deforche, PhD, Karen Vanhoorelbeke, PhD, Niraj H. Tolia, PhD, J. Evan Sadler, MD PhD
Journal: Blood
Blood (2016) 128 (22): 254.
https://doi.org/10.1182/blood.V128.22.254.254
Published: 2016
Journal Articles

A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains

Jian Zhu, PhD, Joshua Muia, PhD, Niraj H. Tolia, PhD, Lisa A Westfield, PhD, J. Evan Sadler, MD PhD
Journal: Blood
Blood (2014) 124 (21): 107.
https://doi.org/10.1182/blood.V124.21.107.107
Published: 2014
Journal Articles

An Optimized Fluorogenic Assay with Increased Sensitivity for ADAMTS13 Activity and Inhibitors for the Characterization of Patients with Thrombotic Thrombocytopenic Purpura,

Joshua Muia, Ph.D., Weiqiang Gao, MD, PhD, J. Evan Sadler, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3298.
https://doi.org/10.1182/blood.V118.21.3298.3298
Published: 2011
Journal Articles

Small-Angle X-Ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution

Jian Zhu, PhD, Joshua Muia, Ph.D., Joseph D. Batchelor, Ph.D., Bruce C. Linders, Niraj H. Tolia, Ph.D., J. Evan Sadler, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1191.
https://doi.org/10.1182/blood.V118.21.1191.1191
Published: 2011