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Issue Archive

Volume 131, Issue 14
April 5 2018
Issue Cover

Table of Contents

Red Cells, Iron, and Erythropoiesis
Patrolling the endothelium in sickle cell disease
Victor R. Gordeuk
View Articletitled, Patrolling the endothelium in sickle cell disease
IMMUNOBIOLOGY AND IMMUNOTHERAPY
BAFF bestows longevity on splenic plasma cells
Julie Tellier
View Articletitled, BAFF bestows longevity on splenic plasma cells
Lymphoid Neoplasia
Biomarkers in AL amyloidosis: is the summit in sight?
Ashutosh D. Wechalekar
View Articletitled, Biomarkers in AL amyloidosis: is the summit in sight?
CLINICAL TRIALS AND OBSERVATIONS
Blinatumomab for MRD+ B-ALL: the evidence strengthens
Clinical Trials & Observations
Patrick Brown
View Articletitled, Blinatumomab for MRD<sup>+</sup> B-ALL: the evidence strengthens
TRANSFUSION MEDICINE
Molecular mechanism of P1 antigen expression
Lesley J. Bruce
View Articletitled, Molecular mechanism of P1 antigen expression
Hematopoiesis and Stem Cells
Et tu, E2F1? The assassins of CML stem cells
Daniela S. Krause
View Articletitled, Et tu, E2F1? The assassins of CML stem cells

BLOOD SPOTLIGHT

The interplay of leukemia cells and the bone marrow microenvironment
Delfim Duarte,Edwin D. Hawkins,Cristina Lo Celso
View Articletitled, The interplay of leukemia cells and the bone marrow microenvironment

REVIEW ARTICLE

Mechanisms of platelet clearance and translation to improve platelet storage
M. Edward Quach,Wenchun Chen,Renhao Li
View Articletitled, Mechanisms of platelet clearance and translation to improve platelet storage

CLINICAL TRIALS AND OBSERVATIONS

Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia
Clinical Trials & Observations
Nicola Gökbuget,Hervé Dombret,Massimiliano Bonifacio,Albrecht Reichle,Carlos Graux,Christoph Faul,Helmut Diedrich,Max S. Topp,Monika Brüggemann,Heinz-August Horst,Violaine Havelange,Julia Stieglmaier,Hendrik Wessels,Vincent Haddad,Jonathan E. Benjamin,Gerhard Zugmaier,Dirk Nagorsen,Ralf C. Bargou
View Articletitled, Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Francesca Pellicano,Laura Park,Lisa E. M. Hopcroft,Mansi M. Shah,Lorna Jackson,Mary T. Scott,Cassie J. Clarke,Amy Sinclair,Sheela A. Abraham,Alan Hair,G. Vignir Helgason,Mark Aspinall-O’Dea,Ravi Bhatia,Gustavo Leone,Kamil R. Kranc,Anthony D. Whetton,Tessa L. Holyoake
View Articletitled, <em>hsa-mir183/EGR1</em>–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

BAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
Lan-Huong Thai,Simon Le Gallou,Ailsa Robbins,Etienne Crickx,Tatiana Fadeev,Zhicheng Zhou,Nicolas Cagnard,Jérôme Mégret,Christine Bole,Jean-Claude Weill,Claude-Agnès Reynaud,Matthieu Mahévas
View Articletitled, BAFF and CD4<sup>+</sup> T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
Supplemental data

LYMPHOID NEOPLASIA

Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation
Clarissa D. Osswald,Linka Xie,Hanfeng Guan,Franziska Herrmann,Sarah M. Pick,Marion J. Vogel,Franziska Gehringer,Fong Chun Chan,Christian Steidl,Thomas Wirth,Alexey Ushmorov
View Articletitled, Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation
Supplemental data
Growth differentiation factor-15 is a new biomarker for survival and renal outcomes in light chain amyloidosis
Clinical Trials & Observations
Efstathios Kastritis,Ioannis Papassotiriou,Giampaolo Merlini,Paolo Milani,Evangelos Terpos,Marco Basset,Athanasios Akalestos,Francesca Russo,Erasmia Psimenou,Filia Apostolakou,Maria Roussou,Maria Gavriatopoulou,Evangelos Eleutherakis-Papaiakovou,Despina Fotiou,Dimitrios C. Ziogas,Elektra Papadopoulou,Constantinos Pamboucas,Meletios A. Dimopoulos,Giovanni Palladini
View Articletitled, Growth differentiation factor-15 is a new biomarker for survival and renal outcomes in light chain amyloidosis
Supplemental data

MYELOID NEOPLASIA

Integrated molecular profiling of juvenile myelomonocytic leukemia
Norihiro Murakami,Yusuke Okuno,Kenichi Yoshida,Yuichi Shiraishi,Genta Nagae,Kyogo Suzuki,Atsushi Narita,Hirotoshi Sakaguchi,Nozomu Kawashima,Xinan Wang,Yinyan Xu,Kenichi Chiba,Hiroko Tanaka,Asahito Hama,Masashi Sanada,Masafumi Ito,Masashi Hirayama,Arata Watanabe,Toshihide Ueno,Seiji Kojima,Hiroyuki Aburatani,Hiroyuki Mano,Satoru Miyano,Seishi Ogawa,Yoshiyuki Takahashi,Hideki Muramatsu
View Articletitled, Integrated molecular profiling of juvenile myelomonocytic leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8
Yang Zhao,Xiaofei Shen,Ning Na,Zhulang Chu,Huiting Su,Shanshan Chao,Lu Shi,Yanan Xu,Lianfeng Zhang,Bingyi Shi,Yong Zhao
View Articletitled, mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

HO-1hi patrolling monocytes protect against vaso-occlusion in sickle cell disease
Yunfeng Liu,Fangmiao Jing,Woelsung Yi,Avital Mendelson,Patricia Shi,Ronald Walsh,David F. Friedman,Caterina Minniti,Deepa Manwani,Stella T. Chou,Karina Yazdanbakhsh
View Articletitled, HO-1<sup>hi</sup> patrolling monocytes protect against vaso-occlusion in sickle cell disease
Supplemental data

TRANSFUSION MEDICINE

Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT
Brief Report
Julia S. Westman,Linn Stenfelt,Karina Vidovic,Mattias Möller,Åsa Hellberg,Sven Kjellström,Martin L. Olsson
View Articletitled, Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of <em>A4GALT</em>
Supplemental data

LETTERS TO BLOOD

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia
Marina Wierz,Sandrine Pierson,Léa Guyonnet,Elodie Viry,Audrey Lequeux,Anaïs Oudin,Simone P. Niclou,Markus Ollert,Guy Berchem,Bassam Janji,Coralie Guérin,Jerome Paggetti,Etienne Moussay
View Articletitled, Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia
Supplemental data
No red blood cell damage and no hemolysis in G6PD-deficient subjects after ingestion of low vicine/convicine Vicia faba seeds
Valentina Gallo,Oleksii A. Skorokhod,Luigi Felice Simula,Tiziana Marrocco,Elisa Tambini,Evelin Schwarzer,Pascal Marget,Gérard Duc,Paolo Arese
View Articletitled, No red blood cell damage and no hemolysis in G6PD-deficient subjects after ingestion of low vicine/convicine <em>Vicia faba</em> seeds

BLOOD WORK

Abnormalities of platelet aggregation associated with giant granules in a subset of platelets
Chen Yang,Ronald Jackups, Jr
View Articletitled, Abnormalities of platelet aggregation associated with giant granules in a subset of platelets
A neonate presenting with jaundice, anemia, and thrombocytopenia
Helle Borgstrøm Hager,Mari Tjernsmo Andersen
View Articletitled, A neonate presenting with jaundice, anemia, and thrombocytopenia
All Issues

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Cardiac complete response in AL amyloidosis has similar survival to matched general population
Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma
Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.
NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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