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Issue Archive

Volume 132, Issue 12
September 20 2018
Issue Cover

Table of Contents

BLOOD COMMENTARIES

MYELOID NEOPLASIA
An RNA bestiary in splicing-mutant MDS
David P. Steensma
View Articletitled, An RNA bestiary in splicing-mutant MDS
Lymphoid Neoplasia
CRISPRing the CRL4CRBN RING in multiple myeloma
Paola Neri
View Articletitled, CRISPRing the CRL4<sup>CRBN</sup> RING in multiple myeloma
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
SRP54 and a need for a new neutropenia nosology
Usua Oyarbide,Seth J. Corey
View Articletitled, SRP54 and a need for a new neutropenia nosology
PLATELETS AND THROMBOPOIESIS
Platelets in malaria pathogenesis
Jamie M. O’Sullivan,James S. O’Donnell
View Articletitled, Platelets in malaria pathogenesis

PLENARY PAPER

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
CME
Andrea Pellagatti,Richard N. Armstrong,Violetta Steeples,Eshita Sharma,Emmanouela Repapi,Shalini Singh,Andrea Sanchi,Aleksandar Radujkovic,Patrick Horn,Hamid Dolatshad,Swagata Roy,John Broxholme,Helen Lockstone,Stephen Taylor,Aristoteles Giagounidis,Paresh Vyas,Anna Schuh,Angela Hamblin,Elli Papaemmanuil,Sally Killick,Luca Malcovati,Marco L. Hennrich,Anne-Claude Gavin,Anthony D. Ho,Thomas Luft,Eva Hellström-Lindberg,Mario Cazzola,Christopher W. J. Smith,Stephen Smith,Jacqueline Boultwood
View Articletitled, Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
Supplemental data

BLOOD SPOTLIGHT

Targeted therapy for fusion-driven high-risk acute leukemia
Clinical Trials & Observations
Yana Pikman,Kimberly Stegmaier
View Articletitled, Targeted therapy for fusion-driven high-risk acute leukemia

REVIEW ARTICLE

The rise of apoptosis: targeting apoptosis in hematologic malignancies
Rebecca Valentin,Stephanie Grabow,Matthew S. Davids
View Articletitled, The rise of apoptosis: targeting apoptosis in hematologic malignancies

HEMATOPOIESIS AND STEM CELLS

Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis
Elodie Pronier,Robert L. Bowman,Jihae Ahn,Jacob Glass,Cyriac Kandoth,Tiffany R. Merlinsky,Justin T. Whitfield,Benjamin H. Durham,Antoine Gruet,Amritha Varshini Hanasoge Somasundara,Raajit Rampal,Ari Melnick,Richard P. Koche,Barry S. Taylor,Ross L. Levine
View Articletitled, Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
Qing Wang,Ran Yan,Nancy Pinnell,Anna C. McCarter,Yeonjoo Oh,Yiran Liu,Cher Sha,Noah F. Garber,Yitong Chen,Qingqing Wu,Chia-Jui Ku,Ivy Tran,Amparo Serna Alarcon,Rork Kuick,James Douglas Engel,Ivan Maillard,Tomasz Cierpicki,Mark Y. Chiang
View Articletitled, Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
Supplemental data

LYMPHOID NEOPLASIA

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity
Quinlan L. Sievers,Jessica A. Gasser,Glenn S. Cowley,Eric S. Fischer,Benjamin L. Ebert
View Articletitled, Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4<sup>CRBN</sup> activity
Supplemental data
Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis
Phaik Ju Teoh,Omer An,Tae-Hoon Chung,Jing Yuan Chooi,Sabrina H. M. Toh,Shuangyi Fan,Wilson Wang,Bryan T. H. Koh,Melissa J. Fullwood,Melissa G. Ooi,Sanjay de Mel,Cinnie Y. Soekojo,Leilei Chen,Siok Bian Ng,Henry Yang,Wee Joo Chng
View Articletitled, Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome
Christine Bellanné-Chantelot,Barbara Schmaltz-Panneau,Caroline Marty,Odile Fenneteau,Isabelle Callebaut,Séverine Clauin,Aurélie Docet,Gandhi-Laurent Damaj,Thierry Leblanc,Isabelle Pellier,Cécile Stoven,Sylvie Souquere,Iléana Antony-Debré,Blandine Beaupain,Nathalie Aladjidi,Vincent Barlogis,Frédéric Bauduer,Philippe Bensaid,Odile Boespflug-Tanguy,Claire Berger,Yves Bertrand,Liana Carausu,Claire Fieschi,Claire Galambrun,Aline Schmidt,Hubert Journel,Françoise Mazingue,Brigitte Nelken,Thuan Chong Quah,Eric Oksenhendler,Marie Ouachée,Marlène Pasquet,Véronique Saada,Felipe Suarez,Gérard Pierron,William Vainchenker,Isabelle Plo,Jean Donadieu
View Articletitled, Mutations in the <em>SRP54</em> gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelets kill circulating parasites of all major Plasmodium species in human malaria
Steven Kho,Bridget E. Barber,Edison Johar,Benediktus Andries,Jeanne R. Poespoprodjo,Enny Kenangalem,Kim A. Piera,Anna Ehmann,Ric N. Price,Timothy William,Tonia Woodberry,Simon Foote,Gabriela Minigo,Tsin W. Yeo,Matthew J. Grigg,Nicholas M. Anstey,Brendan J. McMorran
View Articletitled, Platelets kill circulating parasites of all major <em>Plasmodium</em> species in human malaria
Supplemental data

LETTERS TO BLOOD

High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT
Clinical Trials & Observations
Theodore E. Warkentin,Jo-Ann I. Sheppard,Lori-Ann Linkins,Donald M. Arnold,Ishac Nazy
View Articletitled, High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT
Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes
Hemanth Tummala,Laura C. Collopy,Amanda J. Walne,Alicia Ellison,Shirleny Cardoso,Tekin Aksu,Nese Yarali,Deniz Aslan,Rüştü Fikret Akata,Juliana Teo,Zhou Songyang,Nikolas Pontikos,Jude Fitzgibbon,Kazunori Tomita,Tom Vulliamy,Inderjeet Dokal
View Articletitled, Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes
Supplemental data

BLOOD WORK

A rare case of renal intravascular NK/T-cell lymphoma
Mohamed Elshiekh,Kikkeri N. Naresh
View Articletitled, A rare case of renal intravascular NK/T-cell lymphoma

ERRATUM

Heeney MM, Guo D, De Falco L, et al. Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. Blood. 2018;132(4):448-452.
View Articletitled, Heeney MM, Guo D, De Falco L, et al. Normalizing hepcidin predicts <em>TMPRSS6</em> mutation status in patients with chronic iron deficiency. <em>Blood.</em> 2018;132(4):448-452.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Aberrant splicing in splicing factor mutant MDS
CME
View Articletitled, Aberrant splicing in splicing factor mutant MDS
  • Cover Image

    Cover Image

    issue cover

    Analysis by transmission electron microscopy of the ultrastructural aspect of bone marrow cells in a patient with a heterozygous mutation in the SRP54 gene, which encodes the signal recognition particle 54 (SRP54) GTPase protein. Notice the preapoptotic neutrophil granulocytes with abnormal clumped chromatin and large cytoplasmic vacuoles. See the article by Bellanné-Chantelot et al on page 1318.

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